3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors

Trends in Pharmacological Sciences

Volumn 29, Issue 9, 2008, Pages 437-444

  Jensen, Anders A ^a   Davies, Paul A ^b   Bräuner Osborne, Hans ^a   Krzywkowski, Karen ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; SEROTONIN 3B RECEPTOR; UNCLASSIFIED DRUG;

CENTRAL NERVOUS SYSTEM; DRUG TARGETING; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR DENSITY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

HUMANS; RECEPTORS, SEROTONIN, 5-HT3;

EID: 50249105158     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2008.06.001     Document Type: Review

References (63)

1. 3 receptors. Curr. Pharm. Des. 12 (2006) 3615-3630
2. Jensen A.A., et al. Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications and therapeutic inspirations. J. Med. Chem. 48 (2005) 4705-4745
3. Whiting P.J. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?. Drug Discov. Today 8 (2003) 445-450
4. Lynch J.W. Molecular structure and function of the glycine receptor chloride channel. Physiol. Rev. 84 (2004) 1051-1095
5. 3 receptors in the central nervous system. Cell Tissue Res. 326 (2006) 573-581
6. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
7. Hornby P.J. Central neurocircuitry associated with emesis. Am. J. Med. 111 (2001) 106S-112S
8. 3 receptor as a therapeutic target. Expert Opin. Ther. Targets 11 (2007) 527-540
9. 3 receptor, a serotonin-gated ion channel. Science 254 (1991) 432-437
10. 3 receptors really homomeric complexes?. Trends Pharmacol. Sci. 19 (1998) 212-215
11. 3B subunit is a major determinant of serotonin-receptor function. Nature 397 (1999) 359-363
12. 3B receptor subunit. J. Biol. Chem. 274 (1999) 30799-30810
13. 3 receptors in rodents. J. Neurochem. 75 (2000) 240-247
14. 3A receptor isoforms. Naunyn Schmiedebergs Arch. Pharmacol. 362 (2000) 392-401
15. Tzvetkov M.V., et al. Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. Gene 386 (2007) 52-62
16. Dubin, A.E. et al. (2002) Ortho-McNeil Pharmaceutical. DNA encoding a human subunit 5-HT3-C of the 5-HT3 serotonin receptor. United States Patent 6,365,370
17. 3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 310 (2003) 101-111
18. Karnovsky A.M., et al. A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene 319 (2003) 137-148
19. 3E. Mol. Pharmacol. 72 (2007) 8-17
20. 3 receptors in the CNS: 3B or not 3B?. Trends Pharmacol. Sci. 24 (2003) 157-160
21. 2+-permeable ion channels. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 11456-11461
22. 3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. J. Neurosci. 22 (2002) 7389-7397
23. 3 receptors in rat CA1 hippocampal interneurons: functional and molecular characterization. J. Physiol. 544 (2002) 715-726
24. 3 receptors synthesized in the rat CNS and peripheral nervous system. J. Neurosci. 22 (2002) 6732-6741
25. 3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus. Neuropharmacology 41 (2001) 1013-1016
26. 3B receptor subunit in the central and peripheral nervous systems in rodents. Eur. J. Neurosci. 26 (2007) 355-366
27. 3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci. 7 (2006) 27
28. 3 subtype of serotonin receptor in primary cultures of rodent hippocampus. Neurosci. Lett. 174 (1994) 133-136
29. 3 receptors in clonal cell lines studied by patch-clamp techniques. Br. J. Pharmacol. 97 (1989) 27-40
30. Hussy N., et al. Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors. J. Physiol. 481 (1994) 311-323
31. 3 receptor ligand-gated ion channels. Receptors Channels 3 (1995) 7-12
32. 3 receptor. J. Neurophysiol. 65 (1991) 630-638
33. 3B receptor subunits in human hippocampus. Neuropharmacology 52 (2007) 1284-1290
34. 3 receptors. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 12595-12600
35. Nelson M.E., et al. Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors. Mol. Pharmacol. 63 (2003) 332-341
36. 3 human acetylcholine receptors. Mol. Pharmacol. 71 (2007) 769-776
37. Niesler B., et al. Association between the 5′ UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder. Pharmacogenetics 11 (2001) 471-475
38. Meineke C., et al. Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene. Pharmacogenet. Genomics 18 (2008) 219-230
39. 3 receptor mutations identified in schizophrenic patients. J. Mol. Neurosci. 30 (2006) 273-281
40. 3 receptor function and expression. Pharmacogenet. Genomics 17 (2007) 255-266
41. 3AB receptor. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 722-727
42. Small K.M., et al. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 381-411
43. D'Souza U.M., and Craig I.W. Functional polymorphisms in dopamine and serotonin pathway genes. Hum. Mutat. 27 (2006) 1-13
44. Steinlein O.K. Genetic mechanisms that underlie epilepsy. Nat. Rev. Neurosci. 5 (2004) 400-408
45. 3 genes contribute to pathological phenotypes?. Biochem. Soc. Trans. 34 (2006) 872-876
46. Niesler B., et al. Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients. Pharmacogenetics 11 (2001) 21-27
47. Melke J., et al. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. Arch. Gen. Psychiatry 60 (2003) 1017-1023
48. Tremblay P.B., et al. Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients. J. Clin. Oncol. 21 (2003) 2147-2155
49. Iidaka T., et al. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J. Neurosci. 25 (2005) 6460-6466
50. Jönsson E.G., et al. Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers. BMC Psychiatry 4 (2004) 4. www.biomedcentral.com 10.1186/1471-244X-4-4
51. Frank B., et al. Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 131 (2004) 1-5
52. Kato M., et al. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology 53 (2006) 186-195
53. Yamada K., et al. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol. Psychiatry 60 (2006) 192-201
54. Sugai T., et al. The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine. Pharmacogenomics J. 6 (2006) 351-356
55. Mizuta N., et al. Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder. Psychiatr. Genet. 18 (2008) 44
56. Ruano G., et al. Physiogenomic association of statin-related myalgia to serotonin receptors. Muscle Nerve 36 (2007) 329-335
57. Fasching P.A., et al. Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J. Cancer Res. Clin. Oncol. (2008). http://www.springerlink.com 10.1007/s00432-008-0387-1
58. Suzuki Y., et al. Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients. Neuropsychopharmacology 31 (2006) 825-831
59. Tanaka M., et al. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. Int. J. Neuropsychopharmacol. 11 (2008) 261-267
60. Niesler B., et al. Serotonin receptor genes HTR3A and HTR3B are not involved in Gilles de la Tourette syndrome. Psychiatr. Genet. 15 (2005) 303-304
61. Frank B., et al. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. Clin. Rheumatol. 23 (2004) 338-344
62. 3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2002) G1398-G1411
63. Houtani T., et al. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. Biochem. Biophys. Res. Commun. 335 (2005) 277-285