Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 3, 2012, Pages 718-726

  Lee, Seung Hee ^a   Kim, Jooyeon ^a   Ryu, Joo Young ^a   Lee, Suho ^a   Yang, Dong Kwon ^a   Jeong, Dongtak ^b   Kim, Jaetaek ^c   Lee, Sang Hee ^d   Kim, Jin Man ^d   Hajjar, Roger J ^b   Park, Woo Jin ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Chung Ang University   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

Cardiac protection; Eyes absent 2; MTOR; Physiological cardiac hypertrophy; Six1

Indexed keywords

LUCIFERASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL DNA; PROTEIN EYA2; REGULATOR PROTEIN; TRANSCRIPTION FACTOR SIX1; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PHYSIOLOGICAL HYPERTROPHY; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TRANSGENE; UPREGULATION; WILD TYPE;

ANIMALS; CELL ENLARGEMENT; CELL LINE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASES; RATS; RATS, SPRAGUE-DAWLEY; TOR SERINE-THREONINE KINASES;

ADENOVIRIDAE; MUS MUSCULUS;

EID: 84862816399     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.12.002     Document Type: Article

References (46)

1. Kehat I., Molkentin J.D. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation Dec. 21 2010, 122(25):2727-2735.
2. Hunter J.J., Chien K.R. Signaling pathways for cardiac hypertrophy and failure. N Engl J Med Oct. 21 1999, 341(17):1276-1283.
3. Molkentin J.D., Dorn G.W. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 2001, 63:391-426.
4. Hardt S.E., Sadoshima J. Negative regulators of cardiac hypertrophy. Cardiovasc Res Aug. 15 2004, 63(3):500-509.
5. Heineke J., Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol Aug. 2006, 7(8):589-600.
6. Dorn G.W. The fuzzy logic of physiological cardiac hypertrophy. Hypertension May 2007, 49(5):962-970.
7. Bernardo B.C., Weeks K.L., Pretorius L., McMullen J.R. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther Oct. 2010, 128(1):191-227.
8. Abel E.D., Doenst T. Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc Res May 1 2011, 90(2):234-242.
9. Dorn G.W., Force T. Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest Mar. 2005, 115(3):527-537.
10. Mudd J.O., Kass D.A. Tackling heart failure in the twenty-first century. Nature Feb. 21 2008, 451(7181):919-928.
11. Lee S.H., Yang D.K., Choi B.Y., Lee Y.H., Kim S.Y., Jeong D., et al. The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling. J Mol Cell Cardiol Apr. 2009, 46(4):596-605.
12. Galindo C.L., Skinner M.A., Errami M., Olson L.D., Watson D.A., Li J., et al. Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure. BMC Physiol 2009, 9:23.
13. Jeong D., Cha H., Kim E., Yang D.K., Kim J.M., Yoon P.O., et al. PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circ Res Aug. 4 2006, 99(3):307-314.
14. LaBarre D.D., Lowy R.J. Improvements in methods for calculating virus titer estimates from TCID50 and plaque assays. J Virol Methods Aug. 2001, 96(2):107-126.
15. Quandt K., Freck K., Karas H., Wingender E., Werner T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res Dec. 11 1995, 23(23):4878-4884.
16. Werner T. Computer-assisted analysis of transcription control regions. Matinspector and other programs. Methods Mol Biol 2000, 132:337-349.
17. Ziv-Av A., Taller D., Attia M., Xiang C., Lee H.K., Cazacu S., et al. RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration. Cell Signal Dec. 12 2011, 23(12):1936-1943.
18. Cartharius K., Frech K., Grote K., Klocke B., Haltmeier M., Klingenhoff A., et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics Jul. 1 2005, 21(13):2933-2942.
19. Foster K.G., Fingar D.C. Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem May 7 2010, 285(19):14071-14077.
20. Kenessey A., Ojamaa K. Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. J Biol Chem Jul. 28 2006, 281(30):20666-20672.
21. Kim J., Wende A.R., Sena S., Theobald H.A., Soto J., Sloan C., et al. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol Nov. 2008, 22(11):2531-2543.
22. Sakamoto M., Minamino T., Toko H., Kayama Y., Zou Y., Sano M., et al. Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circ Res Dec. 8 2006, 99(12):1411-1418.
23. Bostrom P., Mann N., Wu J., Quintero P.A., Plovie E.R., Panakova D., et al. C/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Dec. 23 2010, 143(7):1072-1083.
24. Fentzke R.C., Korcarz C.E., Lang R.M., Lin H., Leiden J.M. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest Jun. 1 1998, 101(11):2415-2426.
25. Konhilas J.P., Watson P.A., Maass A., Boucek D.M., Horn T., Stauffer B.L., et al. Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. Circ Res Mar. 3 2006, 98(4):540-548.
26. Muller F.U., Boknik P., Horst A., Knapp J., Linck B., Schmitz W., et al. In vivo isoproterenol treatment leads to downregulation of the mRNA encoding the cAMP response element binding protein in the rat heart. Biochem Biophys Res Commun Oct. 24 1995, 215(3):1043-1049.
27. Jang C.Y., Wong J., Coppinger J.A., Seki A., Yates J.R., Fang G. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol Apr. 21 2008, 181(2):255-267.
28. Jang C.Y., Fang G. The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3. Cell Cycle Oct. 1 2009, 8(19):3165-3171.
29. Goodyear S., Sharma M.C. Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5. Exp Mol Pathol Feb. 2007, 82(1):25-32.
30. Lin H., Chen M.C., Chiu C.Y., Song Y.M., Lin S.Y. Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. J Biol Chem Feb. 2 2007, 282(5):2776-2784.
31. Sharma M.R., Tuszynski G.P., Sharma M.C. Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J Cell Biochem Feb. 1 2004, 91(2):398-409.
32. Qian L., Wythe J.D., Liu J., Cartry J., Vogler G., Mohapatra B., et al. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol Jun. 27 2011, 193(7):1181-1196.
33. Huss J.M., Kelly D.P. Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest Mar. 2005, 115(3):547-555.
34. Halder G., Callaerts P., Flister S., Walldorf U., Klote U., Gehring W.J. Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development Jun. 1998, 125(12):2181-2191.
35. Bonini N.M., Bui Q.T., Gray-Board G.L., Warrick J.M. The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. Development Dec. 1997, 124(23):4819-4826.
36. Bonini N.M., Leiserson W.M., Benzer S. Multiple roles of the eyes absent gene in Drosophila. Dev Biol Apr. 1 1998, 196(1):42-57.
37. Chen R., Amoui M., Zhang Z., Mardon G. Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell Dec. 26 1997, 91(7):893-903.
38. Leiserson W.M., Benzer S., Bonini N.M. Dual functions of the Drosophila eyes absent gene in the eye and embryo. Mech Dev May 1998, 73(2):193-202.
39. Zimmerman J.E., Bui Q.T., Liu H., Bonini N.M. Molecular genetic analysis of Drosophila eyes absent mutants reveals an eye enhancer element. Genetics Jan. 2000, 154(1):237-246.
40. Yang D.K., Choi B.Y., Lee Y.H., Kim Y.G., Cho M.C., Hong S.E., et al. Gene profiling during regression of pressure overload-induced cardiac hypertrophy. Physiol Genomics Jun. 19 2007, 30(1):1-7.
41. Zhang D., Contu R., Latronico M.V., Zhang J., Rizzi R., Catalucci D., et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest Aug. 2 2010, 120(8):2805-2816.
42. Shende P., Plaisance I., Morandi C., Pellieux C., Berthonneche C., Zorzato F., et al. Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation Mar. 15 2011, 123(10):1073-1082.
43. Wang X., Proud C.G. mTORC1 signaling: what we still don't know. J Mol Cell Biol Dec. 7 2011, 3(4):206-220.
44. Heanue T.A., Reshef R., Davis R.J., Mardon G., Oliver G., Tomarev S., et al. Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Genes Dev Dec. 15 1999, 13(24):3231-3243.
45. Ridgeway A.G., Skerjanc I.S. Pax3 is essential for skeletal myogenesis and the expression of Six1 and Eya2. J Biol Chem Jun. 1 2001, 276(22):19033-19039.
46. Ohto H., Kamada S., Tago K., Tominaga S.I., Ozaki H., Sato S., et al. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol Oct. 1999, 19(10):6815-6824.