Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia

Clinical Gastroenterology and Hepatology

Volumn 4, Issue 2, 2006, Pages 212-218

  Osborn, Neal K ^a   Zou, Hongzhi ^a   Molina, Julian R ^a   Lesche, Ralf ^b   Lewin, Joern ^b   Lofton Day, Cathy ^b   Klatt, Kristie K ^a   Harrington, Jonathan J ^a   Burgart, Lawrence J ^a   Ahlquist, David A ^a  

^a MAYO CLINIC   (United States)

^b EPIGENOMICS AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; DYSPLASIA; EYA4 GENE; FEMALE; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA GENE; ULCERATIVE COLITIS;

AZACITIDINE; BIOLOGICAL MARKERS; CELL LINE; CHRONIC DISEASE; COLITIS, ULCERATIVE; COLONIC NEOPLASMS; COLONIC POLYPS; HUMANS; HYDROXAMIC ACIDS; METHYLATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 32044471583     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2005.11.009     Document Type: Article

References (23)

1. W.R. Connell, J.E. Lennard-Jones, C.B. Williams Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis Gastroenterology 107 1994 934 944
2. D. Provenzale, J. Onken Surveillance issues in inflammatory bowel disease ulcerative colitis J Clin Gastroenterol 32 2001 99 105
3. S. Fujii, T. Fujimori, H. Kashida Ulcerative colitis-associated neoplasia Pathol Int 52 2002 195 203
4. C.J. Hsieh, B. Klump, K. Holzmann Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis Cancer Res 58 1998 3942 3945
5. A.S. Fleisher, M. Esteller, N. Harpaz Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1 Cancer Res 60 2000 4864 4868
6. J.M. Wheeler, H.C. Kim, J.A. Efstathiou Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer Gut 48 2001 367 371
7. P. Azarschab, R. Porschen, M. Gregor Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis Genes Chromosomes Cancer 35 2002 121 126
8. F. Sato, N. Harpaz, D. Shibata Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis Cancer Res 62 2002 1148 1151
9. F. Sato, D. Shibata, N. Harpaz Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma Cancer Res 62 2002 6820 6822
10. S. Cottrell, S. Mooney, N. Goodman Analysis of two methylated sequences in colon cancer tissue and serum samples Proc AACR 44 2003 225
11. H. Zou, N. Osborn, J. Harrington Frequent methylation of eyes absent 4 (EYA4) in Barrett's esophagus and esophageal adenocarcinoma Cancer Epidemiol Biomarkers Prev 14 2005 830 834
12. J. Lewin, A. Schmitt, P. Adorján Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates Bioinformatics 20 2004 3005 3012
13. J.G. Herman, A. Umari, K. Polyak Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma Proc Natl Acad Sci U S A 95 1998 6870 6875
14. J.P. Issa, N. Ahuja, M. Toyota Accelerated age-related CpG island methylation in ulcerative colitis Cancer Res 61 2001 3573 3577
15. C. Bariol, N. Hawkins, J. Turner Histopathological and clinical evaluation of serrated adenomas of the colon and rectum Mod Pathol 16 2003 417 423
16. C. Bariol, C. Suter, K. Cheong The relationship between hypomethylation and CpG island methylation in colorectal neoplasia Am J Pathol 162 2003 1361 1371
17. N. Osborn, D. Ahlquist Stool screening for colorectal cancer molecular approaches Gastroenterology 128 2005 192 206
18. D.S.A. Ahlquist, K.K. Klatt, J.J. Harrington Novel use of hypermethylated DNA markers in stool for detection of colorectal cancer a feasibility study Gastroenterology 122 Suppl 2002 A40
19. H. Müller, M. Oberwalder, H. Fiegi Methylation changes in faecal DNA a marker for colorectal cancer screening? Lancet 363 2004 1283 1285
20. K. Lenhard, G. Bommer, S. Asutay Analysis of promoter methylation in stool a novel method for the detection of colorectal cancer Clin Gastroenterol Hepatol 3 2005 142 149
21. W. Leung, K. To, E. Man Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer a feasibility study Clin Chem 50 2004 2179 2182
22. N. Belshaw, G. Elliott, E. Williams Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer Cancer Epidemiol Biomarkers Prev 13 2004 1495 1501
23. S.W. Clark, B.E. Fee, J.L. Cleveland Misexpression of the Eyes Absent family triggers the apoptotic program J Biol Chem 277 2002 3560 3567