Design, synthesis and SAR analysis of novel selective σ1 ligands (Part 2)

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1204-1212

  Rossi, Daniela ^a   Urbano, Mariangela ^a   Pedrali, Alice ^a   Serra, Massimo ^a   Zampieri, Daniele ^b   Mamolo, Maria Grazia ^b   Laggner, Christian ^c   Zanette, Caterina ^b   Florio, Chiara ^b   Schepmann, Dirk ^d   Wuensch, Bernard ^d   Azzolina, Ornella ^a   Collina, Simona ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Arylalkenylamines; Arylalkylamines; Arylalkylaminoalcohols; Pd(0) EnCat 30NP(en); Radioligand binding assays; Sigma ligands

Indexed keywords

1 (3,4 DIMETHOXYPHENETHYL) 4 (3 PHENYLPROPYL)PIPERAZINE; 1 [3 (6 METHOXYNAPHTH 2 YL)BUT 2 ENYL]PIPERIDINE; 1 [3 (6 METHOXYNAPHTH 2 YL)BUTYL]PIPERIDINE; 2 (6 METHOXYNAPHTH 2 YL) 4 (PIPERIDIN 1 YL)BUTAN 2 OL; 3 (6 METHOXYNAPHTH 2 YL) N METHYLBUTAN 1 AMINE; 3 (6 METHOXYNAPHTH 2 YL) N,N DIMETHYLBUT 2 EN 1 AMINE; 3 (6 METHOXYNAPHTH 2 YL) N,N DIMETHYLBUTAN 1 AMINE; 3 (BIPHENYL 4 YL) N METHYLBUTAN 1 AMINE; 4 (DIMETHYLAMINO) 2 (6 METHOXYNAPHTH 2 YL)BUTAN 2 OL; 4 [BENZYL(METHYL)AMINO] 2 (6 METHOXYNAPHTH 2 YL)BUTAN 2 OL; 4 [BENZYL(METHYL)AMINO] 2 (BIPHENYL 4 YL)BUTAN 2 OL; ALKENYL GROUP; AMINE; AMINOALCOHOL; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N BENZYL 3 (6 METHOXYNAPHTH 2 YL) N METHYLBUT 2 EN 1 AMINE; N BENZYL 3 (6 METHOXYNAPHTH 2 YL) N METHYLBUTAN 1 AMINE; N BENZYL 3 (BIPHENYL 4 YL) N METHYLBUT 2 EN 1 AMINE; N BENZYL 3 (BIPHENYL 4 YL) N METHYLBUTAN 1 AMINE; NEUROPROTECTIVE AGENT; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALKENES; AMINES; AMINO ALCOHOLS; ANIMALS; GUINEA PIGS; HYDROCARBONS, AROMATIC; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; RATS; RECEPTORS, OPIOID; RECEPTORS, SIGMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75149126120     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.039     Document Type: Article

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