Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 2842-2845

  Powers, Jay P ^a   Li, Shyun ^a   Jaen, Juan C ^a   Liu, Jinqian ^a   Walker, Nigel P C ^a   Wang, Zhulun ^a   Wesche, Holger ^a  

^a AMGEN INC   (United States)

Author keywords

Inflammation; IRAK 4; Kinase; Kinase inhibitor

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4 INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOLECULAR SIZE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKYLATION; AMIDES; BENZIMIDAZOLES; CROSS-LINKING REAGENTS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646069914     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.020     Document Type: Article

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