-
3
-
-
16244362671
-
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells
-
Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73:1907-16.
-
(2005)
Infect Immun
, vol.73
, pp. 1907-1916
-
-
Fink, S.L.1
Cookson, B.T.2
-
4
-
-
79952159132
-
Emerging inflammasome effector mechanisms
-
Lamkanfi, M Emerging inflammasome effector mechanisms. Nat Rev Immunol 2011; 11:213-20.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 213-220
-
-
Lamkanfi, M.1
-
5
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan S, Weiss DS, Newton K et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440:228-32.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
-
6
-
-
67349271142
-
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
-
Gross O, Poeck H, Bscheider M et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009; 459:433-6.
-
(2009)
Nature
, vol.459
, pp. 433-436
-
-
Gross, O.1
Poeck, H.2
Bscheider, M.3
-
7
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440:237-41.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
8
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
-
Halle A, Hornung V, Petzold GC et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat Immunol 2008; 9:857-65.
-
(2008)
Nat Immunol
, vol.9
, pp. 857-865
-
-
Halle, A.1
Hornung, V.2
Petzold, G.C.3
-
9
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008; 320:674-7.
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
10
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 9:847-56.
-
(2008)
Nat Immunol
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
-
11
-
-
77649179433
-
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
-
Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010; 10:210-5.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 210-215
-
-
Tschopp, J.1
Schroder, K.2
-
12
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140:821-32.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
13
-
-
1642285783
-
NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
-
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20:319-25.
-
(2004)
Immunity
, vol.20
, pp. 319-325
-
-
Agostini, L.1
Martinon, F.2
Burns, K.3
McDermott, M.F.4
Hawkins, P.N.5
Tschopp, J.6
-
14
-
-
64049111768
-
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
-
Allen IC, Scull MA, Moore CB et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 2009; 30:556-65.
-
(2009)
Immunity
, vol.30
, pp. 556-565
-
-
Allen, I.C.1
Scull, M.A.2
Moore, C.B.3
-
15
-
-
0037144586
-
A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β
-
Fiorentino L, Stehlik C, Oliveira V, Ariza ME, Godzik A, Reed JC. A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β. J Biol Chem 2002; 277:35333-40.
-
(2002)
J Biol Chem
, vol.277
, pp. 35333-35340
-
-
Fiorentino, L.1
Stehlik, C.2
Oliveira, V.3
Ariza, M.E.4
Godzik, A.5
Reed, J.C.6
-
16
-
-
40749132603
-
ATP binding by monarch-1/NLRP12 is critical for its inhibitory function
-
Ye Z, Lich JD, Moore CB, Duncan JA, Williams KL, Ting JP. ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol 2008; 28:1841-50.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1841-1850
-
-
Ye, Z.1
Lich, J.D.2
Moore, C.B.3
Duncan, J.A.4
Williams, K.L.5
Ting, J.P.6
-
17
-
-
84861460062
-
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling
-
Allen IC, Wilson JE, Schneider M et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity 2012; 36:742-54.
-
(2012)
Immunity
, vol.36
, pp. 742-754
-
-
Allen, I.C.1
Wilson, J.E.2
Schneider, M.3
-
18
-
-
80455176839
-
Non-canonical inflammasome activation targets caspase-11
-
Kayagaki N, Warming S, Lamkanfi M et al. Non-canonical inflammasome activation targets caspase-11. Nature 2011; 479:117-21.
-
(2011)
Nature
, vol.479
, pp. 117-121
-
-
Kayagaki, N.1
Warming, S.2
Lamkanfi, M.3
-
19
-
-
10444241090
-
Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene
-
Arostegui JI, Aldea A, Modesto C et al. Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene. Arthritis Rheum 2004; 50:4045-50.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 4045-4050
-
-
Arostegui, J.I.1
Aldea, A.2
Modesto, C.3
-
20
-
-
0035179970
-
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 2001; 29:301-5.
-
(2001)
Nat Genet
, vol.29
, pp. 301-305
-
-
Hoffman, H.M.1
Mueller, J.L.2
Broide, D.H.3
Wanderer, A.A.4
Kolodner, R.D.5
-
21
-
-
18344385660
-
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes
-
Dode C, Le Du N, Cuisset L et al. New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. Am J Hum Genet 2002; 70:1498-506.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 1498-1506
-
-
Dode, C.1
Le Du, N.2
Cuisset, L.3
-
22
-
-
0036302235
-
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
-
Feldmann J, Prieur AM, Quartier P et al. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet 2002; 71:198-203.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 198-203
-
-
Feldmann, J.1
Prieur, A.M.2
Quartier, P.3
-
23
-
-
66949175347
-
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
-
Meng G, Zhang F, Fuss I, Kitani A, Strober W. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 2009; 30:860-74.
-
(2009)
Immunity
, vol.30
, pp. 860-874
-
-
Meng, G.1
Zhang, F.2
Fuss, I.3
Kitani, A.4
Strober, W.5
-
24
-
-
84859861944
-
Polymorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus
-
Pontillo A, Girardelli M, Kamada AJ, Pancotto JA, Donadi EA, Crovella S, Sandrin-Garcia P. Polymorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. Autoimmunity 2012; 45:271-8.
-
(2012)
Autoimmunity
, vol.45
, pp. 271-278
-
-
Pontillo, A.1
Girardelli, M.2
Kamada, A.J.3
Pancotto, J.A.4
Donadi, E.A.5
Crovella, S.6
Sandrin-Garcia, P.7
-
25
-
-
78149442887
-
Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil
-
Pontillo A, Brandao L, Guimaraes R, Segat L, Araujo J, Crovella S. Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil. Autoimmunity 2010; 43:583-9.
-
(2010)
Autoimmunity
, vol.43
, pp. 583-589
-
-
Pontillo, A.1
Brandao, L.2
Guimaraes, R.3
Segat, L.4
Araujo, J.5
Crovella, S.6
-
26
-
-
70349675610
-
Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis
-
Villani AC, Lemire M, Louis E et al. Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis. PLoS ONE 2009; 4:e7154.
-
(2009)
PLoS ONE
, vol.4
-
-
Villani, A.C.1
Lemire, M.2
Louis, E.3
-
27
-
-
74849111621
-
Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders
-
Glinskii AB, Ma J, Ma S, Grant D, Lim CU, Sell S, Glinsky GV. Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders. Cell Cycle 2009; 8:3925-42.
-
(2009)
Cell Cycle
, vol.8
, pp. 3925-3942
-
-
Glinskii, A.B.1
Ma, J.2
Ma, S.3
Grant, D.4
Lim, C.U.5
Sell, S.6
Glinsky, G.V.7
-
28
-
-
84863253461
-
NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese
-
Sui J, Li H, Fang Y et al. NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese. Arthritis Rheum 2012; 64:647-54.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 647-654
-
-
Sui, J.1
Li, H.2
Fang, Y.3
-
29
-
-
77955853897
-
Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins
-
Veeranki S, Choubey D. Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins. Immunol Lett 2010; 133:1-5.
-
(2010)
Immunol Lett
, vol.133
, pp. 1-5
-
-
Veeranki, S.1
Choubey, D.2
-
30
-
-
0032702860
-
Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study
-
Furlan R, Filippi M, Bergami A et al. Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study. J Neurol Neurosurg Psychiatry 1999; 67:785-8.
-
(1999)
J Neurol Neurosurg Psychiatry
, vol.67
, pp. 785-788
-
-
Furlan, R.1
Filippi, M.2
Bergami, A.3
-
31
-
-
0037094037
-
Caspase-1 expression in multiple sclerosis plaques and cultured glial cells
-
Ming X, Li W, Maeda Y, Blumberg B, Raval S, Cook SD, Dowling PC. Caspase-1 expression in multiple sclerosis plaques and cultured glial cells. J Neurol Sci 2002; 197:9-18.
-
(2002)
J Neurol Sci
, vol.197
, pp. 9-18
-
-
Ming, X.1
Li, W.2
Maeda, Y.3
Blumberg, B.4
Raval, S.5
Cook, S.D.6
Dowling, P.C.7
-
32
-
-
4444254434
-
Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis
-
Huang WX, Huang P, Hillert J. Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis. Mult Scler 2004; 10:482-7.
-
(2004)
Mult Scler
, vol.10
, pp. 482-487
-
-
Huang, W.X.1
Huang, P.2
Hillert, J.3
-
33
-
-
0035999548
-
Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis
-
de Jong BA, Huizinga TW, Bollen EL et al. Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis. J Neuroimmunol 2002; 126:172-9.
-
(2002)
J Neuroimmunol
, vol.126
, pp. 172-179
-
-
de Jong, B.A.1
Huizinga, T.W.2
Bollen, E.L.3
-
34
-
-
67349252457
-
Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients
-
Amorini AM, Petzold A, Tavazzi B et al. Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients. Clin Biochem 2009; 42:1001-6.
-
(2009)
Clin Biochem
, vol.42
, pp. 1001-1006
-
-
Amorini, A.M.1
Petzold, A.2
Tavazzi, B.3
-
35
-
-
84863252356
-
Serum uric acid levels in patients with multiple sclerosis: a meta-analysis
-
Liu B, Shen Y, Xiao K, Tang Y, Cen L, Wei J. Serum uric acid levels in patients with multiple sclerosis: a meta-analysis. Neurol Res 2012; 34:163-71.
-
(2012)
Neurol Res
, vol.34
, pp. 163-171
-
-
Liu, B.1
Shen, Y.2
Xiao, K.3
Tang, Y.4
Cen, L.5
Wei, J.6
-
36
-
-
0028298132
-
Increased cathepsin B activity in peripheral blood mononuclear cells of multiple sclerosis patients
-
Bever CT Jr, Panitch HS, Johnson KP. Increased cathepsin B activity in peripheral blood mononuclear cells of multiple sclerosis patients. Neurology 1994; 44:745-8.
-
(1994)
Neurology
, vol.44
, pp. 745-748
-
-
Bever Jr., C.T.1
Panitch, H.S.2
Johnson, K.P.3
-
37
-
-
0029004145
-
Increased cathepsin B activity in multiple sclerosis brain
-
Bever CT Jr, Garver DW. Increased cathepsin B activity in multiple sclerosis brain. J Neurol Sci 1995; 131:71-3.
-
(1995)
J Neurol Sci
, vol.131
, pp. 71-73
-
-
Bever Jr., C.T.1
Garver, D.W.2
-
38
-
-
34548398189
-
P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis
-
Matute C, Torre I, Perez-Cerda F et al. P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. J Neurosci 2007; 27:9525-33.
-
(2007)
J Neurosci
, vol.27
, pp. 9525-9533
-
-
Matute, C.1
Torre, I.2
Perez-Cerda, F.3
-
39
-
-
29144508718
-
Increased expression and function of glutamate transporters in multiple sclerosis
-
Vallejo-Illarramendi A, Domercq M, Perez-Cerda F, Ravid R, Matute C. Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol Dis 2006; 21:154-64.
-
(2006)
Neurobiol Dis
, vol.21
, pp. 154-164
-
-
Vallejo-Illarramendi, A.1
Domercq, M.2
Perez-Cerda, F.3
Ravid, R.4
Matute, C.5
-
40
-
-
80054005767
-
Gain-of-function of P2X7 receptor gene variants in multiple sclerosis
-
Oyanguren-Desez O, Rodriguez-Antiguedad A, Villoslada P, Domercq M, Alberdi E, Matute C. Gain-of-function of P2X7 receptor gene variants in multiple sclerosis. Cell Calcium 2011; 50:468-72.
-
(2011)
Cell Calcium
, vol.50
, pp. 468-472
-
-
Oyanguren-Desez, O.1
Rodriguez-Antiguedad, A.2
Villoslada, P.3
Domercq, M.4
Alberdi, E.5
Matute, C.6
-
41
-
-
77955475968
-
NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses
-
Gris D, Ye Z, Iocca HA et al. NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol 2010; 185:974-81.
-
(2010)
J Immunol
, vol.185
, pp. 974-981
-
-
Gris, D.1
Ye, Z.2
Iocca, H.A.3
-
42
-
-
78649396261
-
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18
-
Jha S, Srivastava SY, Brickey WJ et al. The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18. J Neurosci 2010; 30:15811-20.
-
(2010)
J Neurosci
, vol.30
, pp. 15811-15820
-
-
Jha, S.1
Srivastava, S.Y.2
Brickey, W.J.3
-
43
-
-
84862988248
-
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
-
Inoue M, Williams KL, Gunn MD, Shinohara ML. NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2012; 109:10480-5.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 10480-10485
-
-
Inoue, M.1
Williams, K.L.2
Gunn, M.D.3
Shinohara, M.L.4
-
44
-
-
84861473687
-
Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome
-
Inoue M, Williams KL, Oliver T, Vandenabeele P, Rajan JV, Miao EA, Shinohara ML. Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. Sci Signal 2012; 5:ra38.
-
(2012)
Sci Signal
, vol.5
-
-
Inoue, M.1
Williams, K.L.2
Oliver, T.3
Vandenabeele, P.4
Rajan, J.V.5
Miao, E.A.6
Shinohara, M.L.7
-
45
-
-
0033198269
-
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination
-
Furlan R, Martino G, Galbiati F et al. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 1999; 163:2403-9.
-
(1999)
J Immunol
, vol.163
, pp. 2403-2409
-
-
Furlan, R.1
Martino, G.2
Galbiati, F.3
-
46
-
-
0036840008
-
A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis: inflammation versus degeneration
-
Ahmed Z, Doward AI, Pryce G et al. A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis: inflammation versus degeneration. Am J Pathol 2002; 161:1577-86.
-
(2002)
Am J Pathol
, vol.161
, pp. 1577-1586
-
-
Ahmed, Z.1
Doward, A.I.2
Pryce, G.3
-
47
-
-
72449132320
-
Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis
-
Soulika AM, Lee E, McCauley E, Miers L, Bannerman P, Pleasure D. Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci 2009; 29:14965-79.
-
(2009)
J Neurosci
, vol.29
, pp. 14965-14979
-
-
Soulika, A.M.1
Lee, E.2
McCauley, E.3
Miers, L.4
Bannerman, P.5
Pleasure, D.6
-
48
-
-
84455205524
-
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
-
Alvarez JI, Dodelet-Devillers A, Kebir H et al. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 2011; 334:1727-31.
-
(2011)
Science
, vol.334
, pp. 1727-1731
-
-
Alvarez, J.I.1
Dodelet-Devillers, A.2
Kebir, H.3
-
49
-
-
7244251521
-
Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain
-
Ferrari CC, Depino AM, Prada F et al. Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. Am J Pathol 2004; 165:1827-37.
-
(2004)
Am J Pathol
, vol.165
, pp. 1827-1837
-
-
Ferrari, C.C.1
Depino, A.M.2
Prada, F.3
-
50
-
-
33745873727
-
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
-
Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006; 203:1685-91.
-
(2006)
J Exp Med
, vol.203
, pp. 1685-1691
-
-
Sutton, C.1
Brereton, C.2
Keogh, B.3
Mills, K.H.4
Lavelle, E.C.5
-
51
-
-
68649088121
-
Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity
-
Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31:331-41.
-
(2009)
Immunity
, vol.31
, pp. 331-341
-
-
Sutton, C.E.1
Lalor, S.J.2
Sweeney, C.M.3
Brereton, C.F.4
Lavelle, E.C.5
Mills, K.H.6
-
52
-
-
79956187649
-
Caspase-1-processed cytokines IL-1β and IL-18 promote IL-17 production by γδ and CD4 T cells that mediate autoimmunity
-
Lalor SJ, Dungan LS, Sutton CE, Basdeo SA, Fletcher JM, Mills KH. Caspase-1-processed cytokines IL-1β and IL-18 promote IL-17 production by γδ and CD4 T cells that mediate autoimmunity. J Immunol 2011; 186:5738-48.
-
(2011)
J Immunol
, vol.186
, pp. 5738-5748
-
-
Lalor, S.J.1
Dungan, L.S.2
Sutton, C.E.3
Basdeo, S.A.4
Fletcher, J.M.5
Mills, K.H.6
-
53
-
-
0034176818
-
Reduced chemokine and chemokine receptor expression in spinal cords of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein
-
Matejuk A, Vandenbark AA, Burrows GG, Bebo BF Jr, Offner H. Reduced chemokine and chemokine receptor expression in spinal cords of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein. J Immunol 2000; 164:3924-31.
-
(2000)
J Immunol
, vol.164
, pp. 3924-3931
-
-
Matejuk, A.1
Vandenbark, A.A.2
Burrows, G.G.3
Bebo Jr., B.F.4
Offner, H.5
-
54
-
-
0034596949
-
Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
-
Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med 2000; 192:1075-80.
-
(2000)
J Exp Med
, vol.192
, pp. 1075-1080
-
-
Izikson, L.1
Klein, R.S.2
Charo, I.F.3
Weiner, H.L.4
Luster, A.D.5
-
55
-
-
71749097979
-
Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites
-
Kim JV, Jiang N, Tadokoro CE, Liu L, Ransohoff RM, Lafaille JJ, Dustin ML. Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods 2010; 352:89-100.
-
(2010)
J Immunol Methods
, vol.352
, pp. 89-100
-
-
Kim, J.V.1
Jiang, N.2
Tadokoro, C.E.3
Liu, L.4
Ransohoff, R.M.5
Lafaille, J.J.6
Dustin, M.L.7
-
56
-
-
0035941106
-
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
-
Chabas D, Baranzini SE, Mitchell D et al. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2001; 294:1731-5.
-
(2001)
Science
, vol.294
, pp. 1731-1735
-
-
Chabas, D.1
Baranzini, S.E.2
Mitchell, D.3
-
57
-
-
18544404188
-
Distinct chemokine receptor and cytokine expression profile in secondary progressive MS
-
Sorensen TL, Sellebjerg F. Distinct chemokine receptor and cytokine expression profile in secondary progressive MS. Neurology 2001; 57:1371-6.
-
(2001)
Neurology
, vol.57
, pp. 1371-1376
-
-
Sorensen, T.L.1
Sellebjerg, F.2
-
58
-
-
0035283409
-
Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling
-
Misu T, Onodera H, Fujihara K et al. Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling. J Neuroimmunol 2001; 114:207-12.
-
(2001)
J Neuroimmunol
, vol.114
, pp. 207-212
-
-
Misu, T.1
Onodera, H.2
Fujihara, K.3
-
59
-
-
28044463563
-
T-bet-dependent expression of osteopontin contributes to T cell polarization
-
Shinohara ML, Jansson M, Hwang ES, Werneck MB, Glimcher LH, Cantor H. T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci USA 2005; 102:17101-6.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17101-17106
-
-
Shinohara, M.L.1
Jansson, M.2
Hwang, E.S.3
Werneck, M.B.4
Glimcher, L.H.5
Cantor, H.6
-
60
-
-
0036499086
-
Cutting edge: attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice
-
Jansson M, Panoutsakopoulou V, Baker J, Klein L, Cantor H. Cutting edge: attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J Immunol 2002; 168:2096-9.
-
(2002)
J Immunol
, vol.168
, pp. 2096-2099
-
-
Jansson, M.1
Panoutsakopoulou, V.2
Baker, J.3
Klein, L.4
Cantor, H.5
-
61
-
-
33846998653
-
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
-
Hur EM, Youssef S, Haws ME, Zhang SY, Sobel RA, Steinman L. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol 2007; 8:74-83.
-
(2007)
Nat Immunol
, vol.8
, pp. 74-83
-
-
Hur, E.M.1
Youssef, S.2
Haws, M.E.3
Zhang, S.Y.4
Sobel, R.A.5
Steinman, L.6
-
62
-
-
44449146212
-
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin
-
Shinohara ML, Kim JH, Garcia VA, Cantor H. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 2008; 29:68-78.
-
(2008)
Immunity
, vol.29
, pp. 68-78
-
-
Shinohara, M.L.1
Kim, J.H.2
Garcia, V.A.3
Cantor, H.4
-
63
-
-
79951740151
-
Type I interferon inhibits interleukin-1 production and inflammasome activation
-
Guarda G, Braun M, Staehli F et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 2011; 34:213-23.
-
(2011)
Immunity
, vol.34
, pp. 213-223
-
-
Guarda, G.1
Braun, M.2
Staehli, F.3
-
64
-
-
84869785875
-
Cutting edge: nitric oxide inhibits the NLRP3 inflammasome
-
Hernandez-Cuellar E, Tsuchiya K, Hara H et al. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 2012; 189:5113-7.
-
(2012)
J Immunol
, vol.189
, pp. 5113-5117
-
-
Hernandez-Cuellar, E.1
Tsuchiya, K.2
Hara, H.3
-
65
-
-
43049101640
-
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
-
Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 2008; 118:1680-90.
-
(2008)
J Clin Invest
, vol.118
, pp. 1680-1690
-
-
Guo, B.1
Chang, E.Y.2
Cheng, G.3
-
66
-
-
43049177588
-
Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
-
Prinz M, Schmidt H, Mildner A et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 2008; 28:675-86.
-
(2008)
Immunity
, vol.28
, pp. 675-686
-
-
Prinz, M.1
Schmidt, H.2
Mildner, A.3
-
67
-
-
77954041785
-
Interferon-β inhibits Th17 cell differentiation in patients with multiple sclerosis
-
Ramgolam VS, Markovic-Plese S. Interferon-β inhibits Th17 cell differentiation in patients with multiple sclerosis. Endocr Metab Immune Disord Drug Targets 2010; 10:161-7.
-
(2010)
Endocr Metab Immune Disord Drug Targets
, vol.10
, pp. 161-167
-
-
Ramgolam, V.S.1
Markovic-Plese, S.2
-
68
-
-
77950526192
-
IFN-β inhibits human Th17 cell differentiation
-
Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S. IFN-β inhibits human Th17 cell differentiation. J Immunol 2009; 183:5418-27.
-
(2009)
J Immunol
, vol.183
, pp. 5418-5427
-
-
Ramgolam, V.S.1
Sha, Y.2
Jin, J.3
Zhang, X.4
Markovic-Plese, S.5
-
69
-
-
49449097216
-
+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells
-
+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells. Mol Immunol 2008; 45:4008-19.
-
(2008)
Mol Immunol
, vol.45
, pp. 4008-4019
-
-
Martin-Saavedra, F.M.1
Gonzalez-Garcia, C.2
Bravo, B.3
Ballester, S.4
-
70
-
-
36249017932
-
IFN-α regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages
-
Pirhonen J, Siren J, Julkunen I, Matikainen S. IFN-α regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages. J Leukoc Biol 2007; 82:1185-92.
-
(2007)
J Leukoc Biol
, vol.82
, pp. 1185-1192
-
-
Pirhonen, J.1
Siren, J.2
Julkunen, I.3
Matikainen, S.4
-
71
-
-
0008376732
-
Interferon β in the treatment of multiple sclerosis: mechanisms of action
-
Yong VW, Chabot S, Stuve O, Williams G. Interferon β in the treatment of multiple sclerosis: mechanisms of action. Neurology 1998; 51:682-9.
-
(1998)
Neurology
, vol.51
, pp. 682-689
-
-
Yong, V.W.1
Chabot, S.2
Stuve, O.3
Williams, G.4
-
72
-
-
0034748842
-
Interferon-β therapy downregulates the anti-apoptosis protein FLIP in T cells from patients with multiple sclerosis
-
Sharief MK, Semra YK, Seidi OA, Zoukos Y. Interferon-β therapy downregulates the anti-apoptosis protein FLIP in T cells from patients with multiple sclerosis. J Neuroimmunol 2001; 120:199-207.
-
(2001)
J Neuroimmunol
, vol.120
, pp. 199-207
-
-
Sharief, M.K.1
Semra, Y.K.2
Seidi, O.A.3
Zoukos, Y.4
-
73
-
-
28044463388
-
Upregulation of TRAIL expression on human T lymphocytes by interferon β and glatiramer acetate
-
Arbour N, Rastikerdar E, McCrea E, Lapierre Y, Dorr J, Bar-Or A, Antel JP. Upregulation of TRAIL expression on human T lymphocytes by interferon β and glatiramer acetate. Mult Scler 2005; 11:652-7.
-
(2005)
Mult Scler
, vol.11
, pp. 652-657
-
-
Arbour, N.1
Rastikerdar, E.2
McCrea, E.3
Lapierre, Y.4
Dorr, J.5
Bar-Or, A.6
Antel, J.P.7
-
74
-
-
84856805188
-
+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis
-
+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. J Neuroimmunol 2012; 242:39-46.
-
(2012)
J Neuroimmunol
, vol.242
, pp. 39-46
-
-
Chen, M.1
Chen, G.2
Deng, S.3
Liu, X.4
Hutton, G.J.5
Hong, J.6
-
75
-
-
0034333256
-
VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis
-
Muraro PA, Leist T, Bielekova B, McFarland HF. VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis. J Neuroimmunol 2000; 111:186-94.
-
(2000)
J Neuroimmunol
, vol.111
, pp. 186-194
-
-
Muraro, P.A.1
Leist, T.2
Bielekova, B.3
McFarland, H.F.4
-
76
-
-
30444450277
-
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon β
-
Boz C, Ozmenoglu M, Velioglu S, Kilinc K, Orem A, Alioglu Z, Altunayoglu V. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon β. Clin Neurol Neurosurg 2006; 108:124-8.
-
(2006)
Clin Neurol Neurosurg
, vol.108
, pp. 124-128
-
-
Boz, C.1
Ozmenoglu, M.2
Velioglu, S.3
Kilinc, K.4
Orem, A.5
Alioglu, Z.6
Altunayoglu, V.7
-
77
-
-
58049099896
-
Changes in matrix metalloproteinases and their inhibitors during interferon-β treatment in multiple sclerosis
-
Comabella M, Rio J, Espejo C et al. Changes in matrix metalloproteinases and their inhibitors during interferon-β treatment in multiple sclerosis. Clin Immunol 2009; 130:145-50.
-
(2009)
Clin Immunol
, vol.130
, pp. 145-150
-
-
Comabella, M.1
Rio, J.2
Espejo, C.3
-
78
-
-
77954478334
-
Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis
-
Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J Immunol 2010; 184:4610-4.
-
(2010)
J Immunol
, vol.184
, pp. 4610-4614
-
-
Shaw, P.J.1
Lukens, J.R.2
Burns, S.3
Chi, H.4
McGargill, M.A.5
Kanneganti, T.D.6
-
79
-
-
84862649049
-
Toll-like receptor (TLR) and inflammasome actions in the central nervous system
-
Hanamsagar R, Hanke ML, Kielian T. Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 2012; 33:333-42.
-
(2012)
Trends Immunol
, vol.33
, pp. 333-342
-
-
Hanamsagar, R.1
Hanke, M.L.2
Kielian, T.3
-
80
-
-
0033017354
-
Immunologic therapy of multiple sclerosis
-
Arnason BG. Immunologic therapy of multiple sclerosis. Annu Rev Med 1999; 50:291-302.
-
(1999)
Annu Rev Med
, vol.50
, pp. 291-302
-
-
Arnason, B.G.1
-
81
-
-
77950534540
-
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
-
Axtell RC, de Jong BA, Boniface K et al. T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis. Nat Med 2010; 16:406-12.
-
(2010)
Nat Med
, vol.16
, pp. 406-412
-
-
Axtell, R.C.1
de, J.B.2
Boniface, K.3
-
82
-
-
0034237667
-
Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis
-
Kantarci OH, Atkinson EJ, Hebrink DD, McMurray CT & Weinshenker BG. Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis. J Neuroimmunol 2000; 106:220-7.
-
(2000)
J Neuroimmunol
, vol.106
, pp. 220-227
-
-
Kantarci, O.H.1
Atkinson, E.J.2
Hebrink, D.D.3
McMurray, C.T.4
Weinshenker, B.G.5
-
83
-
-
0032077870
-
Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells
-
Badovinac V, Mostarica-Stojkovic M, Dinarello CA & Stosic-Grujicic S. Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells. J Neuroimmunol 1998; 85:87-95.
-
(1998)
J Neuroimmunol
, vol.85
, pp. 87-95
-
-
Badovinac, V.1
Mostarica-Stojkovic, M.2
Dinarello, C.A.3
Stosic-Grujicic, S.4
-
84
-
-
0034665289
-
IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells
-
Shi FD, Takeda K, Akira S, Sarvetnick N & Ljunggren HG. IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol 2000; 165:3099-3104.
-
(2000)
J Immunol
, vol.165
, pp. 3099-3104
-
-
Shi, F.D.1
Takeda, K.2
Akira, S.3
Sarvetnick, N.4
Ljunggren, H.G.5
|