Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p53 and p21/WAF1 proteins in skin of mice

Toxicology and Applied Pharmacology

Volumn 234, Issue 2, 2009, Pages 192-201

  Saxena, Neha ^a   Ansari, Kausar M ^a   Kumar, Rahul ^a   Dhawan, Alok ^a   Dwivedi, Premendra D ^a   Das, Mukul ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Apoptosis; Cell cycle; Cytochrome C; p21 WAF1; p53; Patulin

Indexed keywords

BENZO[A]PYRENE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; MYCOTOXIN; ORNITHINE DECARBOXYLASE; PATULIN; POLYAMINE; PROTEIN BAX; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; APPLE; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CHEMICAL STRUCTURE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; FLOW CYTOMETRY; GENOTOXICITY; GRAPE; IMMUNOBLOTTING; MANUAL LABOR; MOUSE; NONHUMAN; ORANGE (FRUIT); PEACH; PEAR; POLYACRYLAMIDE GEL ELECTROPHORESIS; SKIN CELL; SKIN TOXICITY; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL CYCLE; CELL PROLIFERATION; COMET ASSAY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; DNA DAMAGE; GENES, P53; IMMUNOBLOTTING; MICE; MITOCHONDRIA; MUTAGENS; ORNITHINE DECARBOXYLASE; PATULIN; SIGNAL TRANSDUCTION; SKIN PHYSIOLOGICAL PHENOMENA;

MUS; PYRUS; VITACEAE;

EID: 58149312818     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.09.033     Document Type: Article

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