Increased expression of capase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis

Multiple Sclerosis

Volumn 10, Issue 5, 2004, Pages 482-487

  Huang, Wen Xin ^a   Huang, Ping ^a   Hillert, Jan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Caspase 1; IL 18; IL1 ; Multiple sclerosis; RT PCR

Indexed keywords

INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; ACTIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EXPOSURE; FEMALE; HUMAN; HUMAN CELL; MALE; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RELAPSE; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INFLAMMATION; MIDDLE AGED; MONONUCLEAR CELL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTINS; ADULT; AGED; BLOTTING, WESTERN; CASPASE 1; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATION; INTERLEUKIN-18; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 4444254434     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1191/1352458504ms1071oa     Document Type: Article

References (30)

1. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996; 85: 299-302.
2. Link H. The cytokine storm in multiple sclerosis. Mult Scler 1998; 4: 12-15.
3. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87: 2095-147.
4. Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T et al. Purification and characterization of the human interleukin-18 receptor. J Biol Chem 1997; 272: 25737-42.
5. Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, Ohta T et al. Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem Biophys Res Commun 1997; 234: 454-57.
6. Puren AJ, Fantuzzi G, Gu Y, Su MS-S, Dinarello CA. Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest 1998; 101: 711-21.
7. Issazadeh S, Lorentzen JC, Mustafa HT, Hojeberg B, Mussener A, Olsson T. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta. J Neuroimmunol 1996; 69: 103-15.
8. Rothe H, Jenkins NA, Copeland NG, Kolb H. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J Clin Invest 1997; 99: 469-74.
9. Friedlander RM, Yuan J. ICE, neuronal apoptosis and neurodegeneration. Cell Death Differ 1998; 5: 823-31.
10. Furlan R, Martino G, Galbiati F, Poliani PL, Smiroldo S, Bergami A et al. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 1999; 163: 2403-409.
11. Musette P, Benveniste O, Lim A, Bequet D, Kowilsky P, Dormont D et al. The pattern of production of cytokine mRNAs is markedly altered at the onset of multiple sclerosis. Res Immunol 1996; 147: 435-41.
12. Monteyne P, Van Antwerpen MP, Sindic CJ. Expression of costimulatory molecules and cytokines in CSF and peripheral blood mononuclear cells from multiple sclerosis patients. Acta Neurol Belg 1999; 99: 11-20.
13. Poser CM et al. New diagnostic criteria for multiple sclerosis; guidelines for research protocols. Ann Neurol 1983; 13: 227-31.
14. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-59.
15. Celi FS, Zenilman ME, Shuldiner AR. A rapid and versatile method to synthesize internal standards for competitive PCR. Nucleic Acids Res 1993; 21: 1047.
16. Huang W-X, Huang P, Link H, Hillert J. Cytokine analysis in multiple sclerosis by competitive RT-PCR: A decreased expression of IL-10 and an increased expression of TNF-α in chronic progression. Mult Scler 1999; 5: 342-48.
17. Micallef MJ et al. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol 1996; 26: 1647-51.
18. Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T et al. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998; 8: 383-90.
19. Xu D, Chan WL, Leung BP, Hunter D, Schultz K, Carter RW et al. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J Exp Med 1998; 188: 1485-92.
20. Matusevicius D et al. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis. Scand J Immunol 1998; 47: 582-90.
21. McManus C, Berman JW, Brett FM, Staunton H, Farrell M, Brosnan CF et al. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study. J Neuroimmunol, 1998; 86: 20-29.
22. Huang WX, Huang P, Gomes A, Hillert J. Apoptosis-mediators FasL and TRAIL are up-regulated in peripheral blood mononuclear cells in MS. Neurology 2000; 55: 928-34.
23. Fantuzzi G et al. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood 1998; 91: 2118-25.
24. Kuida K et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995; 267: 2000-2003.
25. Jander S, Stoll G. Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat. J Neuroimmunol 1998; 91: 93-99.
26. Badovinac V, Mostarica-Stojkovic M, Dinarello CA, Stosic-Grujicic S. Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells. J Neuroimmunol 1998; 85: 87-95.
27. Furlan R et al. Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study. J Neurol Neurosurg Psychiatry 1999; 67: 785-88.
28. Ming X et al. Caspase-1 expression in multiple sclerosis plaques and cultured glial cells. J Neurol Sci 2002; 197: 9-18.
29. van Boxel-Dezaire AH et al. Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis. J Neuroimmunol 2001; 120: 152-60.
30. Losy J, Niezgoda A. IL-18 in patients with multiple sclerosis. Acta Neurol Scand 2001; 104: 171-73.