메뉴 건너뛰기




Volumn 35, Issue 1, 2013, Pages 107-120

Aftins increase amyloid-β42, lower amyloid- β38, and do not alter Amyloid-β40 extracellular production in vitro: Toward a chemical model of alzheimer's disease?

Author keywords

Aftins; Alzheimer's disease; amyloid ; mitochondria; secretase; secretase modulators

Indexed keywords

AFTIN 1; AFTIN 2; AFTIN 3; AFTIN 4; AFTIN 5; AMYLOID BETA PROTEIN[1-38]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE INHIBITOR; CYTOCHROME C; GAMMA SECRETASE INHIBITOR; OLIGOMER; PROTEIN PRECURSOR; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84876373761     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-121777     Document Type: Article
Times cited : (16)

References (63)
  • 1
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutics strategies
    • Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutics strategies. Cell 148, 1204-1222.
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 3
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. Erratum in: Science 297, 2209. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 4
    • 84857642949 scopus 로고    scopus 로고
    • The toxic Aβ oligomer and Alzheimer's disease: An emperor in need of clothes
    • Benilova I, Karran E, De Strooper B (2012) The toxic Aβ oligomer and Alzheimer's disease: An emperor in need of clothes. Nat Neurosci 15, 349-357.
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 5
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
    • Karran E, Mercken M, De Strooper B (2011) The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics. Nat Rev Drug Discov 10, 698-712.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 7
    • 84863867694 scopus 로고    scopus 로고
    • Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets
    • Lee VM, Brunden KR, Hutton M, Trojanowski JQ (2011) Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harb Perspect Med 1, a006437.
    • (2011) Cold Spring Harb Perspect Med , vol.1
    • Lee, V.M.1    Brunden, K.R.2    Hutton, M.3    Trojanowski, J.Q.4
  • 8
    • 85027949706 scopus 로고    scopus 로고
    • Tau mediated neurodegeneration: An insight into Alzheimer's disease pathology
    • Obulesu M, Venu R, Somashekhar R (2011) Tau mediated neurodegeneration: An insight into Alzheimer's disease pathology. Neurochem Res 36, 1329-1335.
    • (2011) Neurochem Res , vol.36 , pp. 1329-1335
    • Obulesu, M.1    Venu, R.2    Somashekhar, R.3
  • 9
    • 76849086405 scopus 로고    scopus 로고
    • The secretases: Enzymes with therapeutic potential in Alzheimer disease
    • De Strooper B, Vassar R, Golde T (2010) The secretases: Enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6, 99-107.
    • (2010) Nat Rev Neurol , vol.6 , pp. 99-107
    • De Strooper, B.1    Vassar, R.2    Golde, T.3
  • 10
    • 70350451482 scopus 로고    scopus 로고
    • Gamma- Secretase: Successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment
    • Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima- Kawashima M, Funamoto S, Ihara Y (2009) gamma- Secretase: Successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J Neurosci 29, 13042-13052.
    • (2009) J Neurosci , vol.29 , pp. 13042-13052
    • Takami, M.1    Nagashima, Y.2    Sano, Y.3    Ishihara, S.4    Morishima-Kawashima, M.5    Funamoto, S.6    Ihara, Y.7
  • 15
    • 34548812551 scopus 로고    scopus 로고
    • The role of amyloid β peptide 42 in Alzheimer's disease
    • DOI 10.1016/j.pharmthera.2007.06.006, PII S016372580700143X
    • Findeis MA (2007) The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacol Ther 116, 266-286. (Pubitemid 47451506)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.2 , pp. 266-286
    • Findeis, M.A.1
  • 20
    • 33744503967 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid aβ38/aβ42 ratio in alzheimer disease
    • DOI 10.1159/000090363
    • Mehta PD, Pirttila T (2005) Increased cerebrospinal fluid A beta38/A beta42 ratio in Alzheimer disease. Neurodegener Dis 2, 242-245. (Pubitemid 43805907)
    • (2005) Neurodegenerative Diseases , vol.2 , Issue.5 , pp. 242-245
    • Mehta, P.D.1    Pirttila, T.2
  • 21
    • 0033008720 scopus 로고    scopus 로고
    • Quantification of sub-femtomole amounts of Alzheimer amyloid β peptides
    • Potempska A, Mack K, Mehta P, Kim KS, Miller DL (1999) Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid 6, 14-21. (Pubitemid 29249931)
    • (1999) Amyloid , vol.6 , Issue.1 , pp. 14-21
    • Potempska, A.1    Mack, K.2    Mehta, P.3    Kim, K.S.4    Miller, D.L.5
  • 24
    • 0037665145 scopus 로고    scopus 로고
    • Roscovitine and other purines as kinase inhibitors. from starfish oocytes to clinical trials
    • Meijer L, Raymond E (2003) Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Accounts Chem Res 36, 417-425.
    • (2003) Accounts Chem Res , vol.36 , pp. 417-425
    • Meijer, L.1    Raymond, E.2
  • 29
    • 79955426777 scopus 로고    scopus 로고
    • Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds
    • Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C, Steiner H (2011) Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. J Biol Chem 286, 15240-15251.
    • (2011) J Biol Chem , vol.286 , pp. 15240-15251
    • Kretner, B.1    Fukumori, A.2    Gutsmiedl, A.3    Page, R.M.4    Luebbers, T.5    Galley, G.6    Baumann, K.7    Haass, C.8    Steiner, H.9
  • 34
    • 58449101589 scopus 로고    scopus 로고
    • Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
    • Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM (2009) Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 4, e4201.
    • (2009) PLoS One , vol.4
    • Ling, D.1    Song, H.J.2    Garza, D.3    Neufeld, T.P.4    Salvaterra, P.M.5
  • 36
    • 79957917512 scopus 로고    scopus 로고
    • A smallmolecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway
    • Tian Y, Bustos V, Flajolet M, Greengard P (2011) A smallmolecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J 25, 1934-1942.
    • (2011) FASEB J , vol.25 , pp. 1934-1942
    • Tian, Y.1    Bustos, V.2    Flajolet, M.3    Greengard, P.4
  • 37
    • 79451471809 scopus 로고    scopus 로고
    • Brain aging and Aβ1-42 neurotoxicity converge via deterioration in autophagy-lysosomal system: A conditional Drosophila model linking Alzheimer's neurodegeneration with aging
    • Ling D, Salvaterra PM (2011) Brain aging and Aβ1-42 neurotoxicity converge via deterioration in autophagy-lysosomal system: A conditional Drosophila model linking Alzheimer's neurodegeneration with aging. Acta Neuropathol 121, 183- 191.
    • (2011) Acta Neuropathol , vol.121 , pp. 183-191
    • Ling, D.1    Salvaterra, P.M.2
  • 39
    • 79955969705 scopus 로고    scopus 로고
    • Autophagy failure in Alzheimer's disease-locating the primary defect
    • Nixon RA,Yang DS (2011) Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiol Dis 43, 38-45.
    • (2011) Neurobiol Dis , vol.43 , pp. 38-45
    • Nixon, R.A.1    Yang, D.S.2
  • 41
    • 43049163813 scopus 로고    scopus 로고
    • Substrate specificity of gammasecretase and other intramembrane proteases
    • Beel AJ, Sanders CR (2008) Substrate specificity of gammasecretase and other intramembrane proteases. Cell Mol Life Sci 65, 1311-1334.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1311-1334
    • Beel, A.J.1    Sanders, C.R.2
  • 45
  • 49
    • 84655164279 scopus 로고    scopus 로고
    • γ-secretase inhibitors and modulators for Alzheimer's disease
    • Wolfe MS (2012) γ-secretase inhibitors and modulators for Alzheimer's disease. J Neurochem 120(Suppl 1), 89-98.
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 89-98
    • Wolfe, M.S.1
  • 50
    • 79851473226 scopus 로고    scopus 로고
    • γ-secretase modulators as potential disease modifying anti-Alzheimer's drugs
    • Oehlrich D, Berthelot DJ, Gijsen HJ (2011) γ-secretase modulators as potential disease modifying anti-Alzheimer's drugs. J Med Chem 54, 669-698.
    • (2011) J Med Chem , vol.54 , pp. 669-698
    • Oehlrich, D.1    Berthelot, D.J.2    Gijsen, H.J.3
  • 55
    • 81155154306 scopus 로고    scopus 로고
    • Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: Support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region
    • Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE (2011) Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: Support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. J Biol Chem 286, 39804-39812.
    • (2011) J Biol Chem , vol.286 , pp. 39804-39812
    • Kukar, T.L.1    Ladd, T.B.2    Robertson, P.3    Pintchovski, S.A.4    Moore, B.5    Bann, M.A.6    Ren, Z.7    Jansen-West, K.8    Malphrus, K.9    Eggert, S.10    Maruyama, H.11    Cottrell, B.A.12    Das, P.13    Basi, G.S.14    Koo, E.H.15    Golde, T.E.16
  • 58
    • 43149088724 scopus 로고    scopus 로고
    • Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
    • Erratum in: J Biol Chem 283, 12680
    • Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN (2008) Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem 283, 7733-7744. Erratum in: J Biol Chem 283, 12680.
    • (2008) J Biol Chem , vol.283 , pp. 7733-7744
    • Kienlen-Campard, P.1    Tasiaux, B.2    Van Hees, J.3    Li, M.4    Huysseune, S.5    Sato, T.6    Fei, J.Z.7    Aimoto, S.8    Courtoy, P.J.9    Smith, S.O.10    Constantinescu, S.N.11    Octave, J.N.12
  • 59
    • 81155154304 scopus 로고    scopus 로고
    • Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein
    • Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH (2011) Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. J Biol Chem 286, 39794-39803.
    • (2011) J Biol Chem , vol.286 , pp. 39794-39803
    • Sagi, S.A.1    Lessard, C.B.2    Winden, K.D.3    Maruyama, H.4    Koo, J.C.5    Weggen, S.6    Kukar, T.L.7    Golde, T.E.8    Koo, E.H.9
  • 60
    • 78649675852 scopus 로고    scopus 로고
    • Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates
    • Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G (2010) Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem 285, 38042-38052.
    • (2010) J Biol Chem , vol.285 , pp. 38042-38052
    • Gong, P.1    Vetrivel, K.S.2    Nguyen, P.D.3    Meckler, X.4    Cheng, H.5    Kounnas, M.Z.6    Wagner, S.L.7    Parent, A.T.8    Thinakaran, G.9
  • 63
    • 77955402231 scopus 로고    scopus 로고
    • The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future
    • Fox SH, Brotchie JM (2010) The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future. Prog Brain Res 184, 133-157.
    • (2010) Prog Brain Res , vol.184 , pp. 133-157
    • Fox, S.H.1    Brotchie, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.