Inlet ionization: Protein analyses from the solid state without the use of a voltage or a laser producing up to 67 charges on the 66 kDa BSA protein

Rapid Communications in Mass Spectrometry

Volumn 25, Issue 22, 2011, Pages 3453-3456

  Lietz, Christopher B ^a   Richards, Alicia L ^a   Ren, Yue ^a   Trimpin, Sarah ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INLET IONIZATIONS; PROTEIN ANALYSIS;

PROTEINS;

EID: 80054742098     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.5233     Document Type: Letter

References (33)

1. M. Karas, F. Hillenkamp,. Laser desorption ionization of proteins with molecular masses exceeding 10000 daltons. Anal. Chem. 1988, 60, 2299.
2. J. B. Fenn, M. Mann, C. K. Meng, S. F. Wong, C. M. Whitehouse,. Electrospray ionization for mass spectrometry of large biomolecules. Science 1989, 246, 64.
3. N. Mano, J. Goto,. Biomedical and biological mass spectrometry. Anal. Sci. 2003, 19, 3.
4. n capabilities. Rapid. Commun. Mass Spectrom. 2001, 15, 1777.
5. A. G. Marshall, C. L. Hendrickson, G. S. Jackson,. Fourier transform ion cyclotron resonance mass spectrometry: a primer. Mass Spectrom. Rev. 1998, 17, 1.
6. J. E. P. Syka, J. J. Coon, M. J. Schroeder, J. Shabanowitz, D. F. Hunt,. Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc. Natl. Acad. Sci. USA 2004, 101, 9528.
7. S. Trimpin, E. D. Inutan, T. N. Herath, C. N. McEwen,. Laserspray Ionization-a new AP-MALDI method for producing highly charged gas-phase ions of peptides and proteins directly from solid solutions. Mol. Cell. Proteomics 2010, 9, 362.
8. E. D. Inutan, A. L. Richards, J. Wager-Miller, K. Mackie, C. N. McEwen, S. Trimpin,. Laserspray ionization-a new method for protein analysis directly from tissue at atmospheric pressure and with ultra-high mass resolution and electron transfer dissociation sequencing. Mol. Cell. Proteomics 2011, 10, 1.
9. D. D. Marshall, A. L. Richards, E. D. Inutan, S. Trimpin,. Inlet ionization methods for protein characterization and modification sites using a bottom-up approach. Proc. 59th ASMS Conf. Mass Spectrometry and Allied Topics, Denver, Colorado, 2011, MP 597.
10. S. Trimpin, T. N. Herath, E. D. Inutan, S. A. Cernat, J. Wager-Miller, K. Mackie, J. M. Walker,. Field-free transmission geometry atmospheric pressure matrix-assisted laser desorption/ionization for rapid analysis of unadulterated tissue samples. Rapid Commun. Mass Spectrom. 2009, 23, 3023.
11. S. Trimpin, E. D. Inutan, T. N. Herath, C. N. McEwen,. A matrix-assisted laser desorption/ionization mass spectrometry method for selectively producing either singly or multiply charged molecular ions. Anal. Chem. 2010, 82, 11.
12. C. N. McEwen, V. Pagnotti, E. D. Inutan, S. Trimpin,. A new paradigm in ionization: multiply charged ion formation from a solid matrix without a laser or voltage. Anal. Chem. 2010, 82, 9164.
13. C. N. McEwen, B. S. Larsen, S. Trimpin,. Laserspray ionization on a commercial atmospheric pressure-MALDI mass spectrometer ion source: selecting singly or multiply charged ions. Anal. Chem. 2010, 82, 4998.
14. E. D. Inutan, B. Wang, S. Trimpin,. Commercial intermediate pressure MALDI ion mobility spectrometry mass spectrometer capable of producing highly charged laserspray ionization ions. Anal. Chem. 2011, 83, 678.
15. S. Trimpin, Y. Ren, B. Wang, C. B. Lietz, A. L. Richards, D. D. Marshall, E. D. Inutan,. Extending the laserspray ionization concept to produce highly charged ions at high vacuum on a time-of-flight mass analyzer. Anal. Chem. 2011, 83, 5469.
16. Y. Ren, C. B. Lietz, A. L. Richards, B. Wang, E. D. Inutan, S. Trimpin,. Matrix-assisted inlet ionization (MAII) methods operating without voltage or laser to produce highly charged ions: what makes a matrix a better matrix? Proc. 59th ASMS Conf. Mass Spectrometry and Allied Topics, Denver, Colorado, 2011.
17. V. S. Pagnotti, N. D. Chubatyi, C. N. McEwen,. Solvent assisted inlet ionization: an ultrasensitive new liquid introduction ionization method for mass spectrometry. Anal. Chem. 2011, 83, 3981.
18. A. L. Richards, C. B. Lietz, J. Wager-Miller, K. Mackie, S. Trimpin,. Imaging mass spectrometry in transmission geometry. Rapid. Commun. Mass Spectrom. 2011, 25, 815.
19. A. A. Aksenov, M. E. Bier,. The analysis of polystyrene and polystyrene aggregates into the mega Dalton mass range by cryodetection MALDI TOF MS. J. Am. Soc. Mass Spectrom. 2008, 19, 219.
20. X. H. Cheng, D. G. Camp, Q. Y. Wu, R. Bakhitar, D. L. Springer, B. J. Morris, J. E. Bruce, G. A. Anderson, C. G. Edmonds, R. D. Smith,. Molecular weight determination of plasmid DNA using electrospray ionization mass spectrometry. Nucleic Acids Res. 1996, 11, 2183.
21. K. Tanaka, H. Waki, Y. Ido, S. Akita, Y. Yoshida, T. Yoshida,. Protein and polymer analyses up to m/z 100000 by laser ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 1988, 2, 151.
22. Z. X. Miao, H. Chen,. Direct analysis of liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS). J. Am. Soc. Mass Spectrom. 2009, 20, 10.
23. P. Nemes, A. Vertes,. Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry. Anal. Chem. 2007, 79, 8098.
24. S. Trimpin, M. L. Deinzer,. Solvent-free MALDI-MS for the analysis of biological samples via a mini-ball mill approach. J. Am. Soc. Mass Spectrom. 2005, 16, 542.
25. S. Trimpin, E. D. Inutan, T. N. Herath, S. M. Weidner, P. Kowalski, E. Claude, H. Major, C. N. McEwen, K. Mackie, M. Walker,. Total solvent-free analysis using mass spectrometry. Proc. 57th ASMS Conf. Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, 2009.
26. A. L. Richards, D. D. Marshall, E. D. Inutan, C. N. McEwen, S. Trimpin,. High throughput analysis of peptides and proteins by laserspray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25, 247.
27. E. D. Inutan, S. Trimpin,. Laserspray ionization-ion mobility spectrometry-mass spectrometry: baseline separation of isomeric amyloids without use of solvents desorbed and ionized directly from a surface. J. Proteome Res. 2010, 9, 6077.
28. C. B. Lietz, A. L. Richards, Y. Ren, S. Trimpin,. Highs and lows: small to large protein analysis with matrix-assisted inlet ionization (MAII) techniques in positive and negative ion mode. Proc. 59th ASMS Conf. Mass Spectrometry and Allied Topics, Denver, Colorado, 2011.
29. L. Wu, B. Yang, J. Bi, J. Wang,. Development of a bovine serum albumin certified reference material. Anal. Bioanal. Chem. 2011, 400, 3443.
30. M. L. Vestal,. Studies of ionization mechanisms involved in thermospray LC-MS. Int. J. Mass Spectrom. Ion Phys. 1983, 46, 193.
31. M. Dole, L. L. Mack, R. L. Hines, R. C. Molbley, L. D. Ferguson, M. B. Alice,. Molecular beams of macroions. J. Chem. Phys. 1968, 49, 2240.
32. C. L. Hendrickson, M. R. Emmett,. Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Annu. Rev. Phys. Chem. 1999, 50, 517.
33. E. N. Nikolaev, I. A. Boldin, R. Jertz, G. Baykut,. Initial experimental characterization of a new ultra-high resolution FTICR cell with dynamic harmonization. J. Am. Soc. Mass Spectrom. 2011, 22, 1125.