PAMAM dendrimers for siRNA delivery: Computational and experimental Insights

Chemistry - A European Journal

Volumn 16, Issue 26, 2010, Pages 7781-7795

  Pavan, Giovanni Maria ^a   Posocco, Paola ^b   Tagliabue, Aaron ^c   Maly, Marek ^a,d   Malek, Anastasia ^e   Danani, Andrea ^a   Ragg, Enzio ^c   Catapano, Carlo V ^e   Pricl, Sabrina ^b  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d J E PURKINJE UNIVERSITY   (Czech Republic)

^e ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

Binding process; Molecular simulations; Nmr spectroscopy; Pamam dendrimers; SiRNA delivery

Indexed keywords

BINDING PROCESS; MOLECULAR SIMULATIONS; NMR SPECTROSCOPY; PAMAM DENDRIMER; SIRNA DELIVERY;

BINDING ENERGY; COMPLEXATION; COMPUTER SIMULATION; DENDRIMERS; FUNCTIONAL POLYMERS; GELS; GENE EXPRESSION; GENETIC ENGINEERING; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STOICHIOMETRY;

RNA;

DENDRIMER; DOUBLE STRANDED RNA; DRUG CARRIER; PAMAM STARBURST; SMALL INTERFERING RNA;

ARTICLE; CHEMISTRY; COMPUTER SIMULATION; CULTURE TECHNIQUE; GENE SILENCING; GENETICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RNA INTERFERENCE;

CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; DENDRIMERS; DRUG CARRIERS; GENE SILENCING; MAGNETIC RESONANCE SPECTROSCOPY; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING;

EID: 77954322325     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200903258     Document Type: Article

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66. NOTE ADDED IN PROOF (24.2.2010): During the production process another related paper appeared (G. M. Pavan, L. Albertazzi, A. Danani, J. Phys. Chem. B 2010, 114, 2667-2675) presenting data in agreement with the findings reported herein.