Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis

Journal of Neuroscience

Volumn 24, Issue 41, 2004, Pages 9097-9104

  Beene, Darren L ^a   Price, Kerry L ^c   Lester, Henry A ^b   Dougherty, Dennis A ^a   Lummis, Sarah C R ^c,d  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NONE   (United Kingdom)

Author keywords

5 HT3 receptor binding site; Activation mechanism; Cys loop receptor; Hydrogen bond; Ligand gated ion channel; Serotonin; Unnatural amino acids

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; COMPLEMENTARY RNA; ION CHANNEL; MESSENGER RNA; SEROTONIN; SEROTONIN 3 RECEPTOR; TRANSFER RNA; TYROSINE;

ANIMAL CELL; ARTICLE; BINDING SITE; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; XENOPUS LAEVIS;

AMINO ACIDS; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELLS, CULTURED; HYDROGEN BONDING; ION CHANNEL GATING; LIGANDS; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; RECEPTORS, SEROTONIN, 5-HT3; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; XENOPUS LAEVIS;

EID: 5644237713     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2429-04.2004     Document Type: Article

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