-
1
-
-
58149489177
-
Ovarian carcinoma subtypes are different diseases: implications for biomarker studies
-
Kobel M, Kalloger SE, Boyd N, McKinney S, Mehl E, et al. (2008) Ovarian carcinoma subtypes are different diseases: implications for biomarker studies. PLoS Med 5: e232.
-
(2008)
PLoS Med
, vol.5
-
-
Kobel, M.1
Kalloger, S.E.2
Boyd, N.3
McKinney, S.4
Mehl, E.5
-
2
-
-
77950361629
-
Trials with impact on clinical management: first line
-
Bookman MA, (2009) Trials with impact on clinical management: first line. Int J Gynecol Cancer 19 (Suppl 2): S55-62.
-
(2009)
Int J Gynecol Cancer
, vol.19
, Issue.SUPPL. 2
-
-
Bookman, M.A.1
-
3
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, et al. (2008) Resistance to therapy caused by intragenic deletion in BRCA2. Nature 451: 1111-1115.
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
-
4
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, et al. (2009) Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361: 123-134.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
-
5
-
-
52649085237
-
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
-
Tothill RW, Tinker AV, George J, Brown R, Fox SB, et al. (2008) Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 14: 5198-5208.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5198-5208
-
-
Tothill, R.W.1
Tinker, A.V.2
George, J.3
Brown, R.4
Fox, S.B.5
-
6
-
-
79954570902
-
The role of Let-7 in cell differentiation and cancer
-
Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME, (2009) The role of Let-7 in cell differentiation and cancer. Endocr Relat Cancer.
-
(2009)
Endocr Relat Cancer
-
-
Boyerinas, B.1
Park, S.M.2
Hau, A.3
Murmann, A.E.4
Peter, M.E.5
-
7
-
-
52949091534
-
The let-7 family of microRNAs
-
Roush S, Slack FJ, (2008) The let-7 family of microRNAs. Trends Cell Biol 18: 505-516.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 505-516
-
-
Roush, S.1
Slack, F.J.2
-
8
-
-
65349162096
-
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression
-
Peter ME, (2009) Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle 8: 843-852.
-
(2009)
Cell Cycle
, vol.8
, pp. 843-852
-
-
Peter, M.E.1
-
9
-
-
36849023466
-
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2
-
Park SM, Shell S, Radjabi AR, Schickel R, Feig C, et al. (2007) Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle 6: 2585-2590.
-
(2007)
Cell Cycle
, vol.6
, pp. 2585-2590
-
-
Park, S.M.1
Shell, S.2
Radjabi, A.R.3
Schickel, R.4
Feig, C.5
-
10
-
-
58249088751
-
MicroRNAs: target recognition and regulatory functions
-
Bartel DP, (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
11
-
-
69449099275
-
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells
-
Beilharz TH, Humphreys DT, Clancy JL, Thermann R, Martin DI, et al. (2009) microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS ONE 4: e6783.
-
(2009)
PLoS ONE
, vol.4
-
-
Beilharz, T.H.1
Humphreys, D.T.2
Clancy, J.L.3
Thermann, R.4
Martin, D.I.5
-
12
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
-
Filipowicz W, Bhattacharyya SN, Sonenberg N, (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
13
-
-
36849078711
-
let-7 regulates self renewal and tumorigenicity of breast cancer cells
-
Yu F, Yao H, Zhu P, Zhang X, Pan Q, et al. (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109-1123.
-
(2007)
Cell
, vol.131
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
Zhang, X.4
Pan, Q.5
-
14
-
-
34547463506
-
Let-7 expression defines two differentiation stages of cancer
-
Shell S, Park SM, Radjabi AR, Schickel R, Kistner EO, et al. (2007) Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci U S A 104: 11400-11405.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11400-11405
-
-
Shell, S.1
Park, S.M.2
Radjabi, A.R.3
Schickel, R.4
Kistner, E.O.5
-
15
-
-
53749098061
-
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression
-
Nishino J, Kim I, Chada K, Morrison SJ, (2008) Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 135: 227-239.
-
(2008)
Cell
, vol.135
, pp. 227-239
-
-
Nishino, J.1
Kim, I.2
Chada, K.3
Morrison, S.J.4
-
16
-
-
38849089984
-
The HMGA proteins: a myriad of functions (Review)
-
Cleynen I, Van de Ven WJ, (2008) The HMGA proteins: a myriad of functions (Review). Int J Oncol 32: 289-305.
-
(2008)
Int J Oncol
, vol.32
, pp. 289-305
-
-
Cleynen, I.1
van de Ven, W.J.2
-
17
-
-
67649881121
-
Lin28 promotes transformation and is associated with advanced human malignancies
-
Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, et al. (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 41: 843-848.
-
(2009)
Nat Genet
, vol.41
, pp. 843-848
-
-
Viswanathan, S.R.1
Powers, J.T.2
Einhorn, W.3
Hoshida, Y.4
Ng, T.L.5
-
18
-
-
44949237000
-
HMGA2 gene is a promising target for ovarian cancer silencing therapy
-
Malek A, Bakhidze E, Noske A, Sers C, Aigner A, et al. (2008) HMGA2 gene is a promising target for ovarian cancer silencing therapy. Int J Cancer 123: 348-356.
-
(2008)
Int J Cancer
, vol.123
, pp. 348-356
-
-
Malek, A.1
Bakhidze, E.2
Noske, A.3
Sers, C.4
Aigner, A.5
-
19
-
-
62549160957
-
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
-
Chang TC, Zeitels LR, Hwang HW, Chivukula RR, Wentzel EA, et al. (2009) Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A.
-
(2009)
Proc Natl Acad Sci U S A
-
-
Chang, T.C.1
Zeitels, L.R.2
Hwang, H.W.3
Chivukula, R.R.4
Wentzel, E.A.5
-
20
-
-
67149099142
-
N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b
-
Cotterman R, Knoepfler PS, (2009) N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PLoS ONE 4: e5799.
-
(2009)
PLoS ONE
, vol.4
-
-
Cotterman, R.1
Knoepfler, P.S.2
-
21
-
-
33644551073
-
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers
-
Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, et al. (2006) Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 3: e47.
-
(2006)
PLoS Med
, vol.3
-
-
Chi, J.T.1
Wang, Z.2
Nuyten, D.S.3
Rodriguez, E.H.4
Schaner, M.E.5
-
22
-
-
65949112275
-
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis
-
Murph MM, Liu W, Yu S, Lu Y, Hall H, et al. (2009) Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis. PLoS ONE 4: e5583.
-
(2009)
PLoS ONE
, vol.4
-
-
Murph, M.M.1
Liu, W.2
Yu, S.3
Lu, Y.4
Hall, H.5
-
23
-
-
63149190291
-
Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas
-
Etemadmoghadam D, deFazio A, Beroukhim R, Mermel C, George J, et al. (2009) Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas. Clin Cancer Res 15: 1417-1427.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1417-1427
-
-
Etemadmoghadam, D.1
de Fazio, A.2
Beroukhim, R.3
Mermel, C.4
George, J.5
-
24
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
25
-
-
48549092983
-
A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer
-
Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, et al. (2008) A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res 68: 5478-5486.
-
(2008)
Cancer Res
, vol.68
, pp. 5478-5486
-
-
Bonome, T.1
Levine, D.A.2
Shih, J.3
Randonovich, M.4
Pise-Masison, C.A.5
-
26
-
-
60149095444
-
Most mammalian mRNAs are conserved targets of microRNAs
-
Friedman RC, Farh KK, Burge CB, Bartel DP, (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19: 92-105.
-
(2009)
Genome Res
, vol.19
, pp. 92-105
-
-
Friedman, R.C.1
Farh, K.K.2
Burge, C.B.3
Bartel, D.P.4
-
27
-
-
58049213696
-
Dicer, Drosha, and outcomes in patients with ovarian cancer
-
Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, et al. (2008) Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 359: 2641-2650.
-
(2008)
N Engl J Med
, vol.359
, pp. 2641-2650
-
-
Merritt, W.M.1
Lin, Y.G.2
Han, L.Y.3
Kamat, A.A.4
Spannuth, W.A.5
-
28
-
-
77952019174
-
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells
-
Jakymiw A, Patel RS, Deming N, Bhattacharyya I, Shah P, et al. (2010) Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer 49: 549-559.
-
(2010)
Genes Chromosomes Cancer
, vol.49
, pp. 549-559
-
-
Jakymiw, A.1
Patel, R.S.2
Deming, N.3
Bhattacharyya, I.4
Shah, P.5
-
29
-
-
49949117302
-
Widespread changes in protein synthesis induced by microRNAs
-
Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R, et al. (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455: 58-63.
-
(2008)
Nature
, vol.455
, pp. 58-63
-
-
Selbach, M.1
Schwanhausser, B.2
Thierfelder, N.3
Fang, Z.4
Khanin, R.5
-
30
-
-
53949088050
-
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
-
Heo I, Joo C, Cho J, Ha M, Han J, et al. (2008) Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell 32: 276-284.
-
(2008)
Mol Cell
, vol.32
, pp. 276-284
-
-
Heo, I.1
Joo, C.2
Cho, J.3
Ha, M.4
Han, J.5
-
31
-
-
47949100595
-
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
-
Newman MA, Thomson JM, Hammond SM, (2008) Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14: 1539-1549.
-
(2008)
RNA
, vol.14
, pp. 1539-1549
-
-
Newman, M.A.1
Thomson, J.M.2
Hammond, S.M.3
-
32
-
-
48649103982
-
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
-
Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl EE, et al. (2008) A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol 10: 987-993.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 987-993
-
-
Rybak, A.1
Fuchs, H.2
Smirnova, L.3
Brandt, C.4
Pohl, E.E.5
-
33
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X, Xu H, Yuan P, Fang F, Huss M, et al. (2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133: 1106-1117.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
-
34
-
-
58049215467
-
A novel signaling pathway impact analysis
-
Tarca AL, Draghici S, Khatri P, Hassan SS, Mittal P, et al. (2009) A novel signaling pathway impact analysis. Bioinformatics 25: 75-82.
-
(2009)
Bioinformatics
, vol.25
, pp. 75-82
-
-
Tarca, A.L.1
Draghici, S.2
Khatri, P.3
Hassan, S.S.4
Mittal, P.5
-
35
-
-
0842309106
-
MYCN in neuronal tumours
-
Schwab M, (2004) MYCN in neuronal tumours. Cancer Lett 204: 179-187.
-
(2004)
Cancer Lett
, vol.204
, pp. 179-187
-
-
Schwab, M.1
-
36
-
-
79952313664
-
Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma
-
Zitterbart K, Filkova H, Tomasikova L, Necesalova E, Zambo I, et al. (2010) Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma. J Neurooncol.
-
(2010)
J Neurooncol
-
-
Zitterbart, K.1
Filkova, H.2
Tomasikova, L.3
Necesalova, E.4
Zambo, I.5
-
37
-
-
77952009538
-
HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma
-
Mahajan A, Liu Z, Gellert L, Zou X, Yang G, et al. (2010) HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma. Mod Pathol 23: 673-681.
-
(2010)
Mod Pathol
, vol.23
, pp. 673-681
-
-
Mahajan, A.1
Liu, Z.2
Gellert, L.3
Zou, X.4
Yang, G.5
-
38
-
-
77950794030
-
Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
-
Peng S, Maihle NJ, Huang Y, (2010) Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene 29: 2153-2159.
-
(2010)
Oncogene
, vol.29
, pp. 2153-2159
-
-
Peng, S.1
Maihle, N.J.2
Huang, Y.3
-
39
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, et al. (2000) Molecular portraits of human breast tumours. Nature 406: 747-752.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
van de Rijn, M.4
Jeffrey, S.S.5
-
40
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98: 10869-10874.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
Aas, T.4
Geisler, S.5
-
41
-
-
0034598746
-
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
-
Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403: 503-511.
-
(2000)
Nature
, vol.403
, pp. 503-511
-
-
Alizadeh, A.A.1
Eisen, M.B.2
Davis, R.E.3
Ma, C.4
Lossos, I.S.5
-
42
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
-
Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, et al. (2009) Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 459: 717-721.
-
(2009)
Nature
, vol.459
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
-
43
-
-
0037142053
-
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
-
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, et al. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 346: 1937-1947.
-
(2002)
N Engl J Med
, vol.346
, pp. 1937-1947
-
-
Rosenwald, A.1
Wright, G.2
Chan, W.C.3
Connors, J.M.4
Campo, E.5
|