High-resolution mass spectrometry elucidates metabonate (false metabolite) formation from alkylamine drugs during in vitro metabolite profiling

Drug Metabolism and Disposition

Volumn 40, Issue 10, 2012, Pages 1966-1975

  Barbara, Joanna E ^a   Kazmi, Faraz ^a   Muranjan, Seema ^a   Toren, Paul C ^a   Parkinson, Andrew ^b  

^a XenoTech LLC   (United States)

^b XPD Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC AMINE; CYANIDE; DILTIAZEM; DINORDILTIAZEM; DRUG METABOLITE; NORDILTIAZEM; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; DEMETHYLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; ISOTOPE LABELING; LIVER MICROSOME; OXIDATION KINETICS; PREDICTION; PRIORITY JOURNAL; REACTION TIME; SENSITIVITY AND SPECIFICITY; TIME OF FLIGHT MASS SPECTROMETRY;

AMINES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA MINING; DILTIAZEM; HUMANS; METABOLOMICS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; WORKFLOW;

EID: 84866442707     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.047027     Document Type: Article

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