Functional studies and modeling of pore-lining residue mutants of the influenza A virus M2 ion channel

Biochemistry

Volumn 49, Issue 4, 2010, Pages 696-708

  Balannik, Victoria ^a   Carnevale, Vincenzo ^b   Fiorin, Giacomo ^b   Levine, Benjamin G ^b   Lamb, Robert A ^a   Klein, Michael L ^b   DeGrado, William F ^c   Pinto, Lawrence H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Temple University   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; ANTI-VIRAL DRUGS; CHANNEL ACTIVATION; CHANNEL ACTIVITY; CHANNEL PORE; IN-VITRO; INFLUENZA A VIRUS; ION CHANNEL; ION SELECTIVITY; MULTI-STEP MECHANISM; PH-DEPENDENT; PROTON CONCENTRATIONS; PROTON CONDUCTION; PROTONATION STATE; RATE PROFILES; RESISTANT MUTANTS; RESISTANT STRAINS; SPECIFIC ACTIVITY; XENOPUS OOCYTE;

BINDING ENERGY; IONS; PROTEINS; PROTONATION; PROTONS; VIRUSES;

AMINES;

AMANTADINE; ION CHANNEL; PROTEIN M2; PROTON; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONDUCTANCE; CONTROLLED STUDY; INFLUENZA VIRUS A; MUTATION; NONHUMAN; OOCYTE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTON TRANSPORT; XENOPUS;

ANTIVIRAL AGENTS; BINDING SITES; DRUG RESISTANCE, VIRAL; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; ION CHANNEL GATING; ION CHANNELS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTONS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL MATRIX PROTEINS;

INFLUENZA A VIRUS;

EID: 75149171465     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901799k     Document Type: Article

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