Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome

Experimental and Molecular Pathology

Volumn 91, Issue 2, 2011, Pages 596-602

  Luo, Lijing ^a   Zeng, Jianfang ^a   Liang, Bing ^a   Zhao, Zhe ^a,b   Sun, Lulu ^a   Cao, Dongyan ^a   Yang, Jiaxin ^a   Shen, Keng ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Cancer stem cells; CD117; Chemoresistance; Ovarian cancer

Indexed keywords

PACLITAXEL; STEM CELL FACTOR RECEPTOR;

ADULT; ADVANCED CANCER; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER STEM CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL POPULATION; CELL REGENERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OVARY CANCER; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR XENOGRAFT;

AGED; ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CYSTADENOCARCINOMA, SEROUS; FEMALE; FLOW CYTOMETRY; HUMANS; MICE; MICE, NUDE; MIDDLE AGED; OVARIAN NEOPLASMS; PHENOTYPE; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-KIT; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 79961119901     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2011.06.005     Document Type: Article

References (42)

1. Al-Hajj M., et al. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:3983-3988.
2. Al-Hajj M., et al. Therapeutic implications of cancer stem cells. Curr. Opin. Genet. Dev. 2004, 14:43-47.
3. Baba T., et al. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene 2009, 28:209-218.
4. Bapat S.A., et al. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res. 2005, 65:3025-3029.
5. Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
6. Catalano A., et al. Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. J. Biol. Chem. 2004, 279:46706-46714.
7. Choi Y.P., et al. Molecular portraits of intratumoral heterogeneity in human ovarian cancer. Cancer Lett. 2011.
8. Clarke M.F., et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006, 66:9339-9344.
9. Cohen P.S., et al. Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group. Blood 1994, 84:3465-3472.
10. Curtin J.A., et al. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 2006, 24:4340-4346.
11. Dalerba P., et al. Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:10158-10163.
12. Dean M., et al. Tumour stem cells and drug resistance. Nat. Rev. Cancer 2005, 5:275-284.
13. Duensing A., et al. Biology of gastrointestinal stromal tumors: KIT mutations and beyond. Cancer Invest. 2004, 22:106-116.
14. Eramo A., et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ. 2008, 15:504-514.
15. Gao M.Q., et al. CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene 2010, 29:2672-2680.
16. Hassan H.T. c-Kit expression in human normal and malignant stem cells prognostic and therapeutic implications. Leuk. Res. 2009, 33:5-10.
17. Hassan H.T., El-Sheemy M. Adult bone-marrow stem cells and their potential in medicine. J. R. Soc. Med. 2004, 97:465-471.
18. Hoei-Hansen C.E., et al. Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers. Mol. Cancer 2007, 6:12.
19. Jordan C.T., et al. Cancer stem cells. N. Engl. J. Med. 2006, 355:1253-1261.
20. Lapidot T., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367:645-648.
21. Levina V., et al. Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res. 2010, 70:338-346.
22. Li L., Neaves W.B. Normal stem cells and cancer stem cells: the niche matters. Cancer Res. 2006, 66:4553-4557.
23. Li C., et al. Identification of pancreatic cancer stem cells. Cancer Res. 2007, 67:1030-1037.
24. Lu M., et al. Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality. Exp. Hematol. 2007, 35:1293-1302.
25. McCluggage W.G. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J. Clin. Pathol. 2000, 53:327-334.
26. Moserle L., et al. The side population of ovarian cancer cells is a primary target of IFN-alpha antitumor effects. Cancer Res. 2008, 68:5658-5668.
27. Naeem M., et al. Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis. Hum. Pathol. 2002, 33:1182-1187.
28. O'Brien C.A., et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
29. Ozols R.F. Treatment goals in ovarian cancer. Int. J. Gynecol. Cancer 2005, 15(Suppl 1):3-11.
30. Palmqvist L., et al. Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency. Stem Cells 2005, 23:663-680.
31. Prince M.E., et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:973-978.
32. Raspollini M.R., et al. c-KIT expression and correlation with chemotherapy resistance in ovarian carcinoma: an immunocytochemical study. Ann. Oncol. 2004, 15:594-597.
33. Reya T., et al. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111.
34. Ricci-Vitiani L., et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445:111-115.
35. Schatton T., et al. Identification of cells initiating human melanomas. Nature 2008, 451:345-349.
36. Singh S.K., et al. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
37. Todaro M., et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007, 1:389-402.
38. Tsuda H., et al. Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features. Cancer Sci. 2005, 96:333-339.
39. Yang Z.F., et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 2008, 13:153-166.
40. Yasuda A., et al. The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. Mol. Cancer 2006, 5:46.
41. Yasuda A., et al. Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. Dig. Dis. Sci. 2007, 52:2292-2300.
42. Zhang S., et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 2008, 68:4311-4320.