A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery

Biochemical Journal

Volumn 451, Issue 2, 2013, Pages 313-328

  Gao, Yinghong ^a   Davies, Stephen P ^b   Augustin, Martin ^b   Woodward, Anna ^b   Patel, Umesh A ^c   Kovelman, Robert ^a   Harvey, Kevin J ^a  

^a EMD Millipore   (United States)

^b Millipore UK Ltd   (United Kingdom)

^c EMD Millipore   (United States)

Author keywords

DFG motif; Functional genomics; Inhibitor; Kinase; Polypharmacology; Profile

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (3 BROMOANILINO) 6 (METHYLAMINO)PYRIDO[3,4 D]PYRIMIDINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (2 AMINO 4 PYRIMIDINYL) 4 (4 FLUOROPHENYL) 1 (4 PIPERIDINYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; FASUDIL; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE SYK INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; CHEMICAL STRUCTURE; CLUSTER ANALYSIS; CROSS REACTION; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR PROBE; POLYPHARMACY; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

CLUSTER ANALYSIS; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875619719     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121418     Document Type: Article

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