Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

Journal of the American Chemical Society

Volumn 133, Issue 35, 2011, Pages 13844-13847

  Wang, Jun ^a   Ma, Chunlong ^c   Wu, Yibing ^a   Lamb, Robert A ^b   Pinto, Lawrence H ^c   Degrado, William F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON ANALOGUES; DRUG BINDING; INFLUENZA A VIRUS; MEMBRANE PROTEINS; N-TERMINALS; ORGANOSILANES; POTENT INHIBITOR; PROTON CHANNELS; STRUCTURAL PROBES;

BIOLOGICAL MEMBRANES; ORGANIC COMPOUNDS; PROBES; PROTONS; VIRUSES;

SILANES;

4,4 DIMETHYL SILACYCLOHEXANE AMINE DERIVATIVE; AMANTADINE; AMINE; ANTIVIRUS AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; INFLUENZA A VIRUS M2 PROTON CHANNEL; INFLUENZA A VIRUS M2 PROTON CHANNEL INHIBITOR; SILASPIRANE AMINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; IC 50; INFLUENZA VIRUS A; MOLECULAR PROBE; NONHUMAN;

AMINES; ANTIVIRAL AGENTS; BINDING SITES; DRUG RESISTANCE, VIRAL; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MODELS, MOLECULAR; MUTATION; PROTON PUMP INHIBITORS; PROTON PUMPS; SILANES; VIRAL PROTEINS;

EID: 80052318334     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2050666     Document Type: Article

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