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Volumn 28, Issue 6, 2013, Pages 299-306

Antioxidative and antigenotoxic effect of vitamin E against patulin cytotoxicity and genotoxicity in HepG2 cells

Author keywords

Antigenotoxicity; Antioxidant; Cytoprotection; Patulin; Vitamin E

Indexed keywords

ANTIGENOTOXIC EFFECTS; ANTIGENOTOXICITY; CELL MORTALITY; CHROMOSOME ABERRATION; CYTOPROTECTION; INTRACELLULAR LEVELS; PATULIN; VITAMIN-E;

EID: 84877627216     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20720     Document Type: Article
Times cited : (52)

References (68)
  • 1
    • 4644308846 scopus 로고    scopus 로고
    • Ferns regional accumulation of aluminium in the rat brain is affected by dietary vitamin E
    • Abubakar MGA, Taylor GA. 2004. Ferns regional accumulation of aluminium in the rat brain is affected by dietary vitamin E. J Trace Elem Med Biol 18: 53-59.
    • (2004) J Trace Elem Med Biol , vol.18 , pp. 53-59
    • Abubakar, M.G.A.1    Taylor, G.A.2
  • 2
    • 0347318033 scopus 로고    scopus 로고
    • Potential role of vitamins in chromium induced spermatogenesis in Swiss mice
    • Acharya R, Mishra M, Mishra I, Tripathy RR. 2004. Potential role of vitamins in chromium induced spermatogenesis in Swiss mice. Environ Toxicol Pharmacol 15: 53-59.
    • (2004) Environ Toxicol Pharmacol , vol.15 , pp. 53-59
    • Acharya, R.1    Mishra, M.2    Mishra, I.3    Tripathy, R.R.4
  • 5
    • 0036065301 scopus 로고    scopus 로고
    • The effects of fenthion on lipid peroxidation and some liver enzymes: The possible protective role of vitamins E and C
    • Altuntas I, Delibas N. 2002. The effects of fenthion on lipid peroxidation and some liver enzymes: The possible protective role of vitamins E and C. Turk J Med Sci 32: 293-297.
    • (2002) Turk J Med Sci , vol.32 , pp. 293-297
    • Altuntas, I.1    Delibas, N.2
  • 6
    • 0034067139 scopus 로고    scopus 로고
    • Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: Role of ascorbic acid as a modulator of patulin clastogenicity
    • Alves I, Oliveira NG, Laires A, Rodrigues AS, Rueff J. 2000. Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: Role of ascorbic acid as a modulator of patulin clastogenicity. Mutagenesis 15: 229-234.
    • (2000) Mutagenesis , vol.15 , pp. 229-234
    • Alves, I.1    Oliveira, N.G.2    Laires, A.3    Rodrigues, A.S.4    Rueff, J.5
  • 7
    • 0032500996 scopus 로고    scopus 로고
    • Effects of high doses of Vitamin C and E against doxorubicin-induced chromosomal damages in Wistar rat bone marrow cells
    • Antunes LM, Takahashi CS. 1998. Effects of high doses of Vitamin C and E against doxorubicin-induced chromosomal damages in Wistar rat bone marrow cells. Mutat Res 419: 137-143.
    • (1998) Mutat Res , vol.419 , pp. 137-143
    • Antunes, L.M.1    Takahashi, C.S.2
  • 8
    • 1642295517 scopus 로고    scopus 로고
    • Patulin in apple juice and children's apple food
    • Askar A. 1999. Patulin in apple juice and children's apple food. Fruit Processing 3: 74-77.
    • (1999) Fruit Processing , vol.3 , pp. 74-77
    • Askar, A.1
  • 9
    • 33745094431 scopus 로고    scopus 로고
    • Occurrence of patulin in organic, conventional, and handcrafted apple juices marketed in Belgium
    • Baert K, De Meulenaer B, Kamala A, Kasase C, Devlieghere F. 2006. Occurrence of patulin in organic, conventional, and handcrafted apple juices marketed in Belgium. J Food Protect 69: 1371-1378.
    • (2006) J Food Protect , vol.69 , pp. 1371-1378
    • Baert, K.1    De Meulenaer, B.2    Kamala, A.3    Kasase, C.4    Devlieghere, F.5
  • 10
    • 0027973899 scopus 로고
    • The role of ascorbate in antioxidantt protection of biomolecules: Interaction with vitamin E and coenzyme Q
    • Beyer RE. 1994. The role of ascorbate in antioxidantt protection of biomolecules: Interaction with vitamin E and coenzyme Q. J Bioenerg Biomembr 26: 349-58.
    • (1994) J Bioenerg Biomembr , vol.26 , pp. 349-358
    • Beyer, R.E.1
  • 11
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 12
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E, Davies KJ. 2000. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29: 222-230.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 13
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semi-automated colorimetric assay: Assessment of chemosensitivity testing
    • Carmichael J, De Graff WG, Gadza AF, Minna JD, Mitchell J. 1987. Evaluation of a tetrazolium-based semi-automated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res 47: 936-942.
    • (1987) Cancer Res , vol.47 , pp. 936-942
    • Carmichael, J.1    De Graff, W.G.2    Gadza, A.F.3    Minna, J.D.4    Mitchell, J.5
  • 14
    • 0028922827 scopus 로고
    • Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxantine, and (+)-catechin against oxidative damage to rat blood and tissues in vivo
    • Chen H, Tappel AL. 1995. Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxantine, and (+)-catechin against oxidative damage to rat blood and tissues in vivo. Free Radic Biol Med 18: 949-953.
    • (1995) Free Radic Biol Med , vol.18 , pp. 949-953
    • Chen, H.1    Tappel, A.L.2
  • 15
    • 0017143224 scopus 로고
    • Teratogenicity of patulin and patulin adducts formed with cysteine
    • Ciegler A, Becwith AC, Jackson LK. 1976. Teratogenicity of patulin and patulin adducts formed with cysteine. Appl Environ Microb 31: 664-667.
    • (1976) Appl Environ Microb , vol.31 , pp. 664-667
    • Ciegler, A.1    Becwith, A.C.2    Jackson, L.K.3
  • 17
    • 33747889203 scopus 로고    scopus 로고
    • Induction of Hsp 70 in Vero cells in response to mycotoxins Cytoprotection by sub-lethal heat shock and by Vitamin E
    • El Golli E, Hassen W, Bouslimi A, Bouaziz C, Ladjimi M, Bacha H. 2006. Induction of Hsp 70 in Vero cells in response to mycotoxins Cytoprotection by sub-lethal heat shock and by Vitamin E. Toxicol Lett 166: 122-130.
    • (2006) Toxicol Lett , vol.166 , pp. 122-130
    • El Golli, E.1    Hassen, W.2    Bouslimi, A.3    Bouaziz, C.4    Ladjimi, M.5    Bacha, H.6
  • 18
    • 0025989696 scopus 로고
    • Genotoxicity of singlet oxygen
    • Epe B. 1991. Genotoxicity of singlet oxygen. Chem Biol Interact 80: 239-260.
    • (1991) Chem Biol Interact , vol.80 , pp. 239-260
    • Epe, B.1
  • 19
    • 0034091786 scopus 로고    scopus 로고
    • Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model
    • Factor VM, Laskowska D, Jensen MR, Woitach JT. 2000. Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Proc Natl Acad Sci USA 97: 2196-2201.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2196-2201
    • Factor, V.M.1    Laskowska, D.2    Jensen, M.R.3    Woitach, J.T.4
  • 20
    • 70350705954 scopus 로고    scopus 로고
    • Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells
    • Ferrer E, Juan-García A, Font G, Ruiz MJ. 2009. Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells. Toxicol in Vitro 23: 1504-1509.
    • (2009) Toxicol in Vitro , vol.23 , pp. 1504-1509
    • Ferrer, E.1    Juan-García, A.2    Font, G.3    Ruiz, M.J.4
  • 22
    • 0035798725 scopus 로고    scopus 로고
    • Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol
    • Giray B, Gurbay A, Hincal F. 2001. Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol. Toxicol Lett 118: 139-146.
    • (2001) Toxicol Lett , vol.118 , pp. 139-146
    • Giray, B.1    Gurbay, A.2    Hincal, F.3
  • 23
    • 0035044396 scopus 로고    scopus 로고
    • In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats
    • Gultekin F, Delibas N, Yasar S, Kilinc I. 2001. In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Arch Toxicol 75: 88-96.
    • (2001) Arch Toxicol , vol.75 , pp. 88-96
    • Gultekin, F.1    Delibas, N.2    Yasar, S.3    Kilinc, I.4
  • 24
    • 0029194750 scopus 로고
    • The definition and measurement of antioxidants in biological systems
    • Halliwell B, Gutteridge JMC. 1995. The definition and measurement of antioxidants in biological systems. Free Radic Biol Med 18: 125-126.
    • (1995) Free Radic Biol Med , vol.18 , pp. 125-126
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 25
    • 84987593478 scopus 로고
    • Presence and stability of patulin in apple products: A review
    • Harrison MA. 1989. Presence and stability of patulin in apple products: A review. J. Food Safety 9: 147-153.
    • (1989) J. Food Safety , vol.9 , pp. 147-153
    • Harrison, M.A.1
  • 27
    • 0033864129 scopus 로고    scopus 로고
    • Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria
    • Ibrahim WH, Blagavan HN, Chopra RK, Chow CK. 2000. Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria. J Nutr 130: 2343-2349.
    • (2000) J Nutr , vol.130 , pp. 2343-2349
    • Ibrahim, W.H.1    Blagavan, H.N.2    Chopra, R.K.3    Chow, C.K.4
  • 28
    • 0020322591 scopus 로고
    • Quantitative analysis of initiating and promoting activities of five mycotoxins in liver carcinogenesis in rats
    • Imaida K, Hirose M, Ogiso T, Kurata Y, Ito N. 1982. Quantitative analysis of initiating and promoting activities of five mycotoxins in liver carcinogenesis in rats. Cancer Lett 16: 137-143.
    • (1982) Cancer Lett , vol.16 , pp. 137-143
    • Imaida, K.1    Hirose, M.2    Ogiso, T.3    Kurata, Y.4    Ito, N.5
  • 30
    • 23944513331 scopus 로고    scopus 로고
    • Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2
    • Kouadio JH, Mobio TA, Baudrimont I, Moukha S, Dano SD, Creppy EE. 2005. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 213: 56-65.
    • (2005) Toxicology , vol.213 , pp. 56-65
    • Kouadio, J.H.1    Mobio, T.A.2    Baudrimont, I.3    Moukha, S.4    Dano, S.D.5    Creppy, E.E.6
  • 31
    • 0002690211 scopus 로고    scopus 로고
    • Determination of mycotoxin patulin in apple juice
    • Lai CL, Fu YM, Shih YC. 2000. Determination of mycotoxin patulin in apple juice. J Food Drug Analysis 8: 85-96.
    • (2000) J Food Drug Analysis , vol.8 , pp. 85-96
    • Lai, C.L.1    Fu, Y.M.2    Shih, Y.C.3
  • 32
    • 0043234938 scopus 로고    scopus 로고
    • Evaluation of genotoxic risk and oxidative DNA damage in mammalian cells exposed to mycotoxins, patulin and citrinin
    • Liu BH, Yu FY, Wu TS, Li SY, Su MC, Wang MC, Shih SM. 2003. Evaluation of genotoxic risk and oxidative DNA damage in mammalian cells exposed to mycotoxins, patulin and citrinin. Toxicol Appl Pharmacol 191: 255-263.
    • (2003) Toxicol Appl Pharmacol , vol.191 , pp. 255-263
    • Liu, B.H.1    Yu, F.Y.2    Wu, T.S.3    Li, S.Y.4    Su, M.C.5    Wang, M.C.6    Shih, S.M.7
  • 33
    • 0034039040 scopus 로고    scopus 로고
    • Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
    • Ljungman M. 2000. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2: 209-225.
    • (2000) Neoplasia , vol.2 , pp. 209-225
    • Ljungman, M.1
  • 34
    • 14944344958 scopus 로고    scopus 로고
    • Effect of vitamin E on gene expression changes in diet-related carcinogenesis
    • Lunec J, Halligan E, Mistry N, Karakoula K. 2004. Effect of vitamin E on gene expression changes in diet-related carcinogenesis. Ann NY Acad Sci 1031: 169-183.
    • (2004) Ann NY Acad Sci , vol.1031 , pp. 169-183
    • Lunec, J.1    Halligan, E.2    Mistry, N.3    Karakoula, K.4
  • 35
    • 0034676493 scopus 로고    scopus 로고
    • Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
    • Mates JM. 2000. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153: 83-104.
    • (2000) Toxicology , vol.153 , pp. 83-104
    • Mates, J.M.1
  • 36
    • 0025878888 scopus 로고
    • Effects of toluene and its metabolites on cerebral reactive oxygen species generation
    • Mattia CJ, LeBel CP, Bondy SC. 1991. Effects of toluene and its metabolites on cerebral reactive oxygen species generation. Biochem Pharmacol 42: 879-882.
    • (1991) Biochem Pharmacol , vol.42 , pp. 879-882
    • Mattia, C.J.1    LeBel, C.P.2    Bondy, S.C.3
  • 37
    • 0022258907 scopus 로고
    • A limited survey of retail apple and grape juices for the mycotoxin patulin
    • Mortimer DM, Parker L, Stephard MJ.Gilbert JA. 1985. A limited survey of retail apple and grape juices for the mycotoxin patulin. Food Addit Contam 2: 165-170.
    • (1985) Food Addit Contam , vol.2 , pp. 165-170
    • Mortimer, D.M.1    Parker, L.2    Stephard, M.J.3    Gilbert, J.A.4
  • 38
    • 0033579412 scopus 로고    scopus 로고
    • Regulation of the p53 tumor suppressor protein
    • Oren M. 1999. Regulation of the p53 tumor suppressor protein. J Biol Chem 274: 36031-36034.
    • (1999) J Biol Chem , vol.274 , pp. 36031-36034
    • Oren, M.1
  • 39
    • 0018075192 scopus 로고
    • Long term testing of patulin administer orally to Sprague-Dawley rats and Swiss mice
    • Osswald H, Frank HK, Komitowski D, Winter H. 1978. Long term testing of patulin administer orally to Sprague-Dawley rats and Swiss mice. Food Cosmet Toxicol 16: 243-247.
    • (1978) Food Cosmet Toxicol , vol.16 , pp. 243-247
    • Osswald, H.1    Frank, H.K.2    Komitowski, D.3    Winter, H.4
  • 40
    • 0038433245 scopus 로고    scopus 로고
    • Induction of micronuclei by zearalenone in Vero monkey kidney cells and in bone marrow cells of mice. Protective effect of Vitamin E
    • Ouanes Z, Abid S, Ayed I, Anane R, Mobio T, Creppy EE, Bacha H. 2003. Induction of micronuclei by zearalenone in Vero monkey kidney cells and in bone marrow cells of mice. Protective effect of Vitamin E. Mutat Res 538: 63-70.
    • (2003) Mutat Res , vol.538 , pp. 63-70
    • Ouanes, Z.1    Abid, S.2    Ayed, I.3    Anane, R.4    Mobio, T.5    Creppy, E.E.6    Bacha, H.7
  • 41
    • 12344305164 scopus 로고    scopus 로고
    • Zearalenone induces chromosome aberrations in mouse bone marrow: Preventive effect of 17β estradiol, progesterone and Vitamin E
    • Ouanes Z, Ayed-Boussema I, Baati T, Creppy EE, Bacha H. 2005. Zearalenone induces chromosome aberrations in mouse bone marrow: Preventive effect of 17β estradiol, progesterone and Vitamin E. Mutat Res 565: 139-149.
    • (2005) Mutat Res , vol.565 , pp. 139-149
    • Ouanes, Z.1    Ayed-Boussema, I.2    Baati, T.3    Creppy, E.E.4    Bacha, H.5
  • 42
    • 33749627734 scopus 로고    scopus 로고
    • Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment
    • Park SY, Lee SM, Ye SK, Yoon SH, Chung MH, Choi J. 2006. Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment. Toxicol Lett 167: 27-33.
    • (2006) Toxicol Lett , vol.167 , pp. 27-33
    • Park, S.Y.1    Lee, S.M.2    Ye, S.K.3    Yoon, S.H.4    Chung, M.H.5    Choi, J.6
  • 43
    • 0028947275 scopus 로고
    • Production of patulinby different strains of Penicillium expansum in pear and apple cultivars stored at different temperatures and modified atmospheres
    • Paster N, Huppert D, Barkai-Golan R. 1995. Production of patulinby different strains of Penicillium expansum in pear and apple cultivars stored at different temperatures and modified atmospheres. Food Addit Contam 12: 15-58.
    • (1995) Food Addit Contam , vol.12 , pp. 15-58
    • Paster, N.1    Huppert, D.2    Barkai-Golan, R.3
  • 44
    • 0031927107 scopus 로고    scopus 로고
    • Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin
    • Pfeiffer E, Gross K, Metzler M. 1998. Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. Carcinogenesis 19: 1313-1318.
    • (1998) Carcinogenesis , vol.19 , pp. 1313-1318
    • Pfeiffer, E.1    Gross, K.2    Metzler, M.3
  • 45
    • 0032945331 scopus 로고    scopus 로고
    • Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome
    • Pincheira J, Navarrete MH, de la Torre C, Tapia G, Santos MJ. 1999. Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome. Clin Genet 55: 192-197.
    • (1999) Clin Genet , vol.55 , pp. 192-197
    • Pincheira, J.1    Navarrete, M.H.2    de la Torre, C.3    Tapia, G.4    Santos, M.J.5
  • 46
    • 34249992834 scopus 로고    scopus 로고
    • Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway
    • Rickmann M, Vaquero EC, Malagelada JR, Molero X. 2007. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology 132: 2518-2532.
    • (2007) Gastroenterology , vol.132 , pp. 2518-2532
    • Rickmann, M.1    Vaquero, E.C.2    Malagelada, J.R.3    Molero, X.4
  • 47
    • 0025736665 scopus 로고
    • The mechanism of patulin's cytotoxicity and the antoixidant activity of indole tetramic acids
    • Riley RT, Showker JL. 1991. The mechanism of patulin's cytotoxicity and the antoixidant activity of indole tetramic acids. Toxicol Appl Pharm 109: 108-126.
    • (1991) Toxicol Appl Pharm , vol.109 , pp. 108-126
    • Riley, R.T.1    Showker, J.L.2
  • 48
    • 58149312818 scopus 로고    scopus 로고
    • Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p53 and p21/WAF1 proteins in skin of mice
    • Saxena N, Ansari KM, Kumar R, Dhawan Al, Dwivedi PD, Das M. 2009. Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p53 and p21/WAF1 proteins in skin of mice. Toxicol Appl Pharmacol 234: 192-201.
    • (2009) Toxicol Appl Pharmacol , vol.234 , pp. 192-201
    • Saxena, N.1    Ansari, K.M.2    Kumar, R.3    Dhawan, A.4    Dwivedi, P.D.5    Das, M.6
  • 49
    • 18044383908 scopus 로고    scopus 로고
    • Antigenotoxic effects of ascorbic acid against megestrol acetate-induced genotoxicity in mice
    • Siddique YH, Beg T, Afzal M. 2005. Antigenotoxic effects of ascorbic acid against megestrol acetate-induced genotoxicity in mice. Hum Exp Toxicol 24: 121-127.
    • (2005) Hum Exp Toxicol , vol.24 , pp. 121-127
    • Siddique, Y.H.1    Beg, T.2    Afzal, M.3
  • 50
    • 0004198354 scopus 로고
    • Oxydative stress: Introductory remarks. In: Sies H, editor. . London: Academic Press.Chapter 1
    • Sies H. 1985. Oxydative stress: Introductory remarks. In: Sies H, editor. Oxidative Stress. London: Academic Press.Chapter 1, pp 1-8.
    • (1985) Oxidative Stress , pp. 1-8
    • Sies, H.1
  • 52
    • 55049131936 scopus 로고    scopus 로고
    • Atrazine-induced alterations in rat erythrocyte membranes: Ameliorating effect of vitamin E
    • Singh M, Sandhir R, Kiran R. 2008. Atrazine-induced alterations in rat erythrocyte membranes: Ameliorating effect of vitamin E. J Biochem Mol Toxicol 22: 363-369.
    • (2008) J Biochem Mol Toxicol , vol.22 , pp. 363-369
    • Singh, M.1    Sandhir, R.2    Kiran, R.3
  • 53
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191.
    • (1988) Exp Cell Res , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 55
    • 0023837587 scopus 로고
    • Subacute toxicity study of patulin in the rat: Effects on the kidney and the gastro-intestinal tract
    • Speijers GJ, Franken MA, van Leeuwen FX. 1988. Subacute toxicity study of patulin in the rat: Effects on the kidney and the gastro-intestinal tract. Food Chem Toxicol 26: 23-30.
    • (1988) Food Chem Toxicol , vol.26 , pp. 23-30
    • Speijers, G.J.1    Franken, M.A.2    van Leeuwen, F.X.3
  • 57
    • 0026886862 scopus 로고
    • Effect of vitamin E on cytotoxicity. DNA single strand breaks, chromosomal aberrations, and mutation in Chinese hamster V-79 cells exposed to ultraviolet-B light
    • Sugiyama M, Tsuzuki K, Matsumoto K, Ogura R. 1992. Effect of vitamin E on cytotoxicity. DNA single strand breaks, chromosomal aberrations, and mutation in Chinese hamster V-79 cells exposed to ultraviolet-B light. Photochem Photobiol 56: 31-34.
    • (1992) Photochem Photobiol , vol.56 , pp. 31-34
    • Sugiyama, M.1    Tsuzuki, K.2    Matsumoto, K.3    Ogura, R.4
  • 58
    • 0031050629 scopus 로고    scopus 로고
    • Effects of antioxidant supplementation on DNA damage and repair in human lymphoblastoid cells
    • Sweetman SF, Strain JJ, McKelvey-Martin VJ. 1997. Effects of antioxidant supplementation on DNA damage and repair in human lymphoblastoid cells. Nutr Cancer 27: 122-130.
    • (1997) Nutr Cancer , vol.27 , pp. 122-130
    • Sweetman, S.F.1    Strain, J.J.2    McKelvey-Martin, V.J.3
  • 60
    • 34249868200 scopus 로고    scopus 로고
    • Vitamin E, antioxidant and nothing more
    • Traber MG, Atkinson J. 2007. Vitamin E, antioxidant and nothing more. Free Radic Biol Med 43: 4-15.
    • (2007) Free Radic Biol Med , vol.43 , pp. 4-15
    • Traber, M.G.1    Atkinson, J.2
  • 62
    • 0036063849 scopus 로고    scopus 로고
    • The mycotoxins citrinin,gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells
    • Wichmann G, Herbarth O, Lehmann I. 2002. The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells. Environ Toxicol 17: 211-218.
    • (2002) Environ Toxicol , vol.17 , pp. 211-218
    • Wichmann, G.1    Herbarth, O.2    Lehmann, I.3
  • 63
    • 56549106546 scopus 로고    scopus 로고
    • Mechanism of patulin-induced apoptosis in human leukemia cells (HL-60)
    • Wu TS, Liao YC, Yu FY, Chang CH, Liu BH. 2008. Mechanism of patulin-induced apoptosis in human leukemia cells (HL-60). Toxicol Lett 183: 105-111.
    • (2008) Toxicol Lett , vol.183 , pp. 105-111
    • Wu, T.S.1    Liao, Y.C.2    Yu, F.Y.3    Chang, C.H.4    Liu, B.H.5
  • 65
    • 0035543244 scopus 로고    scopus 로고
    • Incidence of patulin in apple juices marketed in Turkey
    • Yurdun T, Omurtag GZ, Ersoy O. 2001. Incidence of patulin in apple juices marketed in Turkey. J Food Protect 64: 1851-1853.
    • (2001) J Food Protect , vol.64 , pp. 1851-1853
    • Yurdun, T.1    Omurtag, G.Z.2    Ersoy, O.3
  • 66
    • 61449262757 scopus 로고    scopus 로고
    • Patulin-induced genotoxicity and modulation of glutathione in HepG2 cells
    • Zhou S, Jiang L, Geng C, Cao J, Zhong L. 2009. Patulin-induced genotoxicity and modulation of glutathione in HepG2 cells. Toxicon 53: 584-586.
    • (2009) Toxicon , vol.53 , pp. 584-586
    • Zhou, S.1    Jiang, L.2    Geng, C.3    Cao, J.4    Zhong, L.5
  • 67
    • 72749095740 scopus 로고    scopus 로고
    • Patulin-induced oxidative DNA damage and p53 modulation in HepG2 cells
    • Zhou S, Jiang L, Geng C, Cao J, Zhong L. 2010. Patulin-induced oxidative DNA damage and p53 modulation in HepG2 cells. Toxicon 55: 390-395.
    • (2010) Toxicon , vol.55 , pp. 390-395
    • Zhou, S.1    Jiang, L.2    Geng, C.3    Cao, J.4    Zhong, L.5
  • 68
    • 35448977648 scopus 로고    scopus 로고
    • Vitamin E: An overview of major research directions
    • Zingg JM. 2007. Vitamin E: An overview of major research directions. Mol Asp Med 28: 400-422.
    • (2007) Mol Asp Med , vol.28 , pp. 400-422
    • Zingg, J.M.1


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