Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 16, 2008, Pages 6081-6086

  Weng, Jinsheng ^a   Luo, Jian ^a,b   Cheng, Xuhong ^a   Jin, Chang ^c   Zhou, Xiangtian ^c   Qu, Jia ^c   Tu, Lili ^c   Ai, Di ^a   Li, Dali ^a,b   Wang, Jun ^a   Martin, James F ^a   Amendt, Brad A ^a   Liu, Mingyao ^a,b,c  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cataract; Eye development; Glaucoma; Lgr4

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; TRANSCRIPTION FACTOR PITX2; CREB1 PROTEIN, MOUSE; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HOMEODOMAIN PROTEIN; LGR4 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR EYE SEGMENT; ARTICLE; CATARACT; CELL LOSS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; EYE DEVELOPMENT; EYE MALFORMATION; FEMALE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GLAUCOMA; IN VITRO STUDY; IRIS; KNOCKOUT MOUSE; MALE; MICROPHTHALMIA; MOLECULAR MECHANICS; MOUSE; MUSCLE DEVELOPMENT; NERVE CELL; NONHUMAN; OPTIC NERVE HYPOPLASIA; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; ANIMAL; CONGENITAL MALFORMATION; CORNEA; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE MUTANT; PROMOTER REGION; SIGNAL TRANSDUCTION;

MAMMALIA; MUS;

ANIMALS; ANTERIOR EYE SEGMENT; CATARACT; CORNEA; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; DOWN-REGULATION; EYE ABNORMALITIES; GENE DELETION; GENE EXPRESSION REGULATION; GLAUCOMA; HOMEODOMAIN PROTEINS; IRIS; MICE; MICE, KNOCKOUT; PROMOTER REGIONS (GENETICS); RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 43149099246     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708257105     Document Type: Article

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