The potential for clinical applications using a new ionization method combined with ion mobility spectrometry-mass spectrometry

International Journal for Ion Mobility Spectrometry

Volumn 16, Issue 2, 2013, Pages 145-159

  Inutan, Ellen D ^a   Wager Miller, James ^b   Narayan, Srinivas B ^c   Mackie, Ken ^b   Trimpin, Sarah ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c DETROIT MEDICAL CENTER   (United States)

Author keywords

Blood; Clinical mass spectrometry; Drugs; Ion mobility spectrometry mass spectrometry; Matrix assisted ionization vacuum; Nested data; Non selected MS MS; Non targeted; Plasma; Profiling; Proteins; Tissue

Indexed keywords

BLOOD; CHEMICAL ANALYSIS; ELECTROSPRAY IONIZATION; GASES; IONIZATION OF GASES; IONIZATION POTENTIAL; IONS; MASS SPECTROMETRY; METABOLITES; MIXTURES; PLASMAS; PROTEINS; TISSUE;

CLINICAL MASS SPECTROMETRY; DRUGS; ION MOBILITY SPECTROMETRY; MATRIX ASSISTED; NESTED DATA; NON-SELECTED MS/MS; NON-TARGETED; PROFILING;

ION MOBILITY SPECTROMETERS;

EID: 84876918010     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-013-0131-7     Document Type: Article

References (112)

1. Pieper R, Su Q, Gatlin CL, Huang ST, Anderson NL, Steiner S (2003) Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome. Proteomics 3: 422-432.
2. Pieper R, Gatlin CL, McGrath AM, Makusky AJ, Mondal M, Seonarain M, Field E, Schatz CR, Estock MA, Ahmed N, Anderson NG, Steiner S (2004) Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics 4: 1159-1174.
3. Wang H, Hanash S (2003) Multi-dimensional liquid phase based separations in proteomics. J Chromatog B 787: 11-18.
4. Shushan B (2010) A review of clinical diagnostic applications of liquid chromatography-tandem mass spectrometry. Mass Spectrom Rev 29: 930-944.
5. Kasper DC, Herman J, De Jesus VR, Mechtler TP, Metz TF, Shushan B (2010) The application of multiplexed, multi-dimensional ultra-high-performance liquid chromatography/tandem mass spectrometry to the high-throughput screening of lysosomal storage disorders in newborn dried bloodspots. Rapid Commun Mass Spectrom 24: 986-994.
6. Ang CS, Rothacker J, Patsiouras H, Gibbs P, Burgess AW, Nice EC (2011) Use of multiple reaction monitoring for multiplex analysis of colorectal cancer-associated proteins in human feces. Electrophoresis 32: 1926-1938.
7. Zhang X, Fang A, Riley CP, Wang M, Regnier FE, Buck C (2010) Multi-dimensional liquid chromatography in proteomics. Anal Chim Acta 664: 101-113.
8. Issaq HJ (2001) The role of separation science in proteomics research. Electrophoresis 22: 3629-3638.
9. Zhang J, Xu X, Gao M, Yang P, Zhang X (2007) Comparison of 2-D LC and 3-D LC with post-and pre-tryptic-digestion SEC fractionation for proteome analysis of normal human liver tissue. Proteomics 7: 500-512.
10. Dixon SP, Pitfield ID, Perrett D (2006) Comprehensive multi-dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review. Biomedical Chromatog 20: 508-529.
11. Han H, Miyoshi Y, Ueno K, Okamura C, Tojo Y, Mita M, Lindner W, Zaitsu K, Hamase K (2011) Simultaneous determination of d-aspartic acid and d-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure. J Chromatog B 879: 3196-3202.
12. Zerefos PG, Aivaliotis M, Baumann M, Vlahou A (2012) Analysis of the urine proteome via a combination of multi-dimensional approaches. Proteomics 12: 391-400.
13. Liu W, Liu B, Cai Q, Li J, Chen X, Zhu Z (2012) Proteomic identification of serum biomarkers for gastric cancer using multi-dimensional liquid chromatography and 2D differential gel electrophoresis. Clinica Chim Acta 413: 1098-1106.
14. Gray TR, Shakleya DM, Huestis MA (2009) A liquid chromatography tandem mass spectrometry method for the simultaneous quantification of 20 drugs of abuse and metabolites in human meconium. Anal Bioanal Chem 393: 1977-1990.
15. Liu XY, Valentine SJ, Plasencia MD, Trimpin S, Naylor S, Clemmer DE (2007) Mapping the human plasma proteome by SCX-LC-IMS-MS. J Am Soc Mass Spectrom 18: 1249-1264.
16. Isailovic D, Plasencia MD, Gaye MM, Stokes ST, Kurulugama RT, Pungpapong V, Zhang M, Kyselova Z, Goldman R, Mechref Y, Novotny MV, Clemmer DE (2012) Delineating diseases by IMS-MS profiling of serum N-linked glycans. J Proteome Res 11: 576-585.
17. Trimpin S, Tan B, O'Dell DK, Bohrer BC, Merenbloom SI, Pazos MX, Clemmer DE, Walker JM (2009) Profiling of phospholipids and related lipid structures using multidimensional ion mobility spectrometry-mass spectrometry. Int J Mass Spectrom 287: 58-69.
18. Wyttenbach T, von Helden G, Bowers MT (1996) Gas-phase conformation of biological molecules: bradykinin. J Am Chem Soc 118: 8355-8364.
19. Kanu AB, Dwivedi P, Tam M, Matz L, Hill HH Jr (2008) Ion mobility-mass spectrometry. J Mass Spectrom 43: 1-22.
20. Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE (2006) Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci 15: 420-428.
21. Wu C, Siems WF, Klasmeier J, Hill HH (2000) Separation of isomeric peptides using electrospray ionization/high-resolution ion mobility spectrometry. Anal Chem 72: 391-395.
22. Ruotolo BT, Verbeck GF, Thomson LM, Woods AS, Gillig KJ, Russell DH (2002) Distinguishing between phosphorylated and nonphosphorylated peptides with ion mobility-mass spectrometry. J Proteome Res 1: 303-306.
23. Hoaglund CS, Valentine SJ, Sporleder CR, Reilly JP, Clemmer DE (1998) Three-dimensional ion mobility/TOFMS analysis of electrosprayed biomolecules. Anal Chem 70: 2236-2242.
24. Thalassinos K, Slade SE, Jennings KR, Scrivens JH, Giles K, Wildgoose J, Hoyes J, Bateman RH, Bowers MT (2004) Ion mobility mass spectrometry of proteins in a modified commercial mass spectrometer. Int J Mass Spectrom 236: 55-63.
25. Ruotolo BT, Giles K, Campuzano I, Sandercock AM, Bateman RH, Robinson CV (2005) Evidence for macromolecular protein rings in the absence of bulk water. Science 310: 1658-1661.
26. Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT (2009) Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem 1: 326-331.
27. Benesch JL, Ruotolo BT, Simmons DA, Robinson CV (2007) Protein complexes in the gas phase: technology for structural genomics and proteomics. Chemical Reviews-Columbus 107: 3544-3567.
28. Seo Y, Andaya A, Leary JA (2012) Preparation, separation, and conformational analysis of differentially sulfated heparin octasaccharide isomers using ion mobility mass spectrometry. Anal Chem 84: 2416-2423.
29. Niñonuevo MR, Leary JA (2012) Ion mobility mass spectrometry coupled with rapid protein threading predictor structure prediction and collision-induced dissociation for probing chemokine conformation and stability. Anal Chem 84: 3208-3214.
30. Giles K, Williams JP, Campuzano I (2011) Enhancements in travelling wave ion mobility resolution. Rapid Commun Mass Spectrom 25: 1559-1566.
31. Li H, Giles K, Bendiak B, Kaplan K, Siems WF, Hill HH Jr (2012) Resolving structural isomers of monosaccharide methyl glycosides using drift tube and traveling wave ion mobility mass spectrometry. Anal Chem 84: 3231-3239.
32. Chawner R, McCullough B, Giles K, Barran PE, Gaskell SJ, Eyers CE (2012) A QconCAT standard for calibration of ion mobility mass spectrometry systems. J Proteome Res 11: 5564-5572.
33. Jungmann JH, Heeren RMA (2012) Emerging technologies in mass spectrometry imaging. J Proteomics 75: 5077-5092.
34. Syka JEP, Coon JJ, Schroeder MJ, Shabanowitz J, Hunt DF (2004) Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc Natl Acad Sci 101: 9528-9533.
35. Reid GE, McLuckey SA (2002) Top down protein characterization via tandem mass spectrometry. J Mass Spectrom 37: 663-675.
36. Mikesh LM, Ueberheide B, Chi A, Coon JJ, Syka JEP, Shabanowitz J, Hunt DF (2006) The utility of ETD mass spectrometry in proteomic analysis. Biochimica et Biophysica Acta-Proteins and Proteomics 1764: 1811-1822.
37. Moss CL, Chamot-Rooke J, Nicol E, Brown J, Campuzano I, Richardson K, Williams JP, Bush MF, Bythell B, Paizs B, Turecek F (2012) Assigning structures to gas-phase peptide cations and cation-radicals. An infrared multiphoton dissociation, ion mobility, electron transfer, and computational study of a histidine peptide ion. The Journal of Physical Chemistry B 116: 3445-3456.
38. Rand KD, Pringle SD, Morris M, Engen JR, Brown JM (2011) ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements. J Am Soc Mass Spectrom 22: 1784-1793.
39. Takats Z, Wiseman JM, Gologan B, Cooks RG (2004) Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306: 471-473.
40. Cody RB, Laramee JA, Durst HD (2005) Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal Chem 77: 2297-2302.
41. McEwen CN, McKay RG, Larsen BS (2005) Analysis of Solids Liquids and Biological Tissues using Solid Probe Introduction at Atmospheric Pressure on Commercial LC/MS Instruments. Anal Chem 77: 7826-7831.
42. Shiea J, Huang MZ, Hsu HJ, Lee CY, Yuan CH, Beech I, Sunner J (2005) Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids. Rapid Commun Mass Spectrom 19: 3701-3704.
43. Sampson JS, Hawkridge AM, Muddiman DC (2006) Generation and detection of multiply-charged peptides and proteins by Matrix-Assisted Laser Desorption Electrospray Ionization (MALDESI) fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom 17: 712-1716.
44. Trimpin S, Inutan ED, Herath T, McEwen CN (2010) Laserspray ionization-a new atmospheric pressure MALDI method for producing highly charged gas-phase ions of peptides and proteins directly from solid solutions. Mol Cell Proteomics 9: 362-367.
45. McEwen CN, Trimpin S (2011) An alternative ionization paradigm for atmospheric pressure mass spectrometry: flying elephants from Trojan Horses. Int J Mass Spectrom 300: 167-172.
46. Li J, Inutan ED, Wang B, Lietz CB, Green DR, Manly CD, Richards AL, Marshall DD, Lingenfelter S, Ren Y, Trimpin S (2012) Matrix assisted ionization: new aromatic and non aromatic matrix compounds producing multiply charged lipid peptide and protein ions in the positive and negative mode observed directly from surfaces. J Am Soc Mass Spectrom 23: 1625-1643.
47. Trimpin S, Wang B, Inutan ED, Li J, Lietz CB, Pagnotti VS, Harron A, Sardelis D, McEwen CN (2012) A mechanism for ionization of nonvolatile compounds in mass spectrometry: considerations from MALDI and inlet ionization. J Am Soc Mass Spectrom 23: 1644-1660.
48. Frankevich V, Nieckarz RJ, Sagulenko PN, Barylyuk K, Zenobi R, Levitsky LI, Yu Agapov A, Perlova TY, Gorshkov MV, Tarasova IA (2012) Probing the mechanisms of ambient ionization by laser-induced fluorescence spectroscopy. Rapid Commun Mass Spectrom 26: 1567-1572.
49. Trimpin S, Inutan ED, Herath T, McEwen CN (2010) Matrix-assisted laser desorption/ionization mass spectrometry method for selectively producing either singly or multiply charged molecular ions. Anal Chem 82: 11-15.
50. Inutan ED, Trimpin S (2010) Laserspray ionization (LSI) ion mobility spectrometry (IMS) mass spectrometry. J Am Soc Mass Spectrom 21: 1260-1264.
51. Inutan ED, Trimpin S (2010) Laserspray ionization-ion mobility spectrometry-mass spectrometry: baseline separation of isomeric amyloids without the use of solvents desorbed and ionized directly from a surface. J Proteome Res 9: 6077-6081.
52. McEwen CN, Pagnotti V, Inutan ED, Trimpin S (2010) A new paradigm in ionization: multiply charged ion formation from a solid matrix without a laser or voltage. Anal Chem 82: 9164-9168.
53. Lietz CB, Richards AL, Ren Y, Trimpin S (2011) Inlet ionization: protein analyses from the solid state without the use of a voltage or a laser producing up to 67 charges on the 66 kDa BSA protein. Rapid Commun Mass Spectrom 25: 3453-3456.
54. Pagnotti VS, Chubatyi ND, McEwen CN (2011) Solvent assisted inlet ionization: an ultrasensitive new liquid introduction ionization method for mass spectrometry. Anal Chem 83: 3981-3985.
55. Pagnotti VS, Inutan ED, Marshall DD, McEwen CN, Trimpin S (2011) Inlet ionization: a new highly sensitive approach for liquid chromatography-mass spectrometry of small and large molecules. Anal Chem 83: 7591-7594.
56. Wang B, Inutan ED, Trimpin S (2012) A new approach to high sensitivity liquid chromatography-mass spectrometry of peptides using nanoflow solvent assisted inlet ionization. J Am Soc Mass Spectrom 23: 442-445.
57. Chubatyi ND, Pagnotti VS, Bentzley CM, McEwen CN (2012) High sensitivity steroid analysis using liquid chromatography/solvent-assisted inlet ionization mass spectrometry. Rapid Commun Mass Spectrom 26: 887-892.
58. Inutan ED, Wang B, Trimpin S (2010) Commercial intermediate pressure MALDI Ion mobility spectrometry mass spectrometer capable of producing highly charged laserspray ionization ions. Anal Chem 83: 678-684.
59. Trimpin S, Ren Y, Wang B, Lietz CB, Richards AL, Marshall DD, Inutan ED (2011) Extending the laserspray ionization concept to produce highly charged ions at high vacuum on a time-of-flight mass analyzer. Anal Chem 83: 5469-5475.
60. Inutan ED, Wager-Miller J, Mackie K, Trimpin S (2012) Laserspray ionization imaging of multiply charged ions using a commercial vacuum MALDI ion source. Anal Chem 84: 9079-9084.
61. Inutan ED, Li J, Manly CM, Wang B, Trimpin S (2012) Laserspray ionization and solvent assisted inlet ionization developments and ion mobility spectrometry mass spectrometry applications. 60th ASMS Conference on Mass Spectrometry and Allied Topics, May 20-24 2012, Vancouver, Canada, WP30-slot 627.
62. Inutan ED, Trimpin S (2013) Matrix assisted ionization vacuum, a new ionization method for biological materials analysis using mass spectrometry. Mol Cell Proteomics 12: 792-796.
63. Trimpin S, Inutan ED (2013) Matrix assisted ionization in vacuum, a sensitive and widely applicable ionization method for mass spectrometry. J Am Soc Mass Spectrom. doi: 10. 1007/s13361-012-0571-z.
64. Inutan ED, Richards AL, Wager-Miller J, Mackie K, McEwen CN, Trimpin S (2011) Laserspray ionization, a new method for protein analysis directly from tissue at atmospheric pressure with ultrahigh mass resolution and electron transfer dissociation. Mol Cell Proteomics 10: 1-8.
65. Richards AL, Lietz CB, Wager-Miller JB, Mackie K, Trimpin S (2011) Imaging mass spectrometry in transmission geometry. Rapid Commun Mass Spectrom 25: 815-820.
66. Hoaglund-Hyzer CS, Lee YJ, Counterman AE, Clemmer DE (2002) Coupling ion mobility separations, collisional activation techniques, and multiple stages of MS for analysis of complex peptide mixtures. Anal Chem 74: 992-1006.
67. Ferrige AG, Seddon MJ, Green BN, Jarvis SA, Skilling J, Staunton J (1992) Disentangling electrospray spectra with maximum entropy. Rapid Commun Mass Spectrom 6: 707-711.
68. Krutchinsky AN, Chait BT (2002) On the nature of the chemical noise in MALDI mass spectra. J Am Soc Mass Spectrom 13: 129-134.
69. Eibisch M, Zellmer S, Gebhardt R, Suss R, Fuchs B, Schiller J (2011) Phosphatidylcholine dimers can be easily misinterpreted as cardiolipins in complex lipid mixtures: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of lipids from hepatocytes. Rapid Commun Mass Spectrom pp 2619-2626.
70. James PF, Perugini MA, O'Hair RAJ (2006) Sources of artefacts in the electrospray ionization mass spectra of saturated diacylglycerophosphocholines: From condensed phase hydrolysis reactions through to gas phase intercluster reactions. J Am Soc Mass Spectrom 17: 384-394.
71. Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, Gonin M, Schultz JA (2004) Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS. Anal Chem 76: 2187-2195.
72. Fenn LS, Kliman M, Mahsut A, Zhao SR, McLean JA (2009) Characterizing ion mobility-mass spectrometry conformation space for the analysis of complex biological samples. Anal Bioanal Chem 394: 235-244.
73. Vestal ML, Juhasz P, Martin SA (1995) Delayed extraction MALDI TOF MS. Rapid Commun Mass Spectrom 9: 1044-1050.
74. Shariatgorji M, Nilsson A, Goodwin Richard JA, Svenningsson P, Schintu N, Banka Z, Kladni L, Hasko T, Szabo A, Andren PE (2012) Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules. Anal Chem 84: 7152-7157.
75. Sun J, Baker A, Chen P (2011) Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 25: 2591-2602.
76. Plumb RS, Johnson KA, Rainville P, Smith BW, Wilson ID, Castro-Perez JM, Nicholson JK (2006) UPLC/MSE; a new approach for generating molecular fragment information for biomarker structure elucidation. Rapid Commun Mass Spectrom 20: 1989-1994.
77. Bateman KP, Castro-Perez J, Wrona M, Shockcor JP, Yu K, Oballa R, Nicoll-Griffith DA (2007) MSE with mass defect filtering for in vitro and in vivo metabolite identification. Rapid Commun Mass Spectrom 21: 1485-1496.
78. Ronci M, Bonanno E, Colantoni A, Pieroni L, Di Ilio C, Spagnoli LG, Federici G, Urbani A (2008) Protein unlocking procedures of formalin-fixed paraffin-embedded tissues: Application to MALDI-TOF Imaging MS investigations. Proteomics 8: 3702-3714.
79. Cheng FY, Blackburn K, Lin YM, Goshe MB, Williamson JD (2009) Absolute protein quantification by LC/MSE for global analysis of salicylic acid-induced plant protein secretion responses. J Proteome Res 8: 82-93.
80. Castro-Perez JM, Kamphorst J, DeGroot J, Lafeber F, Goshawk J, Yu K, Shockcor JP, Vreeken RJ, Hankemeier T (2010) Comprehensive LC- MSE lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. J Proteome Res 9: 2377-2389.
81. Finamore F, Pieroni L, Ronci M, Marzano V, Mortera SL, Romano M, Cortese C, Federici G, Urbani A (2010) Proteomics investigation of human platelets by shotgun nUPLC-MSE and 2DE experimental strategies: a comparative study. Blood Transfusion 8: S140-S148.
82. Prasad B, Garg A, Takwani H, Singh S (2011) Metabolite identification by liquid chromatography-mass spectrometry. Trends Anal Chem 30: 360-387.
83. Bijlsma L, Sancho JV, Hernández F, Niessen W (2011) Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MSE accurate-mass spectra. J Mass Spectrom 46: 865-875.
84. Martins-de-Souza D, Guest PC, Guest FL, Bauder C, Rahmoune H, Pietsch S, Roeber S, Kretzschmar H, Mann D, Baborie A, Bahn S (2012) Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses. Proteomics 12: 500-504.
85. Cha IS, Kwon J, Park SH, Nho SW, Jang HB, Park SB, del Castillo CS, Hikima J, Aoki T, Jung TS (2012) Kidney proteome responses in the teleost fish Paralichthys olivaceus indicate a putative immune response against Streptococcus parauberis. J Proteomics 75: 5166-5175.
86. Dong W, Wang P, Meng X, Sun H, Zhang A, Wang W, Dong H, Wang XJ (2012) Ultra-performance liquid chromatography-high-definition mass spectrometry analysis of constituents in the root of radix stemonae and those absorbed in blood after oral administration of the extract of the crude drug. Phytochemical Analysis 23: 657-667.
87. Barbara JE, Kazmi F, Muranjan S, Toren PC, Parkinson A (2012) High-resolution mass spectrometry elucidates metabonate (False Metabolite) formation from alkylamine drugs during in vitro metabolite profiling. Drug Metabolism Disposition 40: 1966-1975.
88. Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT (2005) Amyloid β-protein: monomer structure and early aggregation states of Aβ42 and its pro19 alloform. J Am Chem Soc 127: 2075-2084.
89. Aluise CD, Robinson RA, Becket TL, Murphy MP, Cai J, Pierce WM, Markesbery WR, Butterfield DA (2010) Preclinical Alzheimer disease: brain oxidative stress, Aβ peptide and proteomics. Neuro Disease 39: 221-228.
90. Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ (1993) 18-Amyloid-(142) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A 90: 10836-10840.
91. Pan J, Han J, Borchers CH, Konermann L (2011) Conformer-specific hydrogen exchange analysis of a beta(1-42) oligomers by top-down electron capture dissociation mass spectrometry. Anal Chem 83: 5386-5393.
92. Kraus M, Bienert M, Krause E (2003) Hydrogen exchange studies on Alzheimer's amyloid-beta peptides by mass spectrometry using matrix-assisted laser desorption/ionization and electrospray ionization. Rapid Commun Mass Spectrom 17: 222-228.
93. Seeley EH, Oppenheimer SR, Mi D, Chaurand P, Caprioli RM (2008) Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections. J Am Soc Mass Spectrom 19: 1069-1077.
94. Ceuppens R, Dumont D, van Brussel L, van de Plas B, Daniels R, Noben JP, Verhaert P, van der Gucht E, Robben J, Clerens S, Arckens L (2007) Direct profiling of myelinated and demyelinated regions in mouse brain by imaging mass spectrometry. Int J Mass Spectrom 260: 185-194.
95. Issaq HJ, Nativ O, Waybright T, Luke B, Veenstra TD, Issaq EJ, Kravstov A, Mullerad M (2008) Detection of bladder cancer in human urine by Metabolomic profiling using high performance liquid chromatography/mass spectrometry. The J Urology 179: 2422-2426.
96. Hoke SH (2001) Transformations in pharmaceutical research and development, driven by innovations in multidimensional mass spectrometry-based technologies. Int J Mass Spectrom 212: 135-196.
97. Vogeser M, Seger C (2008) A decade of HPLC-MS/MS in the routine clinical laboratory-Goals for further developments. Clin Biochem 41: 649-662.
98. Gruener BM, Hahne H, Mazur PK, Trajkovic-Arsic M, Maier S, Esposito I, Kalideris E, Michalski CW, Kleeff J, Rauser S, Schmid RM, Kuster B, Walch A, Siveke JT (2012) MALDI imaging mass spectrometry for in situ proteomic analysis of preneoplastic lesions in pancreatic cancer. PLoS One 7: e39424.
99. Nicolaou N, Xu Y, Goodacre R (2011) MALDI-MS and multivariate analysis for the detection and quantification of different milk species. Anal Bioanal Chem 399: 3491-3502.
100. Kjellström S, Jensen N (2003) In situ liquid-liquid extraction as a sample preparation method for matrix-assisted laser desorption/ionization ms analysis of polypeptide mixtures. Anal Chem 75: 2362-2369.
101. Warren ME, Brockman AH, Orlando R (1998) On-probe solid-phase extraction/MALDI-MS using ion-pairing interactions for the clean-up of peptides and proteins. Anal Chem 70: 3757-3761.
102. McCombie G, Staab D, Stoeckli M, Knochenmuss R (2005) Spatial and spectral correlations in MALDI mass spectrometry images by clustering and multivariate analysis. Anal Chem 77: 6118-6124.
103. Schwudke D, Hannich JT, Surendranath V, Grimard V, Moehring T, Burton L, Kurzchalia T, Shevchenko A (2007) Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra. Anal Chem 79: 4083-4093.
104. Miura D, Fujimura Y, Tachibana H, Wariishi H (2010) Highly sensitive matrix-assisted laser desorption ionization-mass spectrometry for high-throughput metabolic profiling. Anal Chem 82: 498-504.
105. Waloszczyk P, Janus T, Alchimowicz J, Grodzki T, Borowiak K (2011) Proteomic patterns analysis with multivariate calculations as a promising tool for prompt differentiation of early stage lung tissue with cancer and unchanged tissue material. Diagn Pathol 6: 1-7.
106. Broadhurst DI, Kell DB (2006) Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2: 171-196.
107. Gowda GN, Zhang S, Gu H, Asiago V, Shanaiah N, Raftery D (2008) Metabolomics-based methods for early disease diagnostics. Expert Rev Mol Diagn 8: 617-633.
108. Carpentier SC, Pani B, Vertommen A, Swennen R, Sergeant K, Renaut J, Laukens K, Witters E, Devreese B (2008) Proteome analysis of non-model plants: a challenging but powerful approach. Mass Spectrom Rev 27: 354-377.
109. Trimpin S, Clemmer DE (2008) Ion mobility spectrometry/mass spectrometry snapshots for assessing the molecular compositions of complex polymeric systems. Anal Chem 80: 9073-9083.
110. Park AY, Robinson CV (2011) Protein-nucleic acid complexes and the role of mass spectrometry in their structure determination. Crit Rev Biochem Mol Biol 46: 152-164.
111. Dhong S, Qin Y, Zhang F (2010) Mathematical tools and statistical techniques for proteomic data mining. Computer Sci 5: 123-140.
112. Franck J, Arafah K, Elayed M, Bonnel D, Vergara D, Jacquet A, Vinatier D, Wisztorski M, Day R, Fournier I, Salzet M (2009) MALDI imaging mass spectrometry: state of the art. Tech clinical proteomics. Mol Cell Proteomics 8: 2023-2033.