MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2

Gynecologic Oncology

Volumn 122, Issue 1, 2011, Pages 149-154

  Wu, Qiuhua ^a   Guo, Rongjiao ^a   Lin, Min ^a   Zhou, Bing ^a   Wang, Yifeng ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cancer stem cells; CD133 antigen; Metastasis; MicroRNA; ZEB2

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 200A; PROTEIN ZEB2; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CANCER STEM CELL; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ANTIGENS, CD; BASE SEQUENCE; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; FEMALE; GLYCOPROTEINS; HOMEODOMAIN PROTEINS; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; OVARIAN NEOPLASMS; PEPTIDES; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 79957741034     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.03.026     Document Type: Article

References (26)

1. Li F, Tiede B, Massagué J, Kang Y. beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007;17(1):3-14. (Pubitemid 46096419)
2. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003;15(6):740-6. (Pubitemid 37487967)
3. Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001;7(6):1267-78. (Pubitemid 32607360)
4. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101(9):2999-3004. (Pubitemid 38327724)
5. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008 Jun 24;6:14.
6. Ji J, Yamashita T, Budhu A, ForguesM, Jia HL, Li C, et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009;50(2):472-80.
7. Ji Q, Hao X, Zhang M, Tang W, Yang M, Li L, et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor- initiating cells. PLoS One 2009;4(8):e6816.
8. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, et al. ThemiR-17-92 microRNA polycistron regulatesMLL leukemia stemcell potential bymodulating p21 expression. Cancer Res 2010;70(9):3833-42.
9. Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 2008;10(2):202-10.
10. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008;451(7175):147-52.
11. Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007;449(7163):682-8. (Pubitemid 47552092)
12. Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 2008;18(3):350-9. (Pubitemid 351333899)
13. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, et al. MicroRNA-21 post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008;27(15):2128-36. (Pubitemid 351485639)
14. Yoshihara K, Tajima A, Komata D, Yamamoto T, Kodama S, Fujiwara H, et al. Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis. Cancer Sci 2009;100(8):1421-8.
15. Baba T, Convery PA, Matsumura N,Whitaker RS, Kondoh E, Perry T, et al. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene 2009;28(2):209-18.
16. Guo R, Wu Q, Liu F, Wang Y. Description of the CD133+ subpopulation of the human ovarian cancer cell line OVCAR3. Oncol Rep 2011;25(1):141-6.
17. Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressor ZEB1 and ZEB2. Genes Dev 2008;22(7):894-907. (Pubitemid 351482843)
18. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting- ZEB1 and SIP1. Nat Cell Biol 2008;10(5):593-601. (Pubitemid 351627379)
19. Korpal M, Lee ES, Hu G, Kang Y, et al. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressor ZEB1 and ZEB2. J Biol Chem 2008;283(22):14910-4.
20. Xia M, Hu M, Wang J, Xu Y, Chen X, Ma Y, et al. Identification of the role of Smad interacting protein 1 (SIP1) in glioma. J Neurooncol 2010;97(2):225-32.
21. Das S, Becker BN, Hoffmann FM, Mertz JE. Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway. BMC Cell Biol 2009 Dec 21;10:94.
22. Graham TR, Zhau HE, Odero-Marah VA, Osunkoya AO, Kimbro KS, Tighiouart M, et al. Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to- mesenchymal transition in human prostate cancer cells. Cancer Res 2008;68(7):2479-88. (Pubitemid 351521824)
23. Hu X, Macdonald DM, Huettner PC, Feng Z, El Naqa IM, Schwarz JK, et al. A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecol Oncol 2009;114(3):457-64.
24. Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009;138(3):592-603.
25. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003;115(7):787-98. (Pubitemid 38058492)
26. Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, Mourelatos Z, et al. A combined computational-experimental approach predicts human microRNA targets. Genes Dev 2004;18(10):1165-78. (Pubitemid 38669037)