Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: G-Scale synthesis, physicochemical characterization and in vitro metabolic stability

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 9, 2013, Pages 2577-2586

  Rossi, Daniela ^a   Marra, Annamaria ^a   Picconi, Pietro ^a   Serra, Massimo ^a   Catenacci, Laura ^a   Sorrenti, Milena ^a   Laurini, Erik ^b   Fermeglia, Maurizio ^b   Pricl, Sabrina ^b   Brambilla, Stefania ^c   Almirante, Nicoletta ^c   Peviani, Marco ^a   Curti, Daniela ^a   Collina, Simona ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c NicOx Research Institute SRL   (Italy)

Author keywords

1 Agonist; In silico study; Metabolic stability; Physicochemical properties; Synthetic scale up

Indexed keywords

DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; NERVE GROWTH FACTOR; RC 33; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; DRUG DEGRADATION; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MOUSE; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; PC12 CELL; PHYSICAL CHEMISTRY; PREDICTION; RAT; RECEPTOR BINDING; SCALE UP; SOLID STATE; SPECIES DIFFERENCE; THERMAL ANALYSIS;

ANIMALS; BIPHENYL COMPOUNDS; CHEMISTRY, PHYSICAL; DOGS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NERVE GROWTH FACTOR; NEURITES; PC12 CELLS; PIPERIDINES; RATS; RECEPTORS, SIGMA;

CANIS FAMILIARIS; RATTUS;

EID: 84876131740     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.029     Document Type: Article

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