Exploring the requirements for the hydrophobic scaffold and polar amine in inhibitors of M2 from influenza A virus

ACS Medicinal Chemistry Letters

Volumn 2, Issue 4, 2011, Pages 307-312

  Wang, Jun ^a   Ma, Chunlong ^b   Balannik, Victoria ^b   Pinto, Lawrence H ^b   Lamb, Robert A ^b   Degrado, William F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

A M2 channel inhibitor; Influenza A M2; two electrode voltage clamp assay (TEVC)

Indexed keywords

AMANTADINE; AMIDINE; AMINE; ANTIVIRUS AGENT; GUANIDINE; HYDROXYL GROUP;

ANIMAL CELL; ARTICLE; HYDROPHOBICITY; IC 50; INFLUENZA A VIRUS M2; INFLUENZA VIRUS A; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TWO ELECTRODE VOLTAGE PATCH CLAMP ASSAY; XENOPUS LAEVIS;

INFLUENZA A VIRUS; XENOPUS LAEVIS;

EID: 79954623305     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100297w     Document Type: Article

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