Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats

Journal of Controlled Release

Volumn 75, Issue 1-2, 2001, Pages 83-91

  Takeuchi, Hirofumi ^a   Kojima, Hiroyuki ^a   Yamamoto, Hiromitsu ^a   Kawashima, Yoshiaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Dispersing stability; Liposomes; Long circulating; Molecular weight; Polymer coating; Reticuloendothelial system

Indexed keywords

CHOLESTEROL; DISTEAROYLPHOSPHATIDYLCHOLINE; LIPOSOME; MC 8080; PHOSPHATIDYLCHOLINE; POLYVINYL ALCOHOL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CIRCULATION TIME; CONTROLLED STUDY; DISPERSION; DRUG EFFECT; EVALUATION; HYDRATION; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRASOUND;

ANIMALS; AREA UNDER CURVE; CATTLE; CHEMISTRY, PHYSICAL; DRUG STABILITY; LIPOSOMES; MALE; MOLECULAR WEIGHT; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYL ALCOHOL; RATS; RATS, WISTAR;

EID: 0035838391     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00368-6     Document Type: Article

References (25)

1. Liposomes formulations with prolonged circulation time in blood and enhanced uptake by tumors
2. Liposomes for the sustained release in vivo
3. Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery
4. Fate and behavior of liposomes in vivo: A review of controlling factors
5. Large unilamellar liposomes with low uptake into the reticuloendothelial system
6. Liposomes with prolonged circulation times: Factors affecting uptake by reticuloendothelial and other tissues
7. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
8. Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
9. Glucuronate-modified liposomes with prolonged circulation time
10. Prolonged circulation time of doxorubicin loaded liposomes coated with a modified polyvinyl alcohol after intravenous injection in rats
11. Enhanced tumor accumulation of doxorubicin with polymer-coated liposomes in rats
12. Polymer coating of liposomes with a modified polyvinyl alcohol and their systemic circulation and RES uptake in rats
13. Why do polyethylene glycol coated liposomes circulate so long?
14. The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes
15. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesicles
16. Effect of polyethyleneglycol chain length and phospholipid acyl chain composition on the interaction of polyethyleneglycol-phospholipid conjugates with phospholipid: Implications in liposomal drug delivery
17. The role of surface charge and hydrophilic groups on liposome clearance in vivo
18. Repulsive interactions and mechanical stability if polymer grafted lipid membranes
19. Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin
20. Physical stability of size controlled small unilamellar liposomes coated with a modified polyvinyl alcohol
21. Effect of molecular weight in amphipathic polyethyleneglycol on prolonging the circulation time of large unilamellar liposomes
22. Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoyl phosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol)
23. Influence of the steric barrier activity if amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes
24. Targeted delivery of diagnostic agents by surface-modified liposomes
25. Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice