Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides

Medicinal Chemistry

Volumn 2, Issue 6, 2006, Pages 577-589

  Carta, Antonio ^a   Loriga, Giovanni ^a   Piras, Sandra ^a   Paglietti, Giuseppe ^a   Ferrone, Marco ^b   Fermeglia, Maurizio ^b   Pricl, Sabrina ^b   La Colla, Paolo ^c   Secci, Barbara ^c   Collu, Gabriella ^c   Loddo, Roberta ^c  

^a Dipartimento Farmaco Chimico Tossicologico   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Anti viral activity; Benzotriazolylphenylcarboxamides; Cytotoxicity; In silico evaluation; Picornaviridae; Polio virus (Sb 1) helicase; SAR

Indexed keywords

1 (4 AMINOPHENYL) 5 TRIFLUOROMETHYLBENZOTRIAZOLE; 1 (4 AMINOPHENYL) 5,6 DIMETHYLBENZOTRIAZOLE; 1 (4 AMINOPHENYL) 6 TRIFLUOROMETHYLBENZOTRIAZOLE; 1 (4 AMINOPHENYL)BENZOTRIAZOLE; 2 (4 AMINOPHENYL) 5 TRIFLUOROMETHYLBENZOTRIAZOLE; 2 (4 AMINOPHENYL) 5,6 DIMETHYLBENZOTRIAZOLE; 2 (4 AMINOPHENYL)BENZOTRIAZOLE; ANTIVIRUS AGENT; BENZOTRIAZOLE DERIVATIVE; CYTOTOXIC AGENT; DOUBLE STRANDED RNA; HELICASE; N [4 (1H BENZOTRIAZOL 1 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (1H BENZOTRIAZOL 1 YL)PHENYL]BUTYRILCARBOXAMIDE; N [4 (1H BENZOTRIAZOL 1 YL)PHENYL]PROPIONYLCARBOXAMIDE; N [4 (2H BENZIMIDAZOL 2 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (2H BENZOTRIAZOL 2 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (2H BENZOTRIAZOL 2 YL)PHENYL]BUTYRILCARBOXAMIDE; N [4 (2H BENZOTRIAZOL 2 YL)PHENYL]PROPIONYLCARBOXAMIDE; N [4 (5 TRIFLUOROMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (5 TRIFLUOROMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (5,6 DIMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (5,6 DIMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]PROPIONYLCARBOXAMIDE; N [4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]BUTYRILCARBOXAMIDE; N [4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]PROPIONYLCARBOXAMIDE; N [4 (6 TRIFLUOROMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]ACETYLCARBOXAMIDE; N [4 [1H(2H) BENZOTRIAZOL 2 YL]PHENYL]ALKYLCARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL LINE; CELL STRAIN BHK; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; COXSACKIE VIRUS B; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PICORNAVIRUS; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REOVIRUS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA VIRUS; STRUCTURE ACTIVITY RELATION; YELLOW FEVER FLAVIVIRUS;

EID: 33750991616     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/1573406410602060577     Document Type: Article

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