-
1
-
-
84862222859
-
New-onset diabetes in pancreatic cancer: A study in the primary care setting
-
(doi:10.1016/j.pan.2012.02.003)
-
Aggarwal G, Rabe KG, Petersen GM & Chari ST 2012 New-onset diabetes in pancreatic cancer: a study in the primary care setting. Pancreatology 12 156-161. (doi:10.1016/j.pan.2012.02.003)
-
(2012)
Pancreatology
, vol.12
, pp. 156-161
-
-
Aggarwal, G.1
Rabe, K.G.2
Petersen, G.M.3
Chari, S.T.4
-
2
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
doi:10.1016/0092-8674(88)90571-5
-
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N & Perucho M 1988 Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53 549-554. (doi:10.1016/0092-8674(88)90571-5)
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
Martin, J.4
Arnheim, N.5
Perucho, M.6
-
3
-
-
84887606268
-
Amgen announces termination of ganitumab phase 3 study for futility
-
Amgen 2012 Amgen announces termination of ganitumab phase 3 study for futility. In Metastatic Pancreatic Cancer.
-
(2012)
Metastatic Pancreatic Cancer
-
-
Amgen1
-
4
-
-
84866517360
-
KRAS (G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling
-
(doi:10.1158/1541-7786.MCR-12-0340-T)
-
Appleman VA, Ahronian LG, Cai J, Klimstra DS & Lewis BC 2012 KRAS (G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. Molecular Cancer Research 10 1228-1239. (doi:10.1158/1541-7786.MCR-12-0340-T)
-
(2012)
Molecular Cancer Research
, vol.10
, pp. 1228-1239
-
-
Appleman, V.A.1
Ahronian, L.G.2
Cai, J.3
Klimstra, D.S.4
Lewis, B.C.5
-
5
-
-
84866007085
-
EGF receptor is required for KRAS-induced pancreatic tumorigenesis
-
(doi:10.1016/j.ccr.2012.07.024)
-
Ardito CM, Gruner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC et al. 2012 EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 22 304-317. (doi:10.1016/j.ccr.2012.07.024)
-
(2012)
Cancer Cell
, vol.22
, pp. 304-317
-
-
Ardito, C.M.1
Gruner, B.M.2
Takeuchi, K.K.3
Lubeseder-Martellato, C.4
Teichmann, N.5
Mazur, P.K.6
Delgiorno, K.E.7
Carpenter, E.S.8
Halbrook, C.J.9
Hall, J.C.10
-
6
-
-
27144478642
-
Insulin receptor substrate is amediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells
-
(doi:10.1158/0008-5472.CAN-05-0779)
-
Asano T, Yao Y, Shin S, McCubrey J, Abbruzzese JL & Reddy SA 2005 Insulin receptor substrate is amediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. Cancer Research 65 9164-9168. (doi:10.1158/0008-5472.CAN-05-0779)
-
(2005)
Cancer Research
, vol.65
, pp. 9164-9168
-
-
Asano, T.1
Yao, Y.2
Shin, S.3
McCubrey, J.4
Abbruzzese, J.L.5
Reddy, S.A.6
-
7
-
-
78651355589
-
The complexities of obesity and diabetes with the development and progression of pancreatic cancer
-
(doi:10.1016/j.bbcan.2010.11.003)
-
Bao B, Wang Z, Li Y, Kong D, Ali S, Banerjee S, Ahmad A & Sarkar FH 2011 The complexities of obesity and diabetes with the development and progression of pancreatic cancer. Biochimica et Biophysica Acta 1815 135-146. (doi:10.1016/j.bbcan.2010.11.003)
-
(2011)
Biochimica Et Biophysica Acta
, vol.1815
, pp. 135-146
-
-
Bao, B.1
Wang, Z.2
Li, Y.3
Kong, D.4
Ali, S.5
Banerjee, S.6
Ahmad, A.7
Sarkar, F.H.8
-
9
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
doi:10.1038/nrc949
-
Bardeesy N & DePinho RA 2002 Pancreatic cancer biology and genetics. Nature Reviews. Cancer 2 897-909. (doi:10.1038/nrc949)
-
(2002)
Nature Reviews. Cancer
, vol.2
, pp. 897-909
-
-
Bardeesy, N.1
Depinho, R.A.2
-
11
-
-
70849120946
-
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
-
(doi:10.1210/er.2008-0047)
-
Belfiore A, Frasca F, Pandini G, Sciacca L & Vigneri R 2009 Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocrine Reviews 30 586-623. (doi:10.1210/er.2008-0047)
-
(2009)
Endocrine Reviews
, vol.30
, pp. 586-623
-
-
Belfiore, A.1
Frasca, F.2
Pandini, G.3
Sciacca, L.4
Vigneri, R.5
-
12
-
-
78650710888
-
The relationship between new-onset diabetes mellitus and pancreatic cancer risk: A case-control study
-
(doi:10.1016/ j.ejca.2010.07.010)
-
Ben Q, Cai Q, Li Z, Yuan Y, Ning X, Deng S & Wang K 2011 The relationship between new-onset diabetes mellitus and pancreatic cancer risk: a case-control study. European Journal of Cancer 47 248-254. (doi:10.1016/ j.ejca.2010.07.010)
-
(2011)
European Journal of Cancer
, vol.47
, pp. 248-254
-
-
Ben, Q.1
Cai, Q.2
Li, Z.3
Yuan, Y.4
Ning, X.5
Deng, S.6
Wang, K.7
-
13
-
-
0028997487
-
Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
-
Bergmann U, Funatomi H, Yokoyama M, Beger HG & Korc M 1995 Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Research 55 2007-2011.
-
(1995)
Cancer Research
, vol.55
, pp. 2007-2011
-
-
Bergmann, U.1
Funatomi, H.2
Yokoyama, M.3
Beger, H.G.4
Korc, M.5
-
14
-
-
0029890372
-
Increased expression of insulin receptor substrate-1 in human pancreatic cancer
-
(doi:10.1006/bbrc.1996.0500)
-
Bergmann U, Funatomi H, Kornmann M, Beger HG & Korc M 1996 Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Biochemical and Biophysical Research Communications 220 886-890. (doi:10.1006/bbrc.1996.0500)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.220
, pp. 886-890
-
-
Bergmann, U.1
Funatomi, H.2
Kornmann, M.3
Beger, H.G.4
Korc, M.5
-
15
-
-
72449164412
-
Pancreatic duct replication is increased with obesity and type 2 diabetes in humans
-
(doi:10.1007/s00125-009-1556-8)
-
Butler AE, Galasso R, Matveyenko A, Rizza RA, Dry S & Butler PC 2010 Pancreatic duct replication is increased with obesity and type 2 diabetes in humans. Diabetologia 53 21-26. (doi:10.1007/s00125-009-1556-8)
-
(2010)
Diabetologia
, vol.53
, pp. 21-26
-
-
Butler, A.E.1
Galasso, R.2
Matveyenko, A.3
Rizza, R.A.4
Dry, S.5
Butler, P.C.6
-
16
-
-
0032559272
-
Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
-
doi:10.1126/science.279.5350.563
-
Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH & Pollak M 1998 Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279 563-566. (doi:10.1126/science.279.5350.563)
-
(1998)
Science
, vol.279
, pp. 563-566
-
-
Chan, J.M.1
Stampfer, M.J.2
Giovannucci, E.3
Gann, P.H.4
Ma, J.5
Wilkinson, P.6
Hennekens, C.H.7
Pollak, M.8
-
17
-
-
84867416241
-
Diabetes and pancreatic cancer
-
doi:10.1530/ERC-12-0105
-
Cui Y & Andersen DK 2012 Diabetes and pancreatic cancer. Endocrine-Related Cancer 19 F9-F26. (doi:10.1530/ERC-12-0105)
-
(2012)
Endocrine-Related Cancer
, vol.19
-
-
Cui, Y.1
Andersen, D.K.2
-
18
-
-
0025320906
-
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
-
(doi:10.1038/345078a0)
-
DeChiara TM, Efstratiadis A & Robertson EJ 1990 A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345 78-80. (doi:10.1038/345078a0)
-
(1990)
Nature
, vol.345
, pp. 78-80
-
-
Dechiara, T.M.1
Efstratiadis, A.2
Robertson, E.J.3
-
19
-
-
10844223660
-
Insulin and its receptor: Structure, function and evolution
-
(doi:10.1002/bies.20151)
-
De Meyts P 2004 Insulin and its receptor: structure, function and evolution. BioEssays 26 1351-1362. (doi:10.1002/bies.20151)
-
(2004)
BioEssays
, vol.26
, pp. 1351-1362
-
-
de Meyts, P.1
-
20
-
-
77955497635
-
Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer
-
(473 e461-463). (doi:10.1053/j.gastro.2010.04.042
-
Dong X, Javle M, Hess KR, Shroff R, Abbruzzese JL & Li D 2010 Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer. Gastroenterology 139 464-473 (473 e461-463). (doi:10.1053/j.gastro.2010.04.042)
-
(2010)
Gastroenterology
, vol.139
, pp. 464-473
-
-
Dong, X.1
Javle, M.2
Hess, K.R.3
Shroff, R.4
Abbruzzese, J.L.5
Li, D.6
-
21
-
-
84858793843
-
Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer
-
(doi:10.1016/j.canep.2011.05.013)
-
Dong X, Li Y, Tang H, Chang P, Hess KR, Abbruzzese JL & Li D 2012 Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. Cancer Epidemiology 36 206-211. (doi:10.1016/j.canep.2011.05.013)
-
(2012)
Cancer Epidemiology
, vol.36
, pp. 206-211
-
-
Dong, X.1
Li, Y.2
Tang, H.3
Chang, P.4
Hess, K.R.5
Abbruzzese, J.L.6
Li, D.7
-
22
-
-
0021869257
-
Elevated growth hormone levels in sera from breast cancer patients
-
(doi:10.1055/s-2007-1013563)
-
Emerman JT, Leahy M, Gout PW & Bruchovsky N 1985 Elevated growth hormone levels in sera from breast cancer patients. Hormone and Metabolic Research 17 421-424. (doi:10.1055/s-2007-1013563)
-
(1985)
Hormone and Metabolic Research
, vol.17
, pp. 421-424
-
-
Emerman, J.T.1
Leahy, M.2
Gout, P.W.3
Bruchovsky, N.4
-
23
-
-
0029933939
-
Insulin promotes pancreatic cancer: Evidence for endocrine influence on exocrine pancreatic tumors
-
(doi:10.1006/jsre.1996.0266)
-
Fisher WE, Boros LG & Schirmer WJ 1996 Insulin promotes pancreatic cancer: evidence for endocrine influence on exocrine pancreatic tumors. Journal of Surgical Research 63 310-313. (doi:10.1006/jsre.1996.0266)
-
(1996)
Journal of Surgical Research
, vol.63
, pp. 310-313
-
-
Fisher, W.E.1
Boros, L.G.2
Schirmer, W.J.3
-
24
-
-
0032932822
-
Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
-
Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A & Vigneri R 1999 Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Molecular and Cellular Biology 19 3278-3288.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 3278-3288
-
-
Frasca, F.1
Pandini, G.2
Scalia, P.3
Sciacca, L.4
Mineo, R.5
Costantino, A.6
Goldfine, I.D.7
Belfiore, A.8
Vigneri, R.9
-
25
-
-
79959466358
-
Minireview: IGF, insulin, and cancer
-
(doi:10.1210/en.2011-0231)
-
Gallagher EJ & LeRoith D 2011 Minireview: IGF, insulin, and cancer. Endocrinology 152 2546-2551. (doi:10.1210/en.2011-0231)
-
(2011)
Endocrinology
, vol.152
, pp. 2546-2551
-
-
Gallagher, E.J.1
Leroith, D.2
-
26
-
-
0034679058
-
Abnormal glucose metabolism and pancreatic cancer mortality
-
doi:10.1001/jama.283.19.2552
-
Gapstur SM, Gann PH, Lowe W, Liu K, Colangelo L & Dyer A 2000 Abnormal glucose metabolism and pancreatic cancer mortality. Journal of the American Medical Association 283 2552-2558. (doi:10.1001/jama.283.19.2552)
-
(2000)
Journal of the American Medical Association
, vol.283
, pp. 2552-2558
-
-
Gapstur, S.M.1
Gann, P.H.2
Lowe, W.3
Liu, K.4
Colangelo, L.5
Dyer, A.6
-
27
-
-
0036584593
-
Genetic analysis of insulin signaling in Drosophila
-
doi:10.1016/S1043-2760(01)00548-3
-
Garofalo RS 2002 Genetic analysis of insulin signaling in Drosophila. Trends in Endocrinology and Metabolism 13 156-162. (doi:10.1016/S1043-2760(01)00548-3)
-
(2002)
Trends In Endocrinology and Metabolism
, vol.13
, pp. 156-162
-
-
Garofalo, R.S.1
-
28
-
-
71449120059
-
Insulin resistance and hyperinsulinaemia in the development and progression of cancer
-
(doi:10.1042/CS20090399)
-
Godsland IF 2010 Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clinical Science 118 315-332. (doi:10.1042/CS20090399)
-
(2010)
Clinical Science
, vol.118
, pp. 315-332
-
-
Godsland, I.F.1
-
29
-
-
72449184470
-
Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues
-
Reply to Nagel JM, Mansmann U, Wegscheider K et al. [letter] and Simon D [letter] (doi:10.1007/s00125-009-1582-6)
-
Grouven U, Hemkens LG, Bender R & Sawicki PT 2010 Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues. Reply to Nagel JM, Mansmann U, Wegscheider K et al. [letter] and Simon D [letter]. Diabetologia 53 209-211. (doi:10.1007/s00125-009-1582-6)
-
(2010)
Diabetologia
, vol.53
, pp. 209-211
-
-
Grouven, U.1
Hemkens, L.G.2
Bender, R.3
Sawicki, P.T.4
-
30
-
-
0242403449
-
Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma
-
(doi:10.1023/A:1026122421369)
-
Hakam A, Fang Q, Karl R & Coppola D 2003 Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Digestive Diseases and Sciences 48 1972-1978. (doi:10.1023/A:1026122421369)
-
(2003)
Digestive Diseases and Sciences
, vol.48
, pp. 1972-1978
-
-
Hakam, A.1
Fang, Q.2
Karl, R.3
Coppola, D.4
-
31
-
-
0032499440
-
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
-
doi:10.1016/S0140-6736(97)10384-1
-
Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE & Pollak M 1998 Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351 1393-1396. (doi:10.1016/S0140-6736(97)10384-1)
-
(1998)
Lancet
, vol.351
, pp. 1393-1396
-
-
Hankinson, S.E.1
Willett, W.C.2
Colditz, G.A.3
Hunter, D.J.4
Michaud, D.S.5
Deroo, B.6
Rosner, B.7
Speizer, F.E.8
Pollak, M.9
-
32
-
-
33646577163
-
Genetics and biology of pancreatic ductal adenocarcinoma
-
(doi:10.1101/gad.1415606)
-
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N & Depinho RA 2006 Genetics and biology of pancreatic ductal adenocarcinoma. Genes and Development 20 1218-1249. (doi:10.1101/gad.1415606)
-
(2006)
Genes and Development
, vol.20
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
Bardeesy, N.4
Depinho, R.A.5
-
33
-
-
77951755278
-
Pancreatic cancer
-
(doi:10.1056/NEJMra0901557)
-
Hidalgo M 2010 Pancreatic cancer. New England Journal of Medicine 362 1605-1617. (doi:10.1056/NEJMra0901557)
-
(2010)
New England Journal of Medicine
, vol.362
, pp. 1605-1617
-
-
Hidalgo, M.1
-
34
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
doi:10.1016/S1535-6108(03)00309-X
-
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA et al. 2003 Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4 437-450. (doi:10.1016/S1535-6108(03)00309-X)
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
Rajapakse, V.4
King, C.5
Jacobetz, M.A.6
Ross, S.7
Conrads, T.P.8
Veenstra, T.D.9
Hitt, B.A.10
-
35
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
(doi:10.1016/j.ccr.2005.04.023)
-
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S & Tuveson DA 2005 Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 469-483. (doi:10.1016/j.ccr.2005.04.023)
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
Combs, C.4
Deramaudt, T.B.5
Hruban, R.H.6
Rustgi, A.K.7
Chang, S.8
Tuveson, D.A.9
-
36
-
-
33847387472
-
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
-
(doi:10.1016/j.ccr.2007.01.017)
-
Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA et al. 2007 Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11 229-243. (doi:10.1016/j.ccr.2007.01.017)
-
(2007)
Cancer Cell
, vol.11
, pp. 229-243
-
-
Izeradjene, K.1
Combs, C.2
Best, M.3
Gopinathan, A.4
Wagner, A.5
Grady, W.M.6
Deng, C.X.7
Hruban, R.H.8
Adsay, N.V.9
Tuveson, D.A.10
-
37
-
-
41349099104
-
Cancer statistics, 2008
-
(doi:10.3322/CA.2007.0010)
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T & Thun MJ 2008 Cancer statistics, 2008. CA: A Cancer Journal for Clinicians 58 71-96. (doi:10.3322/CA.2007.0010)
-
(2008)
CA: A Cancer Journal For Clinicians
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Murray, T.6
Thun, M.J.7
-
38
-
-
0036820322
-
Serum and tissue level of insulin-like growth factor-I (IGF-I) and IGF-I binding proteins as an index of pancreatitis and pancreatic cancer
-
(doi:10.1046/j.1365-2613.2002.00237.x)
-
Karna E, Surazynski A, Orlowski K, Laszkiewicz J, Puchalski Z, Nawrat P & Palka J 2002 Serum and tissue level of insulin-like growth factor-I (IGF-I) and IGF-I binding proteins as an index of pancreatitis and pancreatic cancer. International Journal of Experimental Pathology 83 239-245. (doi:10.1046/j.1365-2613.2002.00237.x)
-
(2002)
International Journal of Experimental Pathology
, vol.83
, pp. 239-245
-
-
Karna, E.1
Surazynski, A.2
Orlowski, K.3
Laszkiewicz, J.4
Puchalski, Z.5
Nawrat, P.6
Palka, J.7
-
40
-
-
0032189403
-
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer
-
Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF & Korc M 1998 Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Research 58 4250-4254.
-
(1998)
Cancer Research
, vol.58
, pp. 4250-4254
-
-
Kornmann, M.1
Maruyama, H.2
Bergmann, U.3
Tangvoranuntakul, P.4
Beger, H.G.5
White, M.F.6
Korc, M.7
-
41
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic b cells creates an insulin secretory defect similar to that in type 2 diabetes
-
doi:10.1016/S0092-8674(00)80546-2
-
Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA & Kahn CR 1999 Tissue-specific knockout of the insulin receptor in pancreatic b cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96 329-339. (doi:10.1016/S0092-8674(00)80546-2)
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
42
-
-
0020440505
-
Exocrine pancreatic function in insulin-dependent diabetes mellitus
-
(doi:10.1159/000198833)
-
Lankisch PG, Manthey G, Otto J, Koop H, Talaulicar M, Willms B & Creutzfeldt W 1982 Exocrine pancreatic function in insulin-dependent diabetes mellitus. Digestion 25 211-216. (doi:10.1159/000198833)
-
(1982)
Digestion
, vol.25
, pp. 211-216
-
-
Lankisch, P.G.1
Manthey, G.2
Otto, J.3
Koop, H.4
Talaulicar, M.5
Willms, B.6
Creutzfeldt, W.7
-
43
-
-
1642588228
-
Pancreatic cancer
-
(doi:10.1016/S0140-6736(04)15841-8
-
Li D, Xie K, Wolff R & Abbruzzese JL 2004 Pancreatic cancer. Lancet 363 1049-1057. (doi:10.1016/S0140-6736(04)15841-8)
-
(2004)
Lancet
, vol.363
, pp. 1049-1057
-
-
Li, D.1
Xie, K.2
Wolff, R.3
Abbruzzese, J.L.4
-
44
-
-
67650945180
-
Antidiabetic therapies affect risk of pancreatic cancer
-
(doi:10.1053/j.gastro.2009.04.013)
-
Li D, Yeung SC, Hassan MM, Konopleva M & Abbruzzese JL 2009 Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 137 482-488. (doi:10.1053/j.gastro.2009.04.013)
-
(2009)
Gastroenterology
, vol.137
, pp. 482-488
-
-
Li, D.1
Yeung, S.C.2
Hassan, M.M.3
Konopleva, M.4
Abbruzzese, J.L.5
-
45
-
-
46949105858
-
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells
-
(doi:10.1093/carcin/bgn026)
-
Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM & Hochwald SN 2008 FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 29 1096-1107. (doi:10.1093/carcin/bgn026)
-
(2008)
Carcinogenesis
, vol.29
, pp. 1096-1107
-
-
Liu, W.1
Bloom, D.A.2
Cance, W.G.3
Kurenova, E.V.4
Golubovskaya, V.M.5
Hochwald, S.N.6
-
46
-
-
84874386146
-
The insulin receptor: A new target for cancer therapy
-
(doi:10.3389/fendo.2011.00093)
-
Malaguarnera R & Belfiore A 2011 The insulin receptor: a new target for cancer therapy. Frontiers in Endocrinology 2 93. (doi:10.3389/fendo.2011.00093)
-
(2011)
Frontiers In Endocrinology
, vol.2
, pp. 93
-
-
Malaguarnera, R.1
Belfiore, A.2
-
47
-
-
78149465086
-
Insulin-like growth factors and insulin control a multifunctional signaling network of significant importance in cancer
-
(doi:10.1038/sj.bjc.6605932)
-
Massoner P, Ladurner-Rennau M, Eder IE & Klocker H 2010 Insulin-like growth factors and insulin control a multifunctional signaling network of significant importance in cancer. British Journal of Cancer 103 1479-1484. (doi:10.1038/sj.bjc.6605932)
-
(2010)
British Journal of Cancer
, vol.103
, pp. 1479-1484
-
-
Massoner, P.1
Ladurner-Rennau, M.2
Eder, I.E.3
Klocker, H.4
-
48
-
-
84866123428
-
Genetically engineered mouse models of pancreatic cancer: Unravelling tumour biology and progressing translational oncology
-
(doi:10.1136/gutjnl-2011-300756)
-
Mazur PK & Siveke JT 2012 Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology. Gut 61 1488-1500. (doi:10.1136/gutjnl-2011-300756)
-
(2012)
Gut
, vol.61
, pp. 1488-1500
-
-
Mazur, P.K.1
Siveke, J.T.2
-
49
-
-
0034913642
-
Insulin secretion as a determinant of pancreatic cancer risk
-
(doi:10.1054/mehy.2001.1316)
-
McCarty MF 2001 Insulin secretion as a determinant of pancreatic cancer risk. Medical Hypotheses 57 146-150. (doi:10.1054/mehy.2001.1316)
-
(2001)
Medical Hypotheses
, vol.57
, pp. 146-150
-
-
McCarty, M.F.1
-
51
-
-
84866035571
-
EGF receptor signaling is essential for k-ras oncogenedriven pancreatic ductal adenocarcinoma
-
(doi:10.1016/j.ccr.2012.08.001)
-
Navas C, Hernandez-Porras I, Schuhmacher AJ, Sibilia M, Guerra C & Barbacid M 2012 EGF receptor signaling is essential for k-ras oncogenedriven pancreatic ductal adenocarcinoma. Cancer Cell 22 318-330. (doi:10.1016/j.ccr.2012.08.001)
-
(2012)
Cancer Cell
, vol.22
, pp. 318-330
-
-
Navas, C.1
Hernandez-Porras, I.2
Schuhmacher, A.J.3
Sibilia, M.4
Guerra, C.5
Barbacid, M.6
-
53
-
-
68549092476
-
The role of liver-derived insulin-like growth factor-I
-
(doi:10.1210/er.2009-0010)
-
Ohlsson C, Mohan S, Sjogren K, Tivesten A, Isgaard J, Isaksson O, Jansson JO & Svensson J 2009 The role of liver-derived insulin-like growth factor-I. Endocrine Reviews 30 494-535. (doi:10.1210/er.2009-0010)
-
(2009)
Endocrine Reviews
, vol.30
, pp. 494-535
-
-
Ohlsson, C.1
Mohan, S.2
Sjogren, K.3
Tivesten, A.4
Isgaard, J.5
Isaksson, O.6
Jansson, J.O.7
Svensson, J.8
-
54
-
-
0024476764
-
Mechanisms of insulin-induced insulin-receptor downregulation
-
Decrease of receptor biosynthesis and mRNA levels. (doi:10.2337/diabetes.38.2.182)
-
Okabayashi Y, Maddux BA, McDonald AR, Logsdon CD, Williams JA & Goldfine ID 1989 Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels. Diabetes 38 182-187. (doi:10.2337/diabetes.38.2.182)
-
(1989)
Diabetes
, vol.38
, pp. 182-187
-
-
Okabayashi, Y.1
Maddux, B.A.2
McDonald, A.R.3
Logsdon, C.D.4
Williams, J.A.5
Goldfine, I.D.6
-
55
-
-
0032800850
-
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanismof IGF-I signaling
-
Pandini G, Vigneri R, Costantino A, Frasca F, Ippolito A, Fujita-Yamaguchi Y, Siddle K, Goldfine ID & Belfiore A 1999 Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanismof IGF-I signaling. Clinical Cancer Research 5 1935-1944.
-
(1999)
Clinical Cancer Research
, vol.5
, pp. 1935-1944
-
-
Pandini, G.1
Vigneri, R.2
Costantino, A.3
Frasca, F.4
Ippolito, A.5
Fujita-Yamaguchi, Y.6
Siddle, K.7
Goldfine, I.D.8
Belfiore, A.9
-
56
-
-
0037131385
-
Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
-
(doi:10.1074/jbc.M202766200)
-
Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R & Belfiore A 2002 Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. Journal of Biological Chemistry 277 39684-39695. (doi:10.1074/jbc.M202766200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 39684-39695
-
-
Pandini, G.1
Frasca, F.2
Mineo, R.3
Sciacca, L.4
Vigneri, R.5
Belfiore, A.6
-
57
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
(doi:10.1038/nrc2536)
-
Pollak M 2008a Insulin and insulin-like growth factor signalling in neoplasia. Nature Reviews. Cancer 8 915-928. (doi:10.1038/nrc2536)
-
(2008)
Nature Reviews. Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
58
-
-
54349093798
-
Insulin, insulin-like growth factors and neoplasia
-
(doi:10.1016/j.beem.2008.08.004)
-
Pollak M 2008b Insulin, insulin-like growth factors and neoplasia. Best Practice & Research. Clinical Endocrinology & Metabolism 22 625-638. (doi:10.1016/j.beem.2008.08.004)
-
(2008)
Best Practice & Research. Clinical Endocrinology & Metabolism
, vol.22
, pp. 625-638
-
-
Pollak, M.1
-
59
-
-
0029037649
-
Pathophysiology of insulin resistance in human disease
-
Reaven GM 1995 Pathophysiology of insulin resistance in human disease. Physiological Reviews 75 473-486.
-
(1995)
Physiological Reviews
, pp. 473-486
-
-
Reaven, G.M.1
-
60
-
-
79958106621
-
Insulin-like growth factor signaling as a therapeutic target in pancreatic cancer
-
(doi:10.2174/187152011795677454)
-
Rieder S, Michalski CW, Friess H & Kleeff J 2011 Insulin-like growth factor signaling as a therapeutic target in pancreatic cancer. Anti-Cancer Agents in Medicinal Chemistry 11 427-433. (doi:10.2174/187152011795677454)
-
(2011)
Anti-Cancer Agents In Medicinal Chemistry
, vol.11
, pp. 427-433
-
-
Rieder, S.1
Michalski, C.W.2
Friess, H.3
Kleeff, J.4
-
61
-
-
77951708711
-
Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: A novel target for the antidiabetic drug metformin in pancreatic cancer
-
(doi:10.1158/1078-0432.CCR-09-2229)
-
Rozengurt E, Sinnett-Smith J & Kisfalvi K 2010 Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clinical Cancer Research 16 2505-2511. (doi:10.1158/1078-0432.CCR-09-2229)
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 2505-2511
-
-
Rozengurt, E.1
Sinnett-Smith, J.2
Kisfalvi, K.3
-
62
-
-
33846874575
-
The role of the IGF system in cancer growth and metastasis: Overview and recent insights
-
(doi:10.1210/er.2006-0001)
-
Samani AA, Yakar S, LeRoith D & Brodt P 2007 The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocrine Reviews 28 20-47. (doi:10.1210/er.2006-0001)
-
(2007)
Endocrine Reviews
, vol.28
, pp. 20-47
-
-
Samani, A.A.1
Yakar, S.2
Leroith, D.3
Brodt, P.4
-
63
-
-
79961004321
-
Signalling by insulin and IGF receptors: Supporting acts and new players
-
doi:10.1530/JME-11-0022
-
Siddle K 2011 Signalling by insulin and IGF receptors: supporting acts and new players. Journal of Molecular Endocrinology 47 R1-R10. (doi:10.1530/JME-11-0022)
-
(2011)
Journal of Molecular Endocrinology
, vol.47
-
-
Siddle, K.1
-
64
-
-
19344376176
-
Chromosomal instability in mousemetastatic pancreatic cancer - it's Kras and Tp53 after all
-
doi:10.1016/j.ccr.2005.04.025
-
Siveke JT & Schmid RM 2005 Chromosomal instability in mousemetastatic pancreatic cancer - it's Kras and Tp53 after all. Cancer Cell 7 405-407. (doi:10.1016/j.ccr.2005.04.025)
-
(2005)
Cancer Cell
, vol.7
, pp. 405-407
-
-
Siveke, J.T.1
Schmid, R.M.2
-
65
-
-
0035863411
-
AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells
-
Tanno S, Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH & Testa JR 2001 AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Research 61 589-593.
-
(2001)
Cancer Research
, vol.61
, pp. 589-593
-
-
Tanno, S.1
Tanno, S.2
Mitsuuchi, Y.3
Altomare, D.A.4
Xiao, G.H.5
Testa, J.R.6
-
66
-
-
77951476693
-
Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer
-
(doi:10.3748/wjg.v16.i15.1854)
-
Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M & Yoshida T 2010 Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer. World Journal of Gastroenterology 16 1854-1858. (doi:10.3748/wjg.v16.i15.1854)
-
(2010)
World Journal of Gastroenterology
, vol.16
, pp. 1854-1858
-
-
Tomizawa, M.1
Shinozaki, F.2
Sugiyama, T.3
Yamamoto, S.4
Sueishi, M.5
Yoshida, T.6
-
67
-
-
33646871998
-
Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer
-
Ueda S, Hatsuse K, Tsuda H, Ogata S, Kawarabayashi N, Takigawa T, Einama T, Morita D, Fukatsu K, Sugiura Y et al. 2006 Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer. Modern Pathology 19 788-796.
-
(2006)
Modern Pathology
, vol.19
, pp. 788-796
-
-
Ueda, S.1
Hatsuse, K.2
Tsuda, H.3
Ogata, S.4
Kawarabayashi, N.5
Takigawa, T.6
Einama, T.7
Morita, D.8
Fukatsu, K.9
Sugiura, Y.10
-
68
-
-
77953973648
-
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
-
(doi:10.1073/pnas.0914076107)
-
Ulanet DB, Ludwig DL, Kahn CR & Hanahan D 2010 Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. PNAS 107 10791-10798. (doi:10.1073/pnas.0914076107)
-
(2010)
PNAS
, vol.107
, pp. 10791-10798
-
-
Ulanet, D.B.1
Ludwig, D.L.2
Kahn, C.R.3
Hanahan, D.4
-
69
-
-
84863319601
-
Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma
-
(doi:10.1002/cncr.26661)
-
Valsecchi ME, McDonald M, Brody JR, Hyslop T, Freydin B, Yeo CJ, Solomides C, Peiper SC & Witkiewicz AK 2012 Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma. Cancer 118 3484-3493. (doi:10.1002/cncr.26661)
-
(2012)
Cancer
, vol.118
, pp. 3484-3493
-
-
Valsecchi, M.E.1
McDonald, M.2
Brody, J.R.3
Hyslop, T.4
Freydin, B.5
Yeo, C.J.6
Solomides, C.7
Peiper, S.C.8
Witkiewicz, A.K.9
-
70
-
-
0034967179
-
The IGF system in thyroid cancer: New concepts
-
(doi:10.1136/mp.54.3.121)
-
Vella V, Sciacca L, Pandini G, Mineo R, Squatrito S, Vigneri R & Belfiore A 2001 The IGF system in thyroid cancer: new concepts. Molecular Pathology 54 121-124. (doi:10.1136/mp.54.3.121)
-
(2001)
Molecular Pathology
, vol.54
, pp. 121-124
-
-
Vella, V.1
Sciacca, L.2
Pandini, G.3
Mineo, R.4
Squatrito, S.5
Vigneri, R.6
Belfiore, A.7
-
71
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Nature Reviews (doi:10.1038/nrc839)
-
Vivanco I & Sawyers CL 2002 The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nature Reviews. Cancer 2 489-501. (doi:10.1038/nrc839)
-
(2002)
Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
72
-
-
57149127369
-
IGF-1 receptor inhibitors in clinical trials - early lessons
-
(doi:10.1007/s10911-008-9104-6)
-
Weroha SJ & Haluska P 2008 IGF-1 receptor inhibitors in clinical trials - early lessons. Journal of Mammary Gland Biology and Neoplasia 13 471-483. (doi:10.1007/s10911-008-9104-6)
-
(2008)
Journal of Mammary Gland Biology and Neoplasia
, vol.13
, pp. 471-483
-
-
Weroha, S.J.1
Haluska, P.2
-
73
-
-
0022356341
-
The insulin-pancreatic acinar axis
-
(doi:10.2337/diabetes.34.10.980)
-
Williams JA & Goldfine ID 1985 The insulin-pancreatic acinar axis. Diabetes 34 980-986. (doi:10.2337/diabetes.34.10.980)
-
(1985)
Diabetes
, vol.34
, pp. 980-986
-
-
Williams, J.A.1
Goldfine, I.D.2
-
74
-
-
84861986394
-
Insulin-like growth factor 1 physiology: Lessons from mouse models
-
(doi:10.1016/j.ecl.2012.04.008)
-
Yakar S & Adamo ML 2012 Insulin-like growth factor 1 physiology: lessons from mouse models. Endocrinology and Metabolism Clinics of North America 41 231-247. (doi:10.1016/j.ecl.2012.04.008)
-
(2012)
Endocrinology and Metabolism Clinics of North America
, vol.41
, pp. 231-247
-
-
Yakar, S.1
Adamo, M.L.2
-
75
-
-
16544382555
-
Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse
-
(Discussion 9-18, 265-268)
-
Yakar S, Pennisi P, Zhao H, Zhang Y & LeRoith D 2004 Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse. Novartis Foundation Symposium 262 3-9 (Discussion 9-18, 265-268).
-
(2004)
Novartis Foundation Symposium
, vol.262
, pp. 3-9
-
-
Yakar, S.1
Pennisi, P.2
Zhao, H.3
Zhang, Y.4
Leroith, D.5
-
76
-
-
0036135151
-
Role of Akt in growth and survival of PANC-1 pancreatic cancer cells
-
(doi:10.1097/00006676-200201000-00006)
-
Yao Z, Okabayashi Y, Yutsudo Y, Kitamura T, Ogawa W & Kasuga M 2002 Role of Akt in growth and survival of PANC-1 pancreatic cancer cells. Pancreas 24 42-46. (doi:10.1097/00006676-200201000-00006)
-
(2002)
Pancreas
, vol.24
, pp. 42-46
-
-
Yao, Z.1
Okabayashi, Y.2
Yutsudo, Y.3
Kitamura, T.4
Ogawa, W.5
Kasuga, M.6
-
77
-
-
84863900275
-
Insulin-like growth factor receptor inhibitors: Baby or the bathwater?
-
(doi:10.1093/jnci/djs258)
-
Yee D 2012 Insulin-like growth factor receptor inhibitors: baby or the bathwater? Journal of the National Cancer Institute 104 975-981. (doi:10.1093/jnci/djs258)
-
(2012)
Journal of the National Cancer Institute
, vol.104
, pp. 975-981
-
-
Yee, D.1
-
78
-
-
0034692430
-
Role of the insulin-like growth factor family in cancer development and progression
-
(doi:10.1093/jnci/92.18.1472)
-
Yu H & Rohan T 2000 Role of the insulin-like growth factor family in cancer development and progression. Journal of the National Cancer Institute 92 1472-1489. (doi:10.1093/jnci/92.18.1472)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, pp. 1472-1489
-
-
Yu, H.1
Rohan, T.2
|