Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 34, 2010, Pages 15075-15080

  Acharya, Rudresh ^a   Carnevale, Vincenzo ^b   Fiorin, Giacomo ^b   Levine, Benjamin G ^b   Polishchuk, Alexei L ^a   Balannik, Victoria ^c   Samish, Ilan ^a   Lamb, Robert A ^c   Pinto, Lawrence H ^c   DeGrado, William F ^a   Klein, Michael L ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Temple University   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Histidine protonation; Ion channels; M2 proton channel; Membrane proteins; Water clusters

Indexed keywords

HISTIDINE; IMIDAZOLE; ION CHANNEL; PROTEIN M2; M2 PROTEIN, INFLUENZA A VIRUS; MATRIX PROTEIN; MUTANT PROTEIN; PROTON; RECOMBINANT PROTEIN;

ARTICLE; CLINICAL ASSESSMENT; CRYSTAL STRUCTURE; CRYSTALLIZATION; INFLUENZA VIRUS A; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; BIOPHYSICS; CHEMICAL STRUCTURE; CHEMISTRY; FEMALE; GENETICS; IN VITRO STUDY; ION TRANSPORT; METABOLISM; MOLECULAR GENETICS; OOCYTE; PH; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; XENOPUS;

INFLUENZA A VIRUS;

AMINO ACID SEQUENCE; ANIMALS; BIOPHYSICAL PHENOMENA; CRYSTALLOGRAPHY, X-RAY; FEMALE; HISTIDINE; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; ION CHANNELS; ION TRANSPORT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; OOCYTES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTONS; RECOMBINANT PROTEINS; VIRAL MATRIX PROTEINS; XENOPUS;

EID: 77956996035     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007071107     Document Type: Article

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