Modeling the multivalent recognition between dendritic molecules and DNA: Understanding how ligand "sacrifice" and screening can enhance binding

Journal of the American Chemical Society

Volumn 131, Issue 28, 2009, Pages 9686-9694

  Pavan, Giovanni M ^a,b   Danani, Andrea ^b   Pricl, Sabrina ^a,b   Smith, David K ^c  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY BINDING; BINDING EFFECTS; COMPENSATION EFFECTS; DENDRITIC MOLECULE; DENDRON; DNA BINDING; DNA DOUBLE HELICES; DOUBLE-HELICAL; ENERGETIC EFFECT; HIGH AFFINITY BINDING; INTERACTION ENERGIES; MODELING STUDIES; MOLECULAR DYNAMICS METHODS; MULTIVALENCY; PREORGANIZATION; SALT CONCENTRATION; SITE SCREENING; SURFACE GROUPS;

BINDING SITES; DENDRIMERS; DNA; GENES; LIGANDS; MOLECULAR DYNAMICS; NUCLEIC ACIDS; SODIUM CHLORIDE;

BINDING ENERGY;

DNA; LIGAND; SODIUM CHLORIDE; SPERMINE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONCENTRATION (PARAMETERS); DNA BINDING; DNA HELIX; ENERGY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; MOLECULE;

ANIMALS; BASE SEQUENCE; CATTLE; DENDRIMERS; DNA; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SPERMINE; THERMODYNAMICS;

EID: 67650504216     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja901174k     Document Type: Article

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