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Volumn 14, Issue 4, 2013, Pages 6624-6648

Regulation of ovarian cancer stem cells or tumor-initiating cells

Author keywords

Cancer stem cell or tumor initiating cells (CSC TICs); Chemoresistance; microRNA; Ovarian cancer; Recurrence; Tumor microenvironment

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; CARBOPLATIN; CD133 ANTIGEN; CD24 ANTIGEN; CISPLATIN; DOXORUBICIN; ENTEROTOXIN; GAMMA SECRETASE INHIBITOR; HERMES ANTIGEN; HYALURONIC ACID; METFORMIN; MICRORNA; NICLOSAMIDE; NOTCH 3 INHIBITOR; PACLITAXEL; PLATINUM DERIVATIVE; PROTEIN INHIBITOR; RETINOID; STEM CELL FACTOR RECEPTOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 84875480132     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14046624     Document Type: Review
Times cited : (66)

References (107)
  • 3
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research, N. Integrated genomic analyses of ovarian carcinoma. Nature 2011, 474, 609-615.
    • (2011) Nature , vol.474 , pp. 609-615
    • Cancer Genome Atlas Research, N.1
  • 4
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • Baccelli, I.; Trumpp, A. The evolving concept of cancer and metastasis stem cells. J. Cell Biol. 2012, 198, 281-293.
    • (2012) J. Cell Biol. , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 5
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers, H. The cancer stem cell: Premises, promises and challenges. Nat. Med. 2011, 17, 313-319.
    • (2011) Nat. Med. , vol.17 , pp. 313-319
    • Clevers, H.1
  • 6
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh, A.; Settleman, J. EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 2010, 29, 4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 7
    • 17144403478 scopus 로고    scopus 로고
    • Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
    • Bapat, S.A.; Mali, A.M.; Koppikar, C.B.; Kurrey, N.K. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res. 2005, 65, 3025-3029.
    • (2005) Cancer Res. , vol.65 , pp. 3025-3029
    • Bapat, S.A.1    Mali, A.M.2    Koppikar, C.B.3    Kurrey, N.K.4
  • 8
    • 84882843353 scopus 로고    scopus 로고
    • Ovarian cancer stem cells: Working towards the root of stemness
    • doi:10.1016/j.canlet.2012.10.023
    • Foster, R.; Buckanovich, R.J.; Rueda, B.R. Ovarian cancer stem cells: Working towards the root of stemness. Cancer Lett. 2012, doi:10.1016/j.canlet.2012.10.023.
    • (2012) Cancer Lett
    • Foster, R.1    Buckanovich, R.J.2    Rueda, B.R.3
  • 9
    • 84865056040 scopus 로고    scopus 로고
    • Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites
    • Wintzell, M.; Hjerpe, E.; Avall Lundqvist, E.; Shoshan, M. Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites. BMC Cancer 2012, 12, 359.
    • (2012) BMC Cancer , vol.12 , pp. 359
    • Wintzell, M.1    Hjerpe, E.2    Avall Lundqvist, E.3    Shoshan, M.4
  • 12
    • 77950862035 scopus 로고    scopus 로고
    • Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant
    • Hu, L.; McArthur, C.; Jaffe, R.B. Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br. J. Cancer 2010, 102, 1276-1283.
    • (2010) Br. J. Cancer , vol.102 , pp. 1276-1283
    • Hu, L.1    McArthur, C.2    Jaffe, R.B.3
  • 15
    • 77956302698 scopus 로고    scopus 로고
    • Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers
    • Deng, S.; Yang, X.; Lassus, H.; Liang, S.; Kaur, S.; Ye, Q.; Li, C.; Wang, L.P.; Roby, K.F.; Orsulic, S.; et al. Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 2010, 5, e10277.
    • (2010) PLoS One , vol.5
    • Deng, S.1    Yang, X.2    Lassus, H.3    Liang, S.4    Kaur, S.5    Ye, Q.6    Li, C.7    Wang, L.P.8    Roby, K.F.9    Orsulic, S.10
  • 17
    • 84863162778 scopus 로고    scopus 로고
    • ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome
    • Wang, Y.C.; Yo, Y.T.; Lee, H.Y.; Liao, Y.P.; Chao, T.K.; Su, P.H.; Lai, H.C. ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome. Am. J. Pathol. 2012, 180, 1159-1169.
    • (2012) Am. J. Pathol. , vol.180 , pp. 1159-1169
    • Wang, Y.C.1    Yo, Y.T.2    Lee, H.Y.3    Liao, Y.P.4    Chao, T.K.5    Su, P.H.6    Lai, H.C.7
  • 18
    • 79957917044 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival
    • Silva, I.A.; Bai, S.; McLean, K.; Yang, K.; Griffith, K.; Thomas, D.; Ginestier, C.; Johnston, C.; Kueck, A.; Reynolds, R.K.; et al. Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res. 2011, 71, 3991-4001.
    • (2011) Cancer Res. , vol.71 , pp. 3991-4001
    • Silva, I.A.1    Bai, S.2    McLean, K.3    Yang, K.4    Griffith, K.5    Thomas, D.6    Ginestier, C.7    Johnston, C.8    Kueck, A.9    Reynolds, R.K.10
  • 20
    • 84870667447 scopus 로고    scopus 로고
    • Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate
    • Wintzell, M.; Lofstedt, L.; Johansson, J.; Pedersen, A.B.; Fuxe, J.; Shoshan, M. Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate. Cancer Biol. Ther. 2012, 13, 1454-1462.
    • (2012) Cancer Biol. Ther. , vol.13 , pp. 1454-1462
    • Wintzell, M.1    Lofstedt, L.2    Johansson, J.3    Pedersen, A.B.4    Fuxe, J.5    Shoshan, M.6
  • 24
    • 79961119901 scopus 로고    scopus 로고
    • Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome
    • Luo, L.; Zeng, J.; Liang, B.; Zhao, Z.; Sun, L.; Cao, D.; Yang, J.; Shen, K. Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome. Exp. Mol. Pathol. 2011, 91, 596-602.
    • (2011) Exp. Mol. Pathol. , vol.91 , pp. 596-602
    • Luo, L.1    Zeng, J.2    Liang, B.3    Zhao, Z.4    Sun, L.5    Cao, D.6    Yang, J.7    Shen, K.8
  • 25
    • 77952240931 scopus 로고    scopus 로고
    • CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
    • Gao, M.Q.; Choi, Y.P.; Kang, S.; Youn, J.H.; Cho, N.H. CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene 2010, 29, 2672-2680.
    • (2010) Oncogene , vol.29 , pp. 2672-2680
    • Gao, M.Q.1    Choi, Y.P.2    Kang, S.3    Youn, J.H.4    Cho, N.H.5
  • 26
    • 78149471398 scopus 로고    scopus 로고
    • Identification of cancer stem cell-like cells from human epithelial ovarian carcinoma cell line
    • Shi, M.F.; Jiao, J.; Lu, W.G.; Ye, F.; Ma, D.; Dong, Q.G.; Xie, X. Identification of cancer stem cell-like cells from human epithelial ovarian carcinoma cell line. Cell. Mol. Life Sci. 2010, 67, 3915-3925.
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 3915-3925
    • Shi, M.F.1    Jiao, J.2    Lu, W.G.3    Ye, F.4    Ma, D.5    Dong, Q.G.6    Xie, X.7
  • 30
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe, N.; Harris, P.J.; Warren, R.Q.; Ivy, S.P. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat. Rev. Clin. Oncol. 2011, 8, 97-106.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 31
    • 77953693899 scopus 로고    scopus 로고
    • Targeting Hedgehog--a cancer stem cell pathway
    • Merchant, A.A.; Matsui, W. Targeting Hedgehog--a cancer stem cell pathway. Clin. Cancer Res. 2010, 16, 3130-3140.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 32
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya, T.; Clevers, H. Wnt signalling in stem cells and cancer. Nature 2005, 434, 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 34
    • 77956522571 scopus 로고    scopus 로고
    • Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin
    • Park, J.T.; Chen, X.; Trope, C.G.; Davidson, B.; Shih Ie, M.; Wang, T.L. Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Am. J. Pathol. 2010, 177, 1087-1094.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1087-1094
    • Park, J.T.1    Chen, X.2    Trope, C.G.3    Davidson, B.4    Shih Ie, M.5    Wang, T.L.6
  • 37
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
    • Liao, X.; Siu, M.K.; Au, C.W.; Wong, E.S.; Chan, H.Y.; Ip, P.P.; Ngan, H.Y.; Cheung, A.N. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009, 30, 131-140.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3    Wong, E.S.4    Chan, H.Y.5    Ip, P.P.6    Ngan, H.Y.7    Cheung, A.N.8
  • 38
    • 33751337806 scopus 로고    scopus 로고
    • Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis
    • Chen, X.; Horiuchi, A.; Kikuchi, N.; Osada, R.; Yoshida, J.; Shiozawa, T.; Konishi, I. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis. Cancer Sci. 2007, 98, 68-76.
    • (2007) Cancer Sci. , vol.98 , pp. 68-76
    • Chen, X.1    Horiuchi, A.2    Kikuchi, N.3    Osada, R.4    Yoshida, J.5    Shiozawa, T.6    Konishi, I.7
  • 41
    • 79960849567 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells
    • Ray, A.; Meng, E.; Reed, E.; Shevde, L.A.; Rocconi, R.P. Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells. Int. J. Oncol. 2011, 39, 797-804.
    • (2011) Int. J. Oncol. , vol.39 , pp. 797-804
    • Ray, A.1    Meng, E.2    Reed, E.3    Shevde, L.A.4    Rocconi, R.P.5
  • 43
    • 84870310745 scopus 로고    scopus 로고
    • Transformation of Epithelial Ovarian Cancer Stemlike Cells into Mesenchymal Lineage via EMT Results in Cellular Heterogeneity and Supports Tumor Engraftment
    • Jiang, H.; Lin, X.; Liu, Y.; Gong, W.; Ma, X.; Yu, Y.; Xie, Y.; Sun, X.; Feng, Y.; Janzen, V.; et al. Transformation of Epithelial Ovarian Cancer Stemlike Cells into Mesenchymal Lineage via EMT Results in Cellular Heterogeneity and Supports Tumor Engraftment. Mol. Med. 2012, 18, 1197-1208.
    • (2012) Mol. Med. , vol.18 , pp. 1197-1208
    • Jiang, H.1    Lin, X.2    Liu, Y.3    Gong, W.4    Ma, X.5    Yu, Y.6    Xie, Y.7    Sun, X.8    Feng, Y.9    Janzen, V.10
  • 44
    • 84861344069 scopus 로고    scopus 로고
    • Tissue transglutaminase links TGF-beta, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
    • Cao, L.; Shao, M.; Schilder, J.; Guise, T.; Mohammad, K.S.; Matei, D. Tissue transglutaminase links TGF-beta, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer. Oncogene 2012, 31, 2521-2534.
    • (2012) Oncogene , vol.31 , pp. 2521-2534
    • Cao, L.1    Shao, M.2    Schilder, J.3    Guise, T.4    Mohammad, K.S.5    Matei, D.6
  • 45
    • 79958807496 scopus 로고    scopus 로고
    • Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment
    • Barbolina, M.V.; Burkhalter, R.J.; Stack, M.S. Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem. J. 2011, 437, 1-12.
    • (2011) Biochem. J. , vol.437 , pp. 1-12
    • Barbolina, M.V.1    Burkhalter, R.J.2    Stack, M.S.3
  • 50
    • 77958484951 scopus 로고    scopus 로고
    • The genesis and evolution of high-grade serous ovarian cancer
    • Bowtell, D.D. The genesis and evolution of high-grade serous ovarian cancer. Nat. Rev. Cancer 2010, 10, 803-808.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 803-808
    • Bowtell, D.D.1
  • 52
    • 84879410940 scopus 로고    scopus 로고
    • c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/beta-catenin-ATP-binding cassette G2 signaling
    • doi:10.1038/onc.2012.290
    • Chau, W.K.; Ip, C.K.; Mak, A.S.; Lai, H.C.; Wong, A.S. c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/beta-catenin-ATP-binding cassette G2 signaling. Oncogene 2012, doi:10.1038/onc.2012.290.
    • (2012) Oncogene
    • Chau, W.K.1    Ip, C.K.2    Mak, A.S.3    Lai, H.C.4    Wong, A.S.5
  • 53
    • 39449133669 scopus 로고    scopus 로고
    • Regulation of cancer cell survival, migration, and invasion by twist: AKT2 comes to interplay
    • Cheng, G.Z.; Zhang, W.Z.; Wang, L.H. Regulation of cancer cell survival, migration, and invasion by twist: AKT2 comes to interplay. Cancer Res. 2008, 68, 957-960.
    • (2008) Cancer Res. , vol.68 , pp. 957-960
    • Cheng, G.Z.1    Zhang, W.Z.2    Wang, L.H.3
  • 54
    • 77953806998 scopus 로고    scopus 로고
    • TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214
    • Yin, G.; Chen, R.; Alvero, A.B.; Fu, H.H.; Holmberg, J.; Glackin, C.; Rutherford, T.; Mor, G. TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene 2010, 29, 3545-3553.
    • (2010) Oncogene , vol.29 , pp. 3545-3553
    • Yin, G.1    Chen, R.2    Alvero, A.B.3    Fu, H.H.4    Holmberg, J.5    Glackin, C.6    Rutherford, T.7    Mor, G.8
  • 56
    • 84871952125 scopus 로고    scopus 로고
    • Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential
    • Yin, G.; Alvero, A.B.; Craveiro, V.; Holmberg, J.C.; Fu, H.H.; Montagna, M.K.; Yang, Y.; Chefetz-Menaker, I.; Nuti, S.; Rossi, M.; et al. Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential. Oncogene 2012, 32, 39-49.
    • (2012) Oncogene , vol.32 , pp. 39-49
    • Yin, G.1    Alvero, A.B.2    Craveiro, V.3    Holmberg, J.C.4    Fu, H.H.5    Montagna, M.K.6    Yang, Y.7    Chefetz-Menaker, I.8    Nuti, S.9    Rossi, M.10
  • 58
    • 84868620339 scopus 로고    scopus 로고
    • Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer
    • Lu, L.; Katsaros, D.; Mayne, S.T.; Risch, H.A.; Benedetto, C.; Canuto, E.M.; Yu, H. Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer. Carcinogenesis 2012, 33, 2119-2125.
    • (2012) Carcinogenesis , vol.33 , pp. 2119-2125
    • Lu, L.1    Katsaros, D.2    Mayne, S.T.3    Risch, H.A.4    Benedetto, C.5    Canuto, E.M.6    Yu, H.7
  • 59
    • 84880923339 scopus 로고    scopus 로고
    • Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers
    • doi:10.1038/onc.2012.363
    • Siu, M.K.; Wong, E.S.; Kong, D.S.; Chan, H.Y.; Jiang, L.; Wong, O.G.; Lam, E.W.; Chan, K.K.; Ngan, H.Y.; Le, X.F.; et al. Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers. Oncogene 2012, doi:10.1038/onc.2012.363.
    • (2012) Oncogene
    • Siu, M.K.1    Wong, E.S.2    Kong, D.S.3    Chan, H.Y.4    Jiang, L.5    Wong, O.G.6    Lam, E.W.7    Chan, K.K.8    Ngan, H.Y.9    Le, X.F.10
  • 60
    • 78549261109 scopus 로고    scopus 로고
    • Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
    • Yang, X.; Lin, X.; Zhong, X.; Kaur, S.; Li, N.; Liang, S.; Lassus, H.; Wang, L.; Katsaros, D.; Montone, K.; et al. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010, 70, 9463-9472.
    • (2010) Cancer Res. , vol.70 , pp. 9463-9472
    • Yang, X.1    Lin, X.2    Zhong, X.3    Kaur, S.4    Li, N.5    Liang, S.6    Lassus, H.7    Wang, L.8    Katsaros, D.9    Montone, K.10
  • 61
    • 77950794030 scopus 로고    scopus 로고
    • Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
    • Peng, S.; Maihle, N.J.; Huang, Y. Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene 2010, 29, 2153-2159.
    • (2010) Oncogene , vol.29 , pp. 2153-2159
    • Peng, S.1    Maihle, N.J.2    Huang, Y.3
  • 64
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm, J.E.; McGarvey, K.M.; Yu, X.; Cheng, L.; Schuebel, K.E.; Cope, L.; Mohammad, H.P.; Chen, W.; Daniel, V.C.; Yu, W.; et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat. Genet. 2007, 39, 237-242.
    • (2007) Nat. Genet. , vol.39 , pp. 237-242
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3    Cheng, L.4    Schuebel, K.E.5    Cope, L.6    Mohammad, H.P.7    Chen, W.8    Daniel, V.C.9    Yu, W.10
  • 65
    • 84884589668 scopus 로고    scopus 로고
    • Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells
    • doi:10.1038/onc.2012.477
    • Chapman-Rothe, N.; Curry, E.; Zeller, C.; Liber, D.; Stronach, E.; Gabra, H.; Ghaem-Maghami, S.; Brown, R. Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells. Oncogene 2012, doi:10.1038/onc.2012.477.
    • (2012) Oncogene
    • Chapman-Rothe, N.1    Curry, E.2    Zeller, C.3    Liber, D.4    Stronach, E.5    Gabra, H.6    Ghaem-Maghami, S.7    Brown, R.8
  • 66
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and Cancer: Short RNAs Go a Long Way
    • Ventura, A.; Jacks, T. MicroRNAs and Cancer: Short RNAs Go a Long Way. Cell 2009, 136, 586-591.
    • (2009) Cell , vol.136 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 67
    • 36849078711 scopus 로고    scopus 로고
    • let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu, F.; Yao, H.; Zhu, P.; Zhang, X.; Pan, Q.; Gong, C.; Huang, Y.; Hu, X.; Su, F.; Lieberman, J.; et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131, 1109-1123.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3    Zhang, X.4    Pan, Q.5    Gong, C.6    Huang, Y.7    Hu, X.8    Su, F.9    Lieberman, J.10
  • 68
    • 77954954098 scopus 로고    scopus 로고
    • Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
    • Yu, F.; Deng, H.; Yao, H.; Liu, Q.; Su, F.; Song, E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010, 29, 4194-4204.
    • (2010) Oncogene , vol.29 , pp. 4194-4204
    • Yu, F.1    Deng, H.2    Yao, H.3    Liu, Q.4    Su, F.5    Song, E.6
  • 71
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park, S.M.; Gaur, A.B.; Lengyel, E.; Peter, M.E. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008, 22, 894-907.
    • (2008) Genes Dev. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 76
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji, Q.; Hao, X.; Meng, Y.; Zhang, M.; Desano, J.; Fan, D.; Xu, L. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 2008, 8, 266.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3    Zhang, M.4    Desano, J.5    Fan, D.6    Xu, L.7
  • 77
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji, J.; Yamashita, T.; Budhu, A.; Forgues, M.; Jia, H.L.; Li, C.; Deng, C.; Wauthier, E.; Reid, L.M.; Ye, Q.H.; et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009, 50, 472-480.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3    Forgues, M.4    Jia, H.L.5    Li, C.6    Deng, C.7    Wauthier, E.8    Reid, L.M.9    Ye, Q.H.10
  • 78
    • 84861193535 scopus 로고    scopus 로고
    • MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells
    • Cheng, W.; Liu, T.; Wan, X.; Gao, Y.; Wang, H. MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells. FEBS J. 2012, 279, 2047-2059.
    • (2012) FEBS J. , vol.279 , pp. 2047-2059
    • Cheng, W.1    Liu, T.2    Wan, X.3    Gao, Y.4    Wang, H.5
  • 79
    • 79957741034 scopus 로고    scopus 로고
    • MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2
    • Wu, Q.; Guo, R.; Lin, M.; Zhou, B.; Wang, Y. MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2. Gynecol. Oncol. 2011, 122, 149-154.
    • (2011) Gynecol. Oncol. , vol.122 , pp. 149-154
    • Wu, Q.1    Guo, R.2    Lin, M.3    Zhou, B.4    Wang, Y.5
  • 80
    • 84861466680 scopus 로고    scopus 로고
    • MicroRNA profiling of a CD133(+) spheroid-forming subpopulation of the OVCAR3 human ovarian cancer cell line
    • doi:10.1186/1755-8794-5-18
    • Nam, E.J.; Lee, M.; Yim, G.W.; Kim, J.H.; Kim, S.; Kim, S.W.; Kim, Y.T. MicroRNA profiling of a CD133(+) spheroid-forming subpopulation of the OVCAR3 human ovarian cancer cell line. BMC Med. Genomics 2012, 5, doi:10.1186/1755-8794-5-18.
    • (2012) BMC Med. Genomics , vol.5
    • Nam, E.J.1    Lee, M.2    Yim, G.W.3    Kim, J.H.4    Kim, S.5    Kim, S.W.6    Kim, Y.T.7
  • 82
    • 79952258618 scopus 로고    scopus 로고
    • Epigenetic Regulation of Cancer-Associated Genes in Ovarian Cancer
    • Kwon, M.J.; Shin, Y.K. Epigenetic Regulation of Cancer-Associated Genes in Ovarian Cancer. Int. J. Mol. Sci. 2011, 12, 983-1008.
    • (2011) Int. J. Mol. Sci. , vol.12 , pp. 983-1008
    • Kwon, M.J.1    Shin, Y.K.2
  • 83
    • 80053030114 scopus 로고    scopus 로고
    • The cancer stem cell niche-there goes the neighborhood?
    • Cabarcas, S.M.; Mathews, L.A.; Farrar, W.L. The cancer stem cell niche-there goes the neighborhood? Int. J. Cancer 2011, 129, 2315-2327.
    • (2011) Int. J. Cancer , vol.129 , pp. 2315-2327
    • Cabarcas, S.M.1    Mathews, L.A.2    Farrar, W.L.3
  • 84
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 85
    • 84861466196 scopus 로고    scopus 로고
    • The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells
    • Liang, D.; Ma, Y.; Liu, J.; Trope, C.G.; Holm, R.; Nesland, J.M.; Suo, Z. The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells. BMC Cancer 2012, 12, 201.
    • (2012) BMC Cancer , vol.12 , pp. 201
    • Liang, D.1    Ma, Y.2    Liu, J.3    Trope, C.G.4    Holm, R.5    Nesland, J.M.6    Suo, Z.7
  • 86
    • 79961006281 scopus 로고    scopus 로고
    • Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
    • McLean, K.; Gong, Y.; Choi, Y.; Deng, N.; Yang, K.; Bai, S.; Cabrera, L.; Keller, E.; McCauley, L.; Cho, K.R.; et al. Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J. Clin. Investig. 2011, 121, 3206-3219.
    • (2011) J. Clin. Investig. , vol.121 , pp. 3206-3219
    • McLean, K.1    Gong, Y.2    Choi, Y.3    Deng, N.4    Yang, K.5    Bai, S.6    Cabrera, L.7    Keller, E.8    McCauley, L.9    Cho, K.R.10
  • 88
    • 77956904572 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts enhance the gland-forming capability of prostate cancer stem cells
    • Liao, C.P.; Adisetiyo, H.; Liang, M.; Roy-Burman, P. Cancer-associated fibroblasts enhance the gland-forming capability of prostate cancer stem cells. Cancer Res. 2010, 70, 7294-7303.
    • (2010) Cancer Res. , vol.70 , pp. 7294-7303
    • Liao, C.P.1    Adisetiyo, H.2    Liang, M.3    Roy-Burman, P.4
  • 89
  • 93
    • 73349093389 scopus 로고    scopus 로고
    • Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides
    • Slomiany, M.G.; Dai, L.; Tolliver, L.B.; Grass, G.D.; Zeng, Y.; Toole, B.P. Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides. Clin. Cancer Res. 2009, 15, 7593-7601.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7593-7601
    • Slomiany, M.G.1    Dai, L.2    Tolliver, L.B.3    Grass, G.D.4    Zeng, Y.5    Toole, B.P.6
  • 96
    • 80051600499 scopus 로고    scopus 로고
    • Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells
    • Alvero, A.B.; Montagna, M.K.; Holmberg, J.C.; Craveiro, V.; Brown, D.; Mor, G. Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells. Mol. Cancer Ther. 2011, 10, 1385-1393.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1385-1393
    • Alvero, A.B.1    Montagna, M.K.2    Holmberg, J.C.3    Craveiro, V.4    Brown, D.5    Mor, G.6
  • 98
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P.B.; Onder, T.T.; Jiang, G.; Tao, K.; Kuperwasser, C.; Weinberg, R.A.; Lander, E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138, 645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 100
    • 84867488416 scopus 로고    scopus 로고
    • Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
    • Mezencev, R.; Wang, L.; McDonald, J.F. Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening. J. Ovarian Res. 2012, 5, 30.
    • (2012) J. Ovarian Res. , vol.5 , pp. 30
    • Mezencev, R.1    Wang, L.2    McDonald, J.F.3
  • 101
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch, H.A.; Iliopoulos, D.; Tsichlis, P.N.; Struhl, K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009, 69, 7507-7511.
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 102
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos, D.; Hirsch, H.A.; Struhl, K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 2011, 71, 3196-3201.
    • (2011) Cancer Res. , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 103
    • 79954460690 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
    • Vazquez-Martin, A.; Oliveras-Ferraros, C.; Del Barco, S.; Martin-Castillo, B.; Menendez, J.A. The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells. Breast Cancer Res. Treat. 2011, 126, 355-364.
    • (2011) Breast Cancer Res. Treat. , vol.126 , pp. 355-364
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Del Barco, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 105
    • 79957438835 scopus 로고    scopus 로고
    • Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins
    • Yasmeen, A.; Beauchamp, M.C.; Piura, E.; Segal, E.; Pollak, M.; Gotlieb, W.H. Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins. Gynecol. Oncol. 2011, 121, 492-498.
    • (2011) Gynecol. Oncol. , vol.121 , pp. 492-498
    • Yasmeen, A.1    Beauchamp, M.C.2    Piura, E.3    Segal, E.4    Pollak, M.5    Gotlieb, W.H.6
  • 106
    • 79955834631 scopus 로고    scopus 로고
    • Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo
    • Rattan, R.; Graham, R.P.; Maguire, J.L.; Giri, S.; Shridhar, V. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 2011, 13, 483-491.
    • (2011) Neoplasia , vol.13 , pp. 483-491
    • Rattan, R.1    Graham, R.P.2    Maguire, J.L.3    Giri, S.4    Shridhar, V.5


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