Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

Free Radical Biology and Medicine

Volumn 46, Issue 12, 2009, Pages 1639-1649

  Lee, Tae Jin ^a,b   Um, Hee Jung ^a   Min, Do Sik ^c   Park, Jong Wook ^a   Choi, Kyeong Sook ^d   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Pusan National University   (South Korea)

^d Ajou University School of Medicine   (South Korea)

Author keywords

c FLIP; CHOP; DR5; Free radicals; NF B; ROS; TRAIL; Withaferin A

Indexed keywords

CATALASE; DEATH RECEPTOR 5; FLICE INHIBITORY PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; WITHAFERIN A;

APOPTOSIS; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; MESANGIUM CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; ERGOSTEROL; GENE EXPRESSION REGULATION; HUMANS; NF-KAPPA B; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 67349228750     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.03.022     Document Type: Article

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