Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

Nature

Volumn 463, Issue 7281, 2010, Pages 689-692

  Cady, Sarah D ^a   Schmidt Rohr, Klaus ^a   Wang, Jun ^b   Soto, Cinque S ^b   Degrado, William F ^b   Hong, Mei ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; ANTIVIRUS AGENT; CARBON 13; MEMBRANE PROTEIN; PROTEIN M2; PROTON; SYNTHETIC PEPTIDE; VIRUS PROTEIN;

DRUG RESISTANCE; INFLUENZA; NUCLEAR MAGNETIC RESONANCE; PHOSPHOLIPID; PROTEIN; VIRUS;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DEUTERON NUCLEAR MAGNETIC RESONANCE; DRUG BINDING SITE; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; ISOTOPE LABELING; LIPID BILAYER; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; SOLID STATE; VIRUS INFECTION;

AMANTADINE; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMYRISTOYLPHOSPHATIDYLCHOLINE; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; VIRAL MATRIX PROTEINS;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

EID: 76249125649     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08722     Document Type: Article

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