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Volumn 13, Issue 1, 2007, Pages 206-214

Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FAS ANTIBODY; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; PERFORIN; PROTEINASE INHIBITOR;

EID: 33846292208     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-1457     Document Type: Article
Times cited : (25)

References (50)
  • 1
    • 0027932782 scopus 로고
    • The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts
    • Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994;331:294-9.
    • (1994) N Engl J Med , vol.331 , pp. 294-299
    • Delattre, O.1    Zucman, J.2    Melot, T.3
  • 2
    • 0033864605 scopus 로고    scopus 로고
    • Prognostic factors in Ewing's tumor of bone: Analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group
    • Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 2000;18:3108-14.
    • (2000) J Clin Oncol , vol.18 , pp. 3108-3114
    • Cotterill, S.J.1    Ahrens, S.2    Paulussen, M.3
  • 3
    • 0028932731 scopus 로고
    • The CTL's kiss of death
    • Berke G. The CTL's kiss of death. Cell 1995;81:9-12.
    • (1995) Cell , vol.81 , pp. 9-12
    • Berke, G.1
  • 4
    • 10644241833 scopus 로고    scopus 로고
    • Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells
    • Screpanti V, Wallin RP, Grandien A, Ljunggren HG. Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells. Mol Immunol 2005;42:495-9.
    • (2005) Mol Immunol , vol.42 , pp. 495-499
    • Screpanti, V.1    Wallin, R.P.2    Grandien, A.3    Ljunggren, H.G.4
  • 5
    • 0030925774 scopus 로고    scopus 로고
    • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
    • Medema JP Scaffidi C, Kischkel FC, et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 1997;16:2794-804.
    • (1997) EMBO J , vol.16 , pp. 2794-2804
    • Medema, J.P.1    Scaffidi, C.2    Kischkel, F.C.3
  • 6
    • 0038725690 scopus 로고    scopus 로고
    • The ABCs of granule-mediated cytotoxicity: New weapons in the arsenal
    • Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 2003;3:361-70.
    • (2003) Nat Rev Immunol , vol.3 , pp. 361-370
    • Lieberman, J.1
  • 7
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997;388:190-5.
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3
  • 8
    • 0035949570 scopus 로고    scopus 로고
    • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/ SPI-6 constitutes a mechanism for immune escape by tumors
    • Medema JP, de Jong J, Peltenburg LT, et al. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/ SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci U S A 2001;98:11515-20.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 11515-11520
    • Medema, J.P.1    de Jong, J.2    Peltenburg, L.T.3
  • 9
    • 33144488766 scopus 로고    scopus 로고
    • Increased expression of cFLIP(L) in colonic adenocarcinoma
    • Ryu BK, Lee MG, Chi SG, Kim YW, Park JH. Increased expression of cFLIP(L) in colonic adenocarcinoma. J Pathol 2001;194:15-9.
    • (2001) J Pathol , vol.194 , pp. 15-19
    • Ryu, B.K.1    Lee, M.G.2    Chi, S.G.3    Kim, Y.W.4    Park, J.H.5
  • 10
    • 0036095702 scopus 로고    scopus 로고
    • Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: A novel protective mechanism for tumor cells to circumvent the immune system?
    • Bladergroen BA, Meijer CJ, ten Berge RL, et al. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood 2002;99:232-7.
    • (2002) Blood , vol.99 , pp. 232-237
    • Bladergroen, B.A.1    Meijer, C.J.2    ten Berge, R.L.3
  • 11
    • 0037097821 scopus 로고    scopus 로고
    • Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma
    • ten Berge RL, Meijer CJ, Dukers DF, et al. Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. Blood 2002;99:4540-6.
    • (2002) Blood , vol.99 , pp. 4540-4546
    • ten Berge, R.L.1    Meijer, C.J.2    Dukers, D.F.3
  • 12
  • 13
    • 0031792776 scopus 로고    scopus 로고
    • Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
    • Bird CH, Sutton VR, Sun J, et al. Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell Biol 1998;18:6387-98.
    • (1998) Mol Cell Biol , vol.18 , pp. 6387-6398
    • Bird, C.H.1    Sutton, V.R.2    Sun, J.3
  • 14
    • 0033523670 scopus 로고    scopus 로고
    • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    • Medema JP, de Jong J, van Hall T, Melief CJ, Offringa R. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J Exp Med 1999;190:1033-8.
    • (1999) J Exp Med , vol.190 , pp. 1033-1038
    • Medema, J.P.1    de Jong, J.2    van Hall, T.3    Melief, C.J.4    Offringa, R.5
  • 15
    • 24344490223 scopus 로고    scopus 로고
    • Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma
    • van Houdt IS, Oudejans JJ, van den Eertwegh AJ, et al. Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. Clin Cancer Res 2005;11:6400-7.
    • (2005) Clin Cancer Res , vol.11 , pp. 6400-6407
    • van Houdt, I.S.1    Oudejans, J.J.2    van den Eertwegh, A.J.3
  • 16
    • 0038311940 scopus 로고    scopus 로고
    • Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis
    • Malta H, Eby MT, Gazdar AF, Chaudhary PM. Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis. Cancer Biol Ther 2002;1:652-60.
    • (2002) Cancer Biol Ther , vol.1 , pp. 652-660
    • Malta, H.1    Eby, M.T.2    Gazdar, A.F.3    Chaudhary, P.M.4
  • 17
    • 32544438637 scopus 로고    scopus 로고
    • c-FLIP inhibits chemotherapy-induced colorectal cancer cell death
    • Longley DB, Wilson TR, McEwan M, et al. c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. Oncogene 2005;25:838-48.
    • (2005) Oncogene , vol.25 , pp. 838-848
    • Longley, D.B.1    Wilson, T.R.2    McEwan, M.3
  • 18
    • 0035931886 scopus 로고    scopus 로고
    • Cytotoxicity of tumor necrosis factor related apoptosis-inducing ligand towards Ewing's sarcoma cell lines
    • Kumar A, Jasmin A, Eby MT, Chaudhary PM. Cytotoxicity of tumor necrosis factor related apoptosis-inducing ligand towards Ewing's sarcoma cell lines. Oncogene 2001;20:1010-4.
    • (2001) Oncogene , vol.20 , pp. 1010-1014
    • Kumar, A.1    Jasmin, A.2    Eby, M.T.3    Chaudhary, P.M.4
  • 19
    • 0035866804 scopus 로고    scopus 로고
    • Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5
    • Mitsiades N, Poulaki V, Mitsiades C, Tsokos M. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Cancer Res 2001;61:2704-12.
    • (2001) Cancer Res , vol.61 , pp. 2704-2712
    • Mitsiades, N.1    Poulaki, V.2    Mitsiades, C.3    Tsokos, M.4
  • 21
    • 33646074516 scopus 로고    scopus 로고
    • Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines
    • Szuhai K, Ijszenga M, Tanke HJ, Rosenberg C, Hogendoorn PC. Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines. Cancer Genet Cytogenet 2006;166:173-9.
    • (2006) Cancer Genet Cytogenet , vol.166 , pp. 173-179
    • Szuhai, K.1    Ijszenga, M.2    Tanke, H.J.3    Rosenberg, C.4    Hogendoorn, P.C.5
  • 22
    • 0035284891 scopus 로고    scopus 로고
    • The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites
    • Bladergroen BA, Strik MC, Bovenschen N, et al. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol 2001;166:3218-25.
    • (2001) J Immunol , vol.166 , pp. 3218-3225
    • Bladergroen, B.A.1    Strik, M.C.2    Bovenschen, N.3
  • 23
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry J Immunol Methods 1991;139:271-9.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 24
    • 0031934148 scopus 로고    scopus 로고
    • Expression of growth factors and their receptors in adamantinoma of long bones and the implication for its histogenesis
    • Bovee JV, van den Broek LJ, de Boer WI, Hogendoorn PC. Expression of growth factors and their receptors in adamantinoma of long bones and the implication for its histogenesis. J Pathol 1998;184:24-30.
    • (1998) J Pathol , vol.184 , pp. 24-30
    • Bovee, J.V.1    van den Broek, L.J.2    de Boer, W.I.3    Hogendoorn, P.C.4
  • 25
    • 0034537352 scopus 로고    scopus 로고
    • Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    • Bovee JV, van den Broek LJ, Cleton-Jansen AM, Hogendoorn PC. Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. Lab Invest 2000;80:1925-34.
    • (2000) Lab Invest , vol.80 , pp. 1925-1934
    • Bovee, J.V.1    van den Broek, L.J.2    Cleton-Jansen, A.M.3    Hogendoorn, P.C.4
  • 26
    • 0035827569 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
    • Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 2001;276:20633-40.
    • (2001) J Biol Chem , vol.276 , pp. 20633-20640
    • Krueger, A.1    Schmitz, I.2    Baumann, S.3    Krammer, P.H.4    Kirchhoff, S.5
  • 27
    • 0030826338 scopus 로고    scopus 로고
    • FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
    • Scaffidi C, Medema JP, Krammer PH, Peter ME. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J Biol Chem 1997;272:26953-8.
    • (1997) J Biol Chem , vol.272 , pp. 26953-26958
    • Scaffidi, C.1    Medema, J.P.2    Krammer, P.H.3    Peter, M.E.4
  • 28
    • 0030005837 scopus 로고    scopus 로고
    • Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity
    • Kataoka T, Shinohara N, Takayama H, et al. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol 1996;156:3678-86.
    • (1996) J Immunol , vol.156 , pp. 3678-3686
    • Kataoka, T.1    Shinohara, N.2    Takayama, H.3
  • 29
    • 4744355872 scopus 로고    scopus 로고
    • Escape from immunotherapy: Possible mechanisms that influence tumor regression/progression
    • Ahmad M, Rees RC, Ali SA. Escape from immunotherapy: possible mechanisms that influence tumor regression/progression. Cancer Immunol Immunother 2004;53:844-54.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 844-854
    • Ahmad, M.1    Rees, R.C.2    Ali, S.A.3
  • 30
    • 32644431934 scopus 로고    scopus 로고
    • Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells
    • Jiang X, Orr BA, Kranz DM, Shapiro DJ. Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells. Endocrinology 2006;147:1419-26.
    • (2006) Endocrinology , vol.147 , pp. 1419-1426
    • Jiang, X.1    Orr, B.A.2    Kranz, D.M.3    Shapiro, D.J.4
  • 31
    • 0033530269 scopus 로고    scopus 로고
    • Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors
    • Mitsiades N, Poulaki V, Leone A, Tsokos M. Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors. J Natl Cancer Inst 1999;91:1678-84.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1678-1684
    • Mitsiades, N.1    Poulaki, V.2    Leone, A.3    Tsokos, M.4
  • 32
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick SL, Dacwag CS, Golub TR. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 2002;1:393-401.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 33
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A, Tirode F, Cohen P, Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004;24:7275-83.
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 34
    • 20144388169 scopus 로고    scopus 로고
    • c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome
    • Valnet-Rabier MB, Challier B, Thiebault S, et al. c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome. Br J Haematol 2005;128:767-73.
    • (2005) Br J Haematol , vol.128 , pp. 767-773
    • Valnet-Rabier, M.B.1    Challier, B.2    Thiebault, S.3
  • 35
    • 20144387309 scopus 로고    scopus 로고
    • Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas
    • Muris JJ, Cillessen SA, Vos W, et al. Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 2005;105:2916-23.
    • (2005) Blood , vol.105 , pp. 2916-2923
    • Muris, J.J.1    Cillessen, S.A.2    Vos, W.3
  • 36
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • Fulda S, Kufer MU, Meyer E, van Valen F, Dockhorn-Dworniczak B, Debatin KM. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001;20:5865-77.
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.M.6
  • 37
    • 0033658582 scopus 로고    scopus 로고
    • Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma
    • Takita J, Yang HW, Bessho F, et al. Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma. Med Pediatr Oncol 2000;35:541-3.
    • (2000) Med Pediatr Oncol , vol.35 , pp. 541-543
    • Takita, J.1    Yang, H.W.2    Bessho, F.3
  • 38
    • 0037108859 scopus 로고    scopus 로고
    • Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines
    • Harada K, Toyooka S, Shivapurkar N, et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res 2002;62:5897-901.
    • (2002) Cancer Res , vol.62 , pp. 5897-5901
    • Harada, K.1    Toyooka, S.2    Shivapurkar, N.3
  • 39
    • 30144434107 scopus 로고    scopus 로고
    • Potentiation of neuroblastoma metastasis by loss of caspase-8
    • Stupack DG, Teitz T, Potter MD, et al. Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature 2006;439:95-9.
    • (2006) Nature , vol.439 , pp. 95-99
    • Stupack, D.G.1    Teitz, T.2    Potter, M.D.3
  • 40
    • 4344669257 scopus 로고    scopus 로고
    • Prevalence and clinical significance of resistance to perforin- and FAS-mediated cell death in leukemia
    • Otten HG, van Ginkel WG, Hagenbeek A, Petersen EJ. Prevalence and clinical significance of resistance to perforin- and FAS-mediated cell death in leukemia. Leukemia 2004;18:1401-5.
    • (2004) Leukemia , vol.18 , pp. 1401-1405
    • Otten, H.G.1    van Ginkel, W.G.2    Hagenbeek, A.3    Petersen, E.J.4
  • 41
    • 0033864866 scopus 로고    scopus 로고
    • Killing of Fas ligand-resistant renal carcioma cells by interleukin-2- and BCG-activated effector cells
    • Brandau S, Suttmann H, Flad HD, Jocham D, Bohle A. Killing of Fas ligand-resistant renal carcioma cells by interleukin-2- and BCG-activated effector cells. Cancer Immunol Immunother 2000;49:369-76.
    • (2000) Cancer Immunol Immunother , vol.49 , pp. 369-376
    • Brandau, S.1    Suttmann, H.2    Flad, H.D.3    Jocham, D.4    Bohle, A.5
  • 44
    • 0029914913 scopus 로고    scopus 로고
    • Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity
    • Esser MT, Krishnamurthy B, Braciale VL. Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity. J Exp Med 1996;183:1697-706.
    • (1996) J Exp Med , vol.183 , pp. 1697-1706
    • Esser, M.T.1    Krishnamurthy, B.2    Braciale, V.L.3
  • 45
    • 0032534684 scopus 로고    scopus 로고
    • Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production
    • Kessler B, Hudrisier D, Schroeter M, Tschopp J, Cerottini JC, Luescher IF. Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production. J Immunol 1998;161:6939-46.
    • (1998) J Immunol , vol.161 , pp. 6939-6946
    • Kessler, B.1    Hudrisier, D.2    Schroeter, M.3    Tschopp, J.4    Cerottini, J.C.5    Luescher, I.F.6
  • 48
    • 0028236937 scopus 로고
    • Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2
    • Leger-Ravet MB, Mathiot C, Portier A, et al. Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2. Cancer Immunol Immunother 1994;39:53-8.
    • (1994) Cancer Immunol Immunother , vol.39 , pp. 53-58
    • Leger-Ravet, M.B.1    Mathiot, C.2    Portier, A.3
  • 49
    • 17644376884 scopus 로고    scopus 로고
    • The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-α treatment
    • Guillot B, Portales P, Thanh AD, et al. The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-α treatment. Br J Dermatol 2005;152:690-6.
    • (2005) Br J Dermatol , vol.152 , pp. 690-696
    • Guillot, B.1    Portales, P.2    Thanh, A.D.3
  • 50
    • 2942559140 scopus 로고    scopus 로고
    • Functional and molecular characterization of interleukin-2 transgenic Ewing tumor cells for in vivo immunotherapy
    • Staege MS, Hansen G, Baersch G, Burdach S. Functional and molecular characterization of interleukin-2 transgenic Ewing tumor cells for in vivo immunotherapy. Pediatr Blood Cancer 2004;43:23-34.
    • (2004) Pediatr Blood Cancer , vol.43 , pp. 23-34
    • Staege, M.S.1    Hansen, G.2    Baersch, G.3    Burdach, S.4


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