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Volumn 2, Issue DEC, 2011, Pages

The insulin receptor: A new target for cancer therapy

Author keywords

Cancer; Igf i; IGF I receptor; Igf ii; Insulin receptor; Insulin resistance; IR isoform A; Target therapy

Indexed keywords


EID: 84874386146     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2011.00093     Document Type: Review
Times cited : (72)

References (198)
  • 1
    • 84874102233 scopus 로고    scopus 로고
    • Insulin-like growth factor pathway: a link between androgen deprivation therapy (ADT), insulin resistance, and disease progression in patients with prostate cancer
    • doi: 10.1016/j.urolonc.2011.05.001
    • Aggarwal, R. R., Ryan, C. J., and Chan, J. M. (2011). Insulin-like growth factor pathway: a link between androgen deprivation therapy (ADT), insulin resistance, and disease progression in patients with prostate cancer? Urol. Oncol.doi: 10.1016/j.urolonc.2011.05.001.
    • (2011) Urol. Oncol
    • Aggarwal, R.R.1    Ryan, C.J.2    Chan, J.M.3
  • 2
    • 33747610958 scopus 로고    scopus 로고
    • Peroxisomal proliferator-activated receptorgamma agonists induce partial reversion of epithelial-mesenchymal transition in anaplastic thyroid cancer cells
    • Aiello, A., Pandini, G., Frasca, F., Conte, E., Murabito, A., Sacco, A., Genua, M., Vigneri, R., and Belfiore, A. (2006). Peroxisomal proliferator-activated receptorgamma agonists induce partial reversion of epithelial-mesenchymal transition in anaplastic thyroid cancer cells. Endocrinology 147, 4463-4475.
    • (2006) Endocrinology , vol.147 , pp. 4463-4475
    • Aiello, A.1    Pandini, G.2    Frasca, F.3    Conte, E.4    Murabito, A.5    Sacco, A.6    Genua, M.7    Vigneri, R.8    Belfiore, A.9
  • 4
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • Alimova, I. N., Liu, B., Fan, Z., Edgerton, S. M., Dillon, T., Lind, S. E., and Thor, A. D. (2009). Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 8, 909-915.
    • (2009) Cell Cycle , vol.8 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3    Edgerton, S.M.4    Dillon, T.5    Lind, S.E.6    Thor, A.D.7
  • 5
    • 0029553646 scopus 로고
    • Localization of specific amino acids contributing to insulin specificity of the insulin receptor
    • Andersen, A. S., Wiberg, F. C., and Kjeldsen, T. (1995). Localization of specific amino acids contributing to insulin specificity of the insulin receptor. Ann. N. Y. Acad. Sci. 766, 466-468.
    • (1995) Ann. N. Y. Acad. Sci. , vol.766 , pp. 466-468
    • Andersen, A.S.1    Wiberg, F.C.2    Kjeldsen, T.3
  • 6
    • 0033605146 scopus 로고    scopus 로고
    • C-terminal Src kinase associates with ligandstimulated insulin-like growth factor-I receptor
    • Arbet-Engels, C., Tartare-Deckert, S., and Eckhart, W. (1999). C-terminal Src kinase associates with ligandstimulated insulin-like growth factor-I receptor. J. Biol. Chem. 274, 5422-5428.
    • (1999) J. Biol. Chem. , vol.274 , pp. 5422-5428
    • Arbet-Engels, C.1    Tartare-Deckert, S.2    Eckhart, W.3
  • 7
    • 0033991993 scopus 로고    scopus 로고
    • DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma
    • Armengol, G., Knuutila, S., Lluis, F., Capella, G., Miro, R., and Caballin, M. R. (2000). DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma. Cancer Genet. Cytogenet. 116, 133-141.
    • (2000) Cancer Genet. Cytogenet. , vol.116 , pp. 133-141
    • Armengol, G.1    Knuutila, S.2    Lluis, F.3    Capella, G.4    Miro, R.5    Caballin, M.R.6
  • 9
    • 0032549179 scopus 로고    scopus 로고
    • Alengrin, F., and Van Obberghen, E
    • Baron, V., Calleja, V., Ferrari, P., Alengrin, F., and Van Obberghen, E. (1998). p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J. Biol. Chem. 273, 7162-7168.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7162-7168
    • Baron, V.1    Calleja, V.2    Ferrari, P.3
  • 10
    • 0028953268 scopus 로고
    • Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk
    • Beitner-Johnson, D., and LeRoith, D. (1995). Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk. J. Biol. Chem. 270, 5187-5190.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5187-5190
    • Beitner-Johnson, D.1    LeRoith, D.2
  • 11
    • 34047174592 scopus 로고    scopus 로고
    • The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    • Belfiore, A. (2007). The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr. Pharm. Des. 13, 671-686.
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 671-686
    • Belfiore, A.1
  • 12
    • 0030444778 scopus 로고    scopus 로고
    • Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity
    • Belfiore, A., Costantino, A., Frasca, F., Pandini, G., Mineo, R., Vigneri, P., Maddux, B., Goldfine, I. D., and Vigneri, R. (1996). Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity. Mol. Endocrinol. 10, 1318-1326.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1318-1326
    • Belfiore, A.1    Costantino, A.2    Frasca, F.3    Pandini, G.4    Mineo, R.5    Vigneri, P.6    Maddux, B.7    Goldfine, I.D.8    Vigneri, R.9
  • 13
    • 57149142057 scopus 로고    scopus 로고
    • IGF and insulin receptor signaling in breast cancer
    • Belfiore, A., and Frasca, F. (2008). IGF and insulin receptor signaling in breast cancer. J. Mammary Gland Biol. Neoplasia 13, 381-406.
    • (2008) J. Mammary Gland Biol. Neoplasia , vol.13 , pp. 381-406
    • Belfiore, A.1    Frasca, F.2
  • 14
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., and Vigneri, R. (2009a). Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr. Rev. 30, 586-623.
    • (2009) Endocr. Rev. , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 15
    • 68949128792 scopus 로고    scopus 로고
    • PPAR-gamma agonists and their effects on IGF-I receptor signaling: implications for cancer
    • Belfiore, A., Genua, M., and Malaguarnera, R. (2009b). PPAR-gamma agonists and their effects on IGF-I receptor signaling: implications for cancer. PPAR Res. 2009, 830501.
    • (2009) PPAR Res , vol.2009 , pp. 830501
    • Belfiore, A.1    Genua, M.2    Malaguarnera, R.3
  • 17
    • 34247872895 scopus 로고    scopus 로고
    • Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
    • Benyoucef, S., Surinya, K. H., Hadaschik, D., and Siddle, K. (2007). Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation. Biochem. J. 403, 603-613.
    • (2007) Biochem. J. , vol.403 , pp. 603-613
    • Benyoucef, S.1    Surinya, K.H.2    Hadaschik, D.3    Siddle, K.4
  • 20
    • 83655161344 scopus 로고    scopus 로고
    • Cancer mortality reduction and metformin. A retrospective cohort study in type 2 diabetic patients
    • doi: 10.1111/j.1463-1326.2011.01480.x
    • Bo, S., Ciccone, G., Rosato, R., Villois, P., Appendino, G., Ghigo, E., and Grassi, G. (2011). Cancer mortality reduction and metformin. A retrospective cohort study in type 2 diabetic patients. Diabetes Obes. Metab.doi: 10.1111/j.1463-1326.2011.01480.x.
    • (2011) Diabetes Obes. Metab
    • Bo, S.1    Ciccone, G.2    Rosato, R.3    Villois, P.4    Appendino, G.5    Ghigo, E.6    Grassi, G.7
  • 21
    • 78651415908 scopus 로고    scopus 로고
    • Metformin and incident breast cancer among diabetic women: a population-based casecontrol study in Denmark
    • Bosco, J. L., Antonsen, S., Sorensen, H. T., Pedersen, L., and Lash, T. L. (2011). Metformin and incident breast cancer among diabetic women: a population-based casecontrol study in Denmark. Cancer Epidemiol. Biomarkers Prev. 20, 101-111.
    • (2011) Cancer Epidemiol. Biomarkers Prev. , vol.20 , pp. 101-111
    • Bosco, J.L.1    Antonsen, S.2    Sorensen, H.T.3    Pedersen, L.4    Lash, T.L.5
  • 22
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker, S. L., Majumdar, S. R., Veugelers, P., and Johnson, J. A. (2006). Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29, 254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 23
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factorinduced gene expression and cell cycle entry
    • Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S., and Pouyssegur, J. (1999). Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factorinduced gene expression and cell cycle entry. EMBO J. 18, 664-674.
    • (1999) EMBO J , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouyssegur, J.6
  • 24
    • 79953647468 scopus 로고    scopus 로고
    • Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
    • Buck, E., and Mulvihill, M. (2011). Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin. Investig. Drugs 20, 605-621.
    • (2011) Expert Opin. Investig. Drugs , vol.20 , pp. 605-621
    • Buck, E.1    Mulvihill, M.2
  • 25
    • 0037899628 scopus 로고    scopus 로고
    • Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study
    • Burstein, H. J., Demetri, G. D., Mueller, E., Sarraf, P., Spiegelman, B. M., and Winer, E. P. (2003). Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study. Breast Cancer Res. Treat. 79, 391-397.
    • (2003) Breast Cancer Res. Treat. , vol.79 , pp. 391-397
    • Burstein, H.J.1    Demetri, G.D.2    Mueller, E.3    Sarraf, P.4    Spiegelman, B.M.5    Winer, E.P.6
  • 26
    • 0033950982 scopus 로고    scopus 로고
    • Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferatoractivated receptor gamma ligand, 15-deoxy-delta12
    • Butler, R., Mitchell, S. H., Tindall, D. J., and Young, C. Y. (2000). Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferatoractivated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. Cell Growth Differ. 11, 49-61.
    • (2000) 14-prostaglandin J2. Cell Growth Differ. , vol.11 , pp. 49-61
    • Butler, R.1    Mitchell, S.H.2    Tindall, D.J.3    Young, C.Y.4
  • 27
    • 33750453743 scopus 로고    scopus 로고
    • Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
    • Byron, S. A., Horwitz, K. B., Richer, J. K., Lange, C. A., Zhang, X., and Yee, D. (2006). Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br. J. Cancer 95, 1220-1228.
    • (2006) Br. J. Cancer , vol.95 , pp. 1220-1228
    • Byron, S.A.1    Horwitz, K.B.2    Richer, J.K.3    Lange, C.A.4    Zhang, X.5    Yee, D.6
  • 30
    • 77958073952 scopus 로고    scopus 로고
    • Phase I study of intermittent dosing of OSI-906, a dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in patients with advanced solid tumors
    • abstr
    • Carden, C. P., Kim, E. S., Jones, R. L., Alam, S. M., Johnson, F. M., Stephens, A. W., Poondru, S., Gedrich, R., Lippman, S. M., and Kaye, S. B. (2010). Phase I study of intermittent dosing of OSI-906, a dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in patients with advanced solid tumors. J. Clin. Oncol. 28, abstr. 2530.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2530
    • Carden, C.P.1    Kim, E.S.2    Jones, R.L.3    Alam, S.M.4    Johnson, F.M.5    Stephens, A.W.6    Poondru, S.7    Gedrich, R.8    Lippman, S.M.9    Kaye, S.B.10
  • 32
    • 42649104659 scopus 로고    scopus 로고
    • The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance
    • Casa, A. J., Dearth, R. K., Litzenburger, B. C., Lee, A. V., and Cui, X. (2008). The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance. Front. Biosci. 13, 3273-3287.
    • (2008) Front. Biosci. , vol.13 , pp. 3273-3287
    • Casa, A.J.1    Dearth, R.K.2    Litzenburger, B.C.3    Lee, A.V.4    Cui, X.5
  • 33
    • 0031892269 scopus 로고    scopus 로고
    • Insulin regulation of the Ras activation/inactivation cycle
    • Ceresa, B. P., and Pessin, J. E. (1998). Insulin regulation of the Ras activation/inactivation cycle. Mol. Cell. Biochem. 182, 23-29.
    • (1998) Mol. Cell. Biochem. , vol.182 , pp. 23-29
    • Ceresa, B.P.1    Pessin, J.E.2
  • 34
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB1 and ZEB-2
    • Chua, H. L., Bhat-Nakshatri, P., Clare, S. E., Morimiya, A., Badve, S., and Nakshatri, H. (2007). NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB1 and ZEB-2. Oncogene 26, 711-724.
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 35
    • 68449094354 scopus 로고    scopus 로고
    • Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group
    • Colhoun, H. M. (2009). Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia 52, 1755-1765.
    • (2009) Diabetologia , vol.52 , pp. 1755-1765
    • Colhoun, H.M.1
  • 36
    • 0030939427 scopus 로고    scopus 로고
    • Insulin injections promote the growth of aberrant crypt foci in the colon of rats
    • Corpet, D. E., Jacquinet, C., Peiffer, G., and Tache, S. (1997). Insulin injections promote the growth of aberrant crypt foci in the colon of rats. Nutr. Cancer 27, 316-320.
    • (1997) Nutr. Cancer , vol.27 , pp. 316-320
    • Corpet, D.E.1    Jacquinet, C.2    Peiffer, G.3    Tache, S.4
  • 37
    • 2942520997 scopus 로고    scopus 로고
    • Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    • Coughlin, S. S., Calle, E. E., Teras, L. R., Petrelli, J., and Thun, M. J. (2004). Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am. J. Epidemiol. 159, 1160-1167.
    • (2004) Am. J. Epidemiol. , vol.159 , pp. 1160-1167
    • Coughlin, S.S.1    Calle, E.E.2    Teras, L.R.3    Petrelli, J.4    Thun, M.J.5
  • 38
    • 0030995955 scopus 로고    scopus 로고
    • 14-3-3 (Epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserinedependent manner
    • Craparo, A., Freund, R., and Gustafson, T. A. (1997). 14-3-3 (Epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserinedependent manner. J. Biol. Chem. 272, 11663-11669.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11663-11669
    • Craparo, A.1    Freund, R.2    Gustafson, T.A.3
  • 39
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucoselowering therapies on cancer risk in type 2 diabetes
    • Currie, C. J., Poole, C. D., and Gale, E. A. (2009). The influence of glucoselowering therapies on cancer risk in type 2 diabetes. Diabetologia 52, 1766-1777.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 40
    • 0033968126 scopus 로고    scopus 로고
    • Pendergrass, M., Patti, M. E., Pratipanawatr, T., Defronzo, R. A., Kahn, C. R., and Mandarino, L. J
    • Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., Defronzo, R. A., Kahn, C. R., and Mandarino, L. J. (2000). Insulin resistance differentially affects the PI 3-kinaseand MAP kinase-mediated signaling in human muscle. J. Clin. Invest. 105, 311-320.
    • (2000) J. Clin. Invest. , vol.105 , pp. 311-320
    • Cusi, K.1    Maezono, K.2    Osman, A.3
  • 41
    • 0035844282 scopus 로고    scopus 로고
    • Insulin and insulinlikegrowthfactorIreceptorsutilize different G protein signaling components
    • Dalle, S., Ricketts, W., Imamura, T., Vollenweider, P., and Olefsky, J. M. (2001). Insulin and insulinlikegrowthfactorIreceptorsutilize different G protein signaling components. J. Biol. Chem. 276, 15688-15695.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15688-15695
    • Dalle, S.1    Ricketts, W.2    Imamura, T.3    Vollenweider, P.4    Olefsky, J.M.5
  • 43
    • 5044227353 scopus 로고    scopus 로고
    • Structural determinants for high-affinity binding of insulinlike growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR
    • Denley, A., Bonython, E. R., Booker, G. W., Cosgrove, L. J., Forbes, B. E., Ward, C. W., and Wallace, J. C. (2004). Structural determinants for high-affinity binding of insulinlike growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR. Mol. Endocrinol. 18, 2502-2512.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2502-2512
    • Denley, A.1    Bonython, E.R.2    Booker, G.W.3    Cosgrove, L.J.4    Forbes, B.E.5    Ward, C.W.6    Wallace, J.C.7
  • 44
    • 34248180625 scopus 로고    scopus 로고
    • Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors
    • Denley, A., Carroll, J. M., Brierley, G. V., Cosgrove, L., Wallace, J., Forbes, B., and Roberts, C. T. Jr. (2007). Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors. Mol. Cell. Biol. 27, 3569-3577.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3569-3577
    • Denley, A.1    Carroll, J.M.2    Brierley, G.V.3    Cosgrove, L.4    Wallace, J.5    Forbes, B.6    Roberts Jr., C.T.7
  • 47
    • 3042647602 scopus 로고    scopus 로고
    • Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase
    • Drakas, R., Tu, X., and Baserga, R. (2004). Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 101, 9272-9276.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 9272-9276
    • Drakas, R.1    Tu, X.2    Baserga, R.3
  • 48
    • 0027097641 scopus 로고
    • The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake
    • Drejer, K. (1992). The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes Metab. Rev. 8, 259-285.
    • (1992) Diabetes Metab. Rev. , vol.8 , pp. 259-285
    • Drejer, K.1
  • 50
    • 0030738695 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs
    • Dunn, S. E., Hardman, R. A., Kari, F. W., and Barrett, J. C. (1997). Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res. 57, 2687-2693.
    • (1997) Cancer Res , vol.57 , pp. 2687-2693
    • Dunn, S.E.1    Hardman, R.A.2    Kari, F.W.3    Barrett, J.C.4
  • 51
    • 0035854773 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor
    • Dupont, J., Fernandez, A. M., Glackin, C. A., Helman, L., and Leroith, D. (2001). Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor. J. Biol. Chem. 276, 26699-26707.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26699-26707
    • Dupont, J.1    Fernandez, A.M.2    Glackin, C.A.3    Helman, L.4    Leroith, D.5
  • 54
    • 77958073952 scopus 로고    scopus 로고
    • Phase I doseescalation study of continuous oral dosing of OSI-906, a dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), in patients with advanced solid tumors
    • abstr
    • Evans, T., Lindsay, C. R., Chan, E., Tait, B., Michael, S. A., Day, S., Stephens, A. W., Franke, A., Poondru, S., and Puzanov, I. (2010). Phase I doseescalation study of continuous oral dosing of OSI-906, a dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), in patients with advanced solid tumors. J. Clin. Oncol. 28, abstr. 2531.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2531
    • Evans, T.1    Lindsay, C.R.2    Chan, E.3    Tait, B.4    Michael, S.A.5    Day, S.6    Stephens, A.W.7    Franke, A.8    Poondru, S.9    Puzanov, I.10
  • 56
    • 0028214152 scopus 로고
    • Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function
    • Faria, T. N., Blakesley, V. A., Kato, H., Stannard, B., Leroith, D., and Roberts, C. T. Jr. (1994). Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. J. Biol. Chem. 269, 13922-13928.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13922-13928
    • Faria, T.N.1    Blakesley, V.A.2    Kato, H.3    Stannard, B.4    Leroith, D.5    Roberts Jr., C.T.6
  • 57
    • 33644857143 scopus 로고    scopus 로고
    • Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function
    • Feng, Y., Zhu, Z., Xiao, X., Choudhry, V., Barrett, J. C., and Dimitrov, D. S. (2006). Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function. Mol. Cancer Ther. 5, 114-120.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 114-120
    • Feng, Y.1    Zhu, Z.2    Xiao, X.3    Choudhry, V.4    Barrett, J.C.5    Dimitrov, D.S.6
  • 59
    • 77950354885 scopus 로고    scopus 로고
    • Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression
    • Fierz, Y., Novosyadlyy, R., Vijayakumar, A., Yakar, S., and Leroith, D. (2010). Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes 59, 686-693.
    • (2010) Diabetes , vol.59 , pp. 686-693
    • Fierz, Y.1    Novosyadlyy, R.2    Vijayakumar, A.3    Yakar, S.4    Leroith, D.5
  • 60
    • 0037385239 scopus 로고    scopus 로고
    • A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription
    • Foti, D., Iuliano, R., Chiefari, E., and Brunetti, A. (2003). A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol. Cell. Biol. 23, 2720-2732.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2720-2732
    • Foti, D.1    Iuliano, R.2    Chiefari, E.3    Brunetti, A.4
  • 62
  • 63
    • 0030660615 scopus 로고    scopus 로고
    • 14-3-3 Proteins interact with the insulin-like growth factor receptor but not the insulin receptor
    • Furlanetto, R. W., Dey, B. R., Lopaczynski, W., and Nissley, S. P. (1997). 14-3-3 Proteins interact with the insulin-like growth factor receptor but not the insulin receptor. Biochem. J. 327(Pt 3), 765-771.
    • (1997) Biochem. J. , vol.327 , Issue.PART 3 , pp. 765-771
    • Furlanetto, R.W.1    Dey, B.R.2    Lopaczynski, W.3    Nissley, S.P.4
  • 68
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
    • Girnita, A., Girnita, L., Del Prete, F., Bartolazzi, A., Larsson, O., and Axelson, M. (2004). Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64, 236-242.
    • (2004) Cancer Res , vol.64 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    Del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 69
    • 0030690195 scopus 로고    scopus 로고
    • Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway
    • Goalstone, M., Carel, K., Leitner, J. W., and Draznin, B. (1997). Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway. Endocrinology 138, 5119-5124.
    • (1997) Endocrinology , vol.138 , pp. 5119-5124
    • Goalstone, M.1    Carel, K.2    Leitner, J.W.3    Draznin, B.4
  • 70
    • 67650550499 scopus 로고    scopus 로고
    • Chronic inflammation, the tumor microenvironment and carcinogenesis
    • Gonda, T. A., Tu, S., and Wang, T. C. (2009). Chronic inflammation, the tumor microenvironment and carcinogenesis. Cell Cycle 8, 2005-2013.
    • (2009) Cell Cycle , vol.8 , pp. 2005-2013
    • Gonda, T.A.1    Tu, S.2    Wang, T.C.3
  • 71
    • 0032850369 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death proliferative and antiapoptotic effects
    • Gooch, J. L., Van Den Berg, C. L., and Yee, D. (1999). Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death proliferative and antiapoptotic effects. Breast Cancer Res. Treat. 56, 1-10.
    • (1999) Breast Cancer Res. Treat. , vol.56 , pp. 1-10
    • Gooch, J.L.1    Van Den Berg, C.L.2    Yee, D.3
  • 72
    • 70450182195 scopus 로고    scopus 로고
    • Clinical development of inhibitors of the insulin-like growth factor receptor in oncology
    • Gualberto, A., and Pollak, M. (2009). Clinical development of inhibitors of the insulin-like growth factor receptor in oncology. Curr. Drug Targets 10, 923-936.
    • (2009) Curr. Drug Targets , vol.10 , pp. 923-936
    • Gualberto, A.1    Pollak, M.2
  • 75
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N., and Sonenberg, N. (2004). Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 76
    • 0032549647 scopus 로고    scopus 로고
    • Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains
    • He, W., Rose, D. W., Olefsky, J. M., and Gustafson, T. A. (1998). Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. J. Biol. Chem. 273, 6860-6867.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6860-6867
    • He, W.1    Rose, D.W.2    Olefsky, J.M.3    Gustafson, T.A.4
  • 77
    • 0036852624 scopus 로고    scopus 로고
    • Functional PPAR-gamma receptor is a novel therapeutic target for ACTHsecreting pituitary adenomas
    • Heaney, A. P., Fernando, M., Yong, W. H., and Melmed, S. (2002). Functional PPAR-gamma receptor is a novel therapeutic target for ACTHsecreting pituitary adenomas. Nat. Med. 8, 1281-1287.
    • (2002) Nat. Med. , vol.8 , pp. 1281-1287
    • Heaney, A.P.1    Fernando, M.2    Yong, W.H.3    Melmed, S.4
  • 78
    • 68449104156 scopus 로고    scopus 로고
    • Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
    • Hemkens, L. G., Grouven, U., Bender, R., Gunster, C., Gutschmidt, S., Selke, G. W., and Sawicki, P. T. (2009). Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia 52, 1732-1744.
    • (2009) Diabetologia , vol.52 , pp. 1732-1744
    • Hemkens, L.G.1    Grouven, U.2    Bender, R.3    Gunster, C.4    Gutschmidt, S.5    Selke, G.W.6    Sawicki, P.T.7
  • 80
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers, I., Vincent, E. E., and Tavare, J. M. (2011). Akt signalling in health and disease. Cell. Signal. 23, 1515-1527.
    • (2011) Cell. Signal. , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 83
    • 23044493251 scopus 로고    scopus 로고
    • Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
    • Hofmann, F., and Garcia-Echeverria, C. (2005). Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov. Today 10, 1041-1047.
    • (2005) Drug Discov. Today , vol.10 , pp. 1041-1047
    • Hofmann, F.1    Garcia-Echeverria, C.2
  • 86
    • 0035964872 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists
    • Inoue, K., Kawahito, Y., Tsubouchi, Y., Kohno, M., Yoshimura, R., Yoshikawa, T., and Sano, H. (2001). Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. Biochem. Biophys. Res. Commun. 287, 727-732.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 727-732
    • Inoue, K.1    Kawahito, Y.2    Tsubouchi, Y.3    Kohno, M.4    Yoshimura, R.5    Yoshikawa, T.6    Sano, H.7
  • 88
    • 36849015259 scopus 로고    scopus 로고
    • Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses
    • Jensen, M., Hansen, B., De Meyts, P., Schaffer, L., and Urso, B. (2007). Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282, 35179-35186.
    • (2007) J. Biol. Chem. , vol.282 , pp. 35179-35186
    • Jensen, M.1    Hansen, B.2    De Meyts, P.3    Schaffer, L.4    Urso, B.5
  • 92
    • 79953776342 scopus 로고    scopus 로고
    • Intensive glycaemic control and cancer risk in type 2 diabetes: a metaanalysis of major trials
    • Johnson, J. A., and Bowker, S. L. (2010). Intensive glycaemic control and cancer risk in type 2 diabetes: a metaanalysis of major trials. Diabetologia 54, 25-31.
    • (2010) Diabetologia , vol.54 , pp. 25-31
    • Johnson, J.A.1    Bowker, S.L.2
  • 93
    • 0038279359 scopus 로고    scopus 로고
    • Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes
    • Johnson, J. A., Majumdar, S. R., Simpson, S. H., and Toth, E. L. (2002). Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes. Diabetes Care 25, 2244-2248.
    • (2002) Diabetes Care , vol.25 , pp. 2244-2248
    • Johnson, J.A.1    Majumdar, S.R.2    Simpson, S.H.3    Toth, E.L.4
  • 94
    • 68449104625 scopus 로고    scopus 로고
    • Insulin glargine use and shortterm incidence of malignancies-a population-based follow-up study in Sweden
    • Jonasson, J. M., Ljung, R., Talback, M., Haglund, B., Gudbjornsdottir, S., and Steineck, G. (2009). Insulin glargine use and shortterm incidence of malignancies-a population-based follow-up study in Sweden. Diabetologia 52, 1745-1754.
    • (2009) Diabetologia , vol.52 , pp. 1745-1754
    • Jonasson, J.M.1    Ljung, R.2    Talback, M.3    Haglund, B.4    Gudbjornsdottir, S.5    Steineck, G.6
  • 95
    • 0036289457 scopus 로고    scopus 로고
    • Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism
    • Kaaks, R., and Lukanova, A. (2002). Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism. Ann. N. Y. Acad. Sci. 963, 268-281.
    • (2002) Ann. N. Y. Acad. Sci. , vol.963 , pp. 268-281
    • Kaaks, R.1    Lukanova, A.2
  • 96
    • 0036135985 scopus 로고    scopus 로고
    • Growth inhibition and differentiation of pancreatic cancer cell lines by PPAR gamma ligand troglitazone
    • Kawa, S., Nikaido, T., Unno, H., Usuda, N., Nakayama, K., and Kiyosawa, K. (2002). Growth inhibition and differentiation of pancreatic cancer cell lines by PPAR gamma ligand troglitazone. Pancreas 24, 1-7.
    • (2002) Pancreas , vol.24 , pp. 1-7
    • Kawa, S.1    Nikaido, T.2    Unno, H.3    Usuda, N.4    Nakayama, K.5    Kiyosawa, K.6
  • 97
    • 14844293473 scopus 로고    scopus 로고
    • RACK1mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251
    • Kiely, P. A., Leahy, M., O'gorman, D., and O'connor, R. (2005). RACK1mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251. J. Biol. Chem. 280, 7624-7633.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7624-7633
    • Kiely, P.A.1    Leahy, M.2    O'gorman, D.3    O'connor, R.4
  • 98
    • 34249008543 scopus 로고    scopus 로고
    • Expression of a peroxisome proliferator-activated receptor gamma 1 splice variant that was identified in human lung cancers suppresses cell death induced by cisplatin and oxidative stress
    • Kim, H. J., Hwang, J. Y., Choi, W. S., Lee, J. H., Chang, K. C., Nishinaka, T., Yabe-Nishimura, C., and Seo, H. G. (2007a). Expression of a peroxisome proliferator-activated receptor gamma 1 splice variant that was identified in human lung cancers suppresses cell death induced by cisplatin and oxidative stress. Clin. Cancer Res. 13, 2577-2583.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2577-2583
    • Kim, H.J.1    Hwang, J.Y.2    Choi, W.S.3    Lee, J.H.4    Chang, K.C.5    Nishinaka, T.6    Yabe-Nishimura, C.7    Seo, H.G.8
  • 99
    • 34147193818 scopus 로고    scopus 로고
    • Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
    • Kim, H. J., Litzenburger, B. C., Cui, X., Delgado, D. A., Grabiner, B. C., Lin, X., Lewis, M. T., Gottardis, M. M., Wong, T. W., Attar, R. M., Carboni, J. M., and Lee, A. V. (2007b). Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol. Cell. Biol. 27, 3165-3175.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3165-3175
    • Kim, H.J.1    Litzenburger, B.C.2    Cui, X.3    Delgado, D.A.4    Grabiner, B.C.5    Lin, X.6    Lewis, M.T.7    Gottardis, M.M.8    Wong, T.W.9    Attar, R.M.10    Carboni, J.M.11    Lee, A.V.12
  • 100
    • 0036550234 scopus 로고    scopus 로고
    • Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm
    • Kim, J. J., and Accili, D. (2002). Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm. IGF Res. 12, 84-90.
    • (2002) IGF Res , vol.12 , pp. 84-90
    • Kim, J.J.1    Accili, D.2
  • 101
    • 0342657181 scopus 로고    scopus 로고
    • Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use
    • Kurtzhals, P., Schaffer, L., Sorensen, A., Kristensen, C., Jonassen, I., Schmid, C., and Trub, T. (2000). Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 49, 999-1005.
    • (2000) Diabetes , vol.49 , pp. 999-1005
    • Kurtzhals, P.1    Schaffer, L.2    Sorensen, A.3    Kristensen, C.4    Jonassen, I.5    Schmid, C.6    Trub, T.7
  • 102
    • 0030905509 scopus 로고    scopus 로고
    • The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts
    • Laviola, L., Giorgino, F., Chow, J. C., Baquero, J. A., Hansen, H., Ooi, J., Zhu, J., Riedel, H., and Smith, R. J. (1997). The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J. Clin. Invest. 99, 830-837.
    • (1997) J. Clin. Invest. , vol.99 , pp. 830-837
    • Laviola, L.1    Giorgino, F.2    Chow, J.C.3    Baquero, J.A.4    Hansen, H.5    Ooi, J.6    Zhu, J.7    Riedel, H.8    Smith, R.J.9
  • 104
    • 77957654223 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid protects against high-fat dietinduced fatty liver by activating AMP-activated protein kinase in obese mice
    • Lee, M. S., Kim, D., Jo, K., and Hwang, J. K. (2011). Nordihydroguaiaretic acid protects against high-fat dietinduced fatty liver by activating AMP-activated protein kinase in obese mice. Biochem. Biophys. Res. Commun. 401, 92-97.
    • (2011) Biochem. Biophys. Res. Commun. , vol.401 , pp. 92-97
    • Lee, M.S.1    Kim, D.2    Jo, K.3    Hwang, J.K.4
  • 106
    • 67651092235 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling
    • Li, F., Pham, J. D., Anderson, M. O., and Youngren, J. F. (2009). Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling. Eur. J. Pharmacol. 616, 31-37.
    • (2009) Eur. J. Pharmacol. , vol.616 , pp. 31-37
    • Li, F.1    Pham, J.D.2    Anderson, M.O.3    Youngren, J.F.4
  • 107
    • 0041927816 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit cell growth and induce apoptosis in human liver cancer BEL-7402 cells
    • Li, M. Y., Deng, H., Zhao, J. M., Dai, D., and Tan, X. Y. (2003). Peroxisome proliferator-activated receptor gamma ligands inhibit cell growth and induce apoptosis in human liver cancer BEL-7402 cells. WorldJ. Gastroenterol. 9, 1683-1688.
    • (2003) WorldJ. Gastroenterol. , vol.9 , pp. 1683-1688
    • Li, M.Y.1    Deng, H.2    Zhao, J.M.3    Dai, D.4    Tan, X.Y.5
  • 108
    • 0035823574 scopus 로고    scopus 로고
    • A PDZ domain protein interacts with the C-terminal tail of the insulinlikegrowthfactor-1receptorbutnot with the insulin receptor
    • Ligensa, T., Krauss, S., Demuth, D., Schumacher, R., Camonis, J., Jaques, G., and Weidner, K. M. (2001). A PDZ domain protein interacts with the C-terminal tail of the insulinlikegrowthfactor-1receptorbutnot with the insulin receptor. J. Biol. Chem. 276, 33419-33427.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33419-33427
    • Ligensa, T.1    Krauss, S.2    Demuth, D.3    Schumacher, R.4    Camonis, J.5    Jaques, G.6    Weidner, K.M.7
  • 111
    • 0035915421 scopus 로고    scopus 로고
    • Insulinlike growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu, Y., Zi, X., Zhao, Y., Mascarenhas, D., and Pollak, M. (2001). Insulinlike growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J. Natl. Cancer Inst. 93, 1852-1857.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3    Mascarenhas, D.4    Pollak, M.5
  • 112
    • 79951810600 scopus 로고    scopus 로고
    • Phase I study of OSI-906, dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in combination with erlotinib (E) in patients with advanced solid tumors
    • abstr
    • Macaulay, V. M., Middleton, M. R., Eckhardt, S. G., Juergens, R. A., Stephens, A. W., Poondru, S., Mccarthy, S. P., and Gadgeel, S. M. (2010). Phase I study of OSI-906, dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in combination with erlotinib (E) in patients with advanced solid tumors. J. Clin. Oncol. 28, abstr. 3016.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3016
    • Macaulay, V.M.1    Middleton, M.R.2    Eckhardt, S.G.3    Juergens, R.A.4    Stephens, A.W.5    Poondru, S.6    Mccarthy, S.P.7    Gadgeel, S.M.8
  • 113
    • 79952294885 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid
    • Malaguarnera, R., Frasca, F., Garozzo, A., Giani, F., Pandini, G., Vella, V., Vigneri, R., and Belfiore, A. (2011). Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid. J. Clin. Endocrinol. Metab. 96, 766-774.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 766-774
    • Malaguarnera, R.1    Frasca, F.2    Garozzo, A.3    Giani, F.4    Pandini, G.5    Vella, V.6    Vigneri, R.7    Belfiore, A.8
  • 114
    • 47349085657 scopus 로고    scopus 로고
    • Proliferative effects of insulin analogues on mammary epithelial cells
    • Mayer, D., Shukla, A., and Enzmann, H. (2008). Proliferative effects of insulin analogues on mammary epithelial cells. Arch. Physiol. Biochem. 114, 38-44.
    • (2008) Arch. Physiol. Biochem. , vol.114 , pp. 38-44
    • Mayer, D.1    Shukla, A.2    Enzmann, H.3
  • 115
    • 0029145296 scopus 로고
    • Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor
    • Miura, M., Surmacz, E., Burgaud, J. L., and Baserga, R. (1995). Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J. Biol. Chem. 270, 22639-22644.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22639-22644
    • Miura, M.1    Surmacz, E.2    Burgaud, J.L.3    Baserga, R.4
  • 117
    • 0024403208 scopus 로고
    • Tissuespecific expression of two alternatively spliced insulin receptor mRNAs in man
    • Moller, D. E., Yokota, A., Caro, J. F., and Flier, J. S. (1989). Tissuespecific expression of two alternatively spliced insulin receptor mRNAs in man. Mol. Endocrinol. 3, 1263-1269.
    • (1989) Mol. Endocrinol. , vol.3 , pp. 1263-1269
    • Moller, D.E.1    Yokota, A.2    Caro, J.F.3    Flier, J.S.4
  • 119
    • 49649107776 scopus 로고    scopus 로고
    • Rosiglitazone and risk of cancer: a meta-analysis of randomized clinical trials
    • Monami, M., Lamanna, C., Marchionni, N., and Mannucci, E. (2008). Rosiglitazone and risk of cancer: a meta-analysis of randomized clinical trials. Diabetes Care 31, 1455-1460.
    • (2008) Diabetes Care , vol.31 , pp. 1455-1460
    • Monami, M.1    Lamanna, C.2    Marchionni, N.3    Mannucci, E.4
  • 120
    • 79960986160 scopus 로고    scopus 로고
    • Research resource: new and diverse substrates for the insulin receptor isoform a revealed by quantitative proteomics after stimulation with igf-ii or insulin
    • Morcavallo, A., Gaspari, M., Pandini, G., Palummo, A., Cuda, G., Larsen, M. R., Vigneri, R., and Belfiore, A. (2011). Research resource: new and diverse substrates for the insulin receptor isoform a revealed by quantitative proteomics after stimulation with igf-ii or insulin. Mol. Endocrinol. 25, 1456-1468.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1456-1468
    • Morcavallo, A.1    Gaspari, M.2    Pandini, G.3    Palummo, A.4    Cuda, G.5    Larsen, M.R.6    Vigneri, R.7    Belfiore, A.8
  • 121
    • 84856701110 scopus 로고    scopus 로고
    • Further Exploration of the relationship between insulin glargine and incident cancer: a retrospective cohort study of older Medicare patients
    • Morden, N. E., Liu, S. K., Smith, J., Mackenzie, T. A., Skinner, J., and Korc, M. (2011). Further Exploration of the relationship between insulin glargine and incident cancer: a retrospective cohort study of older Medicare patients. Diabetes Care 34, 1965-1971.
    • (2011) Diabetes Care , vol.34 , pp. 1965-1971
    • Morden, N.E.1    Liu, S.K.2    Smith, J.3    Mackenzie, T.A.4    Skinner, J.5    Korc, M.6
  • 122
    • 0025362295 scopus 로고
    • Functionally distinct insulin receptors generated by tissue-specific alternative splicing
    • Mosthaf, L., Grako, K., Dull, T. J., Coussens, L., Ullrich, A., and Mcclain, D. A. (1990). Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J. 9, 2409-2413.
    • (1990) EMBO J , vol.9 , pp. 2409-2413
    • Mosthaf, L.1    Grako, K.2    Dull, T.J.3    Coussens, L.4    Ullrich, A.5    Mcclain, D.A.6
  • 124
    • 0037044821 scopus 로고    scopus 로고
    • Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1
    • Mulligan, C., Rochford, J., Denyer, G., Stephens, R., Yeo, G., Freeman, T., Siddle, K., and O'rahilly, S. (2002). Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1. J. Biol. Chem. 277, 42480-42487.
    • (2002) J. Biol. Chem. , vol.277 , pp. 42480-42487
    • Mulligan, C.1    Rochford, J.2    Denyer, G.3    Stephens, R.4    Yeo, G.5    Freeman, T.6    Siddle, K.7    O'rahilly, S.8
  • 126
    • 0030955431 scopus 로고    scopus 로고
    • Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit
    • Najjar, S. M., Blakesley, V. A., Li Calzi, S., Kato, H., Leroith, D., and Choice, C. V. (1997). Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit. Biochemistry 36, 6827-6834.
    • (1997) Biochemistry , vol.36 , pp. 6827-6834
    • Najjar, S.M.1    Blakesley, V.A.2    Li Calzi, S.3    Kato, H.4    Leroith, D.5    Choice, C.V.6
  • 127
    • 0035719947 scopus 로고    scopus 로고
    • Distinct and overlapping functions of insulin and IGF-I receptors
    • Nakae, J., Kido, Y., and Accili, D. (2001). Distinct and overlapping functions of insulin and IGF-I receptors. Endocr. Rev. 22, 818-835.
    • (2001) Endocr. Rev. , vol.22 , pp. 818-835
    • Nakae, J.1    Kido, Y.2    Accili, D.3
  • 128
    • 11244250660 scopus 로고    scopus 로고
    • Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy
    • Nicholson, R. I., Staka, C., Boyns, F., Hutcheson, I. R., and Gee, J. M. (2004). Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy. Endocr. Relat. Cancer 11, 623-641.
    • (2004) Endocr. Relat. Cancer , vol.11 , pp. 623-641
    • Nicholson, R.I.1    Staka, C.2    Boyns, F.3    Hutcheson, I.R.4    Gee, J.M.5
  • 130
    • 70349684824 scopus 로고    scopus 로고
    • Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation
    • Novosyadlyy, R., Vijayakumar, A., Lann, D., Fierz, Y., Kurshan, N., and Leroith, D. (2009). Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation. Oncogene 28, 3477-3486.
    • (2009) Oncogene , vol.28 , pp. 3477-3486
    • Novosyadlyy, R.1    Vijayakumar, A.2    Lann, D.3    Fierz, Y.4    Kurshan, N.5    Leroith, D.6
  • 131
    • 0031028245 scopus 로고    scopus 로고
    • Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis
    • O'Connor, R., Kauffmann-Zeh, A., Liu, Y., Lehar, S., Evan, G. I., Baserga, R., and Blattler, W. A. (1997). Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol. Cell. Biol. 17, 427-435.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 427-435
    • O'Connor, R.1    Kauffmann-Zeh, A.2    Liu, Y.3    Lehar, S.4    Evan, G.I.5    Baserga, R.6    Blattler, W.A.7
  • 133
    • 0028200567 scopus 로고
    • Insulin-like growth factor-1 (IGF1) specifically binds to bovine lens epithelial cells and increases the number of fibronectin receptor sites
    • Palmade, F., Sechoy-Chambon, O., Coquelet, C., and Bonne, C. (1994). Insulin-like growth factor-1 (IGF1) specifically binds to bovine lens epithelial cells and increases the number of fibronectin receptor sites. Curr. Eye Res. 13, 531-537.
    • (1994) Curr. Eye Res. , vol.13 , pp. 531-537
    • Palmade, F.1    Sechoy-Chambon, O.2    Coquelet, C.3    Bonne, C.4
  • 134
    • 0037131385 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    • Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R., and Belfiore, A. (2002). Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277, 39684-39695.
    • (2002) J. Biol. Chem. , vol.277 , pp. 39684-39695
    • Pandini, G.1    Frasca, F.2    Mineo, R.3    Sciacca, L.4    Vigneri, R.5    Belfiore, A.6
  • 135
    • 0142180099 scopus 로고    scopus 로고
    • Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A
    • Pandini, G., Medico, E., Conte, E., Sciacca, L., Vigneri, R., and Belfiore, A. (2003). Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A. J. Biol. Chem. 278, 42178-42189.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42178-42189
    • Pandini, G.1    Medico, E.2    Conte, E.3    Sciacca, L.4    Vigneri, R.5    Belfiore, A.6
  • 136
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling
    • Pandini, G., Vigneri, R., Costantino, A., Frasca, F., Ippolito, A., FujitaYamaguchi, Y., Siddle, K., Goldfine, I. D., and Belfiore, A. (1999). Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin. Cancer Res. 5, 1935-1944.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1935-1944
    • Pandini, G.1    Vigneri, R.2    Costantino, A.3    Frasca, F.4    Ippolito, A.5    FujitaYamaguchi, Y.6    Siddle, K.7    Goldfine, I.D.8    Belfiore, A.9
  • 137
    • 34248170187 scopus 로고    scopus 로고
    • Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    • Pandini, G., Wurch, T., Akla, B., Corvaia, N., Belfiore, A., and Goetsch, L. (2007). Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur. J. Cancer 43, 1318-1327.
    • (2007) Eur. J. Cancer , vol.43 , pp. 1318-1327
    • Pandini, G.1    Wurch, T.2    Akla, B.3    Corvaia, N.4    Belfiore, A.5    Goetsch, L.6
  • 139
    • 21644449708 scopus 로고    scopus 로고
    • Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma)
    • Patel, K. M., Wright, K. L., Whittaker, P., Chakravarty, P., Watson, M. L., and Ward, S. G. (2005). Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). Cell. Signal. 17, 1098-1110.
    • (2005) Cell. Signal. , vol.17 , pp. 1098-1110
    • Patel, K.M.1    Wright, K.L.2    Whittaker, P.3    Chakravarty, P.4    Watson, M.L.5    Ward, S.G.6
  • 141
    • 35148818315 scopus 로고    scopus 로고
    • IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells
    • Perks, C. M., Vernon, E. G., Rosendahl, A. H., Tonge, D., and Holly, J. M. (2007). IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells. Oncogene 26, 5966-5972.
    • (2007) Oncogene , vol.26 , pp. 5966-5972
    • Perks, C.M.1    Vernon, E.G.2    Rosendahl, A.H.3    Tonge, D.4    Holly, J.M.5
  • 142
    • 0028837993 scopus 로고
    • Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase
    • Pillay, T. S., Sasaoka, T., and Olefsky, J. M. (1995). Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase. J. Biol. Chem. 270, 991-994.
    • (1995) J. Biol. Chem. , vol.270 , pp. 991-994
    • Pillay, T.S.1    Sasaoka, T.2    Olefsky, J.M.3
  • 143
    • 47349117519 scopus 로고    scopus 로고
    • Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies
    • Pisani, P. (2008). Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies. Arch. Physiol. Biochem. 114, 63-70.
    • (2008) Arch. Physiol. Biochem. , vol.114 , pp. 63-70
    • Pisani, P.1
  • 144
    • 68349148204 scopus 로고    scopus 로고
    • Insulin glargine and malignancy: an unwarranted alarm
    • Pocock, S. J., and Smeeth, L. (2009). Insulin glargine and malignancy: an unwarranted alarm. Lancet 374, 511-513.
    • (2009) Lancet , vol.374 , pp. 511-513
    • Pocock, S.J.1    Smeeth, L.2
  • 146
    • 33745072710 scopus 로고    scopus 로고
    • Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors
    • Rakatzi, I., Stosik, M., Gromke, T., Siddle, K., and Eckel, J. (2006). Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors. Arch. Physiol. Biochem. 112, 37-47.
    • (2006) Arch. Physiol. Biochem. , vol.112 , pp. 37-47
    • Rakatzi, I.1    Stosik, M.2    Gromke, T.3    Siddle, K.4    Eckel, J.5
  • 147
    • 0035164289 scopus 로고    scopus 로고
    • Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells
    • Reeves, R., Edberg, D. D., and Li, Y. (2001). Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol. Cell. Biol. 21, 575-594.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 575-594
    • Reeves, R.1    Edberg, D.D.2    Li, Y.3
  • 148
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    • Roux, P. P., and Blenis, J. (2004). ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68, 320-344.
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 149
    • 51049095723 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid, a cytotoxic insulinlike growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer
    • Rowe, D. L., Ozbay, T., Bender, L. M., and Nahta, R. (2008). Nordihydroguaiaretic acid, a cytotoxic insulinlike growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer. Mol. Cancer Ther. 7, 1900-1908.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1900-1908
    • Rowe, D.L.1    Ozbay, T.2    Bender, L.M.3    Nahta, R.4
  • 150
    • 84856715759 scopus 로고    scopus 로고
    • Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large populationbased follow-up study
    • doi: 10.1007/s00125-011-2312-4
    • Ruiter, R., Visser, L. E., Van Herk-Sukel, M. P., Coebergh, J. W., Haak, H. R., Geelhoed-Duijvestijn, P. H., Straus, S. M., Herings, R. M., and Stricker, B. H. (2011). Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large populationbased follow-up study. Diabetologia. doi: 10.1007/s00125-0112312-4.
    • (2011) Diabetologia
    • Ruiter, R.1    Visser, L.E.2    Van Herk-Sukel, M.P.3    Coebergh, J.W.4    Haak, H.R.5    Geelhoed-Duijvestijn, P.H.6    Straus, S.M.7    Herings, R.M.8    Stricker, B.H.9
  • 151
    • 67651160587 scopus 로고    scopus 로고
    • Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A
    • Sacco, A., Morcavallo, A., Pandini, G., Vigneri, R., and Belfiore, A. (2009). Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A. Endocrinology 150, 3594-3602.
    • (2009) Endocrinology , vol.150 , pp. 3594-3602
    • Sacco, A.1    Morcavallo, A.2    Pandini, G.3    Vigneri, R.4    Belfiore, A.5
  • 152
    • 33644555493 scopus 로고    scopus 로고
    • Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer
    • Sachdev, D., Singh, R., FujitaYamaguchi, Y., and Yee, D. (2006). Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer. Cancer Res. 66, 2391-2402.
    • (2006) Cancer Res , vol.66 , pp. 2391-2402
    • Sachdev, D.1    Singh, R.2    FujitaYamaguchi, Y.3    Yee, D.4
  • 153
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: overview and recent insights
    • Samani, A. A., Yakar, S., Leroith, D., and Brodt, P. (2007). The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr. Rev. 28, 20-47.
    • (2007) Endocr. Rev. , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    Leroith, D.3    Brodt, P.4
  • 157
    • 0037191919 scopus 로고    scopus 로고
    • In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A
    • Sciacca, L., Mineo, R., Pandini, G., Murabito, A., Vigneri, R., and Belfiore, A. (2002). In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene 21, 8240-8250.
    • (2002) Oncogene , vol.21 , pp. 8240-8250
    • Sciacca, L.1    Mineo, R.2    Pandini, G.3    Murabito, A.4    Vigneri, R.5    Belfiore, A.6
  • 158
    • 36348970313 scopus 로고    scopus 로고
    • Targeted therapies in Ewing's sarcoma
    • Scotlandi, K. (2006). Targeted therapies in Ewing's sarcoma. Adv. Exp. Med. Biol. 587, 13-22.
    • (2006) Adv. Exp. Med. Biol. , vol.587 , pp. 13-22
    • Scotlandi, K.1
  • 159
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulinlikegrowthfactorIreceptorgene on growth and transformation of mouse embryo fibroblasts
    • Sell, C., Dumenil, G., Deveaud, C., Miura, M., Coppola, D., Deangelis, T., Rubin, R., Efstratiadis, A., and Baserga, R. (1994). Effect of a null mutation of the insulinlikegrowthfactorIreceptorgene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 14, 3604-3612.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3    Miura, M.4    Coppola, D.5    Deangelis, T.6    Rubin, R.7    Efstratiadis, A.8    Baserga, R.9
  • 160
    • 34249948005 scopus 로고    scopus 로고
    • Present concepts and future outlook: function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer
    • Sertznig, P., Seifert, M., Tilgen, W., and Reichrath, J. (2007). Present concepts and future outlook: function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer. J. Cell. Physiol. 212, 1-12.
    • (2007) J. Cell. Physiol. , vol.212 , pp. 1-12
    • Sertznig, P.1    Seifert, M.2    Tilgen, W.3    Reichrath, J.4
  • 162
    • 70349750200 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition
    • Shi, J., Wang, D. M., Wang, C. M., Hu, Y., Liu, A. H., Zhang, Y. L., Sun, B., and Song, J. G. (2009). Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition. Cancer Res. 69, 7180-7187.
    • (2009) Cancer Res , vol.69 , pp. 7180-7187
    • Shi, J.1    Wang, D.M.2    Wang, C.M.3    Hu, Y.4    Liu, A.H.5    Zhang, Y.L.6    Sun, B.7    Song, J.G.8
  • 163
    • 0036117576 scopus 로고    scopus 로고
    • Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells
    • Shimada, T., Kojima, K., Yoshiura, K., Hiraishi, H., and Terano, A. (2002). Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. Gut 50, 658-664.
    • (2002) Gut , vol.50 , pp. 658-664
    • Shimada, T.1    Kojima, K.2    Yoshiura, K.3    Hiraishi, H.4    Terano, A.5
  • 164
    • 64549090709 scopus 로고    scopus 로고
    • Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelialmesenchymal transition
    • Sivakumar, R., Koga, H., Selvendiran, K., Maeyama, M., Ueno, T., and Sata, M. (2009). Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelialmesenchymal transition. Int. J. Oncol. 34, 329-338.
    • (2009) Int. J. Oncol. , vol.34 , pp. 329-338
    • Sivakumar, R.1    Koga, H.2    Selvendiran, K.3    Maeyama, M.4    Ueno, T.5    Sata, M.6
  • 165
    • 33748744723 scopus 로고    scopus 로고
    • Hybrid receptors formed by insulin receptor (IR) and insulinlike growth factor I receptor (IGFIR) have low insulin and high IGF1 affinity irrespective of the IR splice variant
    • Slaaby, R., Schaffer, L., Lautrup-Larsen, I., Andersen, A. S., Shaw, A. C., Mathiasen, I. S., and Brandt, J. (2006). Hybrid receptors formed by insulin receptor (IR) and insulinlike growth factor I receptor (IGFIR) have low insulin and high IGF1 affinity irrespective of the IR splice variant. J. Biol. Chem. 281, 25869-25874.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25869-25874
    • Slaaby, R.1    Schaffer, L.2    Lautrup-Larsen, I.3    Andersen, A.S.4    Shaw, A.C.5    Mathiasen, I.S.6    Brandt, J.7
  • 166
    • 0034811763 scopus 로고    scopus 로고
    • Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects
    • Solomon, C. S., and Goalstone, M. L. (2001). Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects. Biochem. Biophys. Res. Commun. 285, 161-166.
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , pp. 161-166
    • Solomon, C.S.1    Goalstone, M.L.2
  • 167
    • 77949760139 scopus 로고    scopus 로고
    • In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites
    • doi:10.1371/journal.pone.0009540
    • Sommerfeld, M. R., Muller, G., Tschank, G., Seipke, G., Habermann, P., Kurrle, R., and Tennagels, N. (2010). In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites. PLoS ONE 5, e9540. doi:10.1371/journal.pone.0009540.
    • (2010) PLoS ONE , vol.5
    • Sommerfeld, M.R.1    Muller, G.2    Tschank, G.3    Seipke, G.4    Habermann, P.5    Kurrle, R.6    Tennagels, N.7
  • 168
    • 0034077136 scopus 로고    scopus 로고
    • The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor
    • Soni, P., Lakkis, M., Poy, M. N., Fernstrom, M. A., and Najjar, S. M. (2000). The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor. Mol. Cell. Biol. 20, 3896-3905.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3896-3905
    • Soni, P.1    Lakkis, M.2    Poy, M.N.3    Fernstrom, M.A.4    Najjar, S.M.5
  • 171
    • 0027191495 scopus 로고
    • Effects of caloric restriction and dietary fat on epithelial cell proliferation in rat colon
    • Steinbach, G., Kumar, S. P., Reddy, B. S., Lipkin, M., and Holt, P. R. (1993). Effects of caloric restriction and dietary fat on epithelial cell proliferation in rat colon. Cancer Res. 53, 2745-2749.
    • (1993) Cancer Res , vol.53 , pp. 2745-2749
    • Steinbach, G.1    Kumar, S.P.2    Reddy, B.S.3    Lipkin, M.4    Holt, P.R.5
  • 173
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways
    • Tamburini, J., Chapuis, N., Bardet, V., Park, S., Sujobert, P., Willems, L., Ifrah, N., Dreyfus, F., Mayeux, P., Lacombe, C., and Bouscary, D. (2008). Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood 111, 379-382.
    • (2008) Blood , vol.111 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3    Park, S.4    Sujobert, P.5    Willems, L.6    Ifrah, N.7    Dreyfus, F.8    Mayeux, P.9    Lacombe, C.10    Bouscary, D.11
  • 175
    • 0030060965 scopus 로고    scopus 로고
    • Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) receptor: comparative study using the yeast two-hybrid system
    • Tartare-Deckert, S., Murdaca, J., SawkaVerhelle, D., Holt, K. H., Pessin, J. E., and Van Obberghen, E. (1996). Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) receptor: comparative study using the yeast two-hybrid system. Endocrinology 137, 1019-1024.
    • (1996) Endocrinology , vol.137 , pp. 1019-1024
    • Tartare-Deckert, S.1    Murdaca, J.2    SawkaVerhelle, D.3    Holt, K.H.4    Pessin, J.E.5    Van Obberghen, E.6
  • 178
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: the diverse biology of PPARgamma
    • Tontonoz, P., and Spiegelman, B. M. (2008). Fat and beyond: the diverse biology of PPARgamma. Annu. Rev. Biochem. 77, 289-312.
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 182
    • 0036701556 scopus 로고    scopus 로고
    • Weight control and physical activity in cancer prevention: international evaluation of the evidence
    • Vainio, H., Kaaks, R., and Bianchini, F. (2002). Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur. J. Cancer Prev. 11(SUPPL 2), S94-S100.
    • (2002) Eur. J. Cancer Prev. , vol.11 , Issue.SUPPL. 2
    • Vainio, H.1    Kaaks, R.2    Bianchini, F.3
  • 183
    • 0030952501 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor signaling in transformation by src oncogenes
    • Valentinis, B., Morrione, A., Taylor, S. J., and Baserga, R. (1997). Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Mol. Cell. Biol. 17, 3744-3754.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3744-3754
    • Valentinis, B.1    Morrione, A.2    Taylor, S.J.3    Baserga, R.4
  • 184
    • 27144519937 scopus 로고    scopus 로고
    • The causes and consequences of cancer-associated malnutrition
    • Van Cutsem, E., and Arends, J. (2005). The causes and consequences of cancer-associated malnutrition. Eur. J. Oncol. Nurs. 9(SUPPL 2), S51-S63.
    • (2005) Eur. J. Oncol. Nurs. , vol.9 , Issue.SUPPL. 2
    • Van Cutsem, E.1    Arends, J.2
  • 185
    • 0036148531 scopus 로고    scopus 로고
    • A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer
    • Vella, V., Pandini, G., Sciacca, L., Mineo, R., Vigneri, R., Pezzino, V., and Belfiore, A. (2002). A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J. Clin. Endocrinol. Metab. 87, 245-254.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 245-254
    • Vella, V.1    Pandini, G.2    Sciacca, L.3    Mineo, R.4    Vigneri, R.5    Pezzino, V.6    Belfiore, A.7
  • 189
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan, X., Harkavy, B., Shen, N., Grohar, P., and Helman, L. J. (2007). Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26, 1932-1940.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 190
    • 0029885334 scopus 로고    scopus 로고
    • Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer
    • Webster, N. J., Resnik, J. L., Reichart, D. B., Strauss, B., Haas, M., and Seely, B. L. (1996). Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res. 56, 2781-2788.
    • (1996) Cancer Res , vol.56 , pp. 2781-2788
    • Webster, N.J.1    Resnik, J.L.2    Reichart, D.B.3    Strauss, B.4    Haas, M.5    Seely, B.L.6
  • 191
    • 20444411501 scopus 로고    scopus 로고
    • Characterization of the functional insulin binding epitopes of the full length insulin receptor
    • Whittaker, J., and Whittaker, L. (2005). Characterization of the functional insulin binding epitopes of the full length insulin receptor. J. Biol. Chem. 280, 20932-20936.
    • (2005) J. Biol. Chem. , vol.280 , pp. 20932-20936
    • Whittaker, J.1    Whittaker, L.2
  • 192
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: an old idea a paradigm shift
    • discussion 1886-1895
    • Wicha, M. S., Liu, S., and Dontu, G. (2006). Cancer stem cells: an old idea a paradigm shift. Cancer Res. 66, 1883-1890; discussion 1895-1886.
    • (2006) Cancer Res , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 193
    • 0027537050 scopus 로고
    • Ligand-binding properties of the two isoforms of the human insulin receptor
    • Yamaguchi, Y., Flier, J. S., Benecke, H., Ransil, B. J., and Moller, D. E. (1993). Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132, 1132-1138.
    • (1993) Endocrinology , vol.132 , pp. 1132-1138
    • Yamaguchi, Y.1    Flier, J.S.2    Benecke, H.3    Ransil, B.J.4    Moller, D.E.5
  • 195
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani, M., Dowling, R., Fantus, I. G., Sonenberg, N., and Pollak, M. (2006). Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66, 10269-10273.
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 196
    • 0034461581 scopus 로고    scopus 로고
    • Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
    • Zeng, L., Sachdev, P., Yan, L., Chan, J. L., Trenkle, T., Mcclelland, M., Welsh, J., and Wang, L. H. (2000). Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Mol. Cell. Biol. 20, 9212-9224.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9212-9224
    • Zeng, L.1    Sachdev, P.2    Yan, L.3    Chan, J.L.4    Trenkle, T.5    Mcclelland, M.6    Welsh, J.7    Wang, L.H.8
  • 197
    • 33846458639 scopus 로고    scopus 로고
    • Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    • Zhang, H., Pelzer, A. M., Kiang, D. T., andYee, D. (2007). Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res. 67, 391-397.
    • (2007) Cancer Res , vol.67 , pp. 391-397
    • Zhang, H.1    Pelzer, A.M.2    Kiang, D.T.3    Yee, D.4
  • 198
    • 84858719140 scopus 로고    scopus 로고
    • Metformin as an energy restriction mimetic agent for breast cancer prevention
    • Zhu, Z., Jiang, W., Thompson, M. D., Mcginley, J. N., and Thompson, H. J. (2011). Metformin as an energy restriction mimetic agent for breast cancer prevention. J. Carcinog. 10, 17.
    • (2011) J. Carcinog. , vol.10 , pp. 17
    • Zhu, Z.1    Jiang, W.2    Thompson, M.D.3    Mcginley, J.N.4    Thompson, H.J.5


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