Activity and molecular modeling of a new small molecule active against NNRTI-resistant HIV-1 mutants

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 5117-5122

  Carta, Antonio ^a   Pricl, Sabrina ^b   Piras, Sandra ^a   Fermeglia, Maurizio ^b   La Colla, Paolo ^c   Loddo, Roberta ^c  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c Virologia Generale e Biotecnologie Microbiche   (Italy)

Author keywords

HIV; HIV 1wt RT assay; Molecular modeling; NNRTI resistant mutants

Indexed keywords

4,9 DIHYDROTRIAZOLO[4,5 G]QUINOLINE 1 OXIDE; EFAVIRENZ; NEVIRAPINE; QUINOLINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIAZOLO[4,5 G]QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SELECTIVITY; ENZYME ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; VIRUS MUTANT; WILD TYPE;

ANTI-HIV AGENTS; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, VIRAL; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; QUINOLINES; REVERSE TRANSCRIPTASE INHIBITORS; THERMODYNAMICS;

EID: 70449631074     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.08.012     Document Type: Article

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