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Volumn 112, Issue 3, 2008, Pages 690-698

Up-regulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CASPASE 8 INHIBITOR; FAS LIGAND; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR NFAT3; ISOPROTEIN; TRANSCRIPTION FACTOR NFAT;

EID: 49749139424     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-02-141382     Document Type: Article
Times cited : (41)

References (54)
  • 1
    • 0027183703 scopus 로고
    • Activation interferes with the APO-1 pathway in mature human T cells
    • Klas C, Debatin KM, Jonker RR, Krammer PH. Activation interferes with the APO-1 pathway in mature human T cells. Int Immunol. 1993;5:625-630.
    • (1993) Int Immunol , vol.5 , pp. 625-630
    • Klas, C.1    Debatin, K.M.2    Jonker, R.R.3    Krammer, P.H.4
  • 2
    • 0033556310 scopus 로고    scopus 로고
    • The role of c-FLIP in modulation of CD95-induced apoptosis
    • Scaffidi C, Schmitz I, Krammer PH, Peter ME. The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem. 1999;274:1541-1548.
    • (1999) J Biol Chem , vol.274 , pp. 1541-1548
    • Scaffidi, C.1    Schmitz, I.2    Krammer, P.H.3    Peter, M.E.4
  • 4
    • 33847082012 scopus 로고    scopus 로고
    • Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation
    • Arnold R, Frey CR, Muller W, Brenner D, Krammer PH, Kiefer F. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Cell Death Differ. 2007;14:568-575.
    • (2007) Cell Death Differ , vol.14 , pp. 568-575
    • Arnold, R.1    Frey, C.R.2    Muller, W.3    Brenner, D.4    Krammer, P.H.5    Kiefer, F.6
  • 5
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature. 1997;388:190-195.
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3
  • 6
    • 0034548714 scopus 로고    scopus 로고
    • TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity
    • Kirchhoff S, Muller WW, Krueger A, Schmitz I, Krammer PH. TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity. J Immunol. 2000;165:6293-6300.
    • (2000) J Immunol , vol.165 , pp. 6293-6300
    • Kirchhoff, S.1    Muller, W.W.2    Krueger, A.3    Schmitz, I.4    Krammer, P.H.5
  • 7
    • 0842300364 scopus 로고    scopus 로고
    • Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort
    • Schmitz I, Weyd H, Krueger A, et al. Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort. J Immunol. 2004;172:2194-2200.
    • (2004) J Immunol , vol.172 , pp. 2194-2200
    • Schmitz, I.1    Weyd, H.2    Krueger, A.3
  • 8
    • 0035827569 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
    • Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem. 2001;276:20633-20640.
    • (2001) J Biol Chem , vol.276 , pp. 20633-20640
    • Krueger, A.1    Schmitz, I.2    Baumann, S.3    Krammer, P.H.4    Kirchhoff, S.5
  • 9
    • 17644378775 scopus 로고    scopus 로고
    • Golks A, Brenner D, Fritsch C, Krammer PH, Lavrik IN. c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem. 2005;280:14507- 14513.
    • Golks A, Brenner D, Fritsch C, Krammer PH, Lavrik IN. c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem. 2005;280:14507- 14513.
  • 10
    • 40949149811 scopus 로고    scopus 로고
    • Mutational analyses of c-FLIP(R), the only murine short FLIP isoform, reveal requirements for DISC recruitment
    • Ueffing N, Keil E, Freund C, Kuhne R, Schulze-Osthoff K, Schmitz I. Mutational analyses of c-FLIP(R), the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death Differ. 2008;15:773-782.
    • (2008) Cell Death Differ , vol.15 , pp. 773-782
    • Ueffing, N.1    Keil, E.2    Freund, C.3    Kuhne, R.4    Schulze-Osthoff, K.5    Schmitz, I.6
  • 11
    • 0037160117 scopus 로고    scopus 로고
    • The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
    • Micheau O, Thome M, Schneider P, et al. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem. 2002;277:45162-45171.
    • (2002) J Biol Chem , vol.277 , pp. 45162-45171
    • Micheau, O.1    Thome, M.2    Schneider, P.3
  • 12
    • 0037099678 scopus 로고    scopus 로고
    • c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
    • Chang DW, Xing Z, Pan Y, et al. c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 2002;21:3704-3714.
    • (2002) EMBO J , vol.21 , pp. 3704-3714
    • Chang, D.W.1    Xing, Z.2    Pan, Y.3
  • 13
    • 21244449877 scopus 로고    scopus 로고
    • Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8
    • Dohrman A, Russell JQ, Cuenin S, Fortner K, Tschopp J, Budd RC. Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8. J Immunol. 2005;175:311-318.
    • (2005) J Immunol , vol.175 , pp. 311-318
    • Dohrman, A.1    Russell, J.Q.2    Cuenin, S.3    Fortner, K.4    Tschopp, J.5    Budd, R.C.6
  • 14
    • 0042834325 scopus 로고    scopus 로고
    • An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death
    • Schmitz I, Krueger A, Baumann S, Schulze-Bergkamen H, Krammer PH, Kirchhoff S. An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death. J Immunol. 2003;171:2930-2936.
    • (2003) J Immunol , vol.171 , pp. 2930-2936
    • Schmitz, I.1    Krueger, A.2    Baumann, S.3    Schulze-Bergkamen, H.4    Krammer, P.H.5    Kirchhoff, S.6
  • 16
    • 0034744033 scopus 로고    scopus 로고
    • NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    • Kreuz S, Siegmund D, Scheurich P, Wajant H. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol. 2001;21:3964-3973.
    • (2001) Mol Cell Biol , vol.21 , pp. 3964-3973
    • Kreuz, S.1    Siegmund, D.2    Scheurich, P.3    Wajant, H.4
  • 17
    • 0041912330 scopus 로고    scopus 로고
    • Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: Roles of Fas, c-FLIP, and Bcl-xL
    • Mora AL, Corn RA, Stanic AK, et al. Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Cell Death Differ. 2003;10:1032-1044.
    • (2003) Cell Death Differ , vol.10 , pp. 1032-1044
    • Mora, A.L.1    Corn, R.A.2    Stanic, A.K.3
  • 18
    • 22244463588 scopus 로고    scopus 로고
    • NF-kappaB protects Behcet's disease T cells against CD95-induced apoptosis up-regulating antiapoptotic proteins
    • Todaro M, Zerilli M, Triolo G, et al. NF-kappaB protects Behcet's disease T cells against CD95-induced apoptosis up-regulating antiapoptotic proteins. Arthritis Rheum. 2005;52:2179-2191.
    • (2005) Arthritis Rheum , vol.52 , pp. 2179-2191
    • Todaro, M.1    Zerilli, M.2    Triolo, G.3
  • 19
    • 19544382901 scopus 로고    scopus 로고
    • The caspase-8 modulator c-FLIP
    • Kataoka T. The caspase-8 modulator c-FLIP. Crit Rev Immunol. 2005;25:31-58.
    • (2005) Crit Rev Immunol , vol.25 , pp. 31-58
    • Kataoka, T.1
  • 20
    • 2342526607 scopus 로고    scopus 로고
    • A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
    • Noguchi H, Matsushita M, Okitsu T, et al. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med. 2004;10:305-309.
    • (2004) Nat Med , vol.10 , pp. 305-309
    • Noguchi, H.1    Matsushita, M.2    Okitsu, T.3
  • 21
    • 4544253226 scopus 로고    scopus 로고
    • Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity
    • Ricci MS, Jin Z, Dews M, et al. Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol. 2004;24:8541-8555.
    • (2004) Mol Cell Biol , vol.24 , pp. 8541-8555
    • Ricci, M.S.1    Jin, Z.2    Dews, M.3
  • 22
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005;5:472-484.
    • (2005) Nat Rev Immunol , vol.5 , pp. 472-484
    • Macian, F.1
  • 23
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 1992;357:695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 24
    • 0025871394 scopus 로고
    • Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
    • Flanagan WM, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991;352:803-807.
    • (1991) Nature , vol.352 , pp. 803-807
    • Flanagan, W.M.1    Corthesy, B.2    Bram, R.J.3    Crabtree, G.R.4
  • 25
    • 18944393390 scopus 로고    scopus 로고
    • Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells
    • Proksch P, Giaisi M, Treiber MK, et al. Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. J Immunol. 2005;174:7075-7084.
    • (2005) J Immunol , vol.174 , pp. 7075-7084
    • Proksch, P.1    Giaisi, M.2    Treiber, M.K.3
  • 26
    • 0347928864 scopus 로고    scopus 로고
    • Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T cells
    • Baumann B, Bohnenstengel F, Siegmund D, et al. Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T cells. J Biol Chem. 2002;277:44791-44800.
    • (2002) J Biol Chem , vol.277 , pp. 44791-44800
    • Baumann, B.1    Bohnenstengel, F.2    Siegmund, D.3
  • 27
    • 21444443478 scopus 로고    scopus 로고
    • MatInspector and beyond: Promoter analysis based on transcription factor binding sites
    • Cartharius K, Frech K, Grote K, et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics. 2005;21:2933-2942.
    • (2005) Bioinformatics , vol.21 , pp. 2933-2942
    • Cartharius, K.1    Frech, K.2    Grote, K.3
  • 28
    • 0032572740 scopus 로고    scopus 로고
    • Transcription: Activation by cooperating conformations
    • Travers A. Transcription: activation by cooperating conformations. Curr Biol. 1998;8:R616-618.
    • (1998) Curr Biol , vol.8
    • Travers, A.1
  • 29
    • 22844435414 scopus 로고    scopus 로고
    • Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail
    • Poukkula M, Kaunisto A, Hietakangas V, et al. Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail. J Biol Chem. 2005;280:27345-27355.
    • (2005) J Biol Chem , vol.280 , pp. 27345-27355
    • Poukkula, M.1    Kaunisto, A.2    Hietakangas, V.3
  • 30
    • 0032539007 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression
    • Yeh JH, Hsu SC, Han SH, Lai MZ. Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression. J Exp Med. 1998;188:1795-1802.
    • (1998) J Exp Med , vol.188 , pp. 1795-1802
    • Yeh, J.H.1    Hsu, S.C.2    Han, S.H.3    Lai, M.Z.4
  • 31
    • 33646688191 scopus 로고    scopus 로고
    • The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation
    • Golks A, Brenner D, Krammer PH, Lavrik IN. The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. J Exp Med. 2006;203:1295-1305.
    • (2006) J Exp Med , vol.203 , pp. 1295-1305
    • Golks, A.1    Brenner, D.2    Krammer, P.H.3    Lavrik, I.N.4
  • 32
    • 22444438599 scopus 로고    scopus 로고
    • The androgen receptor directly targets the cellular Fas/FasL-associated death domain protein-like inhibitory protein gene to promote the androgen-independent growth of prostate cancer cells
    • Gao S, Lee P, Wang H, et al. The androgen receptor directly targets the cellular Fas/FasL-associated death domain protein-like inhibitory protein gene to promote the androgen-independent growth of prostate cancer cells. Mol Endocrinol. 2005;19:1792-1802.
    • (2005) Mol Endocrinol , vol.19 , pp. 1792-1802
    • Gao, S.1    Lee, P.2    Wang, H.3
  • 33
    • 30844469526 scopus 로고    scopus 로고
    • E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short)
    • Salon C, Eymin B, Micheau O, et al. E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short). Cell Death Differ. 2006;13:260-272.
    • (2006) Cell Death Differ , vol.13 , pp. 260-272
    • Salon, C.1    Eymin, B.2    Micheau, O.3
  • 34
    • 0347723879 scopus 로고    scopus 로고
    • The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP
    • Skurk C, Maatz H, Kim HS, et al. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem. 2004;279:1513-1525.
    • (2004) J Biol Chem , vol.279 , pp. 1513-1525
    • Skurk, C.1    Maatz, H.2    Kim, H.S.3
  • 35
    • 33947206642 scopus 로고    scopus 로고
    • MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L)
    • Li W, Zhang X, Olumi AF. MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res. 2007;67:2247-2255.
    • (2007) Cancer Res , vol.67 , pp. 2247-2255
    • Li, W.1    Zhang, X.2    Olumi, A.F.3
  • 36
    • 17944373682 scopus 로고    scopus 로고
    • Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells
    • Fukazawa T, Fujiwara T, Uno F, et al. Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene. 2001;20:5225-5231.
    • (2001) Oncogene , vol.20 , pp. 5225-5231
    • Fukazawa, T.1    Fujiwara, T.2    Uno, F.3
  • 37
    • 0035253051 scopus 로고    scopus 로고
    • p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
    • Bartke T, Siegmund D, Peters N, et al. p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene. 2001;20:571-580.
    • (2001) Oncogene , vol.20 , pp. 571-580
    • Bartke, T.1    Siegmund, D.2    Peters, N.3
  • 38
    • 18444365894 scopus 로고    scopus 로고
    • Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis
    • Chuvpilo S, Jankevics E, Tyrsin D, et al. Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity. 2002;16:881-895.
    • (2002) Immunity , vol.16 , pp. 881-895
    • Chuvpilo, S.1    Jankevics, E.2    Tyrsin, D.3
  • 39
    • 14944359487 scopus 로고    scopus 로고
    • Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes
    • Uriarte SM, Joshi-Barve S, Song Z, et al. Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes. Cell Death Differ. 2005;12:233-242.
    • (2005) Cell Death Differ , vol.12 , pp. 233-242
    • Uriarte, S.M.1    Joshi-Barve, S.2    Song, Z.3
  • 40
    • 0034333177 scopus 로고    scopus 로고
    • Increased cellular expression of the caspase inhibitor FLIP in intrathecal lymphocytes from patients with multiple sclerosis
    • Sharief MK. Increased cellular expression of the caspase inhibitor FLIP in intrathecal lymphocytes from patients with multiple sclerosis. J Neuroimmunol. 2000;111:203-209.
    • (2000) J Neuroimmunol , vol.111 , pp. 203-209
    • Sharief, M.K.1
  • 41
    • 0035866004 scopus 로고    scopus 로고
    • Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis
    • Semra YK, Seidi OA, Sharief MK. Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis. J Neuroimmunol. 2001;113:268-274.
    • (2001) J Neuroimmunol , vol.113 , pp. 268-274
    • Semra, Y.K.1    Seidi, O.A.2    Sharief, M.K.3
  • 42
    • 10444269440 scopus 로고    scopus 로고
    • NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis
    • Bai S, Liu H, Chen KH, et al. NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis. Arthritis Rheum. 2004;50:3844-3855.
    • (2004) Arthritis Rheum , vol.50 , pp. 3844-3855
    • Bai, S.1    Liu, H.2    Chen, K.H.3
  • 43
    • 0033662341 scopus 로고    scopus 로고
    • Requirement for Casper (c-FLIP) in regulation of death receptorinduced apoptosis and embryonic development
    • Yeh WC, Itie A, Elia AJ, et al. Requirement for Casper (c-FLIP) in regulation of death receptorinduced apoptosis and embryonic development. Immunity. 2000;12:633-642.
    • (2000) Immunity , vol.12 , pp. 633-642
    • Yeh, W.C.1    Itie, A.2    Elia, A.J.3
  • 44
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol. 2002;20:323-370.
    • (2002) Annu Rev Immunol , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 45
    • 0031465970 scopus 로고    scopus 로고
    • Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells
    • Latinis KM, Norian LA, Eliason SL, Koretzky GA. Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. J Biol Chem. 1997;272:31427-31434.
    • (1997) J Biol Chem , vol.272 , pp. 31427-31434
    • Latinis, K.M.1    Norian, L.A.2    Eliason, S.L.3    Koretzky, G.A.4
  • 46
    • 0031903618 scopus 로고    scopus 로고
    • A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation
    • Li-Weber M, Laur O, Hekele A, Coy J, Walczak H, Krammer PH. A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation. Eur J Immunol. 1998;28:2373-2383.
    • (1998) Eur J Immunol , vol.28 , pp. 2373-2383
    • Li-Weber, M.1    Laur, O.2    Hekele, A.3    Coy, J.4    Walczak, H.5    Krammer, P.H.6
  • 47
    • 0033712590 scopus 로고    scopus 로고
    • Sequential involvement of NFAT and Egr transcription factors in FasL regulation
    • Rengarajan J, Mittelstadt PR, Mages HW, et al. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity. 2000;12:293-300.
    • (2000) Immunity , vol.12 , pp. 293-300
    • Rengarajan, J.1    Mittelstadt, P.R.2    Mages, H.W.3
  • 48
    • 0029163387 scopus 로고
    • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
    • Boise LH, Minn AJ, Noel PJ, et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity. 1995;3:87-98.
    • (1995) Immunity , vol.3 , pp. 87-98
    • Boise, L.H.1    Minn, A.J.2    Noel, P.J.3
  • 49
    • 33751563901 scopus 로고    scopus 로고
    • Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3
    • Kerstan A, Armbruster N, Leverkus M, Hunig T. Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3. J Immunol. 2006;177:7689-7697.
    • (2006) J Immunol , vol.177 , pp. 7689-7697
    • Kerstan, A.1    Armbruster, N.2    Leverkus, M.3    Hunig, T.4
  • 50
    • 33846590883 scopus 로고    scopus 로고
    • +/ calcineurin/NFAT signaling in cancerogenesis
    • +/ calcineurin/NFAT signaling in cancerogenesis. Cell Cycle. 2007;6:16-19.
    • (2007) Cell Cycle , vol.6 , pp. 16-19
    • Buchholz, M.1    Ellenrieder, V.2
  • 51
    • 34250002803 scopus 로고    scopus 로고
    • Linking calcineurin activity to leukemogenesis
    • Muller MR, Rao A. Linking calcineurin activity to leukemogenesis. Nat Med. 2007;13:669-671.
    • (2007) Nat Med , vol.13 , pp. 669-671
    • Muller, M.R.1    Rao, A.2
  • 52
    • 39049148397 scopus 로고    scopus 로고
    • Cellular FLICE-like inhibitory protein (C-FLIP): A novel target for cancer therapy
    • Safa AR, Day TW, Wu CH. Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. Curr Cancer Drug Targets. 2008;8:37-46.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 37-46
    • Safa, A.R.1    Day, T.W.2    Wu, C.H.3
  • 53
  • 54
    • 34250025396 scopus 로고    scopus 로고
    • Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
    • Medyouf H, Alcalde H, Berthier C, et al. Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nat Med. 2007;13:736-741.
    • (2007) Nat Med , vol.13 , pp. 736-741
    • Medyouf, H.1    Alcalde, H.2    Berthier, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.