-
1
-
-
0036348616
-
Insulin-like growth factor receptor-1 as an anti- cancer target: Blocking transformation and inducing apoptosis
-
Wang, Y.; Sun, Y. Insulin-like growth factor receptor-1 as an anti- cancer target: blocking transformation and inducing apoptosis. Curr. Cancer Drug Targets, 2002, 2(3), 191-207.
-
(2002)
Curr. Cancer Drug Targets
, vol.2
, Issue.3
, pp. 191-207
-
-
Wang, Y.1
Sun, Y.2
-
2
-
-
0030727705
-
Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
-
Dunn, S.E.; Kari, F.W.; French, J.; Leininger, J.R.; Travlos, G.; Wilson, R.; Barrett, J.C. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res, 1997, 57(21), 4667-4672.
-
(1997)
Cancer Res
, vol.57
, Issue.21
, pp. 4667-4672
-
-
Dunn, S.E.1
Kari, F.W.2
French, J.3
Leininger, J.R.4
Travlos, G.5
Wilson, R.6
Barrett, J.C.7
-
3
-
-
0031558028
-
The IGF-I receptor in cell growth, transformation and apoptosis
-
Baserga, R.; Hongo, A.; Rubini, M.; Prisco, M.; Valentinis, B. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim. Biophys. Acta, 1997, 1332(3), F105-126.
-
(1997)
Biochim. Biophys. Acta
, vol.1332
, Issue.3
-
-
Baserga, R.1
Hongo, A.2
Rubini, M.3
Prisco, M.4
Valentinis, B.5
-
4
-
-
0037131385
-
Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
-
Pandini, G.; Frasca, F.; Mineo, R.; Sciacca, L.; Vigneri, R.; Belfiore, A. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem., 2002, 277(42), 39684-39695.
-
(2002)
J. Biol. Chem
, vol.277
, Issue.42
, pp. 39684-39695
-
-
Pandini, G.1
Frasca, F.2
Mineo, R.3
Sciacca, L.4
Vigneri, R.5
Belfiore, A.6
-
5
-
-
0033920612
-
Insulin-like growth factor (IGF)-binding proteins: Interactions with IGFs and intrinsic bioactivities
-
Baxter, R.C. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am. J. Physiol. Endocrinol. Metab., 2000, 278(6), E967-976.
-
(2000)
Am. J. Physiol. Endocrinol. Metab
, vol.278
, Issue.6
-
-
Baxter, R.C.1
-
6
-
-
0036803018
-
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
-
Mohan, S.; Baylink, D.J. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J. Endocrinol., 2002, 175(1), 19-31.
-
(2002)
J. Endocrinol
, vol.175
, Issue.1
, pp. 19-31
-
-
Mohan, S.1
Baylink, D.J.2
-
7
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N.; Sonenberg, N. Upstream and downstream of mTOR. Genes Dev, 2004. 18(16), 1926-1945.
-
(2004)
Genes Dev
, vol.18
, Issue.16
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
8
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti, M.A.; Houghton, P.J. The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer, 2004, 4(5), 335-348.
-
(2004)
Nat. Rev. Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
9
-
-
33747819801
-
MTOR and cancer: Insights into a complex relationship
-
Sabatini, D.M. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer, 2006, 6(9), 729-734.
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.9
, pp. 729-734
-
-
Sabatini, D.M.1
-
10
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly, K.E.; Rojo, F.; She, Q.B.; Solit, D.; Mills, G.B.; Smith, D.; Lane, H.; Hofmann, F.; Hicklin, D.J.; Ludwig, D.L.; Baselga, J.; Rosen, N. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res., 2006, 66(3), 1500-1508.
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
11
-
-
0023473304
-
Presence of somatomedin receptors on primary human breast and colon carcinomas
-
Pollak, M.N.; Perdue, J.F.; Margolese, R.G.; Baer, K.; Richard, M. Presence of somatomedin receptors on primary human breast and colon carcinomas. Cancer Lett., 1987, 38(1-2), 223-230.
-
(1987)
Cancer Lett
, vol.38
, Issue.1-2
, pp. 223-230
-
-
Pollak, M.N.1
Perdue, J.F.2
Margolese, R.G.3
Baer, K.4
Richard, M.5
-
12
-
-
0032559272
-
Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
-
Chan, J.M.; Stampfer, M.J.; Giovannucci, E.; Gann, P.H.; Ma, J.; Wilkinson, P.; Hennekens, C.H.; Pollak, M. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science, 1998, 279(5350), 563-566.
-
(1998)
Science
, vol.279
, Issue.5350
, pp. 563-566
-
-
Chan, J.M.1
Stampfer, M.J.2
Giovannucci, E.3
Gann, P.H.4
Ma, J.5
Wilkinson, P.6
Hennekens, C.H.7
Pollak, M.8
-
13
-
-
0032499440
-
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
-
Hankinson, S.E.; Willett, W.C.; Colditz, G.A.; Hunter, D.J.; Michaud, D.S.; Deroo, B.; Rosner, B.; Speizer, F.E.; Pollak, M. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet, 1998, 351(9113), 1393-1396.
-
(1998)
Lancet
, vol.351
, Issue.9113
, pp. 1393-1396
-
-
Hankinson, S.E.1
Willett, W.C.2
Colditz, G.A.3
Hunter, D.J.4
Michaud, D.S.5
Deroo, B.6
Rosner, B.7
Speizer, F.E.8
Pollak, M.9
-
14
-
-
0033531765
-
Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
-
Ma, J.; Pollak, M.N.; Giovannucci, E.; Chan, J.M.; Tao, Y.; Hennekens, C.H.; Stampfer, M.J. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J. Natl. Cancer Inst., 1999, 91(7), 620-625.
-
(1999)
J. Natl. Cancer Inst
, vol.91
, Issue.7
, pp. 620-625
-
-
Ma, J.1
Pollak, M.N.2
Giovannucci, E.3
Chan, J.M.4
Tao, Y.5
Hennekens, C.H.6
Stampfer, M.J.7
-
15
-
-
0033521877
-
Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia
-
Petridou, E.; Dessypris, N.; Spanos, E.; Mantzoros, C., Skalkidou, A., Kalmanti, M., Koliouskas, D., Kosmidis, H., Panagiotou, J.P., Piperopoulou, F., Tzortzatou, F., and Trichopoulos, D. Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia. Int. J. Cancer, 1999, 80(4), 494-496.
-
(1999)
Int. J. Cancer
, vol.80
, Issue.4
, pp. 494-496
-
-
Petridou, E.1
Dessypris, N.2
Spanos, E.3
Mantzoros, C.4
Skalkidou, A.5
Kalmanti, M.6
Koliouskas, D.7
Kosmidis, H.8
Panagiotou, J.P.9
Piperopoulou, F.10
Tzortzatou, F.11
Trichopoulos, D.12
-
16
-
-
0028997487
-
Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
-
Bergmann, U.; Funatomi, H.; Yokoyama, M.; Beger, H.G.; Korc, M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res., 1995, 55(10), 2007-2011.
-
(1995)
Cancer Res
, vol.55
, Issue.10
, pp. 2007-2011
-
-
Bergmann, U.1
Funatomi, H.2
Yokoyama, M.3
Beger, H.G.4
Korc, M.5
-
17
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
Lopez, T.; Hanahan, D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell, 2002, 1(4), 339-353.
-
(2002)
Cancer Cell
, vol.1
, Issue.4
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
18
-
-
0032211884
-
Cancer in acromegaly
-
Jenkins, P. Cancer in acromegaly. Trends Endocrinol. Metab., 1998, 9(9), 360-366.
-
(1998)
Trends Endocrinol. Metab
, vol.9
, Issue.9
, pp. 360-366
-
-
Jenkins, P.1
-
19
-
-
0030738695
-
Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs
-
Dunn, S.E.; Hardman, R.A.; Kari, F.W.; Barrett, J.C. Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res., 1997, 57(13), 2687-2693.
-
(1997)
Cancer Res
, vol.57
, Issue.13
, pp. 2687-2693
-
-
Dunn, S.E.1
Hardman, R.A.2
Kari, F.W.3
Barrett, J.C.4
-
20
-
-
0032850369
-
Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects
-
Gooch, J.L.; Van Den Berg, C.L.; Yee, D. Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects. Breast Cancer Res. Treat, 1999, 56(1), 1-10.
-
(1999)
Breast Cancer Res. Treat
, vol.56
, Issue.1
, pp. 1-10
-
-
Gooch, J.L.1
van den Berg, C.L.2
Yee, D.3
-
21
-
-
0242624594
-
Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor I receptor
-
Surmacz, E. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene, 2003, 22(42), 6589-6597.
-
(2003)
Oncogene
, vol.22
, Issue.42
, pp. 6589-6597
-
-
Surmacz, E.1
-
22
-
-
0020962492
-
Monoclonal antibodies to receptors for insulin and somatomedin-C
-
Kull, F.C.; Jacobs, S.; Su, Y.F.; Svoboda, M.E.; Van Wyk, J.J.; Cuatrecasas, P. Monoclonal antibodies to receptors for insulin and somatomedin-C. J. Biol. Chem., 1983, 258(10), 6561-6566.
-
(1983)
J. Biol. Chem
, vol.258
, Issue.10
, pp. 6561-6566
-
-
Kull, F.C.1
Jacobs, S.2
Su, Y.F.3
Svoboda, M.E.4
van Wyk, J.J.5
Cuatrecasas, P.6
-
23
-
-
0024460381
-
Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice
-
Arteaga, C.L.; Kitten, L.J.; Coronado, E.B.; Jacobs, S.; Kull, F.C.; Allred, D.C.; Osborne, C.K. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J. Clin. Invest., 1989, 84(5), 1418-1423.
-
(1989)
J. Clin. Invest
, vol.84
, Issue.5
, pp. 1418-1423
-
-
Arteaga, C.L.1
Kitten, L.J.2
Coronado, E.B.3
Jacobs, S.4
Kull, F.C.5
Allred, D.C.6
Osborne, C.K.7
-
24
-
-
23044493251
-
Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
-
Hofmann, F. and Garcia-Echeverria, C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov. Today, 2005, 10(15), 1041-1047.
-
(2005)
Drug Discov. Today
, vol.10
, Issue.15
, pp. 1041-1047
-
-
Hofmann, F.1
Garcia-Echeverria, C.2
-
25
-
-
57149127369
-
IGF-1 receptor inhibitors in clinical trials--early lessons
-
Weroha, S.J.; Haluska, P. IGF-1 receptor inhibitors in clinical trials--early lessons. J. Mammary Gland Biol. Neoplasia, 2008, 13(4), 471-483.
-
(2008)
J. Mammary Gland Biol. Neoplasia
, vol.13
, Issue.4
, pp. 471-483
-
-
Weroha, S.J.1
Haluska, P.2
-
26
-
-
36148953021
-
Phase I dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
Haluska, P.; Shaw, H.; Batzel, G.N.; Molife, L.R.; Adjei, A.A.; Yap, T.A.; Roberts, M.L.; Gualberto, A.; de Bono, J.S. Phase I dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors. J. Clin. Oncol. (Meeting Abstracts), 2007, 25(18_suppl), 3586.
-
(2007)
J. Clin. Oncol. (Meeting Abstracts)
, vol.25
, Issue.18 SUPPL.
, pp. 3586
-
-
Haluska, P.1
Shaw, H.2
Batzel, G.N.3
Molife, L.R.4
Adjei, A.A.5
Yap, T.A.6
Roberts, M.L.7
Gualberto, A.8
de Bono, J.S.9
-
27
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp, D.D.; Paz-Ares, L.G.; Novello, S.; Haluska, P.; Garland, L.; Cardenal, F.; Blakely, L.J.; Eisenberg, P.D.; Langer, C.J.; Blumenschein, G.; Johnson, F.M.; Green, S.; Gualberto, A. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J. Clin. Oncol., 2009, 27(15), 2516-2522.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.15
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
Haluska, P.4
Garland, L.5
Cardenal, F.6
Blakely, L.J.7
Eisenberg, P.D.8
Langer, C.J.9
Blumenschein, G.10
Johnson, F.M.11
Green, S.12
Gualberto, A.13
-
28
-
-
56149094007
-
A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IGF1R) antibody, in combination with panitumumab (P) or gemcitabine (G)
-
Sarantopoulos, J.; Mita, A.C.; Mulay, M.; Romero, O.; Lu, J.; Capilla, F.; Chen, L.; Hwang, Y.; Friberg, G.; Rosen, L.S. A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IGF1R) antibody, in combination with panitumumab (P) or gemcitabine (G). J. Clin. Oncol. (Meeting Abstracts), 2008, 26(15_suppl), 3583.
-
(2008)
J. Clin. Oncol. (Meeting Abstracts)
, vol.26
, Issue.15 SUPPL.
, pp. 3583
-
-
Sarantopoulos, J.1
Mita, A.C.2
Mulay, M.3
Romero, O.4
Lu, J.5
Capilla, F.6
Chen, L.7
Hwang, Y.8
Friberg, G.9
Rosen, L.S.10
-
29
-
-
77749245782
-
The first-line treatment for advanced pancreatic cancer. Highlights from the 2010 ASCO Gastrointestinal Cancers Symposium
-
Orlando, FL, USA. January 22-24, 2010
-
Merl, M.Y.; Li, J.; Saif, M.W. The first-line treatment for advanced pancreatic cancer. Highlights from the 2010 ASCO Gastrointestinal Cancers Symposium. Orlando, FL, USA. January 22-24, 2010. JOP, 2010, 11(2), 148-150.
-
(2010)
JOP
, vol.11
, Issue.2
, pp. 148-150
-
-
Merl, M.Y.1
Li, J.2
Saif, M.W.3
-
30
-
-
79958151669
-
SWOG S0727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line treatment in patients (pts) with metastatic pancreatic cancer
-
Philip, P.A.; Goldman, B.H.; Ramanathan, R.K.; Lenz, H.; Lowy, A.M.; Whitehead, R.P.; Iqbal, S.; Chung, V.M.; Benedetti, J.K.; Blanke, C.D. SWOG S0727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line treatment in patients (pts) with metastatic pancreatic cancer. J. Clin. Oncol., (Meeting Abstracts), 2010, 28(15_suppl), TPS223.
-
(2010)
J. Clin. Oncol., (Meeting Abstracts)
, vol.28
, Issue.15 SUPPL.
-
-
Philip, P.A.1
Goldman, B.H.2
Ramanathan, R.K.3
Lenz, H.4
Lowy, A.M.5
Whitehead, R.P.6
Iqbal, S.7
Chung, V.M.8
Benedetti, J.K.9
Blanke, C.D.10
-
31
-
-
77950974697
-
A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
-
Kurzrock, R.; Patnaik, A.; Aisner, J.; Warren, T.; Leong, S.; Benjamin, R.; Eckhardt, S.G.; Eid, J.E.; Greig, G.; Habben, K.; McCarthy, C.D.; Gore, L. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin. Cancer Res., 2010, 16(8), 2458-2465.
-
(2010)
Clin. Cancer Res
, vol.16
, Issue.8
, pp. 2458-2465
-
-
Kurzrock, R.1
Patnaik, A.2
Aisner, J.3
Warren, T.4
Leong, S.5
Benjamin, R.6
Eckhardt, S.G.7
Eid, J.E.8
Greig, G.9
Habben, K.10
McCarthy, C.D.11
Gore, L.12
-
32
-
-
57149130704
-
A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor1 receptor) antagonist, in patients(pts) with advanced solid tumor(ST)
-
Tolcher, A.W.; Patnaik, A.; Till, E.; Takimoto, C.H.; Papadopoulos, K.P.; Massard, C.; Mery-Mignard, D.; Deslandes, A.; Ozoux, M.; Soria, J. A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor1 receptor) antagonist, in patients(pts) with advanced solid tumor(ST). J Clin Oncol (Meeting Abstracts), 2008, 26(15_suppl), 3582.
-
(2008)
J Clin Oncol (Meeting Abstracts)
, vol.26
, Issue.15 SUPPL.
, pp. 3582
-
-
Tolcher, A.W.1
Patnaik, A.2
Till, E.3
Takimoto, C.H.4
Papadopoulos, K.P.5
Massard, C.6
Mery-Mignard, D.7
Deslandes, A.8
Ozoux, M.9
Soria, J.10
-
33
-
-
78349267741
-
Phase I/II study of MK-0646, the humanized monoclonal IGF-1R antibody in combination with gemcitabine or gemcitabine plus erlotinib (E) for advanced pancreatic cancer
-
Javle, M.M.; Varadhachary, G.R.; Shroff, R.T.; Bhosale, P.; Overman, M.J.; Weatherly, J.; Wolff, R.A.; Abbruzzese, J.L. Phase I/II study of MK-0646, the humanized monoclonal IGF-1R antibody in combination with gemcitabine or gemcitabine plus erlotinib (E) for advanced pancreatic cancer. J. Clin. Oncol. (Meeting Abstracts), 2010, 28(15_suppl), 4039.
-
(2010)
J. Clin. Oncol. (Meeting Abstracts)
, vol.28
, Issue.15 SUPPL.
, pp. 4039
-
-
Javle, M.M.1
Varadhachary, G.R.2
Shroff, R.T.3
Bhosale, P.4
Overman, M.J.5
Weatherly, J.6
Wolff, R.A.7
Abbruzzese, J.L.8
-
34
-
-
0022800838
-
Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
-
Ullrich, A.; Gray, A.; Tam, A.W.; Yang-Feng, T.; Tsubokawa, M.; Collins, C.; Henzel, W.; Le Bon, T.; Kathuria, S.; Chen, E.; and et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J, 1986. 5(10), 2503-2512.
-
(1986)
EMBO J
, vol.5
, Issue.10
, pp. 2503-2512
-
-
Ullrich, A.1
Gray, A.2
Tam, A.W.3
Yang-Feng, T.4
Tsubokawa, M.5
Collins, C.6
Henzel, W.7
le Bon, T.8
Kathuria, S.9
Chen, E.10
-
35
-
-
20544432746
-
IGF-1: Old growth factor shines as new drug target
-
Garber, K. IGF-1: old growth factor shines as new drug target. J. Natl. Cancer Inst., 2005, 97(11), 790-792.
-
(2005)
J. Natl. Cancer Inst
, vol.97
, Issue.11
, pp. 790-792
-
-
Garber, K.1
-
36
-
-
0030909657
-
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins
-
Parrizas, M.; Gazit, A.; Levitzki, A.; Wertheimer, E.; LeRoith, D. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology, 1997, 138(4), 1427-1433.
-
(1997)
Endocrinology
, vol.138
, Issue.4
, pp. 1427-1433
-
-
Parrizas, M.1
Gazit, A.2
Levitzki, A.3
Wertheimer, E.4
Leroith, D.5
-
37
-
-
0034719133
-
Substrate competitive inhibitors of IGF-1 receptor kinase
-
Blum, G.; Gazit, A.; Levitzki, A. Substrate competitive inhibitors of IGF-1 receptor kinase. Biochemistry, 2000, 39(51), 15705-15712.
-
(2000)
Biochemistry
, vol.39
, Issue.51
, pp. 15705-15712
-
-
Blum, G.1
Gazit, A.2
Levitzki, A.3
-
38
-
-
12144285705
-
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase
-
Garcia-Echeverria, C.; Pearson, M.A.; Marti, A.; Meyer, T.; Mestan, J.; Zimmermann, J.; Gao, J.; Brueggen, J.; Capraro, H.G.; Cozens, R.; Evans, D.B.; Fabbro, D.; Furet, P.; Porta, D.G.; Liebetanz, J.; Martiny-Baron, G.; Ruetz, S.; Hofmann, F. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell, 2004, 5(3), 231-239.
-
(2004)
Cancer Cell
, vol.5
, Issue.3
, pp. 231-239
-
-
Garcia-Echeverria, C.1
Pearson, M.A.2
Marti, A.3
Meyer, T.4
Mestan, J.5
Zimmermann, J.6
Gao, J.7
Brueggen, J.8
Capraro, H.G.9
Cozens, R.10
Evans, D.B.11
Fabbro, D.12
Furet, P.13
Porta, D.G.14
Liebetanz, J.15
Martiny-Baron, G.16
Ruetz, S.17
Hofmann, F.18
-
39
-
-
20944447905
-
Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors
-
Scotlandi, K.; Manara, M.C.; Nicoletti, G.; Lollini, P.L.; Lukas, S.; Benini, S.; Croci, S.; Perdichizzi, S.; Zambelli, D.; Serra, M.; Garcia-Echeverria, C.; Hofmann, F.; Picci, P. Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res., 2005, 65(9), 3868-3876.
-
(2005)
Cancer Res
, vol.65
, Issue.9
, pp. 3868-3876
-
-
Scotlandi, K.1
Manara, M.C.2
Nicoletti, G.3
Lollini, P.L.4
Lukas, S.5
Benini, S.6
Croci, S.7
Perdichizzi, S.8
Zambelli, D.9
Serra, M.10
Garcia-Echeverria, C.11
Hofmann, F.12
Picci, P.13
-
40
-
-
40449095393
-
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: Potential mechanistic involvement of Mdm2 and beta-arrestin1
-
Vasilcanu, R.; Vasilcanu, D.; Rosengren, L.; Natalishvili, N.; Sehat, B.; Yin, S.; Girnita, A.; Axelson, M.; Girnita, L.; Larsson, O. Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1. Oncogene, 2008, 27(11), 1629-1638.
-
(2008)
Oncogene
, vol.27
, Issue.11
, pp. 1629-1638
-
-
Vasilcanu, R.1
Vasilcanu, D.2
Rosengren, L.3
Natalishvili, N.4
Sehat, B.5
Yin, S.6
Girnita, A.7
Axelson, M.8
Girnita, L.9
Larsson, O.10
-
41
-
-
53549121511
-
A phase I trial of nordihydroguareacetic acid (NDGA) in patients with non-metastatic prostate cancer and rising PSA
-
Harzstark, A.L.; Ryan, C.; Diamond, M.; Jones, J.; Zavodovskaya, M.; Maddux, B.; Claros, C.; Goldfine, I.; Small, E.J. A phase I trial of nordihydroguareacetic acid (NDGA) in patients with non-metastatic prostate cancer and rising PSA. J. Clin. Oncol. (Meeting Abstracts), 2007, 25(18_suppl), 15500.
-
(2007)
J. Clin. Oncol. (Meeting Abstracts)
, vol.25
, Issue.18 SUPPL.
, pp. 15500
-
-
Harzstark, A.L.1
Ryan, C.2
Diamond, M.3
Jones, J.4
Zavodovskaya, M.5
Maddux, B.6
Claros, C.7
Goldfine, I.8
Small, E.J.9
-
42
-
-
69449099663
-
Phase I dose escalation study of continuous oral dosing of OSI-906, an insulin like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor, in patients with advanced solid tumors
-
Lindsay, C.R.; Chan, E.; Evans, T.R.; Campbell, S.; Bell, P.; Stephens, A.W.; Franke, A.; Poondru, S.; Rothenberg, M.L.; Puzanov, I. Phase I dose escalation study of continuous oral dosing of OSI-906, an insulin like growth factor-1 receptor (IGF-1R) tyrosine kinase inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. (Meeting Abstracts), 2009, 27(15S), 2559.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, Issue.15 S
, pp. 2559
-
-
Lindsay, C.R.1
Chan, E.2
Evans, T.R.3
Campbell, S.4
Bell, P.5
Stephens, A.W.6
Franke, A.7
Poondru, S.8
Rothenberg, M.L.9
Puzanov, I.10
-
43
-
-
72449155246
-
A phase I study of XL228, a potent IGF1R/ AURORA/SRC inhibitor, in patients with solid tumors or hematologic malignancies
-
Smith, D.C.; Britten, C.; Clary, D.O.; Nguyen, L.T.; Woodard, P.; Hurwitz, H.I. A phase I study of XL228, a potent IGF1R/ AURORA/SRC inhibitor, in patients with solid tumors or hematologic malignancies. J. Clin. Oncol. (Meeting Abstracts), 2009, 27(15S), 3512.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts
, vol.27
, Issue.15
, pp. 3512
-
-
Smith, D.C.1
Britten, C.2
Clary, D.O.3
Nguyen, L.T.4
Woodard, P.5
Hurwitz, H.I.6
-
44
-
-
73149120253
-
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
-
Carboni, J.M.; Wittman, M.; Yang, Z.; Lee, F.; Greer, A.; Hurlburt, W.; Hillerman, S.; Cao, C.; Cantor, G.H.; Dell-John, J.; Chen, C.; Discenza, L.; Menard, K.; Li, A.; Trainor, G.; Vyas, D.; Kramer, R.; Attar, R.M.; Gottardis, M.M. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol. Cancer Ther., 2009, 8(12), 3341-3349.
-
(2009)
Mol. Cancer Ther
, vol.8
, Issue.12
, pp. 3341-3349
-
-
Carboni, J.M.1
Wittman, M.2
Yang, Z.3
Lee, F.4
Greer, A.5
Hurlburt, W.6
Hillerman, S.7
Cao, C.8
Cantor, G.H.9
Dell-John, J.10
Chen, C.11
Discenza, L.12
Menard, K.13
Li, A.14
Trainor, G.15
Vyas, D.16
Kramer, R.17
Attar, R.M.18
Gottardis, M.M.19
-
45
-
-
77956279575
-
Phase I dose-escalation study of daily BMS-754807, an oral, dual IGF-1R/insulin receptor (IR) inhibitor in subjects with solid tumors
-
Desai, J.; Solomon, B.J.; Davis, I.D.; Lipton, L.R.; Hicks, R.; Scott, A.M.; Park, J.; Clemens, P.L.; Gestone, T.A.; Finckenstein, F.G. Phase I dose-escalation study of daily BMS-754807, an oral, dual IGF-1R/insulin receptor (IR) inhibitor in subjects with solid tumors. J. Clin. Oncol. (Meeting Abstracts), 2010, 28(15_suppl), 3104.
-
(2010)
J. Clin. Oncol. (Meeting Abstracts)
, vol.28
, Issue.15 SUPPL.
, pp. 3104
-
-
Desai, J.1
Solomon, B.J.2
Davis, I.D.3
Lipton, L.R.4
Hicks, R.5
Scott, A.M.6
Park, J.7
Clemens, P.L.8
Gestone, T.A.9
Finckenstein, F.G.10
-
46
-
-
77956136788
-
Allosteric IGF-1R Inhibitors
-
Heinrich, T.; Gradler, U.; Bottcher, H.; Blaukat, A.; Shutes, A. Allosteric IGF-1R Inhibitors. ACS Medicinal Chemistry Letters, 2010, 1(5), 199-203.
-
(2010)
ACS Medicinal Chemistry Letters
, vol.1
, Issue.5
, pp. 199-203
-
-
Heinrich, T.1
Gradler, U.2
Bottcher, H.3
Blaukat, A.4
Shutes, A.5
-
47
-
-
4344591505
-
Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors
-
Goya, M.; Miyamoto, S.; Nagai, K.; Ohki, Y.; Nakamura, K.; Shitara, K.; Maeda, H.; Sangai, T.; Kodama, K.; Endoh, Y.; Ishii, G.; Hasebe, T.; Yonou, H.; Hatano, T.; Ogawa, Y.; Ochiai, A. Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors. Cancer Res., 2004, 64(17), 6252-6258.
-
(2004)
Cancer Res
, vol.64
, Issue.17
, pp. 6252-6258
-
-
Goya, M.1
Miyamoto, S.2
Nagai, K.3
Ohki, Y.4
Nakamura, K.5
Shitara, K.6
Maeda, H.7
Sangai, T.8
Kodama, K.9
Endoh, Y.10
Ishii, G.11
Hasebe, T.12
Yonou, H.13
Hatano, T.14
Ogawa, Y.15
Ochiai, A.16
-
48
-
-
53249138207
-
Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models
-
Alami, N.; Page, V.; Yu, Q.; Jerome, L.; Paterson, J.; Shiry, L.; Leyland-Jones, B. Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. Growth Horm IGF Res., 2008, 18(6), 487-496.
-
(2008)
Growth Horm IGF Res
, vol.18
, Issue.6
, pp. 487-496
-
-
Alami, N.1
Page, V.2
Yu, Q.3
Jerome, L.4
Paterson, J.5
Shiry, L.6
Leyland-Jones, B.7
-
49
-
-
0035044213
-
Clinical review 125: The insulin receptor and its cellular targets
-
Kido, Y.; Nakae, J.; Accili, D. Clinical review 125: The insulin receptor and its cellular targets. J. Clin. Endocrinol. Metab., 2001, 86(3), 972-979.
-
(2001)
J. Clin. Endocrinol. Metab
, vol.86
, Issue.3
, pp. 972-979
-
-
Kido, Y.1
Nakae, J.2
Accili, D.3
-
50
-
-
0032932822
-
Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
-
Frasca, F.; Pandini, G.; Scalia, P.; Sciacca, L.; Mineo, R.; Costantino, A.; Goldfine, I.D.; Belfiore, A.; Vigneri, R. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol. Cell Biol., 1999, 19(5), 3278-3288.
-
(1999)
Mol. Cell Biol
, vol.19
, Issue.5
, pp. 3278-3288
-
-
Frasca, F.1
Pandini, G.2
Scalia, P.3
Sciacca, L.4
Mineo, R.5
Costantino, A.6
Goldfine, I.D.7
Belfiore, A.8
Vigneri, R.9
-
51
-
-
0032800850
-
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling
-
Pandini, G.; Vigneri, R.; Costantino, A.; Frasca, F.; Ippolito, A.; Fujita-Yamaguchi, Y.; Siddle, K.; Goldfine, I.D.; Belfiore, A. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin. Cancer Res., 1999, 5(7), 1935-1944.
-
(1999)
Clin. Cancer Res
, vol.5
, Issue.7
, pp. 1935-1944
-
-
Pandini, G.1
Vigneri, R.2
Costantino, A.3
Frasca, F.4
Ippolito, A.5
Fujita-Yamaguchi, Y.6
Siddle, K.7
Goldfine, I.D.8
Belfiore, A.9
-
52
-
-
0032709249
-
Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in thyroid cancer
-
Belfiore, A.; Pandini, G.; Vella, V.; Squatrito, S.; Vigneri, R. Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in thyroid cancer. Biochimie, 1999, 81(4), 403-407.
-
(1999)
Biochimie
, vol.81
, Issue.4
, pp. 403-407
-
-
Belfiore, A.1
Pandini, G.2
Vella, V.3
Squatrito, S.4
Vigneri, R.5
-
53
-
-
0030890973
-
Up-regulation of insulin/insulin-like growth factor-I hybrid receptors during differentiation of HT29-D4 human colonic carcinoma cells
-
Garrouste, F.L.; Remacle-Bonnet, M.M.; Lehmann, M.M.; Marvaldi, J.L.; Pommier, G.J. Up-regulation of insulin/insulin-like growth factor-I hybrid receptors during differentiation of HT29-D4 human colonic carcinoma cells. Endocrinology, 1997, 138(5), 2021-2032.
-
(1997)
Endocrinology
, vol.138
, Issue.5
, pp. 2021-2032
-
-
Garrouste, F.L.1
Remacle-Bonnet, M.M.2
Lehmann, M.M.3
Marvaldi, J.L.4
Pommier, G.J.5
-
54
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina, C.; Kudelski, A.; Sehgal, S.N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo), 1975, 28(10), 721-726.
-
(1975)
J. Antibiot. (Tokyo)
, vol.28
, Issue.10
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
55
-
-
0346362997
-
Rapamycins: Mechanism of action and cellular resistance
-
Huang, S.; Bjornsti, M.A.; Houghton, P.J. Rapamycins: mechanism of action and cellular resistance. Cancer Biol. Ther., 2003, 2(3), 222-232.
-
(2003)
Cancer Biol. Ther
, vol.2
, Issue.3
, pp. 222-232
-
-
Huang, S.1
Bjornsti, M.A.2
Houghton, P.J.3
-
56
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D.H.; Sarbassov, D.D.; Ali, S.M.; King, J.E.; Latek, R.R.; Erdjument-Bromage, H.; Tempst, P.; Sabatini, D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell, 2002, 110(2), 163-175.
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
57
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D.D.; Ali, S.M.; Kim, D.H.; Guertin, D.A.; Latek, R.R.; Erdjument-Bromage, H.; Tempst, P.; Sabatini, D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol., 2004, 14(14), 1296-1302.
-
(2004)
Curr. Biol
, vol.14
, Issue.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
58
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D.D.; Guertin, D.A.; Ali, S.M.; Sabatini, D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science, 2005, 307(5712), 1098-1101.
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
59
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov, D.D.; Ali, S.M.; Sengupta, S.; Sheen, J.H.; Hsu, P.P.; Bagley, A.F.; Markhard, A.L.; Sabatini, D.M. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell, 2006, 22(2), 159-168.
-
(2006)
Mol. Cell
, vol.22
, Issue.2
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
60
-
-
0029775645
-
Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation
-
Busca, R.; Bertolotto, C.; Ortonne, J.P.; Ballotti, R. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation. J. Biol. Chem., 1996, 271(50), 31824-31830.
-
(1996)
J. Biol. Chem
, vol.271
, Issue.50
, pp. 31824-31830
-
-
Busca, R.1
Bertolotto, C.2
Ortonne, J.P.3
Ballotti, R.4
-
61
-
-
0033178702
-
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells
-
Grewe, M.; Gansauge, F.; Schmid, R.M.; Adler, G.; Seufferlein, T. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res., 1999, 59(15), 3581-3587.
-
(1999)
Cancer Res
, vol.59
, Issue.15
, pp. 3581-3587
-
-
Grewe, M.1
Gansauge, F.2
Schmid, R.M.3
Adler, G.4
Seufferlein, T.5
-
62
-
-
79952061529
-
mTOR-inhibition in metastatic renal cell carcinoma. Focus on temsirolimus: A review
-
Gerullis, H.; Ecke, T.H.; Eimer, C.; Heuck, C.J.; Otto, T. mTOR-inhibition in metastatic renal cell carcinoma. Focus on temsirolimus: a review. Minerva Urol. Nefrol., 2010, 62(4), 411-423.
-
(2010)
Minerva Urol. Nefrol
, vol.62
, Issue.4
, pp. 411-423
-
-
Gerullis, H.1
Ecke, T.H.2
Eimer, C.3
Heuck, C.J.4
Otto, T.5
-
63
-
-
58249085318
-
Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
-
Wolpin, B.M.; Hezel, A.F.; Abrams, T.; Blaszkowsky, L.S.; Meyerhardt, J.A.; Chan, J.A.; Enzinger, P.C.; Allen, B.; Clark, J.W.; Ryan, D.P.; Fuchs, C.S. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J. Clin. Oncol., 2009, 27(2), 193-198.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.2
, pp. 193-198
-
-
Wolpin, B.M.1
Hezel, A.F.2
Abrams, T.3
Blaszkowsky, L.S.4
Meyerhardt, J.A.5
Chan, J.A.6
Enzinger, P.C.7
Allen, B.8
Clark, J.W.9
Ryan, D.P.10
Fuchs, C.S.11
-
64
-
-
85038490297
-
Effect of EGFR and IGF1R on feedback activation of AKT arising from inhibition of mTOR in malignant pleural mesothelioma (MPM)
-
Brevet, M.; Shimizu, S.; Zhou, Q.; Olshen, A.; Zakowski, M.F.; Rusch, V.W.; Ladanyi, M. Effect of EGFR and IGF1R on feedback activation of AKT arising from inhibition of mTOR in malignant pleural mesothelioma (MPM). J. Clin. Oncol. (Meeting Abstracts), 2010, 28(15_suppl), e13607.
-
(2010)
J. Clin. Oncol. (Meeting Abstracts)
, vol.28
, Issue.15 SUPPL.
-
-
Brevet, M.1
Shimizu, S.2
Zhou, Q.3
Olshen, A.4
Zakowski, M.F.5
Rusch, V.W.6
Ladanyi, M.7
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