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Volumn 16, Issue 6, 2012, Pages 269-275

Multifunctional nanocarriers and intracellular drug delivery

Author keywords

Cell penetrating peptide; Intracellular delivery; Ligand targeted; Long circulating; Multimodal imaging; Nanocarriers; Stimuli sensitive; Theranostics

Indexed keywords

CONTROLLED DRUG DELIVERY; DIAGNOSIS; DISEASE CONTROL; DISEASES;

EID: 84875238035     PISSN: 13590286     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cossms.2012.09.001     Document Type: Review
Times cited : (43)

References (111)
  • 1
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: Opportunities and challenges
    • M. Ferrari Cancer nanotechnology: opportunities and challenges Nat Rev Cancer 5 2005 161 171
    • (2005) Nat Rev Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 3
    • 0033302303 scopus 로고    scopus 로고
    • Transport of molecules, particles, and cells in solid tumors
    • R.K. Jain Transport of molecules, particles, and cells in solid tumors Annu Rev Biomed Eng 1 1999 241 263
    • (1999) Annu Rev Biomed Eng , vol.1 , pp. 241-263
    • Jain, R.K.1
  • 4
    • 0024505574 scopus 로고
    • Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
    • R.K. Jain Delivery of novel therapeutic agents in tumors: physiological barriers and strategies J Natl Cancer Inst 81 1989 570 576
    • (1989) J Natl Cancer Inst , vol.81 , pp. 570-576
    • Jain, R.K.1
  • 5
    • 0028304405 scopus 로고
    • Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
    • F. Yuan, M. Leunig, S.K. Huang, D.A. Berk, D. Papahadjopoulos, and R.K. Jain Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft Cancer Res 54 1994 3352 3356
    • (1994) Cancer Res , vol.54 , pp. 3352-3356
    • Yuan, F.1    Leunig, M.2    Huang, S.K.3    Berk, D.A.4    Papahadjopoulos, D.5    Jain, R.K.6
  • 6
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 46 1986 6387 6392
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 7
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting
    • H. Maeda The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting Adv Enzyme Regul 41 2001 189 207
    • (2001) Adv Enzyme Regul , vol.41 , pp. 189-207
    • Maeda, H.1
  • 8
    • 0035291191 scopus 로고    scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy
    • H. Maeda SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy Adv Drug Deliv Rev 46 2001 169 185
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 169-185
    • Maeda, H.1
  • 9
    • 0037508920 scopus 로고    scopus 로고
    • Factors and mechanism of "ePR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS
    • J. Fang, T. Sawa, and H. Maeda Factors and mechanism of "EPR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS Adv Exp Med Biol 519 2003 29 49
    • (2003) Adv Exp Med Biol , vol.519 , pp. 29-49
    • Fang, J.1    Sawa, T.2    Maeda, H.3
  • 10
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
    • H. Maeda Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects Bioconjug Chem 21 2010 797 802
    • (2010) Bioconjug Chem , vol.21 , pp. 797-802
    • Maeda, H.1
  • 11
    • 60749108001 scopus 로고    scopus 로고
    • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    • H. Maeda, G.Y. Bharate, and J. Daruwalla Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect Eur J Pharm Biopharm 71 2009 409 419
    • (2009) Eur J Pharm Biopharm , vol.71 , pp. 409-419
    • Maeda, H.1    Bharate, G.Y.2    Daruwalla, J.3
  • 12
    • 0021968171 scopus 로고
    • Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium
    • S. Maki, T. Konno, and H. Maeda Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium Cancer 56 1985 751 757
    • (1985) Cancer , vol.56 , pp. 751-757
    • Maki, S.1    Konno, T.2    Maeda, H.3
  • 13
    • 70449374917 scopus 로고    scopus 로고
    • Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: Cases of advanced solid tumors
    • A. Nagamitsu, K. Greish, and H. Maeda Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors Jpn J Clin Oncol 39 2009 756 766
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 756-766
    • Nagamitsu, A.1    Greish, K.2    Maeda, H.3
  • 14
    • 0033567094 scopus 로고    scopus 로고
    • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor
    • W.L. Monsky, D. Fukumura, T. Gohongi, M. Ancukiewcz, H.A. Weich, and V.P. Torchilin Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor Cancer Res 59 1999 4129 4135
    • (1999) Cancer Res , vol.59 , pp. 4129-4135
    • Monsky, W.L.1    Fukumura, D.2    Gohongi, T.3    Ancukiewcz, M.4    Weich, H.A.5    Torchilin, V.P.6
  • 15
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • R.K. Jain, and T. Stylianopoulos Delivering nanomedicine to solid tumors Nat Rev Clin Oncol 7 2010 653 664
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 16
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • A.L. Klibanov, K. Maruyama, V.P. Torchilin, and L. Huang Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett 268 1990 235 237
    • (1990) FEBS Lett , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 17
    • 84856436072 scopus 로고    scopus 로고
    • Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake
    • C.D. Walkey, J.B. Olsen, H. Guo, A. Emili, and W.C. Chan Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake J Am Chem Soc 134 2012 2139 2147
    • (2012) J Am Chem Soc , vol.134 , pp. 2139-2147
    • Walkey, C.D.1    Olsen, J.B.2    Guo, H.3    Emili, A.4    Chan, W.C.5
  • 18
    • 84867468134 scopus 로고    scopus 로고
    • PEGylated PRINT nanoparticles: The impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics
    • J.L. Perry, K.G. Reuter, M.P. Kai, K.P. Herlihy, S.W. Jones, and J.C. Luft PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics Nano Lett 2012
    • (2012) Nano Lett
    • Perry, J.L.1    Reuter, K.G.2    Kai, M.P.3    Herlihy, K.P.4    Jones, S.W.5    Luft, J.C.6
  • 21
    • 33645815708 scopus 로고    scopus 로고
    • Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes
    • T. Ishida, M. Ichihara, X. Wang, K. Yamamoto, J. Kimura, and E. Majima Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes J Control Release 112 2006 15 25
    • (2006) J Control Release , vol.112 , pp. 15-25
    • Ishida, T.1    Ichihara, M.2    Wang, X.3    Yamamoto, K.4    Kimura, J.5    Majima, E.6
  • 22
    • 33750345700 scopus 로고    scopus 로고
    • Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection
    • T. Ishida, K. Atobe, X. Wang, and H. Kiwada Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin- encapsulation and high-dose first injection J Control Release 115 2006 251 258
    • (2006) J Control Release , vol.115 , pp. 251-258
    • Ishida, T.1    Atobe, K.2    Wang, X.3    Kiwada, H.4
  • 23
    • 0035191756 scopus 로고    scopus 로고
    • Poly(Hpma)-coated liposomes demonstrate prolonged circulation in mice
    • K.R. Whiteman, V. Subr, K. Ulbrich, and V.P. Torchilin Poly(Hpma)-coated liposomes demonstrate prolonged circulation in mice J Liposome Res 11 2001 153 164
    • (2001) J Liposome Res , vol.11 , pp. 153-164
    • Whiteman, K.R.1    Subr, V.2    Ulbrich, K.3    Torchilin, V.P.4
  • 25
    • 0035838391 scopus 로고    scopus 로고
    • Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats
    • H. Takeuchi, H. Kojima, H. Yamamoto, and Y. Kawashima Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats J Control Release 75 2001 83 91
    • (2001) J Control Release , vol.75 , pp. 83-91
    • Takeuchi, H.1    Kojima, H.2    Yamamoto, H.3    Kawashima, Y.4
  • 26
    • 0026742081 scopus 로고
    • Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium
    • V.P. Torchilin, A.L. Klibanov, L. Huang, S. O'Donnell, N.D. Nossiff, and B.A. Khaw Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium Faseb J 6 1992 2716 2719
    • (1992) Faseb J , vol.6 , pp. 2716-2719
    • Torchilin, V.P.1    Klibanov, A.L.2    Huang, L.3    O'Donnell, S.4    Nossiff, N.D.5    Khaw, B.A.6
  • 27
    • 0027399121 scopus 로고
    • Molecular mechanism of the lipid vesicle longevity in vivo
    • G. Blume, and G. Cevc Molecular mechanism of the lipid vesicle longevity in vivo Biochim Biophys Acta 1146 1993 157 168
    • (1993) Biochim Biophys Acta , vol.1146 , pp. 157-168
    • Blume, G.1    Cevc, G.2
  • 28
    • 0036334957 scopus 로고    scopus 로고
    • The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients
    • R.M. Abra, R.B. Bankert, F. Chen, N.K. Egilmez, K. Huang, and R. Saville The next generation of liposome delivery systems: recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients J Liposome Res 12 2002 1 3
    • (2002) J Liposome Res , vol.12 , pp. 1-3
    • Abra, R.M.1    Bankert, R.B.2    Chen, F.3    Egilmez, N.K.4    Huang, K.5    Saville, R.6
  • 30
    • 84860774962 scopus 로고    scopus 로고
    • Challenges in development of targeted liposomal therapeutics
    • R.R. Sawant, and V.P. Torchilin Challenges in development of targeted liposomal therapeutics AAPS J 14 2012 303 315
    • (2012) AAPS J , vol.14 , pp. 303-315
    • Sawant, R.R.1    Torchilin, V.P.2
  • 31
    • 60749121731 scopus 로고    scopus 로고
    • Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
    • V. Torchilin Multifunctional and stimuli-sensitive pharmaceutical nanocarriers Eur J Pharm Biopharm 71 2009 431 444
    • (2009) Eur J Pharm Biopharm , vol.71 , pp. 431-444
    • Torchilin, V.1
  • 32
    • 34249820576 scopus 로고    scopus 로고
    • Multifunctional nanocarriers
    • V.P. Torchilin Multifunctional nanocarriers Adv Drug Deliv Rev 58 2006 1532 1555
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1532-1555
    • Torchilin, V.P.1
  • 33
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • J.L. Wike-Hooley, J. Haveman, and H.S. Reinhold The relevance of tumour pH to the treatment of malignant disease Radiother Oncol 2 1984 343 366
    • (1984) Radiother Oncol , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 34
    • 0024311944 scopus 로고
    • Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts
    • F. Kallinowski, K.H. Schlenger, S. Runkel, M. Kloes, M. Stohrer, and P. Okunieff Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts Cancer Res 49 1989 3759 3764
    • (1989) Cancer Res , vol.49 , pp. 3759-3764
    • Kallinowski, F.1    Schlenger, K.H.2    Runkel, S.3    Kloes, M.4    Stohrer, M.5    Okunieff, P.6
  • 35
    • 0030614893 scopus 로고    scopus 로고
    • 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nat Med 3 1997 177 182
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 36
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
    • L.E. Gerweck, and K. Seetharaman Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer Cancer Res 56 1996 1194 1198
    • (1996) Cancer Res , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 37
    • 0028893192 scopus 로고
    • Kinetic analysis of endocytosis and intracellular fate of liposomes in single macrophages
    • T. Yoshimura, M. Shono, K. Imai, and K. Hong Kinetic analysis of endocytosis and intracellular fate of liposomes in single macrophages J Biochem 117 1995 34 41
    • (1995) J Biochem , vol.117 , pp. 34-41
    • Yoshimura, T.1    Shono, M.2    Imai, K.3    Hong, K.4
  • 38
    • 0347926091 scopus 로고    scopus 로고
    • Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities
    • G. Saito, J.A. Swanson, and K.D. Lee Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities Adv Drug Deliv Rev 55 2003 199 215
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 199-215
    • Saito, G.1    Swanson, J.A.2    Lee, K.D.3
  • 39
    • 79958176375 scopus 로고    scopus 로고
    • Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
    • R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, and Z. Zhong Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery J Control Release 152 2011 2 12
    • (2011) J Control Release , vol.152 , pp. 2-12
    • Cheng, R.1    Feng, F.2    Meng, F.3    Deng, C.4    Feijen, J.5    Zhong, Z.6
  • 40
    • 0034161921 scopus 로고    scopus 로고
    • A new temperature-sensitive liposome for use with mild hyperthermia: Characterization and testing in a human tumor xenograft model
    • D. Needham, G. Anyarambhatla, G. Kong, and M.W. Dewhirst A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model Cancer Res 60 2000 1197 1201
    • (2000) Cancer Res , vol.60 , pp. 1197-1201
    • Needham, D.1    Anyarambhatla, G.2    Kong, G.3    Dewhirst, M.W.4
  • 41
    • 61349107152 scopus 로고    scopus 로고
    • Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes
    • L. Zhu, Z. Huo, L. Wang, X. Tong, Y. Xiao, and K. Ni Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes Int J Pharm 370 2009 136 143
    • (2009) Int J Pharm , vol.370 , pp. 136-143
    • Zhu, L.1    Huo, Z.2    Wang, L.3    Tong, X.4    Xiao, Y.5    Ni, K.6
  • 44
    • 0026786522 scopus 로고
    • Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: Comparison with cationic liposomes
    • J.Y. Legendre, and F.C. Szoka Jr. Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes Pharm Res 9 1992 1235 1242
    • (1992) Pharm Res , vol.9 , pp. 1235-1242
    • Legendre, J.Y.1    Szoka, Jr.F.C.2
  • 45
    • 0033973288 scopus 로고    scopus 로고
    • Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior
    • I.M. Hafez, and P.R. Cullis Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior Biochim Biophys Acta 1463 2000 107 114
    • (2000) Biochim Biophys Acta , vol.1463 , pp. 107-114
    • Hafez, I.M.1    Cullis, P.R.2
  • 46
    • 0031032815 scopus 로고    scopus 로고
    • Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo
    • V.A. Slepushkin, S. Simoes, P. Dazin, M.S. Newman, L.S. Guo, and M.C. Pedroso de Lima Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo J Biol Chem 272 1997 2382 2388
    • (1997) J Biol Chem , vol.272 , pp. 2382-2388
    • Slepushkin, V.A.1    Simoes, S.2    Dazin, P.3    Newman, M.S.4    Guo, L.S.5    Pedroso De Lima, M.C.6
  • 47
    • 0028199067 scopus 로고
    • The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems
    • C. Plank, B. Oberhauser, K. Mechtler, C. Koch, and E. Wagner The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems J Biol Chem 269 1994 12918 12924
    • (1994) J Biol Chem , vol.269 , pp. 12918-12924
    • Plank, C.1    Oberhauser, B.2    Mechtler, K.3    Koch, C.4    Wagner, E.5
  • 48
    • 0031825183 scopus 로고    scopus 로고
    • Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides
    • S. Simoes, V. Slepushkin, R. Gaspar, M.C. de Lima, and N. Duzgunes Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides Gene Ther 5 1998 955 964
    • (1998) Gene Ther , vol.5 , pp. 955-964
    • Simoes, S.1    Slepushkin, V.2    Gaspar, R.3    De Lima, M.C.4    Duzgunes, N.5
  • 49
    • 49049118656 scopus 로고    scopus 로고
    • An artificial virus-like nano carrier system: Enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives
    • K. Sasaki, K. Kogure, S. Chaki, Y. Nakamura, R. Moriguchi, and H. Hamada An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives Anal Bioanal Chem 391 2008 2717 2727
    • (2008) Anal Bioanal Chem , vol.391 , pp. 2717-2727
    • Sasaki, K.1    Kogure, K.2    Chaki, S.3    Nakamura, Y.4    Moriguchi, R.5    Hamada, H.6
  • 50
    • 14644423915 scopus 로고    scopus 로고
    • Differential cytosolic delivery and presentation of antigen by listeriolysin O-liposomes to macrophages and dendritic cells
    • E.M. Stier, M. Mandal, and K.D. Lee Differential cytosolic delivery and presentation of antigen by listeriolysin O-liposomes to macrophages and dendritic cells Mol Pharm 2 2005 74 82
    • (2005) Mol Pharm , vol.2 , pp. 74-82
    • Stier, E.M.1    Mandal, M.2    Lee, K.D.3
  • 51
    • 0033752806 scopus 로고    scopus 로고
    • Current status of pH-sensitive liposomes in drug delivery
    • D.C. Drummond, M. Zignani, and J. Leroux Current status of pH-sensitive liposomes in drug delivery Prog Lipid Res 39 2000 409 460
    • (2000) Prog Lipid Res , vol.39 , pp. 409-460
    • Drummond, D.C.1    Zignani, M.2    Leroux, J.3
  • 53
    • 1942438691 scopus 로고    scopus 로고
    • Membrane-destabilizing polyanions: Interaction with lipid bilayers and endosomal escape of biomacromolecules
    • M.A. Yessine, and J.C. Leroux Membrane-destabilizing polyanions: interaction with lipid bilayers and endosomal escape of biomacromolecules Adv Drug Deliv Rev 56 2004 999 1021
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 999-1021
    • Yessine, M.A.1    Leroux, J.C.2
  • 54
    • 0037954557 scopus 로고    scopus 로고
    • Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles
    • R.A. Jones, C.Y. Cheung, F.E. Black, J.K. Zia, P.S. Stayton, and A.S. Hoffman Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles Biochem J 372 2003 65 75
    • (2003) Biochem J , vol.372 , pp. 65-75
    • Jones, R.A.1    Cheung, C.Y.2    Black, F.E.3    Zia, J.K.4    Stayton, P.S.5    Hoffman, A.S.6
  • 56
    • 0032472276 scopus 로고    scopus 로고
    • Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes
    • O. Meyer, D. Papahadjopoulos, and J.C. Leroux Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes FEBS Lett 421 1998 61 64
    • (1998) FEBS Lett , vol.421 , pp. 61-64
    • Meyer, O.1    Papahadjopoulos, D.2    Leroux, J.C.3
  • 57
    • 0033954201 scopus 로고    scopus 로고
    • In vitro characterization of a novel polymeric-based pH-sensitive liposome system
    • M. Zignani, D.C. Drummond, O. Meyer, K. Hong, and J.C. Leroux In vitro characterization of a novel polymeric-based pH-sensitive liposome system Biochim Biophys Acta 1463 2000 383 394
    • (2000) Biochim Biophys Acta , vol.1463 , pp. 383-394
    • Zignani, M.1    Drummond, D.C.2    Meyer, O.3    Hong, K.4    Leroux, J.C.5
  • 58
    • 0027936349 scopus 로고
    • Novel pH-sensitive liposomes: Liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups
    • K. Kono, K. Zenitani, and T. Takagishi Novel pH-sensitive liposomes: liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups Biochim Biophys Acta 1193 1994 1 9
    • (1994) Biochim Biophys Acta , vol.1193 , pp. 1-9
    • Kono, K.1    Zenitani, K.2    Takagishi, T.3
  • 59
    • 0037177486 scopus 로고    scopus 로고
    • Targetability and intracellular delivery of anti-BCG antibody-modified, pH-sensitive fusogenic immunoliposomes to tumor cells
    • T. Mizoue, T. Horibe, K. Maruyama, T. Takizawa, M. Iwatsuru, and K. Kono Targetability and intracellular delivery of anti-BCG antibody-modified, pH-sensitive fusogenic immunoliposomes to tumor cells Int J Pharm 237 2002 129 137
    • (2002) Int J Pharm , vol.237 , pp. 129-137
    • Mizoue, T.1    Horibe, T.2    Maruyama, K.3    Takizawa, T.4    Iwatsuru, M.5    Kono, K.6
  • 60
    • 44349138168 scopus 로고    scopus 로고
    • Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: Their ability to sensitize stable liposomes to pH
    • N. Sakaguchi, C. Kojima, A. Harada, and K. Kono Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH Bioconjug Chem 19 2008 1040 1048
    • (2008) Bioconjug Chem , vol.19 , pp. 1040-1048
    • Sakaguchi, N.1    Kojima, C.2    Harada, A.3    Kono, K.4
  • 61
    • 0021963363 scopus 로고
    • PH-sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules
    • R.M. Straubinger, N. Duzgunes, and D. Papahadjopoulos PH-sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules FEBS Lett 179 1985 148 154
    • (1985) FEBS Lett , vol.179 , pp. 148-154
    • Straubinger, R.M.1    Duzgunes, N.2    Papahadjopoulos, D.3
  • 63
    • 70349798806 scopus 로고    scopus 로고
    • Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice
    • I.Y. Kim, Y.S. Kang, D.S. Lee, H.J. Park, E.K. Choi, and Y.K. Oh Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice J Control Release 140 2009 55 60
    • (2009) J Control Release , vol.140 , pp. 55-60
    • Kim, I.Y.1    Kang, Y.S.2    Lee, D.S.3    Park, H.J.4    Choi, E.K.5    Oh, Y.K.6
  • 64
    • 0038812123 scopus 로고    scopus 로고
    • Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes
    • L. Xu, C.C. Huang, W. Huang, W.H. Tang, A. Rait, and Y.Z. Yin Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes Mol Cancer Ther 1 2002 337 346
    • (2002) Mol Cancer Ther , vol.1 , pp. 337-346
    • Xu, L.1    Huang, C.C.2    Huang, W.3    Tang, W.H.4    Rait, A.5    Yin, Y.Z.6
  • 65
    • 0037161316 scopus 로고    scopus 로고
    • Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations
    • G. Shi, W. Guo, S.M. Stephenson, and R.J. Lee Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations J Control Release 80 2002 309 319
    • (2002) J Control Release , vol.80 , pp. 309-319
    • Shi, G.1    Guo, W.2    Stephenson, S.M.3    Lee, R.J.4
  • 66
    • 0037136042 scopus 로고    scopus 로고
    • A novel pH-sensitive liposome formulation containing oleyl alcohol
    • J.J. Sudimack, W. Guo, W. Tjarks, and R.J. Lee A novel pH-sensitive liposome formulation containing oleyl alcohol Biochim Biophys Acta 1564 2002 31 37
    • (2002) Biochim Biophys Acta , vol.1564 , pp. 31-37
    • Sudimack, J.J.1    Guo, W.2    Tjarks, W.3    Lee, R.J.4
  • 67
    • 0029877551 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine
    • J.W. Holland, C. Hui, P.R. Cullis, and T.D. Madden Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine Biochemistry 35 1996 2618 2624
    • (1996) Biochemistry , vol.35 , pp. 2618-2624
    • Holland, J.W.1    Hui, C.2    Cullis, P.R.3    Madden, T.D.4
  • 68
    • 0347756920 scopus 로고    scopus 로고
    • Use of block copolymers of poly(ortho esters) and poly (ethylene glycol) micellar carriers as potential tumour targeting systems
    • V. Toncheva, E. Schacht, S.Y. Ng, J. Barr, and J. Heller Use of block copolymers of poly(ortho esters) and poly (ethylene glycol) micellar carriers as potential tumour targeting systems J Drug Target 11 2003 345 353
    • (2003) J Drug Target , vol.11 , pp. 345-353
    • Toncheva, V.1    Schacht, E.2    Ng, S.Y.3    Barr, J.4    Heller, J.5
  • 69
    • 0141921478 scopus 로고    scopus 로고
    • Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids
    • J. Shin, P. Shum, and D.H. Thompson Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids J Control Release 91 2003 187 200
    • (2003) J Control Release , vol.91 , pp. 187-200
    • Shin, J.1    Shum, P.2    Thompson, D.H.3
  • 70
    • 11144308851 scopus 로고    scopus 로고
    • Release kinetics of bovine serum albumin from pH-sensitive poly(vinyl ether) based hydrogels
    • M. Gumusderelioglu, and D. Kesgin Release kinetics of bovine serum albumin from pH-sensitive poly(vinyl ether) based hydrogels Int J Pharm 288 2005 273 279
    • (2005) Int J Pharm , vol.288 , pp. 273-279
    • Gumusderelioglu, M.1    Kesgin, D.2
  • 71
    • 0031981046 scopus 로고    scopus 로고
    • Albumin conjugates of the anticancer drug chlorambucil: Synthesis, characterization, and in vitro efficacy
    • F. Kratz, U. Beyer, T. Roth, M.T. Schutte, A. Unold, and H.H. Fiebig Albumin conjugates of the anticancer drug chlorambucil: synthesis, characterization, and in vitro efficacy Arch Pharm (Weinheim) 331 1998 47 53
    • (1998) Arch Pharm (Weinheim) , vol.331 , pp. 47-53
    • Kratz, F.1    Beyer, U.2    Roth, T.3    Schutte, M.T.4    Unold, A.5    Fiebig, H.H.6
  • 72
    • 0031855765 scopus 로고    scopus 로고
    • Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil
    • U. Beyer, T. Roth, P. Schumacher, G. Maier, A. Unold, and A.W. Frahm Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil J Med Chem 41 1998 2701 2708
    • (1998) J Med Chem , vol.41 , pp. 2701-2708
    • Beyer, U.1    Roth, T.2    Schumacher, P.3    Maier, G.4    Unold, A.5    Frahm, A.W.6
  • 73
    • 0019786031 scopus 로고
    • Cis-Aconityl spacer between daunomycin and macromolecular carriers: A model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate
    • W.C. Shen, and H.J. Ryser Cis-Aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate Biochem Biophys Res Commun 102 1981 1048 1054
    • (1981) Biochem Biophys Res Commun , vol.102 , pp. 1048-1054
    • Shen, W.C.1    Ryser, H.J.2
  • 74
    • 0024840498 scopus 로고
    • Immunoconjugates of doxorubicin and murine antihuman breast carcinoma monoclonal antibodies prepared via an N-hydroxysuccinimide active ester intermediate of cis-aconityl-doxorubicin: Preparation and in vitro cytotoxicity
    • J.R. Ogden, K. Leung, S.A. Kunda, M.W. Telander, B.P. Avner, and S.K. Liao Immunoconjugates of doxorubicin and murine antihuman breast carcinoma monoclonal antibodies prepared via an N-hydroxysuccinimide active ester intermediate of cis-aconityl-doxorubicin: preparation and in vitro cytotoxicity Mol Biother 1 1989 170 174
    • (1989) Mol Biother , vol.1 , pp. 170-174
    • Ogden, J.R.1    Leung, K.2    Kunda, S.A.3    Telander, M.W.4    Avner, B.P.5    Liao, S.K.6
  • 75
    • 4644264045 scopus 로고    scopus 로고
    • Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers
    • E.R. Gillies, T.B. Jonsson, and J.M. Frechet Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers J Am Chem Soc 126 2004 11936 11943
    • (2004) J Am Chem Soc , vol.126 , pp. 11936-11943
    • Gillies, E.R.1    Jonsson, T.B.2    Frechet, J.M.3
  • 76
    • 15244345124 scopus 로고    scopus 로고
    • PH-responsive copolymer assemblies for controlled release of doxorubicin
    • E.R. Gillies, and J.M. Frechet PH-responsive copolymer assemblies for controlled release of doxorubicin Bioconjug Chem 16 2005 361 368
    • (2005) Bioconjug Chem , vol.16 , pp. 361-368
    • Gillies, E.R.1    Frechet, J.M.2
  • 77
    • 27944508780 scopus 로고    scopus 로고
    • Polyketal nanoparticles: A new pH-sensitive biodegradable drug delivery vehicle
    • M.J. Heffernan, and N. Murthy Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle Bioconjug Chem 16 2005 1340 1342
    • (2005) Bioconjug Chem , vol.16 , pp. 1340-1342
    • Heffernan, M.J.1    Murthy, N.2
  • 78
    • 13644254495 scopus 로고    scopus 로고
    • Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
    • M. Oishi, Y. Nagasaki, K. Itaka, N. Nishiyama, and K. Kataoka Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells J Am Chem Soc 127 2005 1624 1625
    • (2005) J Am Chem Soc , vol.127 , pp. 1624-1625
    • Oishi, M.1    Nagasaki, Y.2    Itaka, K.3    Nishiyama, N.4    Kataoka, K.5
  • 79
    • 78650285457 scopus 로고    scopus 로고
    • Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials
    • M.C. Parrott, J.C. Luft, J.D. Byrne, J.H. Fain, M.E. Napier, and J.M. Desimone Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials J Am Chem Soc 132 2010 17928 17932
    • (2010) J Am Chem Soc , vol.132 , pp. 17928-17932
    • Parrott, M.C.1    Luft, J.C.2    Byrne, J.D.3    Fain, J.H.4    Napier, M.E.5    Desimone, J.M.6
  • 80
    • 80054811455 scopus 로고    scopus 로고
    • Development of the novel PEG-PE-based polymer for the reversible attachment of specific ligands to liposomes: Synthesis and in vitro characterization
    • S. Biswas, N.S. Dodwadkar, R.R. Sawant, and V.P. Torchilin Development of the novel PEG-PE-based polymer for the reversible attachment of specific ligands to liposomes: synthesis and in vitro characterization Bioconjug Chem 22 2011 2005 2013
    • (2011) Bioconjug Chem , vol.22 , pp. 2005-2013
    • Biswas, S.1    Dodwadkar, N.S.2    Sawant, R.R.3    Torchilin, V.P.4
  • 81
    • 77949838958 scopus 로고    scopus 로고
    • Tumor-targeting, pH-responsive, and stable unimolecular micelles as drug nanocarriers for targeted cancer therapy
    • X. Yang, J.J. Grailer, S. Pilla, D.A. Steeber, and S. Gong Tumor-targeting, pH-responsive, and stable unimolecular micelles as drug nanocarriers for targeted cancer therapy Bioconjug Chem 21 2010 496 504
    • (2010) Bioconjug Chem , vol.21 , pp. 496-504
    • Yang, X.1    Grailer, J.J.2    Pilla, S.3    Steeber, D.A.4    Gong, S.5
  • 82
    • 84864622019 scopus 로고    scopus 로고
    • Multifunctional drug delivery system for targeting tumor and its acidic microenvironment
    • M. Shen, Y. Huang, L. Han, J. Qin, X. Fang, and J. Wang Multifunctional drug delivery system for targeting tumor and its acidic microenvironment J Control Release 161 2012 884 892
    • (2012) J Control Release , vol.161 , pp. 884-892
    • Shen, M.1    Huang, Y.2    Han, L.3    Qin, J.4    Fang, X.5    Wang, J.6
  • 84
    • 77952537647 scopus 로고    scopus 로고
    • Multimodality imaging probes: Design and challenges
    • A. Louie Multimodality imaging probes: design and challenges Chem Rev 110 2010 3146 3195
    • (2010) Chem Rev , vol.110 , pp. 3146-3195
    • Louie, A.1
  • 85
    • 34249013777 scopus 로고    scopus 로고
    • In vivo performance of a liposomal vascular contrast agent for CT and MR-based image guidance applications
    • J. Zheng, J. Liu, M. Dunne, D.A. Jaffray, and C. Allen In vivo performance of a liposomal vascular contrast agent for CT and MR-based image guidance applications Pharm Res 24 2007 1193 1201
    • (2007) Pharm Res , vol.24 , pp. 1193-1201
    • Zheng, J.1    Liu, J.2    Dunne, M.3    Jaffray, D.A.4    Allen, C.5
  • 86
    • 69049104359 scopus 로고    scopus 로고
    • Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging
    • S. Santra, C. Kaittanis, J. Grimm, and J.M. Perez Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging Small 5 2009 1862 1868
    • (2009) Small , vol.5 , pp. 1862-1868
    • Santra, S.1    Kaittanis, C.2    Grimm, J.3    Perez, J.M.4
  • 87
    • 78650147756 scopus 로고    scopus 로고
    • Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma
    • F.M. Kievit, O. Veiseh, C. Fang, N. Bhattarai, D. Lee, and R.G. Ellenbogen Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma ACS Nano 4 2010 4587 4594
    • (2010) ACS Nano , vol.4 , pp. 4587-4594
    • Kievit, F.M.1    Veiseh, O.2    Fang, C.3    Bhattarai, N.4    Lee, D.5    Ellenbogen, R.G.6
  • 88
    • 33646382113 scopus 로고    scopus 로고
    • In vivo imaging of tumor response to therapy using a dual-modality imaging strategy
    • Z. Medarova, W. Pham, Y. Kim, G. Dai, and A. Moore In vivo imaging of tumor response to therapy using a dual-modality imaging strategy Int J Cancer 118 2006 2796 2802
    • (2006) Int J Cancer , vol.118 , pp. 2796-2802
    • Medarova, Z.1    Pham, W.2    Kim, Y.3    Dai, G.4    Moore, A.5
  • 89
    • 59149092095 scopus 로고    scopus 로고
    • Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging
    • Z. Medarova, L. Rashkovetsky, P. Pantazopoulos, and A. Moore Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging Cancer Res 69 2009 1182 1189
    • (2009) Cancer Res , vol.69 , pp. 1182-1189
    • Medarova, Z.1    Rashkovetsky, L.2    Pantazopoulos, P.3    Moore, A.4
  • 90
    • 77957358317 scopus 로고    scopus 로고
    • Image-guided breast tumor therapy using a small interfering RNA nanodrug
    • M. Kumar, M. Yigit, G. Dai, A. Moore, and Z. Medarova Image-guided breast tumor therapy using a small interfering RNA nanodrug Cancer Res. 70 2010 7553 7561
    • (2010) Cancer Res. , vol.70 , pp. 7553-7561
    • Kumar, M.1    Yigit, M.2    Dai, G.3    Moore, A.4    Medarova, Z.5
  • 91
    • 33847720312 scopus 로고    scopus 로고
    • In vivo imaging of siRNA delivery and silencing in tumors
    • Z. Medarova, W. Pham, C. Farrar, V. Petkova, and A. Moore In vivo imaging of siRNA delivery and silencing in tumors Nat Med 13 2007 372 377
    • (2007) Nat Med , vol.13 , pp. 372-377
    • Medarova, Z.1    Pham, W.2    Farrar, C.3    Petkova, V.4    Moore, A.5
  • 92
    • 77955209935 scopus 로고    scopus 로고
    • In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles
    • H. Koo, H. Lee, S. Lee, K.H. Min, M.S. Kim, and D.S. Lee In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles Chem Commun (Camb) 46 2010 5668 5670
    • (2010) Chem Commun (Camb) , vol.46 , pp. 5668-5670
    • Koo, H.1    Lee, H.2    Lee, S.3    Min, K.H.4    Kim, M.S.5    Lee, D.S.6
  • 93
    • 84864603886 scopus 로고    scopus 로고
    • Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer
    • T.Y. Lin, H. Zhang, J. Luo, Y. Li, T. Gao, and P.N. Lara Jr. Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer Int J Nanomed 7 2012 2793 2804
    • (2012) Int J Nanomed , vol.7 , pp. 2793-2804
    • Lin, T.Y.1    Zhang, H.2    Luo, J.3    Li, Y.4    Gao, T.5    Lara, Jr.P.N.6
  • 94
    • 84855828471 scopus 로고    scopus 로고
    • Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized beta-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties
    • T. Liu, X. Li, Y. Qian, X. Hu, and S. Liu Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized beta-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties Biomaterials 33 2012 2521 2531
    • (2012) Biomaterials , vol.33 , pp. 2521-2531
    • Liu, T.1    Li, X.2    Qian, Y.3    Hu, X.4    Liu, S.5
  • 95
    • 84859475896 scopus 로고    scopus 로고
    • In vitro targeted imaging and delivery of camptothecin using cetuximab-conjugated multifunctional PLGA-ZnS nanoparticles
    • V.G. Deepagan, B. Sarmento, D. Menon, A. Nascimento, A. Jayasree, and M. Sreeranganathan In vitro targeted imaging and delivery of camptothecin using cetuximab-conjugated multifunctional PLGA-ZnS nanoparticles Nanomedicine (Lond) 7 2012 507 519
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 507-519
    • Deepagan, V.G.1    Sarmento, B.2    Menon, D.3    Nascimento, A.4    Jayasree, A.5    Sreeranganathan, M.6
  • 96
    • 84862815497 scopus 로고    scopus 로고
    • Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking
    • J.M. Li, Y.Y. Wang, M.X. Zhao, C.P. Tan, Y.Q. Li, and X.Y. Le Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking Biomaterials 33 2012 2780 2790
    • (2012) Biomaterials , vol.33 , pp. 2780-2790
    • Li, J.M.1    Wang, Y.Y.2    Zhao, M.X.3    Tan, C.P.4    Li, Y.Q.5    Le, X.Y.6
  • 97
    • 32044451341 scopus 로고    scopus 로고
    • A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors
    • R. Hardman A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors Environ Health Perspect 114 2006 165 172
    • (2006) Environ Health Perspect , vol.114 , pp. 165-172
    • Hardman, R.1
  • 98
    • 78651352062 scopus 로고    scopus 로고
    • Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo
    • G.D. Kenny, N. Kamaly, T.L. Kalber, L.P. Brody, M. Sahuri, and E. Shamsaei Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo J Control Release 149 2011 111 116
    • (2011) J Control Release , vol.149 , pp. 111-116
    • Kenny, G.D.1    Kamaly, N.2    Kalber, T.L.3    Brody, L.P.4    Sahuri, M.5    Shamsaei, E.6
  • 99
    • 84863338346 scopus 로고    scopus 로고
    • Multifunctional nanoparticles for multimodal imaging and theragnosis
    • D.E. Lee, H. Koo, I.C. Sun, J.H. Ryu, K. Kim, and I.C. Kwon Multifunctional nanoparticles for multimodal imaging and theragnosis Chem Soc Rev 41 2012 2656 2672
    • (2012) Chem Soc Rev , vol.41 , pp. 2656-2672
    • Lee, D.E.1    Koo, H.2    Sun, I.C.3    Ryu, J.H.4    Kim, K.5    Kwon, I.C.6
  • 100
    • 77949741829 scopus 로고    scopus 로고
    • Intracellular transduction using cell-penetrating peptides
    • R. Sawant, and V. Torchilin Intracellular transduction using cell-penetrating peptides Mol Biosyst 6 2010 628 640
    • (2010) Mol Biosyst , vol.6 , pp. 628-640
    • Sawant, R.1    Torchilin, V.2
  • 101
    • 50849144942 scopus 로고    scopus 로고
    • Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
    • V.P. Torchilin Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery Biopolymers 90 2008 604 610
    • (2008) Biopolymers , vol.90 , pp. 604-610
    • Torchilin, V.P.1
  • 103
  • 104
    • 84865264919 scopus 로고    scopus 로고
    • Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity
    • E. Koren, A. Apte, A. Jani, and V.P. Torchilin Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity J Control Release 2011
    • (2011) J Control Release
    • Koren, E.1    Apte, A.2    Jani, A.3    Torchilin, V.P.4
  • 105
    • 84860365171 scopus 로고    scopus 로고
    • Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting
    • L. Zhu, P. Kate, and V.P. Torchilin Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting ACS Nano 6 2012 3491 3498
    • (2012) ACS Nano , vol.6 , pp. 3491-3498
    • Zhu, L.1    Kate, P.2    Torchilin, V.P.3
  • 106
    • 79959776093 scopus 로고    scopus 로고
    • Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin
    • X.B. Xiong, and A. Lavasanifar Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin ACS Nano 5 2011 5202 5213
    • (2011) ACS Nano , vol.5 , pp. 5202-5213
    • Xiong, X.B.1    Lavasanifar, A.2
  • 107
    • 33847671358 scopus 로고    scopus 로고
    • TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors
    • V.A. Sethuraman, and Y.H. Bae TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors J Control Release 118 2007 216 224
    • (2007) J Control Release , vol.118 , pp. 216-224
    • Sethuraman, V.A.1    Bae, Y.H.2
  • 109
    • 70349482671 scopus 로고    scopus 로고
    • C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    • T. Teesalu, K.N. Sugahara, V.R. Kotamraju, and E. Ruoslahti C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration Proc Natl Acad Sci USA 106 2009 16157 16162
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16157-16162
    • Teesalu, T.1    Sugahara, K.N.2    Kotamraju, V.R.3    Ruoslahti, E.4
  • 110
    • 34848918210 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    • D.W. Bartlett, H. Su, I.J. Hildebrandt, W.A. Weber, and M.E. Davis Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc Natl Acad Sci USA 104 2007 15549 15554
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 111
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • D.B. Kirpotin, D.C. Drummond, Y. Shao, M.R. Shalaby, K. Hong, and U.B. Nielsen Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models Cancer Res 66 2006 6732 6740
    • (2006) Cancer Res , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6


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