3-Aryl-2-[1H-benzotriazol-1-yl]acrylonitriles: A novel class of potent tubulin inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4151-4167

  Carta, Antonio ^a   Briguglio, Irene ^a   Piras, Sandra ^a   Boatto, Giampiero ^a   La Colla, Paolo ^b   Loddo, Roberta ^b   Tolomeo, Manlio ^c   Grimaudo, Stefania ^c   Di Cristina, Antonietta ^c   Pipitone, Rosaria Maria ^c   Laurini, Erik ^d   Paneni, Maria Silvia ^d   Posocco, Paola ^d   Fermeglia, Maurizio ^d   Pricl, Sabrina ^d  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d UNIVERSITY OF TRIESTE   (Italy)

Author keywords

3 Aryl 2 1H benzotriazol 1 yl acrylonitriles; Antiproliferative activity; Cell cycle distribution; Colchicine; Homology studies; Molecular modeling study; Podophyllotoxin; Tubulin

Indexed keywords

2 (1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (3,4 PHENYL)ACRYLONITRILE; 2 (1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (4 METHOXYPHENYL)ACRYLONITRILE; 2 (5,6 DICHLORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (4 METHOXYPHENYL)ACRYLONITRILE; 2 (5,6 DICHLORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 PARA TOLYLACRYLONITRILE; 3 (4 BROMOPHENYL) 2 (5,6 DICHLORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL)ACRYLONITRILE; 3 ARYL 2 (1H BENZOTRIAZOL 1 YL)ACRYLONITRILE; ANTINEOPLASTIC AGENT; ETOPOSIDE; MERCAPTOPURINE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CANCER CELL CULTURE; CELL CYCLE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; DRUG IDENTIFICATION; DRUG POTENCY; HEMATOLOGIC DISEASE; HUMAN; HUMAN CELL; MOLECULAR MODEL; SOLID TUMOR; STRUCTURE ACTIVITY RELATION;

ACRYLONITRILE; BINDING, COMPETITIVE; CELL CYCLE; COLCHICINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUBULIN;

EID: 80052933605     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.018     Document Type: Article

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