The Eyes Absent proteins in development and disease

Cellular and Molecular Life Sciences

Volumn 70, Issue 11, 2013, Pages 1897-1913

  Tadjuidje, Emmanuel ^a   Hegde, Rashmi S ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Cancer; Cell migration; EYA; Eyes absent; Organ development

Indexed keywords

BENZARONE; BENZBROMARONE; DUAL SPECIFICITY PHOSPHATASE; EYES ABSENT 1 PROTEIN; EYES ABSENT 2 PROTEIN; EYES ABSENT 3 PROTEIN; EYES ABSENT 4 PROTEIN; EYES ABSENT PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; BRANCHIOOTORENAL SYNDROME; CELL MIGRATION; CELL POLARITY; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CRANIOFACIAL DEVELOPMENT; DEVELOPMENT; DEVELOPMENTAL DISORDER; DNA REPAIR; DRUG TARGETING; EAR DEVELOPMENT; EMBRYO DEVELOPMENT; EYE DEVELOPMENT; GENE MUTATION; HEART DEVELOPMENT; HUMAN; INNATE IMMUNITY; KIDNEY DEVELOPMENT; NEOPLASM; NONHUMAN; ORGANOGENESIS; PHOTOPERIODICITY; PROTEIN DOMAIN; REVIEW; TRANSACTIVATION;

ANIMALS; BRANCHIO-OTO-RENAL SYNDROME; CELL MOVEMENT; CELL POLARITY; DNA REPAIR; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EMBRYONIC DEVELOPMENT; EYE PROTEINS; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; NUCLEAR PROTEINS; PROTEIN TYROSINE PHOSPHATASES; TRANS-ACTIVATORS;

ANIMALIA;

EID: 84878285037     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1144-9     Document Type: Review

References (156)

1. NM Bonini WM Leiserson S Benzer 1998 Multiple roles of the eyes absent gene in Drosophila Dev Biol 196 1 42 57 9527880 1:CAS:528:DyaK1cXisFSgsr8%3D
2. G Halder P Callaerts S Flister U Walldorf U Kloter WJ Gehring 1998 Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development Development 125 12 2181 2191 9584118 1:CAS:528:DyaK1cXksFanu74%3D
3. WM Leiserson S Benzer NM Bonini 1998 Dual functions of the Drosophila eyes absent gene in the eye and embryo Mech Dev 73 2 193 202 9622628 1:CAS:528:DyaK1cXjtVKksLw%3D
4. NM Bonini WM Leiserson S Benzer 1993 The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye Cell 72 3 379 395 8431945 1:CAS:528:DyaK3sXitlSmtrc%3D
5. NM Bonini QT Bui GL Gray-Board JM Warrick 1997 The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates Development 124 23 4819 4826 9428418 1:CAS:528:DyaK1cXit1CitA%3D%3D
6. H Ohto S Kamada K Tago SI Tominaga H Ozaki S Sato K Kawakami 1999 Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya Mol Cell Biol 19 10 6815 6824 10490620 1:CAS:528: DyaK1MXmtlalsr8%3D
7. X Li KA Oghi J Zhang A Krones KT Bush CK Glass SK Nigam AK Aggarwal R Maas DW Rose MG Rosenfeld 2003 Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis Nature 426 6964 247 254 14628042 1:CAS:528:DC%2BD3sXptVOisLk%3D
8. K Ikeda Y Watanabe H Ohto K Kawakami 2002 Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein Mol Cell Biol 22 19 6759 6766 12215533 1:CAS:528:DC%2BD38XntFansbk%3D
9. JP Rayapureddi C Kattamuri BD Steinmetz BJ Frankfort EJ Ostrin G Mardon RS Hegde 2003 Eyes absent represents a class of protein tyrosine phosphatases Nature 426 6964 295 298 14628052 1:CAS:528:DC%2BD3sXptVOitr8%3D
10. TL Tootle SJ Silver EL Davies V Newman RR Latek IA Mills JD Selengut BE Parlikar I Rebay 2003 The transcription factor Eyes absent is a protein tyrosine phosphatase Nature 426 6964 299 302 14628053 1:CAS:528:DC%2BD3sXptVOitrw%3D
11. NK Tonks 2006 Protein tyrosine phosphatases: from genes, to function, to disease Nat Rev Mol Cell Biol 7 11 833 846 10.1038/nrm2039 17057753 1:CAS:528:DC%2BD28XhtFSms77I
12. A Alonso J Sasin N Bottini I Friedberg A Osterman A Godzik T Hunter J Dixon T Mustelin 2004 Protein tyrosine phosphatases in the human genome Cell 117 6 699 711 15186772 1:CAS:528:DC%2BD2cXltlKisbc%3D
13. GB Moorhead V De Wever G Templeton D Kerk 2009 Evolution of protein phosphatases in plants and animals Biochem J 417 2 401 409 10.1042/BJ20081986 19099538 1:CAS:528:DC%2BD1cXhsFCisLfO
14. SK Jung DG Jeong SJ Chung JH Kim BC Park NK Tonks SE Ryu SJ Kim 2010 Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor FASEB J 24 2 560 569 10.1096/fj.09-143891 19858093 1:CAS:528:DC%2BC3cXhs1Ggsr8%3D
15. N Mermod EA O'Neill TJ Kelly R Tjian 1989 The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain Cell 58 4 741 753 10.1016/0092-8674(89)90108-6 2504497 1:CAS:528:DyaL1MXlvV2lur0%3D
16. PX Xu J Cheng JA Epstein RL Maas 1997 Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function Proc Natl Acad Sci USA 94 22 11974 11979 9342347 1:CAS:528:DyaK2sXntFSmsLs%3D
17. Y Okabe T Sano S Nagata 2009 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature 460 7254 520 524 10.1038/nature08138 19561593 1:CAS:528:DC%2BD1MXnslKqtLk%3D
18. T Sano S Nagata 2011 Characterization of the threonine-phosphatase of mouse eyes absent 3 FEBS Lett 585 17 2714 2719 10.1016/j.febslet.2011.07.029 21821028 1:CAS:528:DC%2BC3MXhtV2it73E
19. Y Takeda S Hatano N Sentoku M Matsuoka 1999 Homologs of animal eyes absent (eya) genes are found in higher plants Mol Gen Genet 262 1 131 138 10503544 1:CAS:528:DyaK1MXmt1yitLY%3D
20. KI Patterson T Brummer PM O'Brien RJ Daly 2009 Dual-specificity phosphatases: critical regulators with diverse cellular targets Biochem J 418 3 475 489 19228121 1:CAS:528:DC%2BD1MXitlWhtbs%3D
21. R Pulido R Hooft van Huijsduijnen 2008 Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease FEBS J 275 5 848 866 10.1111/j.1742-4658.2008.06250.x 18298792 1:CAS:528:DC%2BD1cXivFaqtL4%3D
22. PJ Cook BG Ju F Telese X Wang CK Glass MG Rosenfeld 2009 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions Nature 458 7238 591 596 10.1038/nature07849 19234442 1:CAS:528:DC%2BD1MXitFKls7k%3D
23. N Krishnan DG Jeong SK Jung SE Ryu A Xiao CD Allis SJ Kim NK Tonks 2009 Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent J Biol Chem 284 24 16066 16070 10.1074/jbc.C900032200 19351884 1:CAS:528:DC%2BD1MXmvFSjsLg%3D
24. F Pignoni B Hu KH Zavitz J Xiao PA Garrity SL Zipursky 1997 The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development [published erratum appears in Cell 1998 Feb 20;92(4):following 585] Cell 91 7 881 891 9428512 1:CAS:528:DyaK1cXjtVKjsQ%3D%3D
25. R Chen M Amoui Z Zhang G Mardon 1997 Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila [see comments] Cell 91 7 893 903 9428513 1:CAS:528: DyaK1cXjtVKjtg%3D%3D
26. TA Heanue R Reshef RJ Davis G Mardon G Oliver S Tomarev AB Lassar CJ Tabin 1999 Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation Genes Dev 13 24 3231 3243 10617572 1:CAS:528:DC%2BD3cXktFChtw%3D%3D
27. SJ Silver EL Davies L Doyon I Rebay 2003 Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network Mol Cell Biol 23 17 5989 5999 12917324 1:CAS:528:DC%2BD3sXms1OhsbY%3D
28. J Zhou C Wang Z Wang W Dampier K Wu MC Casimiro I Chepelev VM Popov A Quong A Tozeren K Zhao MP Lisanti RG Pestell 2010 Attenuation of Forkhead signaling by the retinal determination factor DACH1 Proc Natl Acad Sci USA 107 15 6864 6869 10.1073/pnas.1002746107 20351289 1:CAS:528:DC%2BC3cXltFSjurc%3D
29. SS Kim R Zhang SE Braunstein A Joachimiak A Cvekl RS Hegde 2002 Structure of the retinal determination protein dachshund reveals a DNA binding motif Structure 10 6 787 795 12057194 1:CAS:528:DC%2BD38XksFOisr4%3D
30. J Zhou Y Liu W Zhang VM Popov M Wang N Pattabiraman C Sune A Cvekl K Wu J Jiang C Wang RG Pestell 2010 Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1 J Biol Chem 285 51 40342 40350 10.1074/jbc.M110.156141 20956529 1:CAS:528: DC%2BC3cXhsFChtLvO
31. AN Patrick BJ Schiemann K Yang R Zhao HL Ford 2009 Biochemical and functional characterization of six SIX1 branchio-oto-renal syndrome mutations J Biol Chem 284 31 20781 20790 10.1074/jbc.M109.016832 19497856 1:CAS:528:DC%2BD1MXovFWrt7w%3D
32. X Zhu MG Rosenfeld 2004 Transcriptional control of precursor proliferation in the early phases of pituitary development Curr Opin Genet Dev 14 5 567 574 10.1016/j.gde.2004.08.006S0959-437X 15380249 1:CAS:528: DC%2BD2cXnslGms7k%3D
33. RN Pandey R Rani EJ Yeo M Spencer S Hu RA Lang RS Hegde 2010 The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells Oncogene 29 25 3715 3722 10.1038/onc.2010.122 20418914 1:CAS:528:DC%2BC3cXltFKltrk%3D
34. J Jemc I Rebay 2007 The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription Annu Rev Biochem 76 513 538 17341163 1:CAS:528:DC%2BD2sXhtVehtb%2FF
35. X Li V Perissi F Liu DW Rose MG Rosenfeld 2002 Tissue-specific regulation of retinal and pituitary precursor cell proliferation Science 297 5584 1180 1183 12130660 1:CAS:528:DC%2BD38XmsVOht7k%3D
36. F Spitz J Demignon A Porteu A Kahn JP Concordet D Daegelen P Maire 1998 Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site Proc Natl Acad Sci USA 95 24 14220 14225 9826681 1:CAS:528:DyaK1cXns1Gmu78%3D
37. RD Coletta K Christensen KJ Reichenberger J Lamb D Micomonaco L Huang DM Wolf C Muller-Tidow TR Golub K Kawakami HL Ford 2004 The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1 Proc Natl Acad Sci USA 101 17 6478 6483 15123840 1:CAS:528:DC%2BD2cXjvVyitLY%3D
38. K Kawakami H Ohto K Ikeda RG Roeder 1996 Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development Nucleic Acids Res 24 2 303 310 8628654 1:CAS:528:DyaK28Xps1aiug%3D%3D
39. S Brodbeck B Besenbeck C Englert 2004 The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter Mech Dev 121 10 1211 1222 15327782 1:CAS:528:DC%2BD2cXmvFyrtb4%3D
40. R Grifone C Laclef F Spitz S Lopez J Demignon JE Guidotti K Kawakami PX Xu R Kelly BJ Petrof D Daegelen JP Concordet P Maire 2004 Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype Mol Cell Biol 24 14 6253 6267 15226428 1:CAS:528:DC%2BD2cXlslensLY%3D
41. CL Himeda JA Ranish JC Angello P Maire R Aebersold SD Hauschka 2004 Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer Mol Cell Biol 24 5 2132 2143 14966291 1:CAS:528:DC%2BD2cXhvVWgtbs%3D
42. Z Ando S Sato K Ikeda K Kawakami 2005 Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4 FEBS J 272 12 3026 3041 10.1111/j.1742-4658.2005.04716.x 15955062 1:CAS:528:DC%2BD2MXlslCiurk%3D
43. Y Yu E Davicioni TJ Triche G Merlino 2006 The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis Cancer Res 66 4 1982 1989 16488997 1:CAS:528: DC%2BD28XhsFamurg%3D
44. LE Sander JM Blander 2009 Innate immune cells cast an eye on DNA J Mol Cell Biol 1 2 77 79 10.1093/jmcb/mjp023 19789172 1:CAS:528:DC%2BC3cXlsVSitr0%3D
45. S Li CM Armstrong N Bertin H Ge S Milstein M Boxem PO Vidalain JD Han A Chesneau T Hao DS Goldberg N Li M Martinez JF Rual P Lamesch L Xu M Tewari SL Wong LV Zhang GF Berriz L Jacotot P Vaglio J Reboul T Hirozane-Kishikawa Q Li HW Gabel A Elewa B Baumgartner DJ Rose H Yu S Bosak R Sequerra A Fraser SE Mango WM Saxton S Strome S Van Den Heuvel F Piano J Vandenhaute C Sardet M Gerstein L Doucette-Stamm KC Gunsalus JW Harper ME Cusick FP Roth DE Hill M Vidal 2004 A map of the interactome network of the metazoan C. elegans Science 303 5657 540 543 10.1126/science.10914031091403 14704431 1:CAS:528:DC%2BD2cXlt1emtA%3D%3D
46. X Fan LF Brass M Poncz F Spitz P Maire DR Manning 2000 The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins J Biol Chem 275 41 32129 32134 10906137 1:CAS:528:DC%2BD3cXnsFejtrs%3D
47. N Azuma A Hirakiyama T Inoue A Asaka M Yamada 2000 Mutations of a human homologue of the Drosophila eyes absent gene (EYA1) detected in patients with congenital cataracts and ocular anterior segment anomalies Hum Mol Genet 9 3 363 366 10655545 1:CAS:528:DC%2BD3cXhsVOjtbk%3D
48. J Weng J Luo X Cheng C Jin X Zhou J Qu L Tu D Ai D Li J Wang JF Martin BA Amendt M Liu 2008 Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2 Proc Natl Acad Sci USA 105 16 6081 6086 10.1073/pnas.0708257105 18424556 1:CAS:528:DC%2BD1cXltlGitbw%3D
49. K Landgraf F Bollig MO Trowe B Besenbeck C Ebert D Kruspe A Kispert F Hanel C Englert 2010 Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development Mol Cell Biol 30 24 5764 5775 10.1128/MCB.01645-09 20956555 1:CAS:528:DC%2BC3MXpslWhug%3D%3D
50. AH El-Hashash G Turcatel D Al Alam S Buckley H Tokumitsu S Bellusci D Warburton 2011 Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Development 138 7 1395 1407 10.1242/dev.058479 21385765 1:CAS:528:DC%2BC3MXms1Wgu7c%3D
51. MP Stokes J Rush J Macneill JM Ren K Sprott J Nardone V Yang SA Beausoleil SP Gygi M Livingstone H Zhang RD Polakiewicz MJ Comb 2007 Profiling of UV-induced ATM/ATR signaling pathways Proc Natl Acad Sci USA 104 50 19855 19860 10.1073/pnas.0707579104 18077418 1:CAS:528:DC%2BD1cXitFSqsw%3D%3D
52. W Xiong NM Dabbouseh I Rebay 2009 Interactions with the abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm Dev Cell 16 2 271 279 10.1016/j.devcel.2008.12.005 19217428 1:CAS:528:DC%2BD1MXis1aksrk%3D
53. SA Morillo LR Braid EM Verheyen I Rebay 2012 Nemo phosphorylates Eyes absent and enhances output from the Eya-sine oculis transcriptional complex during Drosophila retinal determination Dev Biol 365 1 267 276 10.1016/j.ydbio.2012.02.030 22394486 1:CAS:528:DC%2BC38Xkslaqtr4%3D
54. D Zou C Erickson EH Kim D Jin B Fritzsch PX Xu 2008 Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear Hum Mol Genet 17 21 3340 3356 10.1093/hmg/ddn229 18678597 1:CAS:528:DC%2BD1cXht1entrvM
55. M Ahmed EY Wong J Sun J Xu F Wang PX Xu 2012 Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2 Dev Cell 22 2 377 390 10.1016/j.devcel.2011. 12.006 22340499 1:CAS:528:DC%2BC38Xit12gs7o%3D
56. M Furuya H Qadota AD Chisholm A Sugimoto 2005 The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6 Dev Biol 286 2 452 463 10.1016/j.ydbio.2005.08.011 16154558 1:CAS:528:DC%2BD2MXhtFWntb7F
57. M Kriebel F Muller T Hollemann 2007 Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos Dev Dyn 236 6 1526 1534 17477401 1:CAS:528:DC%2BD2sXnvFOhtr0%3D
58. D Zou D Silvius S Rodrigo-Blomqvist S Enerback PX Xu 2006 Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear Dev Biol 298 2 430 441 16916509 1:CAS:528:DC%2BD28XhtVWqurnL
59. PX Xu J Adams H Peters MC Brown S Heaney R Maas 1999 Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia Nat Genet 23 1 113 117 10471511 1:CAS:528:DyaK1MXlvFWht7k%3D
60. AH El-Hashash D Al Alam G Turcatel S Bellusci D Warburton 2011 Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung Dev Biol 350 1 112 126 10.1016/j.ydbio.2010.11.022 21129374 1:CAS:528:DC%2BC3MXnsVSmtQ%3D%3D
61. SW Clark BE Fee JL Cleveland 2002 Misexpression of the eyes absent family triggers the apoptotic program J Biol Chem 277 5 3560 3567 11700312 1:CAS:528:DC%2BD38XhtVaktL0%3D
62. T Hirose BD Galvin HR Horvitz 2010 Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans Proc Natl Acad Sci USA 107 35 15479 15484 10.1073/pnas.1010023107 20713707 1:CAS:528:DC%2BC3cXhtFaqu77N
63. M Boyle N Bonini S DiNardo 1997 Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm Development 124 5 971 982 9056773 1:CAS:528:DyaK2sXit1ylu70%3D
64. PX Xu I Woo H Her DR Beier RL Maas 1997 Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode Development 124 1 219 231 9006082 1:CAS:528:DyaK2sXnsFCnuw%3D%3D
65. N Mishima S Tomarev 1998 Chicken Eyes absent 2 gene: isolation and expression pattern during development Int J Dev Biol 42 8 1109 1115 9879708 1:CAS:528:DyaK1MXht1yhsLw%3D
66. I Sahly P Andermann C Petit 1999 The zebrafish eya1 gene and its expression pattern during embryogenesis Dev Genes Evol 209 7 399 410 92090399.427 10370123 1:CAS:528:DyaK1MXjslWqtbk%3D
67. R David K Ahrens D Wedlich G Schlosser 2001 Xenopus Eya1 demarcates all neurogenic placodes as well as migrating hypaxial muscle precursors Mech Dev 103 1-2 189 192 S0925477301003550 11335132 1:CAS:528:DC%2BD3MXjtFGhurs%3D
68. E Tadjuidje TS Wang RN Pandey S Sumanas RA Lang RS Hegde 2012 The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone PLoS One 7 4 e34806 22545090 1:CAS:528:DC%2BC38Xmslanu7Y%3D
69. SJ Miller ZD Lan A Hardiman J Wu JJ Kordich DM Patmore RS Hegde TP Cripe JA Cancelas MH Collins N Ratner 2009 Inhibition of Eyes absent homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis Oncogene 29 3 368 379 10.1038/onc.2009.360 19901965
70. A Kinner W Wu C Staudt G Iliakis 2008 Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin Nucleic Acids Res 36 17 5678 5694 10.1093/nar/gkn550 18772227 1:CAS:528:DC%2BD1MXisFOksg%3D%3D
71. A Xiao H Li D Shechter SH Ahn LA Fabrizio H Erdjument-Bromage S Ishibe-Murakami B Wang P Tempst K Hofmann DJ Patel SJ Elledge CD Allis 2009 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity Nature 457 7225 57 62 10.1038/nature07668 19092802 1:CAS:528: DC%2BD1MXhtVGitQ%3D%3D
72. A Xie S Odate G Chandramouly R Scully 2010 H2AX post-translational modifications in the ionizing radiation response and homologous recombination Cell Cycle 9 17 3602 3610 10.4161/cc.9.17.12884 20703100 1:CAS:528: DC%2BC3MXlsVansw%3D%3D
73. M Economopoulou HF Langer A Celeste VV Orlova EY Choi M Ma A Vassilopoulos E Callen C Deng CH Bassing M Boehm A Nussenzweig T Chavakis 2009 Histone H2AX is integral to hypoxia-driven neovascularization Nat Med 15 5 553 558 10.1038/nm.1947 19377486 1:CAS:528:DC%2BD1MXks12kt74%3D
74. CA Wang P Jedlicka AN Patrick DS Micalizzi KC Lemmer E Deitsch M Casas-Selves JC Harrell HL Ford 2012 SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer J Clin Invest 122 5 1895 1906 10.1172/JCI59858 22466647 1:CAS:528:DC%2BC38Xmsl2jsL0%3D
75. RG Edwards HK Beard 1997 Oocyte polarity and cell determination in early mammalian embryos Mol Hum Reprod 3 10 863 905 9395264 1:CAS:528: DyaK2sXnsl2isL0%3D
76. B Plusa AK Hadjantonakis D Gray K Piotrowska-Nitsche A Jedrusik VE Papaioannou DM Glover M Zernicka-Goetz 2005 The first cleavage of the mouse zygote predicts the blastocyst axis Nature 434 7031 391 395 10.1038/nature03388 15772664 1:CAS:528:DC%2BD2MXit1yqsr4%3D
77. J Bai D Montell 2002 Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis Development 129 23 5377 5388 12403709 1:CAS:528:DC%2BD3sXjsFar
78. WM Leiserson NM Bonini S Benzer 1994 Transvection at the eyes absent gene of Drosophila Genetics 138 4 1171 1179 7896099 1:CAS:528:DyaK28Xhs1eit74%3D
79. MK Duncan L Kos NA Jenkins DJ Gilbert NG Copeland SI Tomarev 1997 Eyes absent: a gene family found in several metazoan phyla Mamm Genome 8 7 479 485 9195991 1:CAS:528:DyaK2sXks1Klt7g%3D
80. G Borsani A DeGrandi A Ballabio A Bulfone L Bernard S Banfi C Gattuso M Mariani M Dixon D Donnai K Metcalfe R Winter M Robertson R Axton A Brown V van Heyningen I Hanson 1999 EYA4, a novel vertebrate gene related to Drosophila eyes absent Hum Mol Genet 8 1 11 23 9887327 1:CAS:528:DyaK1MXoslentg%3D%3D
81. JE Zimmerman QT Bui E Steingrimsson DL Nagle W Fu A Genin NB Spinner NG Copeland NA Jenkins M Bucan NM Bonini 1997 Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene Genome Res 7 2 128 141 9049631 1:CAS:528:DyaK2sXhtlemsLY%3D
82. KM Neilson F Pignoni B Yan M SA 2010 Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors Dev Dyn 239 12 3446 3466 10.1002/dvdy.22484 21089078 1:CAS:528:DC%2BC3MXitleitQ%3D%3D
83. F Fougerousse M Durand S Lopez L Suel J Demignon C Thornton H Ozaki K Kawakami P Barbet JS Beckmann P Maire 2002 Six and Eya expression during human somitogenesis and MyoD gene family activation J Muscle Res Cell Motil 23 3 255 264 12500905 1:CAS:528:DC%2BD38Xotleksb0%3D
84. JC Eissenberg JS Ryerse 1991 ey-2: A recessive eyeless mutation on the second chromosome of Drosophila melanogaster Drosophila Inf Serv 70 266 268
85. J Sved 1986 Eyes Absent (eya) Drosophila Inf Serv 63 169
86. QT Bui JE Zimmerman H Liu NM Bonini 2000 Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain Genetics 155 2 709 720 10835393 1:CAS:528:DC%2BD3cXkslyqtbg%3D
87. S Abdelhak V Kalatzis R Heilig S Compain D Samson C Vincent D Weil C Cruaud I Sahly M Leibovici M Bitner-Glindzicz M Francis D Lacombe J Vigneron R Charachon K Boven P Bedbeder N Van Regemorter J Weissenbach C Petit 1997 A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family Nat Genet 15 2 157 164 10.1038/ng0297-157 9020840 1:CAS:528:DyaK2sXhtVOlsLk%3D
88. V Kalatzis I Sahly A El-Amraoui C Petit 1998 Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of branchio-oto-renal (BOR) syndrome Dev Dyn 213 4 486 499 9853969 1:CAS:528:DyaK1cXotVGnsLY%3D
89. T Ishihara K Ikeda S Sato H Yajima K Kawakami 2008 Differential expression of Eya1 and Eya2 during chick early embryonic development Gene Expr Patterns 8 5 357 367 10.1016/j.gep.2008.01.003 18316249 1:CAS:528: DC%2BD1cXkvVOmt7k%3D
90. G Sajithlal D Zou D Silvius PX Xu 2005 Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme Dev Biol 284 2 323 336 10.1016/j.ydbio.2005.05.029 16018995 1:CAS:528:DC%2BD2MXpt1elu7c%3D
91. PX Xu W Zheng L Huang P Maire C Laclef D Silvius 2003 Six1 is required for the early organogenesis of mammalian kidney Development 130 14 3085 3094 12783782 1:CAS:528:DC%2BD3sXlvF2gt7g%3D
92. X Nie J Xu A El-Hashash PX Xu 2011 Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis Dev Biol 352 1 141 151 10.1016/j.ydbio.2011.01.027 21281623 1:CAS:528:DC%2BC3MXjsFaltL4%3D
93. M Self OV Lagutin B Bowling J Hendrix Y Cai GR Dressler G Oliver 2006 Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney EMBO J 25 21 5214 5228 10.1038/sj.emboj.7601381 17036046 1:CAS:528:DC%2BD28XhtFChsrzL
94. G Schlosser K Ahrens 2004 Molecular anatomy of placode development in Xenopus laevis Dev Biol 271 2 439 466 10.1016/j.ydbio.2004.04.013s 15223346 1:CAS:528:DC%2BD2cXlt1ensb4%3D
95. S Abdelhak V Kalatzis R Heilig S Compain D Samson C Vincent F Levi-Acobas C Cruaud M Le Merrer M Mathieu R Konig J Vigneron J Weissenbach C Petit D Weil 1997 Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1 Hum Mol Genet 6 13 2247 2255 9361030 1:CAS:528:DyaK2sXotFSqsb4%3D
96. SH Kim JH Shin CK Yeo SH Chang SY Park EH Cho CS Ki JW Kim 2005 Identification of a novel mutation in the EYA1 gene in a Korean family with branchio-oto-renal (BOR) syndrome Int J Pediatr Otorhinolaryngol 69 8 1123 1128 10.1016/j.ijporl.2005.03.003 16005355
97. S Rickard M Parker W van't Hoff A Barnicoat I Russell-Eggitt RM Winter M Bitner-Glindzicz 2001 Oto-facio-cervical (OFC) syndrome is a contiguous gene deletion syndrome involving EYA1: molecular analysis confirms allelism with BOR syndrome and further narrows the Duane syndrome critical region to 1 cM Hum Genet 108 5 398 403 11409867 1:CAS:528:DC%2BD3MXjvVGhtb8%3D
98. C Vincent V Kalatzis S Abdelhak H Chaib S Compain J Helias FM Vaneecloo C Petit 1997 BOR and BO syndromes are allelic defects of EYA1 Eur J Hum Genet 5 4 242 246 9359046 1:CAS:528:DyaK2sXnt1Orsrk%3D
99. S Wayne NG Robertson F DeClau N Chen K Verhoeven S Prasad L Tranebjarg CC Morton AF Ryan G Van Camp RJ Smith 2001 Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus Hum Mol Genet 10 3 195 200 11159937 1:CAS:528:DC%2BD3MXht1Sktbw%3D
100. S Sato K Ikeda G Shioi H Ochi H Ogino H Yajima K Kawakami 2010 Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR Dev Biol 344 1 158 171 10.1016/j.ydbio.2010.04. 029 20471971 1:CAS:528:DC%2BC3cXhtVClu77P
101. DJ Kozlowski TT Whitfield NA Hukriede WK Lam ES Weinberg 2005 The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line Dev Biol 277 1 27 41 15572137 1:CAS:528:DC%2BD2cXhtVagsrjK
102. BC Bane JM Van Rybroek SJ Kolker DL Weeks JM Manaligod 2005 EYA1 expression in the developing inner ear Ann Otol Rhinol Laryngol 114 11 853 858 16358604
103. Y Li JM Manaligod DL Weeks 2010 EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis Biol Cell 102 5 277 292 10.1042/BC20090098 19951260 1:CAS:528: DC%2BC3cXjtVyisrg%3D
104. M Ahmed J Xu PX Xu 2012 EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear Development 139 11 1965 1977 10.1242/dev.071670 22513373 1:CAS:528:DC%2BC38XhtVGlsLvJ
105. FF Depreux K Darrow DA Conner RD Eavey MC Liberman CE Seidman JG Seidman 2008 Eya4-deficient mice are a model for heritable otitis media J Clin Invest 118 2 651 658 10.1172/JCI32899 18219393 1:CAS:528:DC%2BD1cXhsFOms78%3D
106. J Schonberger L Wang JT Shin SD Kim FF Depreux H Zhu L Zon A Pizard JB Kim CA Macrae AJ Mungall JG Seidman CE Seidman 2005 Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss Nat Genet 37 4 418 422 10.1038/ng1527 15735644
107. N Shimasaki K Watanabe M Hara K Kosaki 2004 EYA1 mutation in a newborn female presenting with cardiofacial syndrome Pediatr Cardiol 25 4 411 413 10.1007/s00246-003-0271-3 15493068 1:STN:280:DC%2BD2critVWqsg%3D%3D
108. T Soker C Dalke O Puk T Floss L Becker I Bolle J Favor W Hans SM Holter M Horsch M Kallnik E Kling C Moerth A Schrewe C Stigloher S Topp V Gailus-Durner B Naton J Beckers H Fuchs B Ivandic T Klopstock H Schulz E Wolf W Wurst L Bally-Cuif MH de Angelis J Graw 2008 Pleiotropic effects in Eya3 knockout mice BMC Dev Biol 8 118 10.1186/1471-213X-8-118 19102749
109. DK Yang BY Choi YH Lee YG Kim MC Cho SE Hong H Kim do RJ Hajjar WJ Park 2007 Gene profiling during regression of pressure overload-induced cardiac hypertrophy Physiol Genomics 30 1 1 7 10.1152/physiolgenomics.00246.2006 17327491 1:CAS:528:DC%2BD2sXptlKqs7k%3D
110. SH Lee DK Yang BY Choi Y-H Lee S-Y Kim D Jeong RJ Hajjar WJ Park 2009 The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling J Mol Cell Cardiol 46 4 596 605 19272299 1:CAS:528: DC%2BD1MXivVenu7o%3D
111. SH Lee J Kim JY Ryu S Lee DK Yang D Jeong JM Kim RJ Hajjar WJ Park 2012 Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy J Mol Cell Cardiol 52 3 718 726 10.1016/j.yjmcc.2011.12.002 22197309 1:CAS:528:DC%2BC38XjtlSms7k%3D
112. JR McMullen GL Jennings 2007 Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure Clin Exp Pharmacol Physiol 34 4 255 262 10.1111/j.1440-1681.2007.04585.x 17324134 1:CAS:528:DC%2BD2sXjvVOiur8%3D
113. MB Walker PA Trainor 2006 Craniofacial malformations: intrinsic vs extrinsic neural crest cell defects in Treacher Collins and 22q11 deletion syndromes Clin Genet 69 6 471 479 10.1111/j.0009-9163.2006.00615.x 16712696 1:STN:280:DC%2BD283otlSgtg%3D%3D
114. C Mercer R Gilbert S Loughlin N Foulds 2006 Patient with an EYA1 mutation with features of branchio-oto-renal and oto-facio-cervical syndrome Clin Dysmorphol 15 4 211 212 10.1097/01.mcd.0000204986.54366.7c 16957474
115. E Estefania R Ramirez-Camacho M Gomar A Trinidad B Arellano JR Garcia-Berrocal JM Verdaguer C Vilches 2006 Point mutation of an EYA1-gene splice site in a patient with oto-facio-cervical syndrome Ann Hum Genet 70 Pt 1 140 144 10.1111/j.1529-8817.2005.00204.x 16441263 1:STN:280: DC%2BD28%2FlslWrtA%3D%3D
116. G Schlosser 2006 Induction and specification of cranial placodes Dev Biol 294 2 303 351 10.1016/j.ydbio.2006.03.009 16677629 1:CAS:528: DC%2BD28XmtVOhtbg%3D
117. D Zou D Silvius B Fritzsch PX Xu 2004 Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes Development 131 22 5561 5572 10.1242/dev.01437 15496442 1:CAS:528:DC%2BD2cXhtFSgs7%2FO
118. G Schlosser T Awtry SA Brugmann ED Jensen K Neilson G Ruan A Stammler D Voelker B Yan C Zhang MW Klymkowsky SA Moody 2008 Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion Dev Biol 320 1 199 214 10.1016/j.ydbio.2008.05.523 18571637 1:CAS:528:DC%2BD1cXptVCgu74%3D
119. N Nakao H Ono T Yamamura T Anraku T Takagi K Higashi S Yasuo Y Katou S Kageyama Y Uno T Kasukawa M Iigo PJ Sharp A Iwasawa Y Suzuki S Sugano T Niimi M Mizutani T Namikawa S Ebihara HR Ueda T Yoshimura 2008 Thyrotrophin in the pars tuberalis triggers photoperiodic response Nature 452 7185 317 322 10.1038/nature06738 18354476 1:CAS:528:DC%2BD1cXjsFCnsLg%3D
120. KH Masumoto M Ukai-Tadenuma T Kasukawa M Nagano KD Uno K Tsujino K Horikawa Y Shigeyoshi HR Ueda 2010 Acute induction of Eya3 by late-night light stimulation triggers TSHbeta expression in photoperiodism Curr Biol 20 24 2199 2206 10.1016/j.cub.2010.11.038 21129973 1:CAS:528:DC%2BC3cXhsF2mtr7N
121. SM Dupre K Miedzinska CV Duval L Yu RL Goodman GA Lincoln JR Davis AS McNeilly DD Burt AS Loudon 2010 Identification of Eya3 and TAC1 as long-day signals in the sheep pituitary Curr Biol 20 9 829 835 10.1016/j.cub.2010.02.066 20434341 1:CAS:528:DC%2BC3cXlvVeis7Y%3D
122. H Dardente CA Wyse MJ Birnie SM Dupre AS Loudon GA Lincoln DG Hazlerigg 2010 A molecular switch for photoperiod responsiveness in mammals Curr Biol 20 24 2193 2198 10.1016/j.cub.2010.10.048 21129971 1:CAS:528:DC%2BC3cXhsF2mtr7M
123. AK Brady KA Snyder PD Vize 2011 Circadian cycles of gene expression in the coral, Acropora millepora PLoS One 6 9 e25072 10.1371/journal.pone.0025072 21949855 1:CAS:528:DC%2BC3MXht1yqsLfN
124. L Spruijt LH Hoefsloot GH van Schaijk D van Waardenburg B Kremer HJ Brackel CE de Die-Smulders 2006 Identification of a novel EYA1 mutation presenting in a newborn with laryngomalacia, glossoptosis, retrognathia, and pectus excavatum Am J Med Genet A 140 12 1343 1345 10.1002/ajmg.a.31285 16691597 1:STN:280:DC%2BD28zgslSnsA%3D%3D
125. C Buller X Xu V Marquis R Schwanke PX Xu 2001 Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome Hum Mol Genet 10 24 2775 2781 11734542 1:CAS:528:DC%2BD3MXptlKrsLk%3D
126. JP Rayapureddi RS Hegde 2006 Branchio-oto-renal syndrome associated mutations in Eyes absent 1 result in loss of phosphatase activity FEBS Lett 580 16 3853 3859 16797546 1:CAS:528:DC%2BD28Xms1ahur0%3D
127. G Miller R Fuchs E Lai 1997 IMAGE cDNA clones, UniGene clustering, and ACeDB: an integrated resource for expressed sequence information Genome Res 7 10 1027 1032 9331373 1:CAS:528:DyaK2sXntFansbs%3D
128. H Zou NK Osborn JJ Harrington KK Klatt JR Molina LJ Burgart DA Ahlquist
129. P Schatz J Distler K Berlin M Schuster 2006 Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection Nucleic Acids Res 34 8 e59 10.1093/nar/gkl218 16670426
130. NK Osborn H Zou JR Molina R Lesche J Lewin C Lofton-Day KK Klatt JJ Harrington LJ Burgart DA Ahlquist 2006 Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia Clin Gastroenterol Hepatol 4 2 212 218 10.1016/j.cgh.2005.11.009 16469682 1:CAS:528:DC%2BD28Xit1Kjsr8%3D
131. YH Kim HC Lee SY Kim YI Yeom KJ Ryu BH Min DH Kim HJ Son PL Rhee JJ Kim JC Rhee HC Kim HK Chun WM Grady YS Kim 2011 Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations Ann Surg Oncol 18 8 2338 2347 10.1245/s10434-011-1573-y 21298349
132. H Li TY Diao ZY Zhou FY Yang Q Ma QH Li 2009 Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus J Exp Clin Cancer Res 28 145 10.1186/1756-9966-28-145 19939248
133. L Zhang N Yang J Huang RJ Buckanovich S Liang A Barchetti C Vezzani A O'Brien-Jenkins J Wang MR Ward MC Courreges S Fracchioli A Medina D Katsaros BL Weber G Coukos 2005 Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth Cancer Res 65 3 925 932 15705892 1:CAS:528:DC%2BD2MXhtVWntLk%3D
134. J Guo C Liang L Ding N Zhou Q Ye 2009 Drosophila Eyes absent homologue 2 is up-regulated in lung adenocarcinoma Chin Ger J Clin Oncol 8 12 681 684 10.1007/s10330-009-0166-8 1:CAS:528:DC%2BC3cXksFCrsA%3D%3D
135. SM Farabaugh DS Micalizzi P Jedlicka R Zhao HL Ford 2012 Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-beta signaling, epithelial-mesenchymal transition, and cancer stem cell properties Oncogene 31 5 552 562 10.1038/onc.2011.259 21706047 1:CAS:528: DC%2BC3MXotV2gs7g%3D
136. KM Drake EC Ruteshouser R Natrajan P Harbor J Wegert M Gessler K Pritchard-Jones P Grundy J Dome V Huff C Jones MA Aldred 2009 Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562 Clin Cancer Res 15 19 5985 5992 10.1158/1078-0432.CCR-09-1065 19789318 1:CAS:528:DC%2BD1MXhtF2ltbbO
137. CM Li M Guo A Borczuk CA Powell M Wei HM Thaker R Friedman U Klein B Tycko 2002 Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition Am J Pathol 160 6 2181 2190 12057921 1:CAS:528:DC%2BD38XltFOrsLo%3D
138. K Matsusaka A Kaneda G Nagae T Ushiku Y Kikuchi R Hino H Uozaki Y Seto K Takada H Aburatani M Fukayama 2011 Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes Cancer Res 71 23 7187 7197 10.1158/0008-5472.CAN-11-1349 21990320 1:CAS:528:DC%2BC3MXhsFCmsb%2FI
139. H Zou JJ Harrington AM Shire RL Rego L Wang ME Campbell AL Oberg DA Ahlquist 2007 Highly methylated genes in colorectal neoplasia: implications for screening Cancer Epidemiol Biomarkers Prev 16 12 2686 2696 10.1158/1055-9965. EPI-07-0518 18086775 1:CAS:528:DC%2BD2sXhsVenur3P
140. ML Gutierrez L Munoz-Bellvis M Abad Mdel O Bengoechea M Gonzalez-Gonzalez A Orfao JM Sayagues 2011 Association between genetic subgroups of pancreatic ductal adenocarcinoma defined by high density 500 K SNP-arrays and tumor histopathology PLoS One 6 7 e22315 10.1371/journal.pone.0022315 21811587 1:CAS:528:DC%2BC3MXhtVGht7fK
141. F Nan Q Lu J Zhou L Cheng VM Popov S Wei B Kong RG Pestell MP Lisanti J Jiang C Wang 2009 Altered expression of DACH1 and cyclin D1 in endometrial cancer Cancer Biol Ther 8 16 1534 1539 19502783 1:CAS:528:DC%2BC3cXks1Clurw%3D
142. VM Popov K Wu J Zhou MJ Powell G Mardon C Wang RG Pestell 2010 The Dachshund gene in development and hormone-responsive tumorigenesis Trends Endocrinol Metab 21 1 41 49 10.1016/j.tem.2009.08.002 19896866 1:CAS:528:DC%2BD1MXhsFyktrfJ
143. K Wu S Katiyar A Li M Liu X Ju VM Popov X Jiao MP Lisanti A Casola RG Pestell 2008 Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8 Proc Natl Acad Sci USA 105 19 6924 6929 18467491 1:CAS:528:DC%2BD1cXmt1Gisbc%3D
144. K Wu A Li M Rao M Liu V Dailey Y Yang D Di Vizio C Wang MP Lisanti G Sauter RG Russell A Cvekl RG Pestell 2006 DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth Mol Cell Biol 26 19 7116 7129 16980615 1:CAS:528:DC%2BD28XhtVCltbbO
145. AN Smith LA Miller N Song MM Taketo RA Lang 2005 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm Dev Biol 285 2 477 489 16102745 1:CAS:528:DC%2BD2MXhtVymsLjO
146. D Hanahan RA Weinberg 2011 Hallmarks of cancer: the next generation Cell 144 5 646 674 10.1016/j.cell.2011.02.013 21376230 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
147. AS Chung N Ferrara 2011 Developmental and pathological angiogenesis Annu Rev Cell Dev Biol 27 563 584 10.1146/annurev-cellbio-092910-154002 21756109 1:CAS:528:DC%2BC3MXhsFyqtbfK
148. A Sarasin A Kauffmann 2008 Overexpression of DNA repair genes is associated with metastasis: a new hypothesis Mutat Res 659 1-2 49 55 10.1016/j.mrrev.2007.12.002 18308619 1:CAS:528:DC%2BD1cXpsVams7s%3D
149. A Kauffmann F Rosselli V Lazar V Winnepenninckx A Mansuet-Lupo P Dessen JJ van den Oord A Spatz A Sarasin 2008 High expression of DNA repair pathways is associated with metastasis in melanoma patients Oncogene 27 5 565 573 10.1038/sj.onc.1210700 17891185 1:CAS:528:DC%2BD1cXhtVKruro%3D
150. AL Hopkins CR Groom 2002 The druggable genome Nat Rev Drug Discovery 1 9 727 730 10.1038/nrd892 1:CAS:528:DC%2BD38XmslamtrY%3D
151. H Park SK Jung KR Yu JH Kim YS Kim JH Ko BC Park SJ Kim 2011 Structure-based virtual screening approach to the discovery of novel inhibitors of eyes absent 2 phosphatase with various metal chelating moieties Chem Biol Drug Des 78 4 642 650 10.1111/j.1747-0285.2011.01192.x 21777393 1:CAS:528:DC%2BC3MXhtF2hsbvE
152. Z Kozmik ND Holland J Kreslova D Oliveri M Schubert K Jonasova LZ Holland M Pestarino V Benes S Candiani 2007 Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo Dev Biol 306 1 143 159 10.1016/j.ydbio.2007.03.009 17477914 1:CAS:528:DC%2BD2sXmvF2nsb4%3D
153. S Hu A Mamedova RS Hegde 2008 DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins Biochemistry 47 11 3586 3594 10.1021/bi702186s 18293925 1:CAS:528:DC%2BD1cXitlOmtrc%3D
154. AC Embry JL Glick ME Linder PJ Casey 2004 Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the G alpha i family Mol Pharmacol 66 5 1325 1331 10.1124/Mol.104.004093 15308761 1:CAS:528:DC%2BD2cXptVKmtbs%3D
155. PX Xu W Zheng C Laclef P Maire RL Maas H Peters X Xu 2002 Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid Development 129 13 3033 3044 12070080 1:CAS:528:DC%2BD38XlsFGhsbk%3D
156. R Grifone J Demignon J Giordani C Niro E Souil F Bertin C Laclef PX Xu P Maire 2007 Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo Dev Biol 302 2 602 616 17098221 1:CAS:528: DC%2BD2sXhs1Cntbw%3D