Tocotrienols Induce Apoptosis and Autophagy in Rat Pancreatic Stellate Cells Through the Mitochondrial Death Pathway

Gastroenterology

Volumn 132, Issue 7, 2007, Pages 2518-2532

  Rickmann, Mariana ^a   Vaquero, Eva C ^a   Malagelada, Juan Ramón ^a   Molero, Xavier ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOTRIENOL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CYCLOSPORIN A; DNA FRAGMENT;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL VIABILITY; CHRONIC PANCREATITIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; LIVER FIBROSIS; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE CELL;

EID: 34249992834     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.03.107     Document Type: Article

References (52)

1. Bachem M.G., Schneider E., Gross H., Weidenbach H., Schmid R.M., Menke A., Siech M., Beger H., Grunert A., and Adler G. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115 (1998) 421-432
2. Apte M.V., Haber P.S., Applegate T.L., Norton I.D., McCaughan G.W., Korsten M.A., Pirola R.C., and Wilson J.S. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43 (1998) 128-133
3. Iredale J.P., Benyon R.C., Pickering J., et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102 (1998) 538-549
4. Saile B., Knittel T., Matthes N., Schott P., and Ramadori G. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during tissue repair. Am J Pathol 151 (1997) 1265-1272
5. Wright M.C., Issa R., Smart D.E., et al. Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances resolution of fibrosis in rats. Gastroenterology 121 (2001) 685-698
6. Oakley F., Meso M., Iredale J.P., Green K., Marek C.J., Zhou X., May M.J., Millward-Sadler H., Wright M.C., and Mann D.A. Inhibition of κB kinases stimulates hepatic stellate cell apoptosis and accelerates recovery from liver fibrosis. Gastroenterology 128 (2005) 108-120
7. Anan A., Baskin-Bey E.S., Isomoto H., Mott J.L., Bronk S.F., Albrecht J.H., and Gores G.J. Proteasome inhibition attenuates hepatic injury in the bile duct-ligated mouse. Am J Physiol Gastrointest Liver Physiol 291 (2006) G709-G716
8. Haber P.S., Keogh G.W., Apte M.V., Moran C.S., Stewart N.L., Crawford D.H., Pirola R.C., McCaughan G.W., Ramm G.A., and Wilson J.S. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 155 (1999) 1087-1095
9. Vaquero E., Molero X., Tian X., Salas A., and Malagelda J.R. Myofibroblast proliferation, fibrosis, and defective pancreatic repair induced by cyclosporin in rats. Gut 45 (1999) 269-277
10. Yamada T., Kuno A., Masuda K., Ogawa K., Sogawa M., Nakamura S., Ando T., Sano H., Nakazawa T., Ohara H., Nomura T., Joh T., and Itoh M. Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J Pharmacol Exp Ther 307 (2003) 17-23
11. Yokota T., Denham W., Murayama K., Pelham C., Joehl R., and Bell Jr. R.H. Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis. J Surg Res 104 (2002) 106-111
12. Gomez J.A., Molero X., Vaquero E., Alonso A., Salas A., and Malagelada J.R. Vitamin E attenuates biochemical and morphological features associated with development of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 287 (2004) G162-G169
13. van Westerloo D.J., Florquin S., de Boer A.M., Daalhuisen J., de Vos A.F., Bruno M.J., and van der Poll T. Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. Am J Pathol 166 (2005) 721-728
14. Kuno A., Yamada T., Masuda K., Ogawa K., Sogawa M., Nakamura S., Nakazawa T., Ohara H., Nomura T., Joh T., Shirai T., and Itoh M. Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology 124 (2003) 1010-1019
15. Guimaraes A.C., and Linden R. Programmed cell deaths. Apoptosis and alternative deathstyles. Eur J Biochem 271 (2004) 1638-1650
16. Leist M., and Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2 (2001) 589-598
17. Kroemer G., and Martin S.J. Caspase-independent cell death. Nat Med 11 (2005) 725-730
18. Tsujimoto Y., and Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ 12 Suppl 2 (2005) 1528-1534
19. Sen C.K., Khanna S., and Roy S. Tocotrienols: vitamin E beyond tocopherols. Life Sci 78 (2006) 2088-2098
20. Khosla P., Patel V., Whinter J.M., Khanna S., Rakhkovskaya M., Roy S., and Sen C.K. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Antioxid Redox Signal 8 (2006) 1059-1068
21. Patel V., Khanna S., Roy S., Ezziddin O., and Sen C.K. Natural vitamin E α-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal. Free Radic Res 40 (2006) 763-771
22. Har C.H., and Keong C.K. Effects of tocotrienols on cell viability and apoptosis in normal murine liver cells (BNL CL.2) and liver cancer cells (BNL 1ME A.7R.1), in vitro. Asia Pac J Clin Nutr 14 (2005) 374-380
23. Wada S., Satomi Y., Murakoshi M., Noguchi N., Yoshikawa T., and Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett 229 (2005) 181-191
24. McIntyre B.S., Briski K.P., Gapor A., and Sylvester P.W. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med 224 (2000) 292-301
25. Nesaretnam K., Dorasamy S., and Darbre P.D. Tocotrienols inhibit growth of ZR-75-1 breast cancer cells. Int J Food Sci Nutr 51 Suppl (2000) S95-S103
26. Shun M.C., Yu W., Gapor A., Parsons R., Atkinson J., Sanders B.G., and Kline K. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form of vitamin E (δ-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer 48 (2004) 95-105
27. Agarwal M.K., Agarwal M.L., Athar M., and Gupta S. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl-2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle 3 (2004) 205-211
28. Srivastava J.K., and Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun 346 (2006) 447-453
29. Sundram K., Khor H.T., Ong A.S., and Pathmanathan R. Effect of dietary palm oils on mammary carcinogenesis in female rats induced by 7,12-dimethylbenz(a)anthracene. Cancer Res 49 (1989) 1447-1451
30. Yu W., Simmons-Menchaca M., Gapor A., Sanders B.G., and Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 33 (1999) 26-32
31. Apte M.V., Phillips P.A., Fahmy R.G., Darby S.J., Rodgers S.C., McCaughan G.W., Korsten M.A., Pirola R.C., Naidoo D., and Wilson J.S. Does alcohol directly stimulate pancreatic fibrogenesis?. Studies with rat pancreatic stellate cells. Gastroenterology 118 (2000) 780-794
32. Gaça M.D., Zhou X., Issa R., Kiriella K., Iredale J.P., and Benyon R.C. Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells. Matrix Biol 22 (2003) 229-239
33. Bouchier-Hayes L., Lartigue L., and Newmeyer D.D. Mitochondria: pharmacological manipulation of cell death. J Clin Invest 115 (2005) 2640-2647
34. Harrison S.A., Torgerson S., Hayashi P., Ward J., and Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 98 (2003) 2485-2490
35. Houglum K., Venkataramani A., Lyche K., and Chojkier M. A pilot study of the effects of d-α-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 113 (1997) 1069-1073
36. Chojkier M., Houglum K., Lee K.S., and Buck M. Long- and short-term D-α-tocopherol supplementation inhibits liver collagen α1(I) gene expression. Am J Physiol 275 (1998) G1480-D1485
37. Brown K.E., Poulos J.E., Li L., Soweid A.M., Ramm G.A., O'Neill R., Britton R.S., and Bacon B.R. Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload. Am J Physiol 272 (1997) G116-G112
38. Parola M., Leonarduzzi G., Biasi F., Albano E., Biocca M.E., Poli G., and Dianzani M.U. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology 16 (1992) 1014-1021
39. Schaffer S., Muller W.E., and Eckert G.P. Tocotrienols: constitutional effects in aging and disease. J Nutr 135 (2005) 151-154
40. Salens X., Festjens N., Vande Walle L., van Gurp M., van Loo G., and Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogene 23 (2004) 2861-2874
41. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
42. von Haefen C., Wieder T., Essmann F., Schulze-Osthoff K., and Daniel P.T. Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. B. Oncogene 22 (2003) 2236-2247
43. Daugas E., Nochy D., Ravagnan L., Loeffler M., Susin S.A., Zamzami N., and Kroemer G. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 476 (2000) 118-123
44. Van Loo G., Schotte P., van Gurp M., Demol H., Hoorelbeke B., Gevaert K., Rodriguez I., Ruiz-Carrillo A., Vandekerckhove J., Declercq W., Beyaert R., and Vandenabeele P. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 8 (2001) 1136-1142
45. Forte M., and Bernardi P. The permeability transition and BCL-2 family proteins in apoptosis: co-conspirators or independent agents?. Cell Death Differ 13 (2006) 1287-1290
46. Kuwana T., Macke M.R., Perkins G., Ellisman M.H., Latterich M., Schneiter R., Green D.R., and Newmeyer D.D. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111 (2002) 331-342
47. Crompton M., Virji S., Doyle V., Johnson N., and Ward J.M. The mitochondrial permeability transition pore. Biochem Soc Symp 66 (1999) 167-179
48. Yang J.Y., and Widmann C. A subset of caspase substrates functions as the Jekyll and Hyde of apoptosis. Eur Cytokine Netw 13 (2002) 404-406
49. Martinou I., Desagher S., Eskes R., Antonsson B., Andre E., Fakan S., and Martinou J.C. The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event. J Cell Biol 144 (1999) 883-889
50. Minamikawa T., Williams D.A., Bowser D.N., and Nagley P. Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells. Exp Cell Res 246 (1999) 26-37
51. Ricci J.E., Gottlieb R.A., and Green D.R. Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol 160 (2003) 65-75
52. Neuzil J., Tomasetti M., Zhao Y., Dong L.F., Birringer M., Wang X.F., Low P., Wu K., Salvatore B.A., and Ralph S.J. Vitamin E analogs, a novel group of "mitocans," as anti-cancer agents: the importance of being redox-silent. Mol Pharmacol 71 (2007) 1185-1199