Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2

Toxicology and Applied Pharmacology

Volumn 240, Issue 3, 2009, Pages 327-336

  Niklas, Jens ^a   Noor, Fozia ^a   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

HepG2 cells; In vitro assays; Metabolic flux analysis; Preclinical drug development; Respiration; Subtoxic effects; Toxicity screening

Indexed keywords

AMIODARONE; DICLOFENAC; TACRINE;

AMINO ACID COMPOSITION; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; CELL RESPIRATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LIVER TOXICITY; METABOLOMICS; OXIDATIVE PHOSPHORYLATION UNCOUPLING; TOXICITY TESTING;

AMIODARONE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRIC ACID CYCLE; DICLOFENAC; DIMETHYL SULFOXIDE; HUMANS; LIVER NEOPLASMS; OXIDATIVE PHOSPHORYLATION; OXYGEN; PHARMACEUTICAL PREPARATIONS; TACRINE;

EID: 70349767923     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.07.005     Document Type: Article

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