Targetability and intracellular delivery of anti-BCG antibody-modified, pH-sensitive fusogenic immunoliposomes to tumor cells

International Journal of Pharmaceutics

Volumn 237, Issue 1-2, 2002, Pages 129-137

  Mizoue, Toshiro ^a   Horibe, Toshiya ^a   Maruyama, Kazuo ^b   Takizawa, Tomoko ^b   Iwatsuru, Motoharu ^b   Kono, Kenji ^c   Yanagie, Hironobu ^d   Moriyasu, Fuminori ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

^c Osaka Prefecture University   (Japan)

^d TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

BCG; Drug delivery system; Immunoliposome; Liposome; pH sensitive liposome

Indexed keywords

GLYCIDOL; IMMUNOLIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BCG POLYGLYCIDOL COMPLEX; PHOSPHATIDYLETHANOLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOCYTOSIS; FLUORESCENCE MICROSCOPY; INTERNALIZATION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; TARGET CELL;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; CATTLE; DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; IMMUNOTOXINS; INTRACELLULAR FLUID; LIPOSOMES; MICE; MYCOBACTERIUM BOVIS; TUMOR CELLS, CULTURED;

EID: 0037177486     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00044-3     Document Type: Article

References (14)

1. Formation and properties of 1000-Å-diameter, single-bilayer phospholipid vesicles
2. Liposomes as vehicles for targeted therapy of cancer. Part 1: Preclinical development
3. Liposomes as vehicles for targeted therapy of cancer. Part 2: Clinical development
4. Extravascular transport in normal and tumor tissue
5. Fusion activity of an amphiphilic polypeptide having acidic amino acid residues: Generation of fusion activity by α-helix formation and charge neutralization
6. Novel pH-sensitive liposomes: Liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups
7. Cytoplasmic delivery of calcein mediated by liposomes modified with a pH-sensitive poly(ethylene glycol) derivative
8. Novel gene delivery systems: Complexes of fusogenic polymer-modified liposomes and lipoplexes
9. Measurement of endosome pH following folate receptor-mediated endocytosis
10. Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies
11. Immunoliposomes bearing polyethyleneglycol-coupled Fab′ fragment show prolonged circulation time and high extravasation
12. Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo
13. Shared antigen between BCG and tumor cells-immunotherapy with BCG for mouse tumor
14. Distribution of BCG antigens among mouse-tumor cells