DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

Nature Chemical Biology

Volumn 8, Issue 12, 2012, Pages 999-1007

  Hsu, Ku Lung ^a   Tsuboi, Katsunori ^a   Adibekian, Alexander ^a   Pugh, Holly ^a   Masuda, Kim ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ENZYME INHIBITOR; ICOSANOID; KT 109; KT 172; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A2; SERINE DEHYDRATASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME RELEASE; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; CELL LINE; CYTOKINES; DRUG DISCOVERY; ENDOCANNABINOIDS; GLYCERIDES; INFLAMMATION; LIPID METABOLISM; LIPOPROTEIN LIPASE; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; NEURONS; PROSTAGLANDINS; PROTEIN ISOFORMS; PROTEOME; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SIGNAL TRANSDUCTION; TRIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84870373692     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1105     Document Type: Article

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