Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 17, 2011, Pages 6811-6816

  Bachovchin, Daniel A ^a   Mohr, Justin T ^b   Speers, Anna E ^a   Wang, Chu ^a   Berlin, Jacob M ^b   Spicer, Timothy P ^c   Fernandez Vega, Virneliz ^c   Chase, Peter ^c   Hodder, Peter S ^c   Schürer, Stephan C ^c   Nomura, Daniel K ^a   Rosen, Hugh ^a   Fu, Gregory C ^b   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIAZETIDIN 3 ONE DERIVATIVE; ABL 112; ABL 127; BETA LACTAM DERIVATIVE; HETEROCYCLIC COMPOUND; PHOSPHATASE METHYLESTERASE 1; PHOSPHATASE METHYLESTERASE 1 INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ASSAY; ESTERIFICATION; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOUSE; NEOPLASM; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN TARGETING;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; NATIONAL INSTITUTES OF HEALTH (U.S.); PROTEIN PHOSPHATASE 2; UNITED STATES;

MUS;

EID: 79955554526     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015248108     Document Type: Article

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