Insulin promotes pancreatic cancer: Evidence for endocrine influence on exocrine pancreatic tumors

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 310-313

  Fisher, William E ^a   Boros, Laszlo G ^a   Schirmer, William J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR;

CANCER CELL CULTURE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 0029933939     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0266     Document Type: Conference Paper

References (25)

1. Kesler, I. I. Cancer mortality among diabetics. J. Natl. Cancer Inst. 44: 673-687, 1970.
2. Joslin, E. P., Lombard, H. L., Burrows, R. E., and Manning, M. D. Diabetes and Cancer. New Engl. J. Med. 260: 486-865, 1959.
3. Bueno DeMesquita, H. B., Maisonnueve, P., Moerman, C. J., and Walker, A. M. Aspects of medical history and exocrine carcinoma of the pancreas: A population-based case-control study in the Netherlands. Int. J. Cancer 52: 17-23, 1992.
4. Friedman, G. D., and Van Den Eeden, S. K. Risk factors for pancreatic cancer: An exploratory study. Int. J. Epidemiol. 22(1): 30-37, 1993.
5. Shibata, A., Mack, T. M., Paganini-Hill, A., Ross, R. K., and Henderson, B. E. A prospective study of pancreatic cancer in the elderly. Int. J. Cancer 58: 46-49, 1994.
6. Schirmer, W. J., Rossi, R. L., Braasch, J. W., Guay, A. T., Heiss, F. W., and Shea, J. A. Diabetes and pancreatic cancer: Association and prognostic implications. Gastroenterology 100(5): A18, 1991.
7. Permert, J., Larsson, J., Westermark, G. T., Herrington, M. K., Christmanson, L., Pour, P. M., et al. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. New Engl. J. Med. 330(5): 313-318, 1994.
8. Pour, P. M. Experimental pancreatic cancer. Am. J. Surg. Pathol. 13: 96-103, 1989.
9. Longnecker, D. S. Models of exocrine pancreatic tumors. In V. L. W. Go, J. D. Gardner, F. P. Brooks, E. Leventhal, E. DiMagno, and G. Scheele (Eds.), The Exocrine Pancreas. Biology, Pathobiology, and Diseases. New York: Raven Press, 1986. Pp. 443-458.
10. Bell, R. H., and Hye, R. J. Animal models of diabetes mellitus: Physiology and pathology. J. Surg. Res. 35: 433-460, 1983.
11. Fisher, W. E., Boros, L. G., O'Dorisio, T. M., O'Dorisio, M. S., and Schirmer, W. J. The influence of diabetes on the growth of pancreatic cancer. Surg. Forum 45: 151, 1994.
12. Munson, P. J., and Rodbard, D. Ligand: A versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107: 220-239, 1980.
13. Fisher, W. E., McCullough, P. J., and Bell, R. H., Jr. Further studies of enhanced growth of pancreatic carcinoma in diabetes. J. Surg. Res. 48: 403-407, 1990.
14. Fisher, W. E., McCullough, P. J., Ray, M. B., Rogers, K. H., and Bell, R. H., Jr. Diabetes enhances growth of pancreatic carcinoma cells. Surgery 104: 431-436, 1988.
15. Fisher, W. E., Boros, L. G., and Schirmer, W. J. Reversal of enhanced pancreatic cancer growth in diabetes by insulin. Surgery 118: 453-458, 1995.
16. Bell, R. H., and Strayer, D. S. Streptozotocin prevents development of nitrosamine-induced pancreatic cancer in the Syrian hamster. J. Surg. Oncol. 24: 258-262, 1983.
17. Bell, R. H., and Pour, P. M. Pancreatic carcinogenicity of N-nitrosobis(2-oxopropyl)-amine in diabetic and non-diabetic Chinese hamsters. Canc. Lett. 34: 221-230, 1987.
18. Fisher, W. E., Boros, L. G., O'Dorisio, T. M., O'Dorisio, M. S., and Schirmer, W. J. Gastrointestinal hormonal changes in diabetes influence pancreatic cancer growth. J. Surg. Res. 58: 754-758, 1995.
19. Liehr, R. M., Melnykovych, G., and Solomon, T. E. Growth effects of regulatory peptides on human pancreatic cancer cell lines Panc-1 and MIA PaCa-2. Gastroenterology 98(6): 1666-1674, 1990.
20. Townsend, C. M., Franklin, R. B., Watson, L. C., Glass, E. J., and Thompson, J. C. Stimulation of pancreatic cancer growth by caerulein and secretin. Surg. Forum 32: 228-229, 1989.
21. Watson, S. A., Crosbee, D. M., Morris, D. L., Robertson, J. F. R., Makovec, F., Rovati, L. C., and Hardcastle, J. D. Therapeutic effect of the gastrin receptor antagonist, CR2093 on gastrointestinal tumor cell growth. Br. J. Cancer 65: 879-883, 1992.
22. Edwards, B. F., Redding, T. W., and Schally, A. V. The effect of gastrointestinal hormones on the incorporation of tritiated thymidine in the pancreatic adenocarcinoma cell line WD PaCa. Int. J. of Pancreatol. 5: 191-201, 1989.
23. Schally, A. V. Oncological applications of somatostatin analogues. Cancer Res. 48: 6977-6985, 1988.
24. Upp, J. R., Olsen, D., Poston, G. J., Alexander, R. W., Townsend, C. M., and Thompson, J. C. Inhibition of growth of two human pancreatic adenocarcinomas in vivo by somatostatin analog SMS 201-995. Am. J. Surg. 155: 29-35, 1988.
25. Nakagawa, A., Samols, E., and Stragner, J. I. Exocrine interstitial insulin and somatostatin in the perfused dog pancreas. Am. J. Physiol. 264: G728-G734, 1993.