메뉴 건너뛰기




Volumn 107, Issue 35, 2010, Pages 15479-15484

Six and eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans

Author keywords

Cell death; Eyes absent; Sine oculis; Transcription

Indexed keywords

BH3 PROTEIN; HOMEODOMAIN PROTEIN; PROTEIN CEH 34; PROTEIN EGL 1; PROTEIN EYA 1; UNCLASSIFIED DRUG;

EID: 77957251870     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010023107     Document Type: Article
Times cited : (36)

References (44)
  • 1
    • 0036791348 scopus 로고    scopus 로고
    • How death shapes life during development
    • Baehrecke EH (2002) How death shapes life during development. Nat Rev Mol Cell Biol 3:779-787.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 779-787
    • Baehrecke, E.H.1
  • 2
    • 5044232018 scopus 로고    scopus 로고
    • Connecting proliferation and apoptosis in development and disease
    • DOI 10.1038/nrm1491
    • Hipfner DR, Cohen SM (2004) Connecting proliferation and apoptosis in development and disease. Nat Rev Mol Cell Biol 5:805-815. (Pubitemid 39336274)
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.10 , pp. 805-815
    • Hipfner, D.R.1    Cohen, S.M.2
  • 3
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100:64-119.
    • (1983) Dev Biol , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 4
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56:110-156.
    • (1977) Dev Biol , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 5
    • 0042469295 scopus 로고    scopus 로고
    • Worms, life, and death (Nobel lecture)
    • Horvitz HR (2003) Worms, life, and death (Nobel lecture). ChemBioChem 4:697-711.
    • (2003) ChemBioChem , vol.4 , pp. 697-711
    • Horvitz, H.R.1
  • 6
    • 0033197540 scopus 로고    scopus 로고
    • The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein
    • Metzstein MM, Horvitz HR (1999) The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. Mol Cell 4:309-319.
    • (1999) Mol Cell , vol.4 , pp. 309-319
    • Metzstein, M.M.1    Horvitz, H.R.2
  • 7
    • 0041827179 scopus 로고    scopus 로고
    • The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins
    • Thellmann M, Hatzold J, Conradt B (2003) The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development 130:4057-4071.
    • (2003) Development , vol.130 , pp. 4057-4071
    • Thellmann, M.1    Hatzold, J.2    Conradt, B.3
  • 8
    • 0033529717 scopus 로고    scopus 로고
    • The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene
    • Conradt B, Horvitz HR (1999) The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 98:317-327.
    • (1999) Cell , vol.98 , pp. 317-327
    • Conradt, B.1    Horvitz, H.R.2
  • 9
    • 33645094394 scopus 로고    scopus 로고
    • Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1
    • Liu H, Strauss TJ, Potts MB, Cameron S (2006) Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Development 133:641-650.
    • (2006) Development , vol.133 , pp. 641-650
    • Liu, H.1    Strauss, T.J.2    Potts, M.B.3    Cameron, S.4
  • 10
    • 67349124418 scopus 로고    scopus 로고
    • Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1
    • Potts MB, Wang DP, Cameron S (2009) Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Dev Biol 329:374-385.
    • (2009) Dev Biol , vol.329 , pp. 374-385
    • Potts, M.B.1    Wang, D.P.2    Cameron, S.3
  • 11
    • 34248180046 scopus 로고    scopus 로고
    • Timing of the onset of a development cell death is controlled by transciptional induction of the C. elegans ced-3 caspase-encoding gene
    • DOI 10.1242/dev.02818
    • Maurer CW, Chiorazzi M, Shaham S (2007) Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. Development 134:1357-1368. (Pubitemid 46706042)
    • (2007) Development , vol.134 , Issue.7 , pp. 1357-1368
    • Maurer, C.W.1    Chiorazzi, M.2    Shaham, S.3
  • 12
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu WS, et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123:641-653.
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1
  • 13
    • 0033197879 scopus 로고    scopus 로고
    • SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
    • Inukai T, et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell 4:343-352.
    • (1999) Mol Cell , vol.4 , pp. 343-352
    • Inukai, T.1
  • 14
    • 35548973782 scopus 로고    scopus 로고
    • The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9
    • Schwartz HT, Horvitz HR (2007) The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes Dev 21:3181-3194.
    • (2007) Genes Dev , vol.21 , pp. 3181-3194
    • Schwartz, H.T.1    Horvitz, H.R.2
  • 15
    • 77954658825 scopus 로고    scopus 로고
    • Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons
    • Nehme R, et al. (2010) Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. Cell Death Differ 17:1266-1276.
    • (2010) Cell Death Differ , vol.17 , pp. 1266-1276
    • Nehme, R.1
  • 16
    • 0036638824 scopus 로고    scopus 로고
    • Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene
    • Li S, et al. (2002) Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 129:3523-3532.
    • (2002) Development , vol.129 , pp. 3523-3532
    • Li, S.1
  • 17
    • 0023663870 scopus 로고
    • A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant
    • Avery L, Horvitz HR (1987) A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. Cell 51:1071-1078.
    • (1987) Cell , vol.51 , pp. 1071-1078
    • Avery, L.1    Horvitz, H.R.2
  • 19
    • 34347243197 scopus 로고    scopus 로고
    • A protocol describing pharynx counts and a review of other assays of apoptotic cell death in the nematode worm Caenorhabditis elegans
    • Schwartz HT (2007) A protocol describing pharynx counts and a review of other assays of apoptotic cell death in the nematode worm Caenorhabditis elegans. Nat Protoc 2:705-714.
    • (2007) Nat Protoc , vol.2 , pp. 705-714
    • Schwartz, H.T.1
  • 20
    • 0032524885 scopus 로고    scopus 로고
    • The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    • Conradt B, Horvitz HR (1998) The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93:519-529.
    • (1998) Cell , vol.93 , pp. 519-529
    • Conradt, B.1    Horvitz, H.R.2
  • 21
    • 0033924215 scopus 로고    scopus 로고
    • Six family genes - Structure and function as transcription factors and their roles in development
    • Kawakami K, Sato S, Ozaki H, Ikeda K (2000) Six family genes - structure and function as transcription factors and their roles in development. Bioessays 22:616-626.
    • (2000) Bioessays , vol.22 , pp. 616-626
    • Kawakami, K.1    Sato, S.2    Ozaki, H.3    Ikeda, K.4
  • 22
    • 67549101891 scopus 로고    scopus 로고
    • A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm
    • Amin NM, Lim SE, Shi H, Chan TL, Liu J (2009) A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. Dev Biol 331:350-360.
    • (2009) Dev Biol , vol.331 , pp. 350-360
    • Amin, N.M.1    Lim, S.E.2    Shi, H.3    Chan, T.L.4    Liu, J.5
  • 23
    • 0028244770 scopus 로고
    • The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system
    • Cheyette BN, et al. (1994) The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12:977-996.
    • (1994) Neuron , vol.12 , pp. 977-996
    • Cheyette, B.N.1
  • 24
    • 34548657817 scopus 로고    scopus 로고
    • The eyes absent family of phosphotyrosine phosphatases: Properties and roles in developmental regulation of transcription
    • Jemc J, Rebay I (2007) The eyes absent family of phosphotyrosine phosphatases: Properties and roles in developmental regulation of transcription. Annu Rev Biochem 76:513-538.
    • (2007) Annu Rev Biochem , vol.76 , pp. 513-538
    • Jemc, J.1    Rebay, I.2
  • 25
    • 0031444287 scopus 로고    scopus 로고
    • The eye-specification proteins so and Eya form a complex and regulate multiple steps in Drosophila eye development
    • DOI 10.1016/S0092-8674(00)80480-8
    • Pignoni F, et al. (1997) The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91:881-891. (Pubitemid 28027823)
    • (1997) Cell , vol.91 , Issue.7 , pp. 881-891
    • Pignoni, F.1    Hu, B.2    Zavitz, K.H.3    Xiao, J.4    Garrity, P.A.5    Zipursky, S.L.6
  • 26
    • 0033573003 scopus 로고    scopus 로고
    • Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation
    • Heanue TA, et al. (1999) Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Genes Dev 13:3231-3243.
    • (1999) Genes Dev , vol.13 , pp. 3231-3243
    • Heanue, T.A.1
  • 27
    • 26644431590 scopus 로고    scopus 로고
    • The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6
    • Furuya M, Qadota H, Chisholm AD, Sugimoto A (2005) The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6. Dev Biol 286:452-463.
    • (2005) Dev Biol , vol.286 , pp. 452-463
    • Furuya, M.1    Qadota, H.2    Chisholm, A.D.3    Sugimoto, A.4
  • 28
    • 21644477891 scopus 로고    scopus 로고
    • Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog
    • Pauli T, Seimiya M, Blanco J, Gehring WJ (2005) Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. Development 132:2771-2782.
    • (2005) Development , vol.132 , pp. 2771-2782
    • Pauli, T.1    Seimiya, M.2    Blanco, J.3    Gehring, W.J.4
  • 29
    • 0036479097 scopus 로고    scopus 로고
    • Misexpression of the eyes absent family triggers the apoptotic program
    • Clark SW, Fee BE, Cleveland JL (2002) Misexpression of the eyes absent family triggers the apoptotic program. J Biol Chem 277:3560-3567.
    • (2002) J Biol Chem , vol.277 , pp. 3560-3567
    • Clark, S.W.1    Fee, B.E.2    Cleveland, J.L.3
  • 30
    • 0027510673 scopus 로고
    • The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye
    • Bonini NM, Leiserson WM, Benzer S (1993) The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye. Cell 72:379-395.
    • (1993) Cell , vol.72 , pp. 379-395
    • Bonini, N.M.1    Leiserson, W.M.2    Benzer, S.3
  • 31
    • 9744281187 scopus 로고    scopus 로고
    • The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line
    • Kozlowski DJ, Whitfield TT, Hukriede NA, Lam WK, Weinberg ES (2005) The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Dev Biol 277:27-41.
    • (2005) Dev Biol , vol.277 , pp. 27-41
    • Kozlowski, D.J.1    Whitfield, T.T.2    Hukriede, N.A.3    Lam, W.K.4    Weinberg, E.S.5
  • 32
    • 0032842838 scopus 로고    scopus 로고
    • Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    • Xu PX, et al. (1999) Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet 23:113-117.
    • (1999) Nat Genet , vol.23 , pp. 113-117
    • Xu, P.X.1
  • 33
    • 0344875035 scopus 로고    scopus 로고
    • Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
    • Li X, et al. (2003) Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 426:247-254.
    • (2003) Nature , vol.426 , pp. 247-254
    • Li, X.1
  • 34
    • 63849187827 scopus 로고    scopus 로고
    • Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
    • Cook PJ, et al. (2009) Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458:591-596.
    • (2009) Nature , vol.458 , pp. 591-596
    • Cook, P.J.1
  • 35
    • 13444252265 scopus 로고    scopus 로고
    • Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth
    • Zhang L, et al. (2005) Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth. Cancer Res 65:925-932.
    • (2005) Cancer Res , vol.65 , pp. 925-932
    • Zhang, L.1
  • 36
    • 0032514597 scopus 로고    scopus 로고
    • Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: A possible mechanism of breast carcinogenesis
    • Ford HL, Kabingu EN, Bump EA, Mutter GL, Pardee AB (1998) Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: A possible mechanism of breast carcinogenesis. Proc Natl Acad Sci USA 95:12608-12613.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12608-12613
    • Ford, H.L.1    Kabingu, E.N.2    Bump, E.A.3    Mutter, G.L.4    Pardee, A.B.5
  • 37
    • 20144387707 scopus 로고    scopus 로고
    • Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss
    • Schönberger J, et al. (2005) Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Nat Genet 37:418-422.
    • (2005) Nat Genet , vol.37 , pp. 418-422
    • Schönberger, J.1
  • 38
    • 0033064156 scopus 로고    scopus 로고
    • Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly
    • Wallis DE, et al. (1999) Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly. Nat Genet 22:196-198.
    • (1999) Nat Genet , vol.22 , pp. 196-198
    • Wallis, D.E.1
  • 39
    • 0031046284 scopus 로고    scopus 로고
    • A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family
    • Abdelhak S, et al. (1997) A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet 15:157-164.
    • (1997) Nat Genet , vol.15 , pp. 157-164
    • Abdelhak, S.1
  • 40
    • 2542620650 scopus 로고    scopus 로고
    • SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes
    • Ruf RG, et al. (2004) SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci USA 101:8090-8095.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8090-8095
    • Ruf, R.G.1
  • 41
    • 48549091913 scopus 로고    scopus 로고
    • Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly
    • Geng X, et al. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell 15:236-247.
    • (2008) Dev Cell , vol.15 , pp. 236-247
    • Geng, X.1
  • 42
    • 0041326752 scopus 로고    scopus 로고
    • The role of Six1 in mammalian auditory system development
    • DOI 10.1242/dev.00628
    • Zheng W, et al. (2003) The role of Six1 in mammalian auditory system development. Development 130:3989-4000. (Pubitemid 37063418)
    • (2003) Development , vol.130 , Issue.17 , pp. 3989-4000
    • Zheng, W.1    Huang, L.2    Wei, Z.-B.3    Silvius, D.4    Tang, B.5    Xu, P.-X.6
  • 43
    • 0041853845 scopus 로고    scopus 로고
    • Six1 is required for the early organogenesis of mammalian kidney
    • Xu PX, et al. (2003) Six1 is required for the early organogenesis of mammalian kidney. Development 130:3085-3094.
    • (2003) Development , vol.130 , pp. 3085-3094
    • Xu, P.X.1
  • 44
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.