Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation

Expert Opinion on Drug Metabolism and Toxicology

Volumn 8, Issue 1, 2012, Pages 11-27

  Louisse, Jochem ^a,b   Verwei, Miriam ^a,b   Woutersen, Ruud A ^a,b   Blaauboer, Bas J ^c   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

3Rs; Biomarkers; Developmental toxicity; Embryotoxicity; in vitro; Kinetic modeling

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ASCORBIC ACID; BIOLOGICAL MARKER; CARBAMAZEPINE; CYCLOPHOSPHAMIDE; CYTARABINE; DINOSEB; DOXYLAMINE; FLUOROURACIL; FLUSILAZOLE; FOLIC ACID; HEXACONAZOLE; ISONIAZID; LEVOTHYROXINE; METHOTREXATE; METHYLMERCURY; METOCLOPRAMIDE; MEVINOLIN; NITROFEN; OCHRATOXIN; PENICILLAMINE; PENICILLIN G; PHENYTOIN; RETINOIC ACID; RETINOL; SACCHARIN; TRIADIMEFON; UNINDEXED DRUG; VALPROIC ACID; WARFARIN;

BIOASSAY; BIOTRANSFORMATION; CELLULAR ASSAY; CHEST TOXICITY TEST; CONCENTRATION RESPONSE; DEVELOPMENTAL TOXICITY; DOSIMETRY; EMBRYONIC STEM CELL TEST; EMBRYOTOXICITY; FETAX SCREENING TEST; HUMAN; KINETICS; LIMB BUD MICROMASS TEST; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SENSITIVITY ANALYSIS; TERATOGENICITY; TOXICITY; TOXICITY TESTING; VALIDATION PROCESS; ZEBRA FISH;

ANIMALS; BIOLOGICAL MARKERS; EMBRYONIC STEM CELLS; HUMANS; PHARMACEUTICAL PREPARATIONS; RISK ASSESSMENT; TOXICITY TESTS;

EID: 84255171164     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2012.639762     Document Type: Review

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