Inhibitor-induced structural change in the HCV IRES domain IIa RNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 16, 2010, Pages 7263-7268

  Paulsen, Ryan B ^a   Seth, Punit P ^c   Swayze, Eric E ^c   Griffey, Richard H ^c   Skalicky, Jack J ^b   Cheatham III, Thomas E ^a   Davis, Darrell R ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

Antiviral; Hepatitis C virus; Molecular dynamics; RNA structure

Indexed keywords

GUANOSINE DIPHOSPHATE; INITIATION FACTOR 2; INTERNAL RIBOSOME ENTRY SITE DOMAIN IIA INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; COMPLEX FORMATION; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE; HEPATITIS C VIRUS; INTERNAL RIBOSOME ENTRY SITE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA GENE; RNA STRUCTURE; RNA TRANSLATION; STEREOISOMERISM; VIRUS INHIBITION; VIRUS MORPHOLOGY; VIRUS REPLICATION;

BASE SEQUENCE; EUKARYOTIC INITIATION FACTOR-2; HEPACIVIRUS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; RNA, RIBOSOMAL; RNA, VIRAL; SOLVENTS; STATIC ELECTRICITY; STEREOISOMERISM;

HEPATITIS C VIRUS;

EID: 77952199248     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911896107     Document Type: Article

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