Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

Journal of Medicinal Chemistry

Volumn 56, Issue 7, 2013, Pages 2804-2812

  Wang, Jizhou ^a   Ma, Chunlong ^b   Wang, Jun ^c   Jo, Hyunil ^c   Canturk, Belgin ^d   Fiorin, Giacomo ^e   Pinto, Lawrence H ^b   Lamb, Robert A ^b,f   Klein, Michael L ^e   DeGrado, William F ^c  

^a Influmedix Inc   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e Temple University   (United States)

^f Department of Molecular Biosciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (ADAMANTAN 1 YLAMINOMETHYL)BENZENE 1,3 DIOL; AMANTADINE DERIVATIVE; ANTIVIRUS AGENT; BENZYL DERIVATIVE; PROTEIN M2; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HYDROGEN BOND; INFLUENZA VIRUS A; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

ANTIVIRAL AGENTS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL MATRIX PROTEINS;

EID: 84876266002     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301538e     Document Type: Article

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